Neuro-psychopharmacogenetics and neurological antecedents of posttraumatic stress disorder: Unlocking the mysteries of resilience and vulnerability

Current Neuropharmacology

Volumn 8, Issue 4, 2010, Pages 335-358

  Bowirrat, Abdalla ^a   Chen, Thomas J H ^b   Blum, Kenneth ^c,d,g,h   Madigan, Margaret ^d   Bailey, John A ^c   Chen, Amanda Lih Chuan ^b   Downs, B William ^d   Braverman, Eric R ^e   Radi, Shahien ^f   Waite, Roger L ^d   Kerner, Mallory ^g   Giordano, John ^h   Morse, Siohban ^h   Oscar Berman, Marlene ⁱ   Gold, Mark ^c  

^a Rebecca Sieff Government Hospital   (Israel)

^b CHANG JUNG CHRISTIAN UNIVERSITY   (Taiwan)

^c UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^d Reward Deficiency Solutions LLC   (United States)

^e WEILL CORNELL MEDICAL COLLEGE   (United States)

^f Clinical Neuroscience and Population Genetics   (Israel)

^g Path Foundation   (United States)

^h Department of Holistic Medicine G G Holistic Addiction Treatment Center   (United States)

ⁱ BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Genes and environment; Neurotransmitters; Post traumatic Stress Disorder (PTSD); Reward Deficiency Syndrome (RDS)

Indexed keywords

EID: 84055206840     PISSN: 1570159X     EISSN: 18756190     Source Type: Journal    
DOI: 10.2174/157015910793358123     Document Type: Article

References (115)

