Cells, biomarkers, and post-traumatic stress disorder: Evidence for peripheral involvement in a central disease

Journal of Neurochemistry

Volumn 120, Issue 1, 2012, Pages 26-36

  Andrews, James A ^a   Neises, Kameran D ^a  

^a NAVAL MEDICAL CENTER SAN DIEGO   (United States)

Author keywords

biomarkers; PBMC; post traumatic stress disorder; PTSD

Indexed keywords

BIOLOGICAL MARKER; CALGRANULIN A; CD14 ANTIGEN; GAMMA INTERFERON; GLUCOCORTICOID; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1; INTERLEUKIN 4; INTERLEUKIN 6; NERVE GROWTH FACTOR; NEUROPEPTIDE Y; STROMAL CELL DERIVED FACTOR 1; TUMOR NECROSIS FACTOR ALPHA;

BLOOD BRAIN BARRIER; BRAIN ATROPHY; CELL MIGRATION; DEPRESSION; HIPPOCAMPUS; HUMAN; MICROGLIA; MULTIPLE SCLEROSIS; NERVE DEGENERATION; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; PARKINSON DISEASE; PERIPHERAL BLOOD MONONUCLEAR CELL; POSTTRAUMATIC STRESS DISORDER; PRIORITY JOURNAL; REVIEW; T LYMPHOCYTE; TINNITUS; TRAUMATIC BRAIN INJURY; WHITE MATTER;

ANIMALS; ANTIGENS, CD14; ATP-BINDING CASSETTE TRANSPORTERS; BIOLOGICAL MARKERS; CENTRAL NERVOUS SYSTEM DISEASES; GLUCOCORTICOIDS; GTP-BINDING PROTEIN ALPHA SUBUNITS, GS; HUMANS; MONOCYTES; NEUROPEPTIDE Y; PERIPHERAL NERVOUS SYSTEM; STRESS DISORDERS, POST-TRAUMATIC; TUMOR NECROSIS FACTOR-ALPHA;

ANIMALIA;

EID: 83855162715     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2011.07545.x     Document Type: Review

References (81)

