The DRD2 gene 957C> T polymorphism is associated with posttraumatic stress disorder in war veterans

Depression and Anxiety

Volumn 26, Issue 1, 2009, Pages 28-33

  Voisey, Joanne ^a   Swagell, Christopher D ^a   Hughes, Ian P ^a   Morris, C Phillip ^a   Van Daal, Angela ^c   Noble, Earnest P ^d   Kann, Burnett ^e   Heslop, Karen A ^a   Young, Ross McD ^a   Lawford, Bruce R ^a,b  

^a QUEENSLAND UNIVERSITY OF TECHNOLOGY   (Australia)

^b BOND UNIVERSITY   (Australia)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d Nambour Selangor Private Hospital   (Australia)

^e ROYAL BRISBANE AND WOMEN'S HOSPITAL   (Australia)

Author keywords

ANKK1; Depression; Dopamine; Genotype; Heritability

Indexed keywords

ANKYRIN; ANKYRIN REPEAT AND KINASE DOMAIN CONTAINING 1; DOPAMINE 2 RECEPTOR; UNCLASSIFIED DRUG;

ALLELE; ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE PREDISPOSITION; DNA POLYMORPHISM; GENE DELETION; GENE FREQUENCY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; POSTTRAUMATIC STRESS DISORDER; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; VETERAN; WAR;

ADULT; ALLELES; AUSTRALIA; COMBAT DISORDERS; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENETIC SCREENING; GENOTYPE; HUMANS; MALE; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, DOPAMINE D2; VETERANS; VIETNAM CONFLICT;

EID: 58549108041     PISSN: 10914269     EISSN: 15206394     Source Type: Journal    
DOI: 10.1002/da.20517     Document Type: Article

References (36)