1. American Psychiatric Association. 309.81 Posttrauatic Stress Disorder. In: Diagnostic and statistical manual of mental disorders, 4th ed. The American Psychiatric Association: Washington, 1994, pp. 424-429.
2. Asmundson, G.J., Taylor, S. PTSD diagnostic criteria: understanding etiology and treatment. Am. J. Psychiatry, 2009, 166(Suppl. 6), 726.
3. Bandura, A. Self-efficacy mechanism in human agency. Am. Psychol., 1982, 37, 122-147.
4. Hofmann, S.G., Richey, J.A., Kashdan, T.B., McKnight, P.E. Anxiety disorders moderate the association between externalizing problems and substance use disorder: data from the National Comorbidity Survey-Revised. J. Anxiety Disord., 2009, 23(4), 529-534.
5. Pearson, V., Phillips, M.R., He, F.S., Ji, H.Y. Attempted Suicide among young rural women in the People’ Republic of China: Possibilities for prevention. Suicide Life Threat Behav., 2002, 32, 359-369.
6. Sareen, J., Cox, B.J., Stein, M.B., Afifi, T.O., Fleet, C., Asmundson, G.J. Physical and mental comorbidity, disability, and suicidal behavior associated with posttraumatic stress disorder in a large community sample. Psychosom. Med., 2007, 69(Suppl 3), 242-248.
7. Kaufer, D., Friedman, A., Seidman, S., Soreq, H. Acute stress facilitates long-lasting changes in cholinergic gene expression. Nature, 1998, 393, 57.
8. Veith, I. Hysteria. The history of a disease. Press of Chicago: Chicago University, 1965, pp. 1-301.
9. Antonoysky A. Health Stress and Coping. Jossey Bass: N.Y. 1981, pp. 70-73.
10. De Bellis, M.D., Keshavan, N.S., Clark, D.B. Developmental traumatology. Part II. Brain development. Biol. Psychiatry, 1999, 45, 1271-1284.
11. Philips, M.R., Yang, G.H., Zhang, Y.P., Wang, L.J., Ji, H.Y., Zhou, M.G. Risk factors for suicide in China: A national case-control psychology autopsy study. Lancet, 2002, 360, 1728-1736.
12. Janet, P. The Mental State of Hystericals. General Books, LLC, London, reprinted Cornell University Library, 2009, Chapter 1, pp. 3-75.
13. Lamprecht, F., Sack, M. Posttraumatic Stress Disorder Revisited. Psychosomatic Med., 2002, 64, 222-237.
14. Davidson, J.R., Hughes, D., Blazer, D.G., George, L.K. Posttraumatic stress disorder in the community: an epidemiological study. Psychol. Med., 1991, 21(Suppl 3), 713-721.
15. D'Souza, D. Post-traumatic stress disorder--a scar for life. Br. J. Clin. Pract., 1995, 49 (Suppl 6), 309-313.
16. Downs, B.W., Chen, A.L., Chen, T.J., Waite, R.L., Braverman, E.R., Kerner, M., Braverman, D., Rhoades, P., Prihoda, T.J., Palomo, T., Oscar-Berman, M., Reinking, J., Blum, S.H., DiNubile, N.A., Liu, H.H., Blum, K. Nutrigenomic targeting of carbohydrate craving behavior: can we manage obesity and aberrant craving behaviors with neurochemical pathway manipulation by Immunological Compatible Substances (nutrients) using a Genetic Positioning System (GPS) Map? Med. Hypotheses., 2009, 73(Suppl. 3), 427-34.
17. Khozhenko, E.V. Neuronal mechanisms underlying main clinical syndromes of post-traumatic stress disorder. Klin. Med., 2009, 87(Suppl 4), 4-9.
18. Kenny, L.M., Bryant, R.A., Silove, D., Creamer, M., O'Donnell, M., McFarlane, A.C. Distant Memories: A Prospective Study of Vantage Point of Trauma Memories.
19. [Epub ahead of print] Psychol. Sci., 2009, 20(9), 1049-52.
20. Hakamata, Y., Matsuoka, Y., Inagaki, M., Nagamine, M., Hara, E., Imoto, S., Murakami, K., Kim, Y., Uchitomi, Y. Structure of orbitofrontal cortex and its longitudinal course in cancer-related posttraumatic stress disorder. Neurosci. Res., 2007, 59(4), 383-389.
