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Volumn 91, Issue 1, 2012, Pages 109-122

Anacetrapib, a novel CETP inhibitor: Pursuing a new approach to cardiovascular risk reduction

Author keywords

[No Author keywords available]

Indexed keywords

ANACETRAPIB; ATORVASTATIN; CHOLESTEROL ESTER TRANSFER PROTEIN; DALCETRAPIB; DIGOXIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PLACEBO; TORCETRAPIB; WARFARIN;

EID: 84055207675     PISSN: 00099236     EISSN: 15326535     Source Type: Journal    
DOI: 10.1038/clpt.2011.271     Document Type: Review
Times cited : (60)

References (92)
  • 1
    • 26244432388 scopus 로고    scopus 로고
    • Efficacy and safety of cholesterol-lowering treatment: Prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins
    • Baigent, C.et al. Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins. Lancet 366, 1267-1278 (2005).
    • (2005) Lancet , vol.366 , pp. 1267-1278
    • Baigent, C.1
  • 2
    • 79960165059 scopus 로고    scopus 로고
    • Biphenyl-substituted oxazolidinones as cholesteryl ester transfer protein inhibitors: Modifications of the oxazolidinone ring leading to the discovery of anacetrapib
    • Smith, C.J.et al. Biphenyl-substituted oxazolidinones as cholesteryl ester transfer protein inhibitors: modifications of the oxazolidinone ring leading to the discovery of anacetrapib. J. Med. Chem. 54, 4880-4895 (2011).
    • (2011) J. Med. Chem. , vol.54 , pp. 4880-4895
    • Smith, C.J.1
  • 4
    • 40749124632 scopus 로고    scopus 로고
    • American Heart Association Statistics Committee and Stroke Statistics Subcommittee
    • A merican Heart Association Statistics Committee and Stroke Statistics Subcommittee. Heart Disease and Stroke Statistics-2008 Update 〈http://circ. ahajournals.org/content/117/4/e25.full〉 (2008).
    • (2008) Heart Disease and Stroke Statistics-2008 Update
  • 5
    • 84855600696 scopus 로고    scopus 로고
    • World Health Organization The top 10 causes of death
    • World Health Organization. The top 10 causes of death 〈http://www.who.int/mediacentre/factsheets/fs310/en/index.html〉.
  • 7
    • 77954866498 scopus 로고    scopus 로고
    • PRIME Study Group. Relative contribution of lipids and apolipoproteins to incident coronary heart disease and ischemic stroke: The PRIME Study
    • Canou-Poitrine, F. et al.; PRIME Study Group. Relative contribution of lipids and apolipoproteins to incident coronary heart disease and ischemic stroke: the PRIME Study. Cerebrovasc. Dis. 30, 252-259 (2010).
    • (2010) Cerebrovasc. Dis. , vol.30 , pp. 252-259
    • Canou-Poitrine, F.1
  • 8
    • 70450081001 scopus 로고    scopus 로고
    • Emerging Risk Factors Collaboration. Major lipids apolipoproteins and risk of vascular disease
    • Di Angelantonio, E. et al.; Emerging Risk Factors Collaboration. Major lipids, apolipoproteins, and risk of vascular disease. JAMA 302, 1993-2000 (2009).
    • (2009) JAMA , vol.302 , pp. 1993-2000
    • Di Angelantonio, E.1
  • 9
    • 0027987849 scopus 로고
    • Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: The Scandinavian Simvastatin Survival Study (4S)
    • Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S). Lancet 344, 1383-1389 (1994).
    • (1994) Lancet , vol.344 , pp. 1383-1389
  • 10
    • 0028883828 scopus 로고
    • Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. West of Scotland Coronary Prevention Study Group
    • Shepherd, J. et al. Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. West of Scotland Coronary Prevention Study Group. N. Engl. J. Med. 333, 1301-1307 (1995).
    • (1995) N. Engl. J. Med. , vol.333 , pp. 1301-1307
    • Shepherd, J.1
  • 12
    • 79958148945 scopus 로고    scopus 로고
    • European atherosclerosis society consensus panel. Triglyceride-rich lipoproteins and high-density lipoprotein cholesterol in patients at high risk of cardiovascular disease: Evidence and guidance for management
    • Chapman, M.J. et al.; European Atherosclerosis Society Consensus Panel. Triglyceride-rich lipoproteins and high-density lipoprotein cholesterol in patients at high risk of cardiovascular disease: evidence and guidance for management. Eur. Heart J. 32, 1345-1361 (2011).
    • (2011) Eur. Heart J. , vol.32 , pp. 1345-1361
    • Chapman, M.J.1
  • 13
    • 77955981022 scopus 로고    scopus 로고
    • High-density lipoproteins suppress chemokines and chemokine receptors in vitro and in vivo
    • Bursill, C.A. et al. High-density lipoproteins suppress chemokines and chemokine receptors in vitro and in vivo. Arterioscler. Thromb. Vasc. Biol. 30, 1773-1778 (2010).