1. Ajmo C. T., Vernon D. O. L., Collier L., Hall A. A., Garbuzova-Davis S., Willing A., and, Pennypacker K. R., (2008) The spleen contributes to stroke-induced neurodegeneration. J. Neurosci. Res. 86, 2227-2234.
2. Aloe L., Bracci-Laudiero L., Alleva E., Lambiase A., Micera A., and, Tirassa P., (1994) Emotional stress induced by parachute jumping enhances blood nerve growth factor levels and the distribution of nerve growth factor receptors in lymphocytes. Proc. Natl. Acad. Sci. USA 91, 10440-10444. (Pubitemid 24329013)
3. American Psychology Association (2000) Diagnostic and Statistical Manual of Mental Disorders. American Psychiatric Association, Washington, DC.
4. Bechmann I., Goldmann J., Kovac A. D., Kwidzinski E., Simburger E., Naftolin F., Dirnagl U., Nitsch R., and, Priller J., (2005) Circulating monocytic cells infiltrate layers of anterograde axonal degeneration where they transform into microglia. FASEB J. 19, 647-649. (Pubitemid 40471273)
5. Belvindrah R., Hankel S., Walker J., Patton B. L., and, Muller U., (2007) Beta1 integrins control the formation of cell chains in the adult rostral migratory stream. J. Neurosci. 27, 2704-2717. (Pubitemid 46393595)
6. Beschorner R., Engel S., Mittelbronn M., Adjodah D., Dietz K., Schluesener H. J., and, Meyermann R., (2000) Differential regulation of the monocytic calcium-binding peptides macrophage-inhibiting factor related protein-8 (MRP8/S100A8) and allograft inflammatory factor-1 (AIF-1) following human traumatic brain injury. Acta Neuropathol. 100, 627-634.
7. Beschorner R., Nguyen T. D., Gozalan F., Pedal I., Mattern R., Schluesener H. J., Meyermann R., and, Schwab J. M., (2002a) CD14 expression by activated parenchymal microglia/macrophages and infiltrating monocytes following human traumatic brain injury. Acta Neuropathol. 103, 541-549. (Pubitemid 36067501)
8. Beschorner R., Schluesener H. J., Gozalan F., Meyermann R., and, Schwab J. M., (2002b) Infiltrating CD14 + monocytes and expression of CD14 by activated parenchymal microglia/macrophages contribute to the pool of CD14 + cells in ischemic brain lesions. J. Neuroimmunol. 126, 107-115. (Pubitemid 34521736)
9. Bremner J. D., Elzinga B., Schmahl C., and, Vermetten E., (2008) Structural and functional plasticity of the human brain in posttraumatic stress disorder. Prog. Brain Res. 167, 171-186.
10. van Buul J. D., and, Hordijk P. L., (2004) Signaling in leukocyte transendothelial migration. Arterioscler. Thromb. Vasc. Biol. 24, 824-833. (Pubitemid 38620858)
11. Cauwels A., Frei K., Sansano S., Fearns C., Ulevitch R., Zimmerli W., and, Landmann R., (1999) The origin and function of soluble CD14 in experimental bacterial meningitis. J. Immunol. 162, 4762-4772. (Pubitemid 29314878)
12. Cavadas C., Cefai D., Rosmaninho-Salgado J., et al. (2006) Deletion of the neuropeptide Y (NPY) Y1 receptor gene reveals a regulatory role of NPY on catecholamine synthesis and secretion. Proc. Natl. Acad. Sci. USA 103, 10497-10502. (Pubitemid 44051195)
13. Ceradini D. J., Kulkarni A. R., Callaghan M. J., Tepper O. M., Bastidas N., Kleinman M. E., Capla J. M., Galiano R. D., Levine J. P., and, Gurtner G. C., (2004) Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1. Nat. Med. 10, 858-864. (Pubitemid 39070860)
14. Chabrier P. E., Demerle-Pallardy C., and, Auguet M., (1999) Nitric oxide synthases: targets for therapeutic strategies in neurological diseases. Cell. Mol. Life Sci. 55, 1029-1035. (Pubitemid 29361069)
15. Chan C. C., (2008) Inflammation: beneficial or detrimental after spinal cord injury? Recent Pathol. CNS Drug Discov. 3, 189-199.
16. Chan W. Y., Kohsaka S., and, Rezaie P., (2007) The origin and cell lineage of microglia: new concepts. Brain Res. Rev. 53, 344-354. (Pubitemid 46177241)
17. Cohen H., Ziv Y., Cardon M., Kaplan Z., Matar M. A., Gidron Y., Schwartz M., and, Kipnis J., (2006) Maladaptation to mental stress mitigated by the adaptive immune system via depletion of naturally occurring regulatory CD4 + CD25 + cells. J. Neurobiol. 66, 552-563.
18. Corbin B. D., Seeley E. H., Raab A., et al. (2008) Metal chelation and inhibition of bacterial growth in tissue abscesses. Science 319, 962-965. (Pubitemid 351263768)
19. Donati R. J., Dwivedi Y., Roberts R. C., Conley R. R., Pandey G. N., and, Rasenick M. M., (2008) Postmortem brain tissue of depressed suicides reveals increased Gs alpha localization in lipid raft domains where it is less likely to activate adenylyl cyclase. J. Neurosci. 28, 3042-3050. (Pubitemid 351442293)
20. Ducreux D., Huynh I., Fillard P., Renoux J., Petit-Lacour M. C., Marsot-Dupuch K., and, Lasjaunias P., (2005) Brain MR diffusion tensor imaging and fibre tracking to differentiate between two diffuse axonal injuries. Neuroradiology 47, 604-608. (Pubitemid 41258709)
21. Elder G. A., and, Cristian A., (2009) Blast-related mild traumatic brain injury: mechanisms of injury and impact on clinical care. Mt Sinai J. Med. 76, 111-118.
22. Fagelson M. A., (2007) The association between tinnitus and posttraumatic stress disorder. Am. J. Audiol. 16, 107-117. (Pubitemid 351250983)
23. Fausti S. A., Wilmington D. J., Gallun F. J., Myers P. J., and, Henry J. A., (2009) Auditory and vestibular dysfunction associated with blast-related traumatic brain injury. J. Rehabil. Res. Dev. 46, 797-810.
24. Fischer-Smith T., Croul S., Sverstiuk A. E., et al. (2001) CNS invasion by CD14 +/CD16 + peripheral blood-derived monocytes in HIV dementia: perivascular accumulation and reservoir of HIV infection. J. Neurovirol. 7, 528-541. (Pubitemid 34041054)