21. Nakas-Ićindić, E, Mujić, M, Knezević, Z, Radovanović, J, Loza, V. Characteristics of arterial blood pressure responses in the treadmill stress test in patients with post-traumatic stress disorder during the war in Sarajevo. Med. Arh., 1998, 52(Suppl 3), 127-130.
22. Lanius, R.A., Williamson, P.C., Hopper, J., Densmore, M., Boksman, K., Gupta, M.A., Neufeld, R.W., Gati, J.S., Menon, R.S. Recall of emotional states in posttraumatic stress disorder: an fMRI investigation. Biol. Psychiatry, 2003, 53(Suppl 3), 204-210.
23. Milad, M.R., Pitman, R.K., Ells, C.B., Gold, A.L., Shin, L.M., Lasko, N.B., Zeidan, M.A., Handwerger, K., Orr, S.P., Ranch, S.L. Neurological basis of failure to recall extinction memory in posttraumatic stress disorder. Biol. Psychiatry, 2009, 66(12), 1075-82.
24. Press, G.A., Squire, L.R. Hippocampal abnormalities in amnesic patients revealed by high-resolution magnetic resonance imaging. Nature, 1989, 341, 54-57.
25. vander Kolk, B.A., Greenberg, M.S., Orr, S.P., Pitman, R.K. Endogenous opioids, stress induced analgesia, and posttraumatic stress disorder. Psychopharmacol. Bull., 1989, 25 (Suppl 3), 417-421.
26. Orth, U., Maercker, A. Posttraumatic anger in crime victims: directed at the perpetrator and at the self. J. Trauma Stress, 2009, 22(Suppl.2), 158-161.
27. Henry, J.P. Psychological and physiological responses to stress: the right hemisphere and the hypothalamo-pituitary-adrenal axis, an inquiry into problems of human bonding. Acta Physiol. Scand, Suppl., 1997, 640, 10-25.
28. Charney, D.S. Psychobiological mechanisms of resilience and vulnerability: implications for successful adaptation to extreme stress. Am. J. Psychiatry, 2004, 611, 195-216.
29. Yehuda, R., Schmeidler, J., Giller, E.L. Relationship between posttraumatic stress disorder characteristics of Holocaust survivors and their adult offspring. Am. J. Psychiatry, 1998, 155, 841-183.
30. Zachariou, V., Georgescu, D., Kansal, L., Priscilla, M., Picciotto, M. Galanin receptor 1 gene expression is regulated by cyclic AMP through a CREB-dependent mechanism. J. Neurochem., 2001, 76(Suppl 1), 191-200.
31. Hensman, R., Gaimaraes, F.S., Wang M, Deakin, J.F.W. Effects of ritanserin on aversive classical conditioning in humans. Psychopharmacology, 1991, 104, 220-224.
32. Joseph, M.H., Kennell, G.A. Corticosteroid response to stress depends upon increased tryptophan availability. Psychopharmacology, 1983, 79, 79-81.
33. Arora, R.C., Fichtner, C.G., O'Connor, F., Crayton, J.W. Paroxetine binding in the blood platelets of post-traumatic stress disorder patients. Life Sci., 1993, 53, 919-928.
34. Fichtner, C.G., Arora, R.C., O'Connor, F.L., Crayton, J.W. Platelet paroxetine binding and fluoxetine pharmacotherapy in posttraumatic stress disorder: Preliminary observations on a possible predictor of clinical treatment response. Life Sci., 1994, 54, 39-44.
35. Shay, J. Fluoxetine reduces explosiveness and elevates mood of Vietnam combat veterans with PTSD. J. Trauma Stress, 1992, 5, 97-101.
36. Southwick, S.M., Krystal, J.H., Morgan, C.A. Abnormal noradrenergic function in Posttraumatic Stress Disorder. Arch. Gen. Psychiatry, 1993, 50, 266-274.
37. Davis, G.W., Schuster, C.M., Goodman, C.S. Genetic analysis of the mechanisms controlling target selection: target-derived Fasciclin II regulates the pattern of synapse formation. Neuron, 1997, 19(Suppl 3), 561-573.
