Severe acute cholestatic hepatitis of unknown etiology successfully treated with the Chinese herbal medicine Inchinko-to (TJ-135)

World Journal of Gastroenterology

Volumn 15, Issue 23, 2009, Pages 2927-2929

  Ohwada, Susumu ^a   Kobayashi, Isao ^a   Harasawa, Nobuo ^a   Tsuda, Kyoichiro ^a   Inui, Yosikatsu ^b  

^a Kanetsu Chuo Hospital   (Japan)

^b Inui Clinic of Internal Medicine   (Japan)

Author keywords

Acute cholestatic hepatitis; Etiology; Herbal medicine; Inchinko to

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; INCHINKO TO; LACTATE DEHYDROGENASE; PREDNISOLONE; URSODEOXYCHOLIC ACID;

ABSENCE OF SIDE EFFECTS; ACUTE DISEASE; ADULT; ANOREXIA; ARTICLE; ASCITES; CASE REPORT; CHINESE MEDICINE; CHOLECYSTITIS; CHOLESTATIC HEPATITIS; COMPLEMENT HEMOLYSIS TEST; COMPUTER ASSISTED TOMOGRAPHY; DISEASE SEVERITY; DRUG EFFECT; ECHOGRAPHY; FATIGUE; GALLBLADDER DISEASE; HUMAN; IDIOPATHIC DISEASE; LIVER BIOPSY; LIVER DYSFUNCTION; LIVER FIBROSIS; LIVER FUNCTION TEST; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; PHYSICAL EXAMINATION; SKIN DISCOLORATION;

EID: 67651241831     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.15.2927     Document Type: Article

References (23)