    • (2010) Arterioscler. Thromb. Vasc. Biol. , vol.30 , pp. 1773-1778
    • Bursill, C.A.1
  • 14
    • 33745369351 scopus 로고    scopus 로고
    • Endothelial and antithrombotic actions of HDL
    • DOI 10.1161/01.RES.0000225982.01988.93, PII 0000301220060609000005
    • Mineo, C., Deguchi, H., Griffin, J.H. & Shaul, P.W. Endothelial and antithrombotic actions of HDL. Circ. Res. 98, 1352-1364 (2006). (Pubitemid 43948059)
    • (2006) Circulation Research , vol.98 , Issue.11 , pp. 1352-1364
    • Mineo, C.1    Deguchi, H.2    Griffin, J.H.3    Shaul, P.W.4
  • 16
    • 77149158139 scopus 로고    scopus 로고
    • Future therapeutic directions in reverse cholesterol transport
    • Khera, A.V. & Rader, D.J. Future therapeutic directions in reverse cholesterol transport. Curr. Atheroscler. Rep. 12, 73-81 (2010).
    • (2010) Curr. Atheroscler. Rep. , vol.12 , pp. 73-81
    • Khera, A.V.1    Rader, D.J.2
  • 17
    • 38849114338 scopus 로고    scopus 로고
    • Cholesterol efflux pathways and other potential mechanisms involved in the athero-protective effect of high density lipoproteins
    • DOI 10.1111/j.1365-2796.2007.01898.x
    • Tall, A.R. Cholesterol efflux pathways and other potential mechanisms involved in the athero-protective effect of high density lipoproteins. J. Intern. Med. 263, 256-273 (2008). (Pubitemid 351207349)
    • (2008) Journal of Internal Medicine , vol.263 , Issue.3 , pp. 256-273
    • Tall, A.R.1
  • 18
    • 78651379500 scopus 로고    scopus 로고
    • Cholesterol efflux capacity, high-density lipoprotein function, and atherosclerosis
    • Khera, A.V. et al. Cholesterol efflux capacity, high-density lipoprotein function, and atherosclerosis. N. Engl. J. Med. 364, 127-135 (2011).
    • (2011) N. Engl. J. Med. , vol.364 , pp. 127-135
    • Khera, A.V.1
  • 20
    • 77952397461 scopus 로고    scopus 로고
    • Meta-analysis of the effect of nicotinic acid alone or in combination on cardiovascular events and atherosclerosis
    • Bruckert, E., Labreuche, J. & Amarenco, P. Meta-analysis of the effect of nicotinic acid alone or in combination on cardiovascular events and atherosclerosis. Atherosclerosis 210, 353-361 (2010).
    • (2010) Atherosclerosis , vol.210 , pp. 353-361
    • Bruckert, E.1    Labreuche, J.2    Amarenco, P.3
  • 21
    • 84855171302 scopus 로고    scopus 로고
    • Niacin in patients with low HDL cholesterol levels receiving intensive statin therapy
    • The AMI-HIGH Investigators e-pub ahead of print 15 November 2011
    • The AMI-HIGH Investigators. Niacin in patients with low HDL cholesterol levels receiving intensive statin therapy. N. Engl. J. Med. (2011); e-pub ahead of print 15 November 2011.
    • (2011) N. Engl. J. Med.
  • 23
    • 77952708442 scopus 로고    scopus 로고
    • Effects of fibrates on cardiovascular outcomes: A systematic review and meta-analysis
    • Jun, M. et al. Effects of fibrates on cardiovascular outcomes: a systematic review and meta-analysis. Lancet 375, 1875-1884 (2010).
    • (2010) Lancet , vol.375 , pp. 1875-1884
    • Jun, M.1
  • 24
    • 77951704587 scopus 로고    scopus 로고
    • ACCORD Study Group. Effects of combination lipid therapy in type 2 diabetes mellitus
    • Ginsberg, H.N. et al.; ACCORD Study Group. Effects of combination lipid therapy in type 2 diabetes mellitus. N. Engl. J. Med. 362, 1563-1574 (2010).
    • (2010) N. Engl. J. Med. , vol.362 , pp. 1563-1574
    • Ginsberg, H.N.1
  • 25
    • 28044452217 scopus 로고    scopus 로고
    • FIELD study investigators. Effects of long-term fenofibrate therapy on cardiovascular events in 9795 people with type 2 diabetes mellitus (the FIELD study): Randomised controlled trial
    • Keech, A. et al.; FIELD study investigators. Effects of long-term fenofibrate therapy on cardiovascular events in 9795 people with type 2 diabetes mellitus (the FIELD study): randomised controlled trial. Lancet 366, 1849-1861 (2005).
    • (2005) Lancet , vol.366 , pp. 1849-1861
    • Keech, A.1
  • 26
    • 33645308302 scopus 로고    scopus 로고
    • Emerging therapies targeting high-density lipoprotein metabolism and reverse cholesterol transport
    • Duffy, D. & Rader, D.J. Emerging therapies targeting high-density lipoprotein metabolism and reverse cholesterol transport. Circulation 113, 1140-1150 (2006).