38. Voisey J., Swagell, C.D., Hughes, I.P, Morris, C.P, van Daal, A, Noble, E.P, Kann, B, Heslop, K.A., Young, R.M., Lawford, B.R. The DRD2 gene 957C>T polymorphism is associated with posttraumatic stress disorder in war veterans. Depress Anxiety, 2009, 26(Suppl 1), 28-33.
39. Gracie, A., Freeman, D., Green, S., Garety, P.A., Kuipers, E., Hardy, A., Ray, K., Dunn, G., Bebbington, P, Fowler, D. The association between traumatic experience, paranoia and hallucinations: a test of the predictions of psychological models. Acta. Psychiatr. Scand., 2007, 116(Suppl 4), 280-289.
40. Kelley, A.E., Berridge, K.C. The neuroscience of natural rewards: relevance to addictive drugs. J. Neurosci., 2002, 22(Suppl 9), 3306-3311.
41. Taylor, B.K., Joshi, C., Uppal, H. Stimulation of dopamine D2 receptors in the nucleus accumbens inhibits inflammatory pain. Brain Res., 2003, 987(Suppl 2), 135-143.
42. Blum, K., Briggs, A.H., Elston, S.F., DeLallo, L., Sheridan, P.J., Sar, M.Reduced leucine-enkephalin--like immunoreactive substance in hamster basal ganglia after long-term ethanol exposure. Science, 1982, 216(4553), 1425-1427.
43. Kanarek, R., D’Anci, K., Jurdak, N. Running and Addiction: Precipitated Withdrawal in a Rat Model of Activity-Based Anorexia. Behav. Neurosci. Am. Psychol. Assoc., 2009, 123(4), 476.
44. Yehuda, R., Harvey, P.D., Golier, J.A., Newmark, R.E., Bowie, C.R., Wohltmann, J.J., Grossman, R.A., Schmeidler, J., Hazlett, E.A, Buchsbaum, M.S. Changes in relative glucose metabolic rate following cortisol administration in aging veterans with posttraumatic stress disorder: an FDG-PET neuroimaging study. J. Neuropsychiatry Clin. Neurosci., 2009, 21(Suppl 2), 132-143.
45. Charney, D.S., Deutsch, A.Y., Krystal, J.H., Southwick, S.M., Davis, M.Psychobiologic mechanisms of post-traumatic stress disorder. Arch. Gen. Psychiatry., 1993, 50, 295-305.
46. Bremner, J.D., Licinio, J., Darnell, A. Elevated CSF corticotrophinreleasing factor concentrations in posttraumatic stress disorder. Am. J. Psychiatry, 1997, 154(Suppl 5), 624-629.
47. Sah, R., Ekhator, N.N., Strawn, J.R., Sallee, F.R., Baker, D.G., Horn, P.S., Geracioti, T.D. Low Cerebrospinal Fluid Neuropeptide Y Concentrations in Posttraumatic Stress Disorder Biol. Psychiatry., 2009, 66(7), 705-7.
48. Rauch, S.L., Shin, L.M., Whalen, P.J., Pitman, R.K. Neuroimaging and the neuroanatomy of post-traumatic stress disorder. CNS Spectrums., 1998, 7S, 30-41.
49. Silver, J.M., Shin, C., McNamara, J.O. Antiepileptogenic effects of conventional anticonvulsants in the Kindling Model of Epilepsy. Ann. Neurol., 1991, 29, 356-363.
50. Bremner, J.D., Randall, P., Vermetten, E., Staib, L., Bronen, R.A., Mazure, C., Capelli, S., McCarthy, G., Innis, R.B. Magnetic resonance imaging-based measurement of hippocampal volume in posttraumatic stress disorder related to childhood physical and sexual abuse: a preliminary report. Biol. Psychiatry, 1997, 41, 23-32.
51. Schmahl, C, Berne, K, Krause, A, Kleindienst, N, Valerius, G, Vermetten, E, Bohus, M. Hippocampus and amygdala volumes in patients with borderline personality disorder with or without posttraumatic stress disorder. J. Psychiatry Neurosci., 2009, 34(Suppl 4), 289-295.
52. Bonne, O., Vythilingam, M., Inagaki, M., Wood, S., Neumeister, A, Nugent, A.C, Snow, J., Luckenbaugh, D.A., Bain, E.E., Drevets, W.C., Charney, D.S..Reduced posterior hippocampal volume in posttraumatic stress disorder. J. Clin. Psychiatry, 2008, 69(Suppl 7), 1087-1091.
