Japanese herbal medicine, inchinkoto, inhibits inducible nitric oxide synthase induction in interleukin-1β-stimulated hepatocytes

Hepatology Research

Volumn 42, Issue 1, 2012, Pages 76-90

  Matsuura, Takashi ^a   Kaibori, Masaki ^a   Araki, Yoshiro ^a   Matsumiya, Miho ^a   Yamamoto, Yuka ^b   Ikeya, Yukinobu ^b   Nishizawa, Mikio ^b   Okumura, Tadayoshi ^a,b   Kwon, A Hon ^a  

^a KANSAI MEDICAL UNIVERSITY   (Japan)

^b RITSUMEIKAN UNIVERSITY   (Japan)

Author keywords

Inducible nitric oxide synthase; Interleukin 1 ; Liver injury; Nuclear factor B; Primary cultured hepatocytes; Type I interleukin 1 receptor

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INCHINKO TO; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 1BETA; MESSENGER RNA; NITRIC OXIDE; PROTEIN KINASE B;

ANIMAL CELL; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA BINDING; DRUG EFFECT; ENZYME ACTIVATION; ENZYME INDUCTION; ENZYME INHIBITION; GENE CONSTRUCT; GENE OVEREXPRESSION; GENETIC TRANSFECTION; HERBAL MEDICINE; IN VITRO STUDY; JAPANESE; LIVER CELL; LIVER INJURY; LIVER PROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT; RNA STABILITY; SIGNAL TRANSDUCTION; TRANSACTIVATION;

EID: 84055184772     PISSN: 13866346     EISSN: 1872034X     Source Type: Journal    
DOI: 10.1111/j.1872-034X.2011.00891.x     Document Type: Article

References (37)