1. Fujiwara K, Mochida S, Matsui A, Nakayama N, Nagoshi S, Toda G. Fulminant hepatitis and late onset hepatic failure in Japan. Hepatol Res 2008; 38: 646-657
2. Aburada M, Sasaki H, Harada M. Pharmacological studies of Gardeniae Fructus II. Contribution of the constituent crude drugs to choleretic activity of "Inchiko-to" in rats. Yakugaku Zasshi 1976; 96: 147-153
3. Kobayashi H, Horikoshi K, Yamataka A, Lane GJ, Yamamoto M, Miyano T. Beneficial effect of a traditional herbal medicine (inchin-ko-to) in postoperative biliary atresia patients. Pediatr Surg Int 2001; 17: 386-389
4. Iinuma Y, Kubota M, Yagi M, Kanada S, Yamazaki S, Kinoshita Y. Effects of the herbal medicine Inchinko-to on liver function in postoperative patients with biliary atresia - a pilot study. J Pediatr Surg 2003; 38: 1607-1611
5. Kaiho T, Tsuchiya S, Yanagisawa S, Takeuchi O, Togawa A, Okamoto R, Saigusa N, Miyazaki M. Effect of the herbal medicine Inchin-Ko-To for serum bilirubin in hepatectomized patients. Hepatogastroenterology 2008; 55: 150-154
6. Arai M, Yokosuka O, Fukai K, Kanda T, Kojima H, Kawai S, Imazeki F, Hirasawa H, Saisho H. A case of severe acute hepatitis of unknown etiology treated with the Chinese herbal medicine Inchinko-to. Hepatol Res 2004; 28: 161-165
7. Tang CP, Shiau YT, Huang YH, Tsay SH, Huo TI, Wu JC, Lin HC, Lee SD. Cholestatic jaundice as the predominant presentation in a patient with autoimmune hepatitis. J Chin Med Assoc 2008; 71: 45-48
8. Yamamoto M, Ogawa K, Morita M, Fukuda K, Komatsu Y. The herbal medicine Inchin-ko-to inhibits liver cell apoptosis induced by transforming growth factor beta 1. Hepatology 1996; 23: 552-559
9. Yamamoto M, Miura N, Ohtake N, Amagaya S, Ishige A, Sasaki H, Komatsu Y, Fukuda K, Ito T, Terasawa K. Genipin, a metabolite derived from the herbal medicine Inchin-ko-to, and suppression of Fas-induced lethal liver apoptosis in mice. Gastroenterology 2000; 118: 380-389
10. Takeuchi S, Goto T, Mikami K, Miura K, Ohshima S, Yoneyama K, Sato M, Shibuya T, Watanabe D, Kataoka E, Segawa D, Endo A, Sato W, Yoshino R, Watanabe S. Genipin prevents fulminant hepatic failure resulting in reduction of lethality through the suppression of TNF-alpha production. Hepatol Res 2005; 33: 298-305
11. Shoda J, Miura T, Utsunomiya H, Oda K, Yamamoto M, Kano M, Ikegami T, Tanaka N, Akita H, Ito K, Suzuki H, Sugiyama Y. Genipin enhances Mrp2 (Abcc2)-mediated bile formation and organic anion transport in rat liver. Hepatology 2004; 39: 167-178
12. Huang W, Zhang J, Moore DD. A traditional herbal medicine enhances bilirubin clearance by activating the nuclear receptor CAR. J Clin Invest 2004; 113: 137-143
13. Okada K, Shoda J, Kano M, Suzuki S, Ohtake N, Yamamoto M, Takahashi H, Utsunomiya H, Oda K, Sato K, Watanabe A, Ishii T, Itoh K, Yamamoto M, Yokoi T, Yoshizato K, Sugiyama Y, Suzuki H. Inchinkoto, a herbal medicine, and its ingredients dually exert Mrp2/MRP2-mediated choleresis and Nrf2-mediated antioxidative action in rat livers. Am J Physiol Gastrointest Liver Physiol 2007; 292: G1450-G1463
14. Takeda S, Yuasa K, Endo T, Aburada M. Pharmacological studies on iridoid compounds. II. Relationship between structures and choleretic actions of iridoid compound. J Pharmacobiodyn 1980; 3: 485-492
15. Sakagami Y, Mizoguchi Y, Seki S, Miyajima K, Kobayashi K, Shin T, Takeda H, Morisawa S. Effect of Inchin-koto treatment on intrahepatic cholestasis and acute severe hepatitis [English abstract]. J Med Pharm Soc Wakan-Yaku 1987; 4: 124-129
16. Kondo T, Suda T, Fukuyama H, Adachi M, Nagata S. Essential roles of the Fas ligand in the development of hepatitis. Nat Med 1997; 3: 409-413
17. Ogasawara J, Watanabe-Fukunaga R, Adachi M, Matsuzawa A, Kasugai T, Kitamura Y, Itoh N, Suda T, Nagata S. Lethal effect of the anti-Fas antibody in mice. Nature 1993; 364: 806-809
18. Trauner M, Meier PJ, Boyer JL. Molecular pathogenesis of cholestasis. N Engl J Med 1998; 339: 1217-1227
19. Takano S, Ito Y, Yokosuka O, Ohto M, Uchiumi K, Hirota K, Omata M. A multicenter randomized controlled dose study of ursodeoxycholic acid for chronic hepatitis C. Hepatology 1994; 20: 558-564
20. Kadayifci A, Savas MC, Arslan S, Güllú IH. Ursodeoxycholic acid in the management of prolonged cholestasis of acute hepatitis B. J Clin Gastroenterol 1997; 24: 125-126
21. Beuers U, Boyer JL, Paumgartner G. Ursodeoxycholic acid in cholestasis: potential mechanisms of action and therapeutic applications. Hepatology 1998; 28: 1449-1453
22. Fickert P, Zollner G, Fuchsbichler A, Stumptner C, Pojer C, Zenz R, Lammert F, Stieger B, Meier PJ, Zatloukal K, Denk H, Trauner M. Effects of ursodeoxycholic and cholic acid feeding on hepatocellular transporter expression in mouse liver. Gastroenterology 2001; 121: 170-183
23. Rodrigues CM, Fan G, Ma X, Kren BT, Steer CJ. A novel role for ursodeoxycholic acid in inhibiting apoptosis by modulating mitochondrial membrane perturbation. J Clin Invest 1998; 101: 2790-2799