53. Pissota, A., Frans, O., Fernandez, M., von Knorring, L., Fischer, H., Fredrikson, M. Neurofunctional correlates of posttraumatic stress disorder: a PET symtom provocation study. Eur. Arch. Psychiatry Clin. Neurossci., 2002, 2(2), 68-75.
54. Sapolsky, R.M. Glucocorticoids and hippocampal atrophy in neuropsychiatric disorders. Arch. Gen. Psychiatry, 2000, 57(Suppl 10), 925-935.
55. Yehuda, R., Southwick, S.M., Nussbaum, E. Low urinary cortisol in PTSD. J. Nervous Mental Dis., 1991, 178, 366-378.
56. Yehuda, R, Southwick, S.M., Krystal, J.H., Bremner, D., Charney, D.S., Mason, J.W. Enhanced suppression of cortisol following dexamethasone administration in posttraumatic stress disorder. Am. J. Psychiatry, 1993, 150(Suppl 1), 83-86.
57. Bremner, J.D., Randall, P., Scott, T.M. MRI-based measurement of hippocampal volume in patients with combat-related posttraumatic stress disorder. Am. J. Psychiatry, 1995, 152(Suppl 7), 973-981.
58. Sapolsky, R.M. Why stress is bad for your brain. Science, 1996, 273(Suppl 5276), 749-750.
59. McEwen, B.S. Protection and damage from acute and chronic stress: allostasis and allostatic overload and relevance to the pathophysiology of psychiatric disorders. Ann. NY. Acad. Sci., 2004, 1032, 1-7.
60. McEwen, B.S., Magarinos, A.M. Stress effects on morphology and function of the hippocampus. Ann. NY. Acad. Sci., 1997, 821, 271-284.
61. Bonne, O., Brandes, D., Gilboa, A.J., Gomori, M., Shenton, M.E., Pitman, R.K., Shalev, A.Y. Longitudinal MRI study of hippocampal volume in trauma survivors with PTSD. Am. J. Psychiatry, 2001, 158, 1248-1251.
62. Sapolsky, R.M. (Ed). An introduction to the adrenocortical axis. In Stress, the Aging Brain and the Mechanisms of Neuron Death. Bradford MIT Press: Cambridge, 1992, pp.11-27.
63. McEwen, B.S. Possible mechanisms for atrophy of the human hippocampus. Mol. Psychiatry, 1997, 2, 255-262.
64. Gurvits, T., Shenton, M., Hokama, H., Ohta, H., Lasko, N., Gilbertson, M., Orr, S., Kikinis, R., Jolesz, F., McCarley, R., Pitman, R. Magnetic resonance imaging study of hippocampal volume in chronic, combat-related posttraumatic stress disorder. Biol. Psychiatry, 1996, 40, 1091-1099.
65. Stein, M.B., Koverola, C., Hanna, C. Hippocampal volume in women victimised by childhood sexual abuse. Psychol. Med., 1997, 27, 951-959.
66. Canive, J.M., Lewine, J.D., Orrison, W.W. M.R.I. reveals gross structural abnormalities in PTSD. Ann. N.Y. Acad. Sci., 1997, 821, 512-515.
67. Gould, E., Tanapat, P., McEwen, B.S. Proliferation of granule cell precursors in the dentate gyrus of adult monkeys is diminished by stress. Proc. Natl. Acad. Sci. USA, 1998, 95, 3168-3171.
68. Watanabe, Y.E., Gould, H., Cameron, D. Phenytoin prevents stress and corticosterone induced atrophy of CA3 pyramidal neurons. Hippocampus., 1992, 2, 431-436.
69. Krystal, J.H., D'Souza, D.C., Mathalon, D.K., Crystal, J.H., Perry, E., Belger, A., Hoffman, R. NMDA receptor antagonist effects, cortical glutamatergic function, and schizophrenia: toward a paradigm shift in medication development. Psychopharmacology (Berl)., 2003, 169(Suppl. 3-4), 215-233.
70. Lanius, R.A., Bluhm, R., Lanius, U., Pain, C. A review of neuroimaging studies in PTSD: heterogeneity of response to symptom provocation. J. Psychiatr. Res., 2006, 40(Suppl. 8), 709-729.