1. Kesssler RC. Posttraumatic Stress Disorder. The National Comorbidity Survey of Archives of General Psychiatry 1995;52:1048-1060.
2. Koenen KC, Fu QJ, Ertel K, et al. Common genetic liability to major depression and posttraumatic stress disorder in men. J Affect Disord 2008; 105:109-115.
3. Koenen KC, Harley R, Lyons MJ, Wolfe J, Simpson JC, Goldberg J, Eisen SA, Tsuang M. A twin registry study of familial and individual risk factors for trauma exposure and posttraumatic stress disorder. J Nerv Ment Dis 2002; 190:209-218.
4. True WR, Rice J, Eisen SA, et al. A twin study of genetic and environmental contributions to liability for posttraumatic stress symptoms. Arch Gen Psychiatry 1993;50:257-264.
5. Sack WH, Clarke GN, Seeley J. Posttraumatic stress disorder across two generations of Cambodian refugees. J Am Acad Child Adolesc Psychiatry 1995;34:1160-1166.
6. Klimek V, Schenck JE, Han H, Stockmeier CA, Ordway GA. Dopaminergic abnormalities in amygdaloid nuclei in major depression: a postmortem study. Biol Psychiatry 2002;52:740-748.
7. Lawford BR, Young R, Noble EP, Kann B, Ritchie T. The D2 dopamine receptor (DRD2) gene is associated with co-morbid depression, anxiety and social dysfunction in untreated veterans with post-traumatic stress disorder. Eur Psychiatry 2006;21:180-185.
8. Schneier FR, Liebowitz MR, Abi-Dargham A, Zea-Ponce Y, Lin SH, Laruelle M. Low dopamine D(2) receptor binding potential in social phobia. Am J Psychiatry 2000;157:457-459.
9. Abi-Dargham A, Rodenhiser J, Printz D, et al. Increased baseline occupancy of D2 receptors by dopamine in schizophrenia. Proc Natl Acad Sci USA 2000;97:8104-8109.
10. Seeman P, Kapur S. Schizophrenia: more dopamine, more D2 receptors. Proc Natl Acad Sci USA 2000;97:7673-7675.
11. Noble EP, Blum K, Ritchie T, Montgomery A, Sheridan PJ. Allelic association of the D2 dopamine receptor gene with receptor-binding characteristics in alcoholism. Arch Gen Psychiatry 1991;48:648-654.
12. Thompson J, Thomas N, Singleton A, et al. D2 dopamine receptor gene (DRD2) Taq1 A polymorphism: reduced dopamine D2 receptor binding in the human striatum associated with the A1 allele. Pharmacogenetics 1997;7:479-484.
13. Laakso A, Pohjalainen T, Bergman J, Kajander J, Haaparanta M, Solin O, Syvalahti E, Hietala J. The A1 allele of the human D2 dopamine receptor gene is associated with increased activity of striatal L-amino acid decarboxylase in healthy subjects. Pharma-cogenet Genomics 2005;15:387-391.
14. Hanninen K, Katila H, Kampman O, et al. Association between the C957T polymorphism of the dopamine D2 receptor gene and schizophrenia. Neurosci Lett 2006;407:195-198.
15. Hoenicka J, Aragues M, Rodriguez-Jimenez R, et al. C957T DRD2 polymorphism is associated with schizophrenia in Spanish patients. Acta Psychiatr Scand 2006;114:435-438.
16. Lawford BR, Young RM, Swagell CD, et al. The C/C genotype of the C957T polymorphism of the dopamine D2 receptor is associated with schizophrenia. Schizophr Res 2005;73:31-37.
17. Ohara K, Nagai M, Tani K, Nakamura Y, Ino A. Functional polymorphism of -141C Ins/Del in the dopamine D2 receptor gene promoter and schizophrenia. Psychiatry Res 1998;81:117-123.
18. Duan J, Wainwright MS, Comeron JM, et al. Synonymous mutations in the human dopamine receptor D2 (DRD2) affect mRNA stability and synthesis of the receptor. Hum Mol Genet 2003;12:205-216.
19. Hirvonen M, Laakso A, Nagren K, Rinne JO, Pohjalainen T, Hietala J. C957T polymorphism of the dopamine D2 receptor (DRD2) gene affects striatal DRD2 availability in vivo. Mol Psychiatry 2005;10:889.
20. Neville MJ, Johnstone EC, Walton RT. Identification and characterization of ANKK1: a novel kinase gene closely linked to DRD2 on chromosome band 11q23.1. Hum Mutat 2004;23:540-545.
21. Young RM, Lawford BR, Noble EP, et al. Harmful drinking in military veterans with post-traumatic stress disorder: association with the D2 dopamine receptor A1 allele. Alcohol Alcohol 2002;37:451-456.
22. Dubertret C, Gouya L, Hanoun N, et al. The 3' region of the DRD2 gene is involved in genetic susceptibility to schizophrenia. Schizophr Res 2004;67:75-85.
23. Keane TM, Caddell JM, Taylor KL. Mississippi Scale for Combat-Related Posttraumatic Stress Disorder: three studies in reliability and validity. J Consult Clin Psychol 1988;56:85-90.
24. Abramson JH. WINPEPI (PEPI-for-Windows): computer programs for epidemiologists. Epidemiol Perspect Innov 2004;1:6.
25. Lappalainen J, Kranzler HR, Malison R, et al. A functional neuropeptide Y Leu7Pro polymorphism associated with alcohol dependence in a large population sample from the United States. Arch Gen Psychiatry 2002;59:825-831.
26. Deutch AY, Roth RH. The determinants of stress-induced activation of the prefrontal cortical dopamine system. Prog Brain Res 1990;85:367-402; discussion 402-403.
27. Deutch AY YC. A model of the stress-induced activation of prefrontal cortival dopamine systems: Coping and the development of post-traumatic stress disorder. In: Friedman MJ, Young CD, Deutch AY, eds. Neurobiological and Clinical Consequences of Stress. Philadelphia: Lippincott-Raven Press; 1995;163-176.
28. Comings DE, Muhleman D, Gysin R. Dopamine D2 receptor (DRD2) gene and susceptibility to posttraumatic stress disorder: a study and replication. Biol Psychiatry 1996;40:368-372.
29. Gelernter J, Southwick S, Goodson S, Morgan A, Nagy L, Charney DS. No association between D2 dopamine receptor (DRD2) "A" system alleles, or DRD2 haplotypes, and posttraumatic stress disorder. Biol Psychiatry 1999;45:620-625.
30. Kestler LP, Malhotra AK, Finch C, Adler C, Breier A. The relation between dopamine D2 receptor density and personality: preliminary evidence from the NEO personality inventory-revised. Neuropsychiatry Neuropsychol Behav Neurol 2000;13:48-52.
31. Bressan RA, Costa DC, Jones HM, Ell PJ, Pilowsky LS. Typical antipsychotic drugs - D(2) receptor occupancy and depressive symptoms in schizophrenia. Schizophr Res 2002;56:31-36.
32. de Haan L, Lavalaye J, Linszen D, Dingemans PM, Booij J. Subjective experience and striatal dopamine D(2) receptor occupancy in patients with schizophrenia stabilized by olanzapine or risperidone. Am J Psychiatry 2000;157:1019-1020.
33. Stein MB, Walker JR, Forde DR. Gender differences in susceptibility to posttraumatic stress disorder. Behav Res Ther 2000;38:619-628.
34. Breslau N, Anthony JC. Gender differences in the sensitivity to posttraumatic stress disorder: an epidemiological study of urban young adults. J Abnorm Psychol 2007;116:607-611.
35. Perneger TV What's wrong with Bonferroni adjustments. Br Med J 1998;316:1236-1238.
36. Bachmann AW, Sedgley TL, Jackson RV, Gibson JN, Young RM, Torpy DJ. Glucocorticoid receptor polymorphisms and post-traumatic stress disorder. Psychoneuroendocrinology 2005;30:297-306.