    • (2006) Circulation , vol.113 , pp. 1140-1150
    • Duffy, D.1    Rader, D.J.2
  • 27
    • 34147223018 scopus 로고    scopus 로고
    • Emerging HDL-based therapies for atherothrombotic vascular disease
    • Shah, P.K. Emerging HDL-based therapies for atherothrombotic vascular disease. Curr. Treat. Options Cardiovasc. Med. 9, 60-70 (2007). (Pubitemid 46578390)
    • (2007) Current Treatment Options in Cardiovascular Medicine , vol.9 , Issue.1 , pp. 60-70
    • Shah, P.K.1
  • 28
    • 84952989157 scopus 로고    scopus 로고
    • Cholesteryl ester transfer protein (CETP) inhibitors and their role in cardiovascular disorders
    • Kontush, A. Cholesteryl ester transfer protein (CETP) inhibitors and their role in cardiovascular disorders. Drugs Fut. 36, 377-384 (2011).
    • (2011) Drugs Fut , vol.36 , pp. 377-384
    • Kontush, A.1
  • 30
    • 77952410983 scopus 로고    scopus 로고
    • Dalcetrapib:0 a review of phase II data
    • Robinson, J.G. Dalcetrapib: a review of phase II data. Expert Opin. Investig. Drugs 19, 795-805 (2010).
    • (2010) Expert Opin. Investig. Drugs , vol.19 , pp. 795-805
    • Robinson, J.G.1
  • 31
    • 77249100745 scopus 로고    scopus 로고
    • Safety and tolerability of dalcetrapib (RO4607381/JTT-705): Results from a 48-week trial
    • Stein, E.A., Roth, E.M., Rhyne, J.M., Burgess, T., Kallend, D. & Robinson, J.G. Safety and tolerability of dalcetrapib (RO4607381/JTT-705): results from a 48-week trial. Eur. Heart J. 31, 480-488 (2010).
    • (2010) Eur. Heart J. , vol.31 , pp. 480-488
    • Stein, E.A.1    Roth, E.M.2    Rhyne, J.M.3    Burgess, T.4    Kallend, D.5    Robinson, J.G.6
  • 32
    • 84855600739 scopus 로고    scopus 로고
    • A Study of RO4607381 in Stable Coronary Heart Disease Patients With Recent Acute Coronary Syndrome
    • A Study of RO4607381 in Stable Coronary Heart Disease Patients With Recent Acute Coronary Syndrome 〈http://clinicaltrials.gov/ct2/show/ NCT00658515〉.
  • 33
    • 0020420407 scopus 로고
    • Transfers and exchanges of esterified cholesterol between plasma lipoproteins
    • Barter, P.J., Hopkins, G.J. & Calvert, G.D. Transfers and exchanges of esterified cholesterol between plasma lipoproteins. Biochem. J. 208, 1-7 (1982). (Pubitemid 13215389)
    • (1982) Biochemical Journal , vol.208 , Issue.1 , pp. 1-7
    • Barter, P.J.1    Hopkins, G.J.2    Calvert, G.D.3
  • 37
    • 0025740697 scopus 로고
    • Plasma concentrations of cholesteryl ester transfer protein in hyperlipoproteinemia. Relation to cholesteryl ester transfer protein activity and other lipoprotein variables
    • McPherson, R. et al. Plasma concentrations of cholesteryl ester transfer protein in hyperlipoproteinemia. Relation to cholesteryl ester transfer protein activity and other lipoprotein variables. Arterioscler. Thromb. 11, 797-804 (1991).
    • (1991) Arterioscler. Thromb. , vol.11 , pp. 797-804
    • McPherson, R.1
  • 38
    • 0027098041 scopus 로고
    • Increased concentration of plasma cholesteryl ester transfer protein in nephrotic syndrome: Role in dyslipidemia
    • Moulin, P., Appel, G.B., Ginsberg, H.N. & Tall, A.R. Increased concentration of plasma cholesteryl ester transfer protein in nephrotic syndrome: role in dyslipidemia. J. Lipid Res. 33, 1817-1822 (1992). (Pubitemid 23006658)
    • (1992) Journal of Lipid Research , vol.33 , Issue.12 , pp. 1817-1822
    • Moulin, P.1    Appel, G.B.2    Ginsberg, H.N.3    Tall, A.R.4
  • 42
    • 77949320494 scopus 로고    scopus 로고
    • Association of blood lipids with common DNA sequence variants at 19 genetic loci in the multiethnic United States national health and nutrition examination Survey III
    • Keebler, M.E., Sanders, C.L., Surti, A., Guiducci, C., Burtt, N.P. & Kathiresan, S. Association of blood lipids with common DNA sequence variants at 19 genetic loci in the multiethnic United States National Health and Nutrition Examination Survey III. Circ. Cardiovasc. Genet. 2, 238-243 (2009).