25. Frohman E. M., Eagar T., Monson N., Stuve O., and, Karandikar N., (2008) Immunologic mechanisms of multiple sclerosis. Neuroimaging Clin. N. Am. 18, 577-588.
26. Gaylord K. M., (2006) The psychosocial effects of combat: the frequently unseen injury. Crit. Care Nurs. Clin. North Am. 18, 349-357. (Pubitemid 44311438)
27. Gonzalez-Gay M. A., Garcia-Unzueta M. T., Berja A., Vazquez-Rodriguez T. R., Miranda-Filloy J. A., Gonzalez-Juanatey C., de Matias J. M., Martin J., Dessein P. H., and, Llorca J., (2009) Short-term effect of anti-TNF-alpha therapy on nitric oxide production in patients with severe rheumatoid arthritis. Clin. Exp. Rheumatol. 27, 452-458.
28. Gotovac K., Sabioncello A., Rabatic S., Berki T., and, Dekaris D., (2003) Flow cytometric determination of glucocorticoid receptor (GCR) expression in lymphocyte subpopulations: lower quantity of GCR in patients with post-traumatic stress disorder (PTSD). Clin. Exp. Immunol. 131, 335-339. (Pubitemid 36205148)
29. Gurguis G. N., Andrews R., Antai-Otong D., Vo S. P., Blakeley J. E., Orsulak P. J., and, Rush A. J., (1999) Neutrophil beta2-adrenergic receptor coupling efficiency to Gs protein in subjects with post-traumatic stress disorder and normal controls. Psychopharmacology (Berl) 143, 131-140. (Pubitemid 29187637)
30. Gurvits T. V., Shenton M. E., Hokama H., et al. (1996) Magnetic resonance imaging study of hippocampal volume in chronic, combat-related posttraumatic stress disorder. Biol. Psychiatry 40, 1091-1099. (Pubitemid 26400873)
31. Hedges D. W., Allen S., Tate D. F., Thatcher G. W., Miller M. J., Rice S. A., Cleavinger H. B., Sood S., and, Bigler E. D., (2003) Reduced hippocampal volume in alcohol and substance naive Vietnam combat veterans with posttraumatic stress disorder. Cogn. Behav. Neurol. 16, 219-224. (Pubitemid 37517827)
32. Hirsch E. C., and, Hunot S., (2009) Neuroinflammation in Parkinson's disease: a target for neuroprotection? Lancet Neurol. 8, 382-397.
33. Hitomi J., Christofferson D. E., Ng A., Yao J., Degterev A., Xavier R. J., and, Yuan J., (2008) Identification of a molecular signaling network that regulates a cellular necrotic cell death pathway. Cell 135, 1311-1323.
34. Hoge C. W., McGurk D., Thomas J. L., Cox A. L., Engel C. C., and, Castro C. A., (2008) Mild traumatic brain injury in U.S. Soldiers returning from Iraq. N. Engl. J. Med. 358, 453-463. (Pubitemid 351185801)
35. Holler J., Zakrzewicz A., Kaufmann A., Wilhelm J., Fuchs-Moll G., Dietrich H., Padberg W., Kuncova J., Kummer W., and, Grau V., (2008) Neuropeptide Y is expressed by rat mononuclear blood leukocytes and strongly down-regulated during inflammation. J. Immunol. 181, 6906-6912.
36. Hurn P. D., Subramanian S., Parker S. M., Afentoulis M. E., Kaler L. J., Vandenbark A. A., and, Offner H., (2007) T- and B-cell-deficient mice with experimental stroke have reduced lesion size and inflammation. J. Cereb. Blood Flow Metab. 27, 1798-1805. (Pubitemid 47624547)
37. Idriss H. T., and, Naismith J. H., (2000) TNF alpha and the TNF receptor superfamily: structure-function relationship(s). Microsc. Res. Tech. 50, 184-195. (Pubitemid 30610095)
38. Joachim R. A., Handjiski B., Blois S. M., Hagen E., Paus R., and, Arck P. C., (2008) Stress-induced neurogenic inflammation in murine skin skews dendritic cells towards maturation and migration: key role of intercellular adhesion molecule-1/leukocyte function-associated antigen interactions. Am. J. Pathol. 173, 1379-1388.
39. von Kanel R., Begre S., Abbas C. C., Saner H., Gander M. L., and, Schmid J. P., (2010) Inflammatory biomarkers in patients with posttraumatic stress disorder caused by myocardial infarction and the role of depressive symptoms. Neuroimmunomodulation 17, 39-46.
40. Kawamura N., Kim Y., and, Asukai N., (2001) Suppression of cellular immunity in men with a past history of posttraumatic stress disorder. Am. J. Psychiatry 158, 484-486. (Pubitemid 32205210)
41. Kikuchi A., Shimizu K., Nibuya M., Hiramoto T., Kanda Y., Tanaka T., Watanabe Y., Takahashi Y., and, Nomura S., (2008) Relationship between post-traumatic stress disorder-like behavior and reduction of hippocampal 5-bromo-2'-deoxyuridine-positive cells after inescapable shock in rats. Psychiatry Clin. Neurosci. 62, 713-720.
42. Kraus J., Oschmann P., Engelhardt B., Bauer R., Schiel C., Kern A., Stolz E., Traupe A., and, Dorndorf W., (2000) Soluble and cell surface ICAM-3 in blood and cerebrospinal fluid of patients with multiple sclerosis: influence of methylprednisolone treatment and relevance as markers for disease activity. Acta Neurol. Scand. 101, 135-139. (Pubitemid 30051384)
43. Lew H. L., Jerger J. F., Guillory S. B., and, Henry J. A., (2007) Auditory dysfunction in traumatic brain injury. J. Rehabil. Res. Dev. 44, 921-928.
44. Lewitus G. M., Cohen H., and, Schwartz M., (2008) Reducing post-traumatic anxiety by immunization. Brain Behav. Immun. 22, 1108-1114.
45. Liu B., and, Hong J. S., (2003) Role of microglia in inflammation- mediated neurodegenerative diseases: mechanisms and strategies for therapeutic intervention. J. Pharmacol. Exp. Ther. 304, 1-7. (Pubitemid 36008905)
46. Lorz C., and, Mehmet H., (2009) The role of death receptors in neural injury. Front. Biosci. 14, 583-595.
47. Maccioni R. B., Rojo L. E., Fernandez J. A., and, Kuljis R. O., (2009) The role of neuroimmunomodulation in Alzheimer's disease. Ann. N Y Acad. Sci. 1153, 240-246.
48. Maes M., Lin A