Nutrigenomic targeting of carbohydrate craving behavior: Can we manage obesity and aberrant craving behaviors with neurochemical pathway manipulation by Immunological Compatible Substances (nutrients) using a Genetic Positioning System (GPS) Map?

Medical Hypotheses

Volumn 73, Issue 3, 2009, Pages 427-434

  Downs, B William ^a   Chen, Amanda L C ^b   Chen, Thomas J H ^b   Waite, Roger L ^a   Braverman, Eric R ^c,d   Kerner, Mallory ^d   Braverman, Dasha ^d   Rhoades, Patrick ^e   Prihoda, Thomas J ^f   Palomo, Tomas ^g   Oscar Berman, Marlene ^h   Reinking, Jeffrey ⁱ   Blum, Seth H ^j   DiNubile, Nicholas A ^k   Liu, H H ^l   Blum, Kenneth ^m  

^a LifeGen Inc   (United States)

^b CHANG JUNG CHRISTIAN UNIVERSITY   (Taiwan)

^c WEILL CORNELL MEDICAL COLLEGE   (United States)

^d PATH Clinics   (United States)

^e PATH Clinics ^*  (United States)

^f Mays Cancer Center at UT Health San Antonio   (United States)

^g HOSPITAL UNIVERSITARIO 12 DE OCTUBRE   (Spain)

^h BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

ⁱ UNIVERSITY OF CALIFORNIA   (United States)

^j Synaptamine Inc   (United States)

^k HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

^l CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

^m WAKE FOREST SCHOOL OF MEDICINE   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOBESITY AGENT; BROMOCRIPTINE; DNA; DOPAMINE 2 RECEPTOR; DOPAMINE RECEPTOR BLOCKING AGENT; DOPAMINE RECEPTOR STIMULATING AGENT; GLUCOSE; LG 839; MESSENGER RNA; NEUROTRANSMITTER; NUTRACEUTICAL; PLACEBO; RIMONABANT; SG 8839; SIBUTRAMINE; SYNAPTAMINE; UNCLASSIFIED DRUG;

ARTICLE; BEHAVIOR DISORDER; CARBOHYDRATE CRAVING BEHAVIOR; CLINICAL TRIAL; DRUG EFFICACY; DRUG SAFETY; DRUG TARGETING; GENE EXPRESSION; GENE MAPPING; GENE TARGETING; GENETIC POLYMORPHISM; HEALTH CARE POLICY; HUMAN; HYPOTHESIS; LIPOGENESIS; LIPOLYSIS; NEUROCHEMISTRY; NONHUMAN; NUTRIGENOMICS; OBESITY; OUTCOME ASSESSMENT; PATIENT SAFETY; PREDICTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; REWARD; THEORETICAL MODEL;

CHROMOSOME MAPPING; DIETARY CARBOHYDRATES; EATING DISORDERS; FEEDING BEHAVIOR; GENE TARGETING; GENE THERAPY; HUMANS; OBESITY; SIGNAL TRANSDUCTION;

EID: 67649961275     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mehy.2009.02.037     Document Type: Article

References (49)