71. Koenigs, M., Grafman, J. Post Traumatic Stress Disorder: the Role of Medical Prefrontale Cortex and Amygdale. Neuroscientst, 2009, (Suppl 6683), 373-377.
72. Kilpatrick, K.L., Williams, L.M. Potential mediators of posttraumatic stress disorder in child witnesses to domestic violence. Child Abuse Neglect., 1998, 22(Suppl 4), 319-330.
73. Mitchell, J.K. Hazards research. In: Geography in America. Gaile, G.L., Willmott, C.J., Merill, C.E., Eds., 1989, pp. 410-424.
74. Chambers, R. Vulnerability. How the poor cope. IDS Bulletin., 1989, 20, 1-7.
75. Bonanno, G.A. Loss, trauma, and human resilience: have we underestimated the human capacity to thrive after extremely aversive events? Am. J. Psychol., 2004, 59, 20-28.
76. Southwick, S.M., Vythilingam, M., Charney, D.S. The psychobiology of depression and resilience to stress: Implications for prevention and treatment. Annu. Rev. Clin. Psychol., 2005, 1, 255-291.
77. Blum, K., Chen, A.L, Chen, T.J, Braverman, E.R, Reinking, J, Blum, S.H, Cassel, K, Downs, B.W, Waite, R.L, Williams, L, Prihoda, T.J, Kerner, M.M, Palomo, T, Comings, D.E, Tung, H, Rhoades, P, Oscar-Berman, M. Activation instead of blocking mesolimbic dopaminergic reward circuitry is a preferred modality in the long term treatment of reward deficiency syndrome (RDS): a commentary. Theor. Biol. Med. Model., 2008, 5, 24.
78. Comings, D.E., Blum, K. Reward deficiency syndrome: genetic aspects of behavioral disorders. Prog. Brain Res., 2000, 126, 325-341.
79. Chen, A.L., Chen, T.J., Waite, R.L., Reinking, J., Tung, H.L., Rhoades, P., Downs, B.W., Braverman, E., Braverman, D., Kerner, M., Blum, S.H., DiNubile, N., Smith, D., Oscar-Berman, M., Prihoda, T.J., Floyd, J.B., O'Brien, D., Liu, H.H., Blum, K. Hypothesizing that brain reward circuitry genes are genetic antecedents of pain sensitivity and critical diagnostic and pharmacogenomic treatment targets for chronic pain conditions. Med. Hypotheses., 2009, 72(1), 14-22.
80. Comings, D.E., Muhleman, D., Gysin, R. Dopamine D2 receptor (DRD2) gene and susceptibility to posttraumatic stress disorder: a study and replication. Biol. Psychiatry, 1996, 40(Suppl.5), 368-372.
81. Young, R.M., Lawford, B.R., Noble, E.P., Kann, B, Wilkie, A, Ritchie, T, Arnold, L, Shadforth, S. Alcohol Alcohol, 2002, 37(Suppl 5), 451-456.
82. Gelernter, J., Southwick, S., Goodson, S., Morgan, A., Nagy, L., Charney, D.S. No association between D2 dopamine receptor (DRD2) "A" system alleles, or DRD2 haplotypes, and posttraumatic stress disorder. Biol. Psychiatry, 1999, 45(Suppl 5), 620-625.
83. Lawford, B.R., McDYoung, R., Noble, E.P., Kann, B., Arnold, L., Rowell, J., Ritchie, T.L. D2 dopamine receptor gene polymorphism: paroxetine and social functioning in posttraumatic stress disorder. Eur. Neuropsychopharmacol., 2003, 13(Suppl 5), 313-320.
84. Segman, R.H., Cooper-Kazaz, R., Macciardi, F., Goltser, T., Halfon, Y., Dobroborski, T., Shalev, A.Y. Association between the dopamine transporter gene and posttraumatic stress disorder. Mol. Psychiatry, 2002, 7(Suppl 8), 903-907.
85. Pivac, N., Knezevic, J., Kozaric-Kovacic, D., Dezeljin, M., Mustapic, M., Rak, D., Matijevic, T., Pavelic, J., Muck-Seler, D. Monoamine oxidase (MAO) intron 13 polymorphism and platelet MAO-B activity in combat-related posttraumatic stress disorder. J. Affect. Disord., 2007, 103(Suppl 1-3), 131-138.