    • (2009) Circ. Cardiovasc. Genet. , vol.2 , pp. 238-243
    • Keebler, M.E.1    Sanders, C.L.2    Surti, A.3    Guiducci, C.4    Burtt, N.P.5    Kathiresan, S.6
  • 44
    • 0142010558 scopus 로고    scopus 로고
    • Natural genetic variation as a tool in understanding the role of CETP in lipid levels and disease
    • DOI 10.1194/jlr.R200018-JLR200
    • Boekholdt, S.M. & Thompson, J.F. Natural genetic variation as a tool in understanding the role of CETP in lipid levels and disease. J. Lipid Res. 44, 1080-1093 (2003). (Pubitemid 37279626)
    • (2003) Journal of Lipid Research , vol.44 , Issue.6 , pp. 1080-1093
    • Boekholdt, S.M.1    Thompson, J.F.2
  • 45
    • 67649367650 scopus 로고    scopus 로고
    • Polymorphism in the CETP gene region HDL cholesterol, and risk of future myocardial infarction: Genomewide analysis among 18 245 initially healthy women from the women's genome health study
    • Ridker, P.M., Par-G., Parker, A.N., Zee, R.Y., Miletich, J.P. & Chasman, D.I. Polymorphism in the CETP gene region, HDL cholesterol, and risk of future myocardial infarction: Genomewide analysis among 18 245 initially healthy women from the Women's Genome Health Study. Circ. Cardiovasc. Genet. 2, 26-33 (2009).
    • (2009) Circ. Cardiovasc. Genet. , vol.2 , pp. 26-33
    • Par, G.M.R.P.1    Parker, A.N.2    Zee, R.Y.3    Miletich, J.P.4    Chasman, D.I.5
  • 46
    • 0029948968 scopus 로고    scopus 로고
    • Increased coronary heart disease in Japanese-American men with mutation in the cholesteryl ester transfer protein gene despite increased HDL levels
    • Zhong, S. et al. Increased coronary heart disease in Japanese-American men with mutation in the cholesteryl ester transfer protein gene despite increased HDL levels. J. Clin. Invest. 97, 2917-2923 (1996). (Pubitemid 26197108)
    • (1996) Journal of Clinical Investigation , vol.97 , Issue.12 , pp. 2917-2923
    • Zhong, S.1    Sharp, D.S.2    Grove, J.S.3    Bruce, C.4    Yano, K.5    Curb, J.D.6    Tall, A.R.7
  • 47
    • 2142763867 scopus 로고    scopus 로고
    • A prospective study of HDL-C and cholesteryl ester transfer protein gene mutations and the risk of coronary heart disease in the elderly
    • DOI 10.1194/jlr.M300520-JLR200
    • Curb, J.D. et al. A prospective study of HDL-C and cholesteryl ester transfer protein gene mutations and the risk of coronary heart disease in the elderly. J. Lipid Res. 45, 948-953 (2004). (Pubitemid 38552866)
    • (2004) Journal of Lipid Research , vol.45 , Issue.5 , pp. 948-953
    • Curb, J.D.1    Abbott, R.D.2    Rodriguez, B.L.3    Masaki, K.4    Chen, R.5    Sharp, D.S.6    Tall, A.R.7
  • 48
    • 33644775588 scopus 로고    scopus 로고
    • Description of the torcetrapib series of cholesteryl ester transfer protein inhibitors, including mechanism of action
    • DOI 10.1194/jlr.M500349-JLR200
    • Clark, R.W., Ruggeri, R.B., Cunningham, D. & Bamberger, M.J. Description of the torcetrapib series of cholesteryl ester transfer protein inhibitors, including mechanism of action. J. Lipid Res. 47, 537-552 (2006). (Pubitemid 43345595)
    • (2006) Journal of Lipid Research , vol.47 , Issue.3 , pp. 537-552
    • Clark, R.W.1    Ruggeri, R.B.2    Cunningham, D.3    Bamberger, M.J.4
  • 49
    • 77956513064 scopus 로고    scopus 로고
    • Biochemical characterization of cholesteryl ester transfer protein inhibitors
    • Ranalletta, M. et al. Biochemical characterization of cholesteryl ester transfer protein inhibitors. J. Lipid Res. 51, 2739-2752 (2010).
    • (2010) J. Lipid Res. , vol.51 , pp. 2739-2752
    • Ranalletta, M.1
  • 51
    • 50249186350 scopus 로고    scopus 로고
    • Biophysical and biochemical approach to locating an inhibitor binding site on cholesteryl ester transfer protein
    • Cunningham, D. et al. Biophysical and biochemical approach to locating an inhibitor binding site on cholesteryl ester transfer protein. Bioconjug. Chem. 19, 1604-1613 (2008).
    • (2008) Bioconjug. Chem. , vol.19 , pp. 1604-1613
    • Cunningham, D.1
  • 52
    • 0034644214 scopus 로고    scopus 로고
    • A cholesteryl ester transfer protein inhibitor attenuate atherosclerosis in rabbits
    • DOI 10.1038/35018119
    • Okamoto, H., Yonemori, F., Wakitani, K., Minowa, T., Maeda, K. & Shinkai, H. A cholesteryl ester transfer protein inhibitor attenuates atherosclerosis in rabbits. Nature 406, 203-207 (2000). (Pubitemid 30469005)
    • (2000) Nature , vol.406 , Issue.6792 , pp. 203-207
    • Okamoto, H.1    Yonemori, F.2    Wakitani, K.3    Minowa, T.4    Maeda, K.5    Shinkai, H.6
  • 53
    • 78650054881 scopus 로고    scopus 로고
    • Modulating cholesteryl ester transfer protein activity maintains efficient pre-?-HDL formation and increases reverse cholesterol transport
    • Niesor, E.J. et al. Modulating cholesteryl ester transfer protein activity maintains efficient pre-?-HDL formation and increases reverse cholesterol transport. J. Lipid Res. 51, 3443-3454 (2010).