1. Blum K., Chen A.L., Chen T.J., Braverman E.R., Blum S.H., Cassel K., et al. Activation instead of blocking mesolimbic dopaminergic reward circuitry is a preferred modality in the long term treatment of reward deficiency syndrome (RDS): a commentary. Theor Biol Med Model 5 (2008) 24 [Epub ahead of print]
2. Blum K., Chen T.J.H., Downs B.W., Meshkin B., Blum S.H., Martinez-Pons M., et al. Synaptamine (Sg8839): an amino-acid enkephalinase inhibition nutraceutical improves recovery of alcoholics, a subtype of Reward Deficiency Syndrome (RDS). Trends Appl Sci Res 2 (2007) 132-138
3. Li C.Y., Mao X., and Wei L. Genes and (common) pathways underlying drug addiction. PLoS Comput Biol 4 1 (2008) e2 [Epub 2007 Nov 20]
4. Boundy V.A., Pacheco M.A., Guan W., and Molinoff P.B. Agonists and antagonists differentially regulate the high affinity state of the D2L receptor in human embryonic kidney 293 cells. Mol Pharmacol 48 (1995) 956-964
5. Boundy V.A., Lu L., and Molinoff P.B. Differential coupling of rat D2 dopamine receptor isoforms expressed in Spodoptera frugiperda insect cells. J Pharmacol Exp Ther 276 (1996) 784-794
6. Noble E.P., Blum K., Ritchie T., Montgomery A., and Sheridan P.J. Allelic association of the D2 dopamine receptor gene with receptor-binding characteristics in alcoholism. Arch Gen Psychiatry 48 (1991) 648-654
7. Ferré S., Quiroz C., Woods A.S., Cunha R., Popoli P., Ciruela F., et al. An update on adenosine A2A-dopamine D2 receptor interactions: implications for the function of G protein-coupled receptors. Curr Pharm Des 14 (2008) 1468-1474
8. Kirsch P., Reuter M., Mier D., Lonsdorf T., Stark R., Gallhofer B., et al. Imaging gene-substance interactions: the effect of the DRD2 TaqIA polymorphism and the dopamine agonist bromocriptine on the brain activation during the anticipation of reward. Neurosci Lett 405 (2006) 196-201
9. Lawford B.R., Young R.M., Rowell J.A., Qualichefski J., Fletcher B.H., Syndulko K., et al. Bromocriptine in the treatment of alcoholics with the D2 dopamine receptor A1 allele. Nat Med 1 (1995) 337-341
10. Blum K., Chen T.J., Meshkin B., Waite R.L., Downs B.W., Blum S.H., et al. Manipulation of catechol-O-methyl-transferase (COMT) activity to influence the attenuation of substance seeking behavior, a subtype of Reward Deficiency Syndrome (RDS), is dependent upon gene polymorphisms: a hypothesis. Med Hypotheses 69 (2007) 1054-1060
11. Blum K., Chen A.L., Chen T.J., Rhoades P., Prihoda T.J., Downs B.W., et al. LG839: anti-obesity effects and polymorphic gene correlates of reward deficiency syndrome. Adv Ther 25 (2008) 894-913
12. Blum K., Chen A.L.C., Chen T.L.C., Rhoades P., Prihoda P., Downs B.W., et al. Dopamine D2 Receptor Taq A1 allele predicts treatment compliance of LG839 in a subset analysis of a pilot study in The Netherlands. Gene Therapy Mol Biol 12 (2008) 129-140
13. Blum K, Chen TJH Chen, Williams L, Chen ALC, Downs BW, Waite RL, et al. A short term pilot open label study to evaluate efficacy and safety of LG839, a customized DNA directed nutraceutical in obesity: exploring nutrigenomics. Gene Ther Mol Biol 2008:12.
14. Blum K., Chen T.J.H., Meshkin B., Downs B.W., Gordon C.A., Blum S.H., et al. Reward Deficiency Syndrome in obesity: a preliminary cross-sectional trial with a genotrim variant. Adv Ther 23 (2006) 1040-1051