86. Mustapić, M., Pivac, N., Kozarić-Kovacić, D., Dezeljin, M., Cubells, J.F., Mück-Seler, D. Dopamine beta-hydroxylase (DBH) activity and-1021C/T polymorphism of DBH gene in combatrelated post-traumatic stress disorder. Am. J. Med. Genet B Neuropsychiatr. Genet., 2007, 5(Suppl 8), 1087-1089.
87. Lee, H.J., Lee, M.S., Kang, R.H., Kim, H., Kim, S.D., Kee, B.S., Kim, Y.H., Kim, Y.K., Kim, J.B., Yeon, B.K., Oh, K.S., Oh, B.H., Yoon, J.S., Lee, C., Jung, H.Y., Chee, I.S., Paik, I.H. Influence of the serotonin transporter promoter gene polymorphism on susceptibility to posttraumatic stress disorder. Depress Anxiety, 2005, 21(Suppl 3), 135-139.
88. Feusner, J., Ritchie, T., Lawford, B., Young, R.M., Kann, B., Noble, E.P. GABA(A) receptor beta 3 subunit gene and psychiatric morbidity in a post-traumatic stress disorder population. Psychiatry Res., 2001, 104(Suppl 2), 109-117.
89. Freeman, T., Roca, V., Guggenheim, F., Kimbrell, T., Griffin, W.S. Neuropsychiatric associations of apolipoprotein E alleles in subjects with combat-related posttraumatic stress disorder. J. Neuropsychiatry Clin. Neurosci., 2005, 17(Suppl 4), 541-543.
90. Lu, A.T., Ogdie, M.N., Järvelin, M.R., Moilanen, I.K., Loo, S.K., McCracken, J.T, McGough, J.J., Yang, M.H., Peltonen, L., Nelson, S.F., Cantor, R.M., Smalley, S.L. Association of the cannabinoid receptor gene (CNR1) with ADHD and post-traumatic stress disorder. Am. J. Med. Genet. B Neuropsychiatr. Genet., 2008, 147B (Suppl 8), 1488-1494.
91. Tamaki, K., Kamakura, M., Nakamichi, N., Taniura, H., Yoneda, Y. Upregulation of Myo6 expression after traumatic stress in mouse hippocampus. Neurosci. Lett., 2008, 433(Suppl 3), 183-187.
92. Su, Y.A., Wu, J., Zhang, L., Zhang, Q., Su, D.M., He, P., Wang, B.D., Li, H., Webster, M.J., Rennert, O.M., Ursano, R.J. Traumatic Stress Brain Study Group, Dysregulated mitochondrial genes and networks with drug targets in postmortem brain of patients with posttraumatic stress disorder (PTSD) revealed by human mitochondria-focused cDNA microarrays. Int. J. Biol. Sci., 2008, 4(Suppl 4), 223-235.
93. Binder, E.B., Bradley, R.G., Liu, W., Epstein, M.P., Deveau, T.C., Mercer, K.B., Tang, Y., Gillespie, C.F., Heim, C.M., Nemeroff, C.B., Schwartz, A.C., Cubells, J.F., Ressler, K.J. Association of FKBP polymorphisms and childhood abuse with risk of posttraumatic stress disorder symptoms in adults. JAMA, 2008, 299(11), 1291-305.
94. Koenen, K.C., Saxe, G., Purcell, S., Smoller, J.W., Bartholomew, D., Miller, A., Hall, E., Kaplow, J., Bosquet, M., Moulton, S., Baldwin, C. Polymorphisms in FKBP5 are associated with peritraumatic dissociation in medically injured children. Mol. Psychiatry, 2005, 10(12), 1058-9.
95. Birmes, P., Brunet, A, Carreras, D, Ducassé, J.L, Charlet, J.P, Lauque, D, Sztulman, H, Schmitt, L. The predictive power of peritraumatic dissociation and acute stress symptoms for posttraumatic stress symptoms: a three-month prospective study. Am. J. Psychiatry, 2003 , 160(7), 1337-9.
96. Yehuda, R, Cai, G., Golier, J.A., Sarapas, C., Galea, S., Ising, M., Rein, T., Schmeidier, J., Muller-Myhsok, B., Holsboer, F., Buxbaum, J.D. Gene expression patterns assiciated with posttraumatic stress disorder following exposure to the World Trade Center attacks. Biol. Psychiatry, 2009, 66(7), 708-711.
97. Baumann, C.R., Bassetti, C.L. Valko, P.O. Haybaeck, J., Keller, M., Stocker, R. Tolnay M., Scammell, T.E. Loss of hypocretin (orexin) neurons with traumatic stress brain injury. Ann. Neurol., 2009, 66(4), 555-559.