    • (2010) J. Lipid Res. , vol.51 , pp. 3443-3454
    • Niesor, E.J.1
  • 54
    • 79960648677 scopus 로고    scopus 로고
    • Different effects of compounds decreasing cholesteryl ester transfer protein activity on lipoprotein metabolism
    • Niesor, E.J. Different effects of compounds decreasing cholesteryl ester transfer protein activity on lipoprotein metabolism. Curr. Opin. Lipidol. 22, 288-295 (2011).
    • (2011) Curr. Opin. Lipidol. , vol.22 , pp. 288-295
    • Niesor, E.J.1
  • 56
    • 0033822810 scopus 로고    scopus 로고
    • Vaccine-induced antibodies inhibit CETP activity in vivo and reduce aortic lesions in a rabbit model of atherosclerosis
    • Rittershaus, C.W. et al. Vaccine-induced antibodies inhibit CETP activity in vivo and reduce aortic lesions in a rabbit model of atherosclerosis. Arterioscler. Thromb. Vasc. Biol. 20, 2106-2112 (2000).
    • (2000) Arterioscler. Thromb. Vasc. Biol. , vol.20 , pp. 2106-2112
    • Rittershaus, C.W.1
  • 58
    • 80054094687 scopus 로고    scopus 로고
    • Anacetrapib promotes reverse cholesterol transport and bulk cholesterol excretion in Syrian golden hamsters
    • Castro-Perez, J. et al. Anacetrapib promotes reverse cholesterol transport and bulk cholesterol excretion in Syrian golden hamsters. J. Lipid Res. 52, 1965-1973 (2011).
    • (2011) J. Lipid Res. , vol.52 , pp. 1965-1973
    • Castro-Perez, J.1
  • 59
    • 77953961808 scopus 로고    scopus 로고
    • Cholesterol efflux potential and antiinflammatory properties of high-density lipoprotein after treatment with niacin or anacetrapib
    • Y van-Charvet, L. et al. Cholesterol efflux potential and antiinflammatory properties of high-density lipoprotein after treatment with niacin or anacetrapib. Arterioscler. Thromb. Vasc. Biol. 30, 1430-1438 (2010).
    • (2010) Arterioscler. Thromb. Vasc. Biol. , vol.30 , pp. 1430-1438
    • Yvan-Charvet, L.1
  • 60
    • 0025153614 scopus 로고
    • Accumulation of apolipoprotein E-rich high density lipoproteins in hyperalphalipoproteinemic human subjects with plasma cholesteryl ester transfer protein deficiency
    • Y amashita, S., Sprecher, D.L., Sakai, N., Matsuzawa, Y., Tarui, S. & Hui, D.Y. Accumulation of apolipoprotein E-rich high density lipoproteins in hyperalphalipoproteinemic human subjects with plasma cholesteryl ester transfer protein deficiency. J. Clin. Invest. 86, 688-695 (1990). (Pubitemid 20327355)
    • (1990) Journal of Clinical Investigation , vol.86 , Issue.3 , pp. 688-695
    • Yamashita, S.1    Sprecher, D.L.2    Sakai, N.3    Matsuzawa, Y.4    Tarui, S.5    Hui, D.Y.6
  • 62
    • 0029083670 scopus 로고
    • Increased catabolic rate of low density lipoproteins in humans with cholesteryl ester transfer protein deficiency
    • Ikewaki, K. et al. Increased catabolic rate of low density lipoproteins in humans with cholesteryl ester transfer protein deficiency. J. Clin. Invest. 96, 1573-1581 (1995).