15. Chen T.J., Blum K., Payte J.T., Schoolfield J., Hopper D., and Stanford M. Narcotic antagonists in drug dependence: pilot study showing enhancement of compliance with SYN-10, amino-acid precursors and enkephalinase inhibition therapy. Med Hypotheses 63 (2004) 538-548
16. Thanos P.K., Volkow N.D., Freimuth P., Umegaki H., Ikari H., Roth G., et al. Overexpression of dopamine D2 receptors reduces alcohol self-administration. J Neurochem 78 (2001) 1094-1103
17. Meshkin B., Chen T.J.H., Chen A.L.C., Prihoda T.J.H., Morrisette H., Braverman E.R., et al. Health economics of nutrigenomics in weight management. Gene Ther Mol Biol 12 (2008) 25-30
18. Comings D.E., and Blum K. Reward deficiency syndrome: genetic aspects of behavioral disorders. Prog Brain Res 126 (2000) 325-341
19. Chen A.L.C., Blum K., Chen T.J.H., Rhinking J., Waite R.L., Downs B.W., et al. The impact of biomics technology and DNA directed anti-obesity targeting of the brain reward circuitry. Gene Therapy Mol Biol 12 (2008) 45-68
20. Bowirrat A., and Oscar-Berman M. Relationship between dopaminergic neurotransmission, alcoholism, and Reward Deficiency Syndrome. Am J Med Genet B Neuropsychiatr Genet 132B 1 (2005) 29-37
21. Epstein L.H., Temple J.L., Neaderhiser B.J., Salis R.J., and Erbe R.W. Food reinforcement, the dopamine D2 receptor genotype, and energy intake in obese and nonobese humans. Behav Neurosci 121 (2007) 877-889
22. Maes H.H., Neale M., and Eaves I.J. Genetic and environmental factors in relative body weight and human adiposity. Behav Gen 27 (1997) 325-351
23. Blum K., Braverman E.R., Holder J.M., Lubar J.F., Monastra V.J., Miller D., et al. Reward deficiency syndrome: a biogenetic model for the diagnosis and treatment of impulsive, addictive, and compulsive behaviors. J Psychoactive Drugs 32 Suppl. (2000) 1-100
24. Chen T.J.H., Blum K., Kaats G., Braverman E., Pullin D., Downs B.W., et al. Reviewing the role of putative candidate genes in "Neurobesigenics" a clinical subtype of Reward Deficiency Syndrome (RDS). Gene Ther Mol Biol 11 (2007) 61-74
25. Blum K., Cull J.G., Chen T.J.H., Garcia-Swan S., Holder J.M., Wood R.C., et al. Clinical evidence for effectiveness of PhenCal in maintaining weight loss in an open-label, controlled, 2 year study. Curr Ther Res 58 (1997) 745-763
26. Blum K., Meshkin B., and Downs B.W. DNA based customized nutraceutical "gene therapy" utilizing a genoscore: a hypothesized paradigm shift of a novel approach to the diagnosis, stratification, prognosis and treatment of inflammatory processes in the human. Med Hypotheses 66 (2006) 1008-1018
27. Corthésy-Theulaz I., den Dunnen J.T., Ferré P., Geurts J.M., Müller M., and Van Belzen N. Nutrigenomics: the impact of biomics technology on nutrition research. Ann Nutr Metab 49 (2005) 355-365
28. Crombag H.S., Bossert J.M., Koya E., and Shaham Y. Context-induced relapse to drug seeking: a review. Philos Trans R Soc Lond B Biol Sci 36 (2008) 3233-3243
29. Prentice A.M., Rayco-Solon P., and Moore S.E. Insights from the developing world: thrifty genotypes and thrifty phenotypes. Proc Nutr Soc 64 (2005) 153-161
30. Blum K., Chen T.J.H., Blum S.H., Downs B.W., Braverman E.R., Mengucci J.F., et al. Nutrigenomics and pharmacogenomics: a scientific wonderland. Biol Social Life (Social Sci Inform) 45 (2006) 35-52
31. Martin R. The role of law in the control of obesity in England: looking at the contribution of law to a healthy food culture. Aust New Zealand Health Policy 2008;5:21.