1. Arai M, Yokosuka O, Fukai K etal. A case of severe acute hepatitis of unknown etiology treated with the Chinese herbal medicine Inchinko-to. Hepatol Res 2004; 28: 161-5.
2. Ohwada S, Kobayashi I, Hasegawa N, Tsuda K, Inui Y. Severe acute cholistatic hepatitis of unknown etiology successfully treated with the Chinese herbal medicine Inchinko-to (TJ-135). World J Gastroenterol 2009; 15: 2927-9.
3. Okada K, Shoda J, Kano M etal. Inchinkoto, a herbal medicine, and its ingredients dually exert Mrp2/MRP2-mediated choleresis and Nrf2-mediated antioxidative action in rat livers. Am J Physiol Gastrointest Liver Physiol 2007; 292: G1450-63.
4. Shoda J, Miura T, Utsunomiya H etal. Genipin enhances Mrp2 (Abcc2)-mediated bile formation and organic anion transport in rat liver. Hepatology 2004; 39: 167-78.
5. Ikeda H, Nagashima K, Yanase M etal. The herbal medicine inchin-ko-to (TJ-135) induces apoptosis in cultured rat hepatic stellate cells. Life Sci 2006; 78: 2226-33.
6. Inao M, Mochida S, Matsui A etal. Japanese herbal medicine Inchin-ko-to as a therapeutic drug for liver fibrosis. J Hepatol 2004; 41: 584-91.
7. Colasanti M, Suzuki H. The dual personality of NO. Trends Pharmacol Sci 2000; 21: 249-52.
8. Tsuchiya H, Kaibori M, Yanagida H etal. Pirfenidone prevents endotoxin-induced liver injury after partial hepatectomy in rats. J Hepatol 2004; 40: 94-101.
9. Tsuji K, Kwon A-H, Yoshida H etal. Free radical scavenger (edaravone) prevents endotoxin-induced liver injury after partial hepatectomy in rats. J Hepatol 2005; 42: 94-101.
10. + exchanger inhibitor, FR183998, has protective effect in lethal acute liver failure and prevents iNOS induction in rats. J Hepatol 2008; 48: 289-99.
11. Hijikawa T, Kaibori M, Uchida Y etal. Insulin-like growth factor-I prevents liver injury through the inhibition of TNF-α and iNOS induction in d-galactosamine and lipopolysaccharide-treated rats. Shock 2008; 29: 740-7.
12. + exchanger inhibitor, and its inhibition of iNOS induction in hepatic ischemia-reperfusion injury in rats. Shock 2008; 30: 311-17.
13. Nakanishi H, Kaibori M, Teshima S etal. Pirfenidone inhibits the induction of iNOS stimulated by interleukin-1β at a step of NF-kB DNA binding in hepatocytes. J Hepatol 2004; 41: 730-6.
14. Yoshida H, Kwon A-H, Kaibori M etal. Edaravone prevents iNOS expression by inhibiting its promoter transactivation and mRNA stability in cytokine-stimulated hepatocytes. Nitric Oxide Biol Chem 2008; 18: 105-12.
15. Kanemaki T, Kitade H, Hiramatsu Y, Kamiyama Y, Okumura T. Stimulation of glycogen degradation by prostaglandin E2 in primary cultured rat hepatocytes. Prostaglandins 1993; 45: 459-74.
16. Seglen PO. Preparation of isolated rat liver cells. Methods Cell Biol 1976; 13: 29-83.
17. Horiuti Y, Ogishima M, Yano K, Shibuya Y. Quantification of cell nuclei isolated from hepatocytes by cell lysis with nonionic detergent in citric acid. Cell Struct Funct 1991; 16: 203-7.
18. Green LC, Wagner DA, Glogowski J, Skipper PL, Wishnok JS, Tannenbaum SR. Analysis of nitrate, nitrite and [15N]nitrate in biological fluids. Anal Biochem 1982; 126: 131-8.
19. Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 1987; 162: 156-9.
20. Nishizawa M, Nakajima T, Yasuda K etal. Close kinship of human 20alpha-hydroxysteroid dehydrogenase gene with three aldo-keto reductase genes. Genes Cells 2000; 5: 111-25.
21. Unezaki S, Nishizawa M, Okuda-Ashitaka E etal. Characterization of the isoforms of MOVO zinc finger protein, a mouse homologue of Drosophila Ovo, as transcription factors. Gene 2004; 336: 47-58.
22. Schreiber E, Matthias P, Müller MM, Schaffner W. Rapid detection of octamer binding proteins with mini-extracts, prepared from a small number of cells. Nucleic Acids Res 1989; 17: 6419.
23. Oda M, Sakitani K, Kaibori M, Inoue T, Kamiyama Y, Okumura T. Vicinal dithiol-binding agent, phenylarsine oxide, inhibits iNOS gene expression at a step of NF-κB DNA binding in hepatocytes. J Biol Chem 2000; 275: 4369-73.
24. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976; 72: 248-54.
25. Matsui K, Kawaguchi Y, Ozaki T etal. Effect of active hexose correlated compound on the production of nitric oxide in hepatocytes. JPEN J Parenter Enteral Nutr 2007; 31: 373-81.
26. Inoue T, Kwon A-H, Oda M etal. Hypoxia and heat inhibit inducible nitric oxide synthase gene expression by different mechanisms in rat hepatocytes. Hepatology 2000; 32: 1037-44.
27. Kitade H, Sakitani K, Inoue K etal. Interleukin-1β markedly stimulates nitric oxide formation in the absence of other cytokines or lipopolysaccharide in primary cultured rat hepatocytes, but not in Kupffer cells. Hepatology 1996; 23: 797-802.
28. Sakitani K, Nishizawa M, Inoue K, Masu Y, Okumura T, Ito S. Synergistic regulation of inducible nitric oxide synthase gene by CCAAT/enhancer-binding protein b and nuclear factor-κB in hepatocytes. Genes Cells 1998; 3: 321-30.
29. Yamada M, Nishizawa M, Nakatake R etal. Characterization of alternatively spliced isoforms of the type I interleukin-1 receptor on iNOS induction in rat hepatocytes. Nitric Oxide Biol Chem 2007; 17: 98-105.
30. Kleinert H, Pautz A, Linker K, Schwarz PM. Regulation of the expression of inducible nitric oxide synthase. Eur J Pharmacol 2004; 500: 255-66.
31. Akira S, Kishimoto T. NF-IL6 and NF-kB in cytokine gene regulation. Adv Immunol 1997; 65: 1-46.
32. Teshima S, Nakanishi H, Nishizawa M etal. Up-regulation of IL-1 receptor through PI3K/Akt is essential for the induction of iNOS gene expression in hepatocytes. J Hepatol 2004; 40: 616-23.
33. Pautz A, Linker K, Hubrich R, Korhonen R, Altenhofer S, Kleivert H. The polypyrimidine tract-binding protein (PTB) is involved in the post-transcriptional regulation of human inducible nitric oxide synthase expression. J Biol Chem 2006; 281: 32294-302.
34. Matsui K, Nishizawa M, Ozaki T etal. Natural antisense transcript stabilizes inducible nitric oxide synthase mRNA in rat hepatocytes. Hepatology 2008; 47: 686-97.
35. Araki Y, Matsumiya M, Matsuura T etal. Sivelestat suppresses iNOS gene expression in proinflammatory cytokine-stimulatied hepatocytes. Dig Dis Sci 2011; 56: 1672-81.
36. Kawai K, Yokoyama Y, Kokuryo T, Watanabe K, Kitagawa T, Nagino M. Inchinkoto, an herbal medicine, exerts beneficial effects in the rat liver under stress with hepatic ischemia-reperfusion and subsequent hepatectomy. Ann Surg 2010; 251: 692-700.
37. Akao T, Kobayashi K, Aburada M. Enzymic studies on the animal and intestinal bacterial metabolism of geniposide. Biol Pharm Bull 1994; 17: 1573-6.