    • (1995) J. Clin. Invest. , vol.96 , pp. 1573-1581
    • Ikewaki, K.1
  • 64
    • 33750477286 scopus 로고    scopus 로고
    • Efficacy and Safety of Torcetrapib, a Novel Cholesteryl Ester Transfer Protein Inhibitor, in Individuals With Below-Average High-Density Lipoprotein Cholesterol Levels
    • DOI 10.1016/j.jacc.2006.06.067, PII S0735109706019917
    • Davidson, M.H., McKenney, J.M., Shear, C.L. & Revkin, J.H. Efficacy and safety of torcetrapib, a novel cholesteryl ester transfer protein inhibitor, in individuals with below-average high-density lipoprotein cholesterol levels. J. Am. Coll. Cardiol. 48, 1774-1781 (2006). (Pubitemid 44648633)
    • (2006) Journal of the American College of Cardiology , vol.48 , Issue.9 , pp. 1774-1781
    • Davidson, M.H.1    McKenney, J.M.2    Shear, C.L.3    Revkin, J.H.4
  • 65
    • 33750447972 scopus 로고    scopus 로고
    • Efficacy and Safety of Torcetrapib, a Novel Cholesteryl Ester Transfer Protein Inhibitor, in Individuals With Below-Average High-Density Lipoprotein Cholesterol Levels on a Background of Atorvastatin
    • DOI 10.1016/j.jacc.2006.06.066, PII S0735109706019905
    • McKenney, J.M., Davidson, M.H., Shear, C.L. & Revkin, J.H. Efficacy and safety of torcetrapib, a novel cholesteryl ester transfer protein inhibitor, in individuals with below-average high-density lipoprotein cholesterol levels on a background of atorvastatin. J. Am. Coll. Cardiol. 48, 1782-1790 (2006). (Pubitemid 44648632)
    • (2006) Journal of the American College of Cardiology , vol.48 , Issue.9 , pp. 1782-1790
    • McKenney, J.M.1    Davidson, M.H.2    Shear, C.L.3    Revkin, J.H.4
  • 66
    • 74949136043 scopus 로고    scopus 로고
    • Aldosterone sodium, and hypertension: Lessons from torcetrapib?
    • Funder, J.W. Aldosterone, sodium, and hypertension: lessons from torcetrapib? Hypertension 55, 221-223 (2010).
    • (2010) Hypertension , vol.55 , pp. 221-223
    • Funder, J.W.1
  • 67
    • 61349154804 scopus 로고    scopus 로고
    • Mechanistic studies of blood pressure in rats treated with a series of cholesteryl ester transfer protein inhibitors
    • DePasquale M. et al. Mechanistic studies of blood pressure in rats treated with a series of cholesteryl ester transfer protein inhibitors. Drug Dev. Res. 70, 35-48 (2009).
    • (2009) Drug Dev. Res. , vol.70 , pp. 35-48
    • Depasquale, M.1
  • 68
    • 48149106322 scopus 로고    scopus 로고
    • Torcetrapib-induced blood pressure elevation is independent of CETP inhibition and is accompanied by increased circulating levels of aldosterone
    • Forrest, M.J. et al. Torcetrapib-induced blood pressure elevation is independent of CETP inhibition and is accompanied by increased circulating levels of aldosterone. Br. J. Pharmacol. 154, 1465-1473 (2008).
    • (2008) Br. J. Pharmacol. , vol.154 , pp. 1465-1473
    • Forrest, M.J.1
  • 69
    • 74949083543 scopus 로고    scopus 로고
    • Cardiovascular effects of torcetrapib in conscious and pentobarbital-anesthetized dogs
    • Polakowski, J.S. et al. Cardiovascular effects of torcetrapib in conscious and pentobarbital-anesthetized dogs. J. Cardiovasc. Pharmacol. 54, 543-551 (2009).
    • (2009) J. Cardiovasc. Pharmacol. , vol.54 , pp. 543-551
    • Polakowski, J.S.1
  • 70
    • 71249121107 scopus 로고    scopus 로고
    • Dalcetrapib: No off-target toxicity on blood pressure or on genes related to the renin-angiotensin-aldosterone system in rats
    • Stroes, E.S. et al. Dalcetrapib: no off-target toxicity on blood pressure or on genes related to the renin-angiotensin-aldosterone system in rats. Br. J. Pharmacol. 158, 1763-1770 (2009).
    • (2009) Br. J. Pharmacol. , vol.158 , pp. 1763-1770
    • Stroes, E.S.1
  • 71
    • 79953822473 scopus 로고    scopus 로고
    • Safety tolerability and pharmacokinetics of dalcetrapib following single and multiple ascending doses in healthy subjects: A randomized, double-blind, placebo-controlled, phase i study
    • Derks, M., Anzures-Cabrera, J., Turnbull, L. & Phelan, M. Safety, tolerability and pharmacokinetics of dalcetrapib following single and multiple ascending doses in healthy subjects: a randomized, double-blind, placebo-controlled, phase I study. Clin. Drug Investig. 31, 325-335 (2011).
    • (2011) Clin. Drug Investig. , vol.31 , pp. 325-335
    • Derks, M.1    Anzures-Cabrera, J.2    Turnbull, L.3    Phelan, M.4
  • 72
    • 68249140219 scopus 로고    scopus 로고
    • Effects of CP-532,623 and torcetrapib, cholesteryl ester transfer protein inhibitors, on arterial blood pressure
    • Blasi, E. et al. Effects of CP-532,623 and torcetrapib, cholesteryl ester transfer protein inhibitors, on arterial blood pressure. J. Cardiovasc. Pharmacol. 53, 507-516 (2009).
    • (2009) J. Cardiovasc. Pharmacol. , vol.53 , pp. 507-516
    • Blasi, E.1
  • 73
    • 56549117314 scopus 로고    scopus 로고
    • Multiple-dose pharmacodynamics and pharmacokinetics of anacetrapib, a potent cholesteryl ester transfer protein (CETP) inhibitor, in healthy subjects
    • Krishna, R. et al. Multiple-dose pharmacodynamics and pharmacokinetics of anacetrapib, a potent cholesteryl ester transfer protein (CETP) inhibitor, in healthy subjects. Clin. Pharmacol. Ther. 84, 679-683 (2008).
