Dysregulated mitochondrial genes and networks with drug targets in postmortem brain of patients with posttraumatic stress disorder (PTSD) revealed by human mitochondria-focused cDNA microarrays

International Journal of Biological Sciences

Volumn 4, Issue 4, 2008, Pages 223-235

  Su, Yan A ^a,f   Wu, Jun ^a   Zhang, Lei ^b   Zhang, Qiuyang ^a   Su, David M ^a   He, Ping ^c   Wang, Bi Dar ^a   Li, He ^b   Webster, Maree J ^d,h   Rennert, Owen M ^e   Ursano, Robert J ^b   Benedek, David ^g   Holloway, Harry ^g   Hough, Christopher J ^c   Duman, Ronald ⁱ   Friedman, Matthew ^j   Krystal, John ^i,k   Leskin, Gregory ^l   Meyerhoff, James ^m   Osuch, Elizabeth ⁿ  

^a GEORGE WASHINGTON UNIVERSITY SCHOOL OF MEDICINE AND HEALTH SCIENCES   (United States)

^b UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

^c CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^d Stanley Medical Research Institute   (United States)

^e EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^f Ross Hall ^*  (United States)

^g School of Medicine

^h Stanley Medical Research Institute

ⁱ YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^j DEPARTMENT OF VETERANS AFFAIRS   (United States)

^k VA CONNECTICUT HEALTHCARE SYSTEM   (United States)

^l VA PALO ALTO HEALTH CARE SYSTEM   (United States)

^m GEORGETOWN UNIVERSITY SCHOOL OF MEDICINE   (United States)

ⁿ WESTERN UNIVERSITY   (Canada)

more..

Author keywords

Biomarker; Brain dorsolateral prefrontal cortex BA46; Canonical pathways; Gene expression pattern; Mitochondria; Molecular networks; Neuropsychiatric drug targets; PTSD

Indexed keywords

ADULT; APOPTOSIS; ARTICLE; AUTOPSY; BRAIN REGION; BRODMANN AREA 46; CELL SURVIVAL; CONTROLLED STUDY; DNA FINGERPRINTING; DNA MICROARRAY; DRUG TARGETING; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE FUNCTION; HUMAN; HUMAN TISSUE; MALE; MENTAL PATIENT; MICROARRAY ANALYSIS; MITOCHONDRIAL GENE; MITOCHONDRIAL GENETICS; NERVE CELL; NEUROLOGIC DISEASE; OXIDATIVE PHOSPHORYLATION; POSTTRAUMATIC STRESS DISORDER; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

EID: 49749151022     PISSN: 14492288     EISSN: None     Source Type: Journal    
DOI: 10.7150/ijbs.4.223     Document Type: Article

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