98. Masten, A.S. Commentary: Developmental psychopathology as a unifying context for mental health and education models, research and practice in schools. School Psychol. Rev., 2003, 32, 169-173.
99. Janoff-Bulman, R. From Terror to appreciation: confronting chance after extreme misfortune. Psychol. Inquiry, 1998, 9(Suppl. 2), 99-101.
100. Schnurr, P.P., Lunney, C.A., Sengupta, A. Risk factors for the development versus maintainance of posttraumatic stress disorder. J. Trauma Stress, 2004, 17(2), 85-95.
101. [100] Carver, C.S., Scheier, M.F., Weintraub, J.K. Assessing coping strategies: A theoretically based approach. J. Personal. Social Psychol., 1998, 56, 267-283.
102. [101] Ponniah, K., Hollon, S.D. Empirically supported psychological treatments for adult acute stress disorder and posttraumatic stress disorder: a review. Depress. Anxiety, 2009, 26(12), 1086-1109.
103. [102] Conrad, P. Genetic optimism: framing genes and mental illness in the news. Cult. Med. Psychiatry, 2001, 25(Suppl 2), 225-247.
104. [103] Shin, L.M., Lasko, N.B., Macklin, M.L., Karpf, R.D., Milad, M.R., Orr, S.P., Goetez, J.M., Rauch, S.L., Pitman, R.K. Resting metabolic activityin the cingulate cortex and vulnerability to posttraumatic stress disorder. Arch. Gen. Psychiatry, 2009, 66(10), 1099-1107.
105. [104] Metzger, L.J., Clark, C.R., McFarlane, A.C., Veltmeyer, M.D., Lasko, N.B., Paige, S.R., Pitman, R.K., Orr, S.P. Event related potentials to aditory stimuli in monozygotic twins discordant for combat: association with PTSD. Psychophysiology, 2009, 46(1), 172-178.
106. [105] White, P., Faustman, W. Coexisting physical conditions among inpatients with post-traumatic stress disorder. Mil. Med., 1989, 154(Suppl 2), 66-71.
107. [106] Morren, M., Dirkzwagner, A.J., Kessels, F.J., Yzermans, C.J. The influence of disaster on the health of rescue workers: alongitudinal study. CMAJ, 2007, 176(9), 1279-83.
108. [107] Institute of Medicine (US) Postraumatic Stress Disorder and Assessment. National Academies: Washington DC., 2006.
109. [108] Georgopoulos, A.P., Tan, H.R., Lewis, S.M., Leuthold, A.C., Winskowski, A.M., Lynch, J.K., Engdahl, B. The synchronous neural interactions test as a functional neuromarker for post-traumatic stress disorder (PTSD): a robust classification method based on the bootstrap. J. Neural. Eng., 2010, 7(1), 1-7.
110. [109] Davidson, J., Swartz, M., Storck, M., Krishnan, R.R., Hammett, E. A diagnostic and family study of posttraumatic stress disorder. Am. J. Psychiatry, 1985, 142(Suppl 1), 90-93.
111. [110] Descilo, T., Vedamurtachar, A., Gerbarg, P.L., Nagasaja, D., Gangadhar, B.N., Damadaras, B., Adelson, B., Braslow, L.H., Marcus, S., Brown, R.P. Effects of a yoga breath intervention alone and in combination with an exposure therpy for post-traumatic stress disorder and depression in survivors of the 2004 South-East Asia tsunami. Acta. Psychiatr. Scand., 2010, 121, 289-300.
112. [111] Jiang, J.X. Posttraumatic stress and immune dissonance. Chin. J. Traumatol., 2008, 11(Suppl 4), 203-208.
113. [112] Morina, N., Rudari, V., Bleichhardt, G., Prigerson, H.G. Prolonged grief disorder, depression, and posttraumatic stress disorder among bereaved Kosovar civilian war survivors: A preliminary investigation. Int. J. Soc. Psychiatry, 2009, July 10 (in press).
114. [113] http://news.yahoo.com/s/ap/20090727/ap_on_re_us/us_soldier_slayings.
115. [Accessed on: August 5th, 2009].