    • (2008) Clin. Pharmacol. Ther. , vol.84 , pp. 679-683
    • Krishna, R.1
  • 75
    • 76749125435 scopus 로고    scopus 로고
    • Pharmacokinetics, metabolism, and excretion of anacetrapib, a novel inhibitor of the cholesteryl ester transfer protein, in rats and rhesus monkeys
    • Tan, E.Y. et al. Pharmacokinetics, metabolism, and excretion of anacetrapib, a novel inhibitor of the cholesteryl ester transfer protein, in rats and rhesus monkeys. Drug Metab. Dispos. 38, 459-473 (2010).
    • (2010) Drug Metab. Dispos. , vol.38 , pp. 459-473
    • Tan, E.Y.1
  • 76
    • 76749149144 scopus 로고    scopus 로고
    • Metabolism and excretion of anacetrapib, a novel inhibitor of the cholesteryl ester transfer protein, in humans
    • Kumar, S. et al. Metabolism and excretion of anacetrapib, a novel inhibitor of the cholesteryl ester transfer protein, in humans. Drug Metab. Dispos. 38, 474-483 (2010).
    • (2010) Drug Metab. Dispos. , vol.38 , pp. 474-483
    • Kumar, S.1
  • 77
    • 58149202372 scopus 로고    scopus 로고
    • Assessment of the CYP3A-mediated drug interaction potential of anacetrapib, a potent cholesteryl ester transfer protein (CETP) inhibitor, in healthy volunteers
    • Krishna, R. et al. Assessment of the CYP3A-mediated drug interaction potential of anacetrapib, a potent cholesteryl ester transfer protein (CETP) inhibitor, in healthy volunteers. J. Clin. Pharmacol. 49, 80-87 (2009).
    • (2009) J. Clin. Pharmacol. , vol.49 , pp. 80-87
    • Krishna, R.1
  • 78
    • 54349100968 scopus 로고    scopus 로고
    • Pharmacokinetics, metabolism, and excretion of torcetrapib, a cholesteryl ester transfer protein inhibitor, in humans
    • Dalvie, D. et al. Pharmacokinetics, metabolism, and excretion of torcetrapib, a cholesteryl ester transfer protein inhibitor, in humans. Drug Metab. Dispos. 36, 2185-2198 (2008).
    • (2008) Drug Metab. Dispos. , vol.36 , pp. 2185-2198
    • Dalvie, D.1
  • 79
    • 52949118439 scopus 로고    scopus 로고
    • Metabolism, pharmacokinetics, and excretion of a cholesteryl ester transfer protein inhibitor, torcetrapib, in rats, monkeys, and mice: Characterization of unusual and novel metabolites by high-resolution liquid chromatography-tandem mass spectrometry and 1H nuclear magnetic resonance
    • Prakash, C. et al. Metabolism, pharmacokinetics, and excretion of a cholesteryl ester transfer protein inhibitor, torcetrapib, in rats, monkeys, and mice: characterization of unusual and novel metabolites by high-resolution liquid chromatography-tandem mass spectrometry and 1H nuclear magnetic resonance. Drug Metab. Dispos. 36, 2064-2079 (2008).
    • (2008) Drug Metab. Dispos. , vol.36 , pp. 2064-2079
    • Prakash, C.1
  • 80
    • 79954490677 scopus 로고    scopus 로고
    • Dalcetrapib pharmacokinetics and metabolism in the cynomolgus monkey
    • Kuhlmann, O. & Heinig, K. Dalcetrapib pharmacokinetics and metabolism in the cynomolgus monkey. Xenobiotica. 41, 430-436 (2011).
    • (2011) Xenobiotica , vol.41 , pp. 430-436
    • Kuhlmann, O.1    Heinig, K.2
  • 81
    • 84861225986 scopus 로고    scopus 로고
    • [14C]-Dalcetrapib ADME following a single oral dose in healthy male subjects
    • (abstr.)
    • Derks, M., Busse-Reid, R., Kuhlmann, O. & Paehler, A. [14C]-Dalcetrapib ADME following a single oral dose in healthy male subjects. Clin Pharmacol Ther 87, S37 (abstr.) (2010).
    • (2010) Clin Pharmacol Ther , vol.87
    • Derks, M.1    Busse-Reid, R.2    Kuhlmann, O.3    Paehler, A.4
  • 82
    • 33645838099 scopus 로고    scopus 로고
    • Role of bioactivation in drug-induced hypersensitivity reactions
    • DOI 10.1208/aapsj080107, 7
    • Sanderson, J.P., Naisbitt, D.J. & Park, B.K. Role of bioactivation in drug-induced hypersensitivity reactions. AAPS J. 8, E55-E64 (2006). (Pubitemid 44603864)
    • (2006) AAPS Journal , vol.8 , Issue.1
    • Sanderson, J.P.1    Naisbitt, D.J.2    Park, B.K.3
  • 83
    • 78349264158 scopus 로고    scopus 로고
    • Effect of diltiazem a moderate CYP3A inhibitor, on the pharmacokinetics of anacetrapib, a potent cholesteryl ester transfer protein inhibitor, in healthy subjects
    • Garg, A.et al. Effect of diltiazem a moderate CYP3A inhibitor, on the pharmacokinetics of anacetrapib, a potent cholesteryl ester transfer protein inhibitor, in healthy subjects. J. Clin. Pharmacol. 51, 436-439 (2011).