32. Brownell K.D., and Warner K.E. The perils of ignoring history: m big tobacco played dirty and millions died: how similar is big Food?. The Milbank Quarterly 87 (2009) 259-294
33. Kathiresan S., Willer C.J., Peloso G.M., Demissie S., Musunuru K., Schadt E.E., et al. Common variants at 30 loci contribute to polygenic dyslipidemia. Nat Genet 41 1 (2009) 56-65
34. Oben J.E., Ngondi J.L., and Blum K. Inhibition of Irvingia gabonensis seed extract (OB131) on adipogenesis as mediated via down regulation of the PPARgamma and Leptin genes and up-regulation of the adiponectin gene. Lipids Health Dis 7 (2008) 4450
35. Volkow N.D., Wang G.J., Telang F., Fowler J.S., Thanos P.K., Logan J., et al. Low dopamine striatal D2 receptors are associated with prefrontal metabolism in obese subjects: possible contributing factors. Neuroimage 42 (2008) 1537-1543
36. Barnard N.D., Noble E.P., Ritchie T., Cohen J., Jenkins D.J., Turner-McGrievy G., et al. D2 dopamine receptor Taq1A polymorphism, body weight, and dietary intake in type 2 diabetes. Nutrition 25 (2009) 58-65
37. Bray M.S., Hagberg J.M., Pérusse L., Rankinen T., Roth S.M., Wolfarth B., et al. The human gene map for performance and health-related fitness phenotypes: the 2006-2007 update. Med Sci Sports Exerc 41 (2009) 35-73
38. Stice E., Spoor S., Bohan C., and Small D.M. Relation between Obesity and blunted striatal response to food is moderated by Taq A1 allele. Science 322 (2008) 449-452
39. Geiger B.M., Behr G.G., Frank L.E., Caldera-Siu A.D., Beinfeld M.C., Kokkotou E.G., et al. Evidence for defective mesolimbic dopamine exocytosis in obesity-prone rats. FASEB J 22 8 (2008) 2740-2746
40. Comings D.E., Gade R., MacMurray J.P., Muhleman D., and Peters W.R. Genetic variants of the human obesity (OB) gene: association with psychiatric symptoms and body mass index in young women, and interaction with the dopamine D2 receptor (DRD2) gene. Mol Psychiatry 1 (1996) 325-335
41. Ponce G., Jimenez-Arriero M.A., Rubio G., Hoenicka J., Ampuero I., Ramos J.A., et al. The A1 allele of the DRD2 gene (TaqI A polymorphisms) is associated with antisocial personality in a sample of alcohol-dependent patients. Eur Psychiatry 18 (2003) 356-360
42. Davis CA, Levitan RD, Reid C, Carter JC, Kaplan AS, Patte AS, et al. Dopamine for "Wanting" and Opioids for "Liking": A comparison of Obese adults with and without Binge "Eating". Obesity 2009; in press.
43. Rada P., Avena N.M., and Hoebel B.G. Daily bingeing on sugar repeatedly releases dopamine in the accumbens. Neuroscience 134 (2005) 737-744
44. Chang G.O., Gaysinskaya V., Karatayev O., and Leibowitz S.F. Maternal high-fat diet and fetal programming: increased proliferation of Hypothalmic pepetide-producing neurons that increase risk for overeating and obesity. J Neurosci 28 (2008) 12107-12119
45. Blass E.M. Biological and Environmental determinants of childhood obesity. Nutr Clin Care 6 (2003) 13-19
46. Hodgkins C.C., CaHill K.S., Seraphine A.E., Frost-Pineda K., and Gold M.S. Adolescent drug addiction treatment and weight gain. J Addict Dis (2004) 55-65
47. Grimm J.W., Osincup D., Wells B., Manaois M., Fyall A., Buse C., et al. Environmental enrichment attenuates cue-induced reinforcement of sucrose seeking in rats. Behav Pharmacol 19 (2008) 777-785
48. Lenoir M., Serre F., Cantin L., and Ahmed S.H. Intense sweetness surpasses cocaine reward. Plos One 2 8 (2007) e698
49. Gearhardt A.N., Corbin W.R., and Brownell K.D. Preliminary validation of the Yale Food Addiction Scale. Appetite 52 (2009) 439-446