    • (2011) J. Clin. Pharmacol. , vol.51 , pp. 436-439
    • Garg, A.1
  • 85
    • 82155162318 scopus 로고    scopus 로고
    • Lack of an effect of anacetrapib on the pharmacokinetics of digoxin in healthy subjects
    • e-pub ahead of print 26 October 2011
    • Krishna, R. et al. Lack of an effect of anacetrapib on the pharmacokinetics of digoxin in healthy subjects. Biopharm. Drug. Dispos. (2011): e-pub ahead of print 26 October 2011.
    • (2011) Biopharm. Drug. Dispos.
    • Krishna, R.1
  • 86
    • 70350788822 scopus 로고    scopus 로고
    • Single-dose pharmacokinetics and pharmacodynamics of anacetrapib, a potent cholesteryl ester transfer protein (CETP) inhibitor, in healthy subjects
    • Krishna, R. et al. Single-dose pharmacokinetics and pharmacodynamics of anacetrapib, a potent cholesteryl ester transfer protein (CETP) inhibitor, in healthy subjects. Br. J. Clin. Pharmacol. 68, 535-545 (2009).
    • (2009) Br. J. Clin. Pharmacol. , vol.68 , pp. 535-545
    • Krishna, R.1
  • 87
    • 58649091088 scopus 로고    scopus 로고
    • Efficacy and safety of the cholesteryl ester transfer protein inhibitor anacetrapib as monotherapy and coadministered with atorvastatin in dyslipidemic patients
    • e2
    • Bloomfield, D. et al. Efficacy and safety of the cholesteryl ester transfer protein inhibitor anacetrapib as monotherapy and coadministered with atorvastatin in dyslipidemic patients. Am. Heart J. 157, 352-360.e2 (2009).
    • (2009) Am. Heart J. , vol.157 , pp. 352-360
    • Bloomfield, D.1
  • 88
    • 73549097512 scopus 로고    scopus 로고
    • PROCARDIS Consortium. Genetic variants associated with Lp(a) lipoprotein level and coronary disease
    • Clarke, R. et al.; PROCARDIS Consortium. Genetic variants associated with Lp(a) lipoprotein level and coronary disease. N. Engl. J. Med. 361, 2518-2528 (2009).
    • (2009) N. Engl. J. Med. , vol.361 , pp. 2518-2528
    • Clarke, R.1
  • 89
    • 79957463739 scopus 로고    scopus 로고
    • Model-based development of anacetrapib, a novel cholesteryl ester transfer protein inhibitor
    • Krishna, R., Bergman, A.J., Green, M., Dockendorf, M.F., Wagner, J.A. & Dykstra, K. Model-based development of anacetrapib, a novel cholesteryl ester transfer protein inhibitor. AAPS J. 13, 179-190 (2011).
    • (2011) AAPS J. , vol.13 , pp. 179-190
    • Krishna, R.1    Bergman, A.J.2    Green, M.3    Dockendorf, M.F.4    Wagner, J.A.5    Dykstra, K.6
  • 90
    • 78549235583 scopus 로고    scopus 로고
    • Determining the efficacy and tolerability investigators. Safety of anacetrapib in patients with or at high risk for coronary heart disease
    • Cannon, C.P. et al.; Determining the Efficacy and Tolerability Investigators. Safety of anacetrapib in patients with or at high risk for coronary heart disease. N. Engl. J. Med. 363, 2406-2415 (2010).
    • (2010) N. Engl. J. Med. , vol.363 , pp. 2406-2415
    • Cannon, C.P.1
  • 91
    • 70349213361 scopus 로고    scopus 로고
    • DEFINE investigators. Design of the DEFINE trial: Determining the efficacy and tolerability of CETP inhibition with anacetrapib
    • e3
    • Cannon, C.P. et al.; DEFINE investigators. Design of the DEFINE trial: determining the efficacy and tolerability of CETP inhibition with anacetrapib. Am. Heart J. 158, 513-519.e3 (2009).
    • (2009) Am. Heart J. , vol.158 , pp. 513-519
    • Cannon, C.P.1
  • 92
    • 78650727768 scopus 로고    scopus 로고
    • Applications of "decisionable"biomarkers in cardiovascular drug development
    • Krishna, R. & Wagner, J.A. Applications of "decisionable" biomarkers in cardiovascular drug development. Biomark. Med. 4, 815-827 (2010).
    • (2010) Biomark. Med. , vol.4 , pp. 815-827
    • Krishna, R.1    Wagner, J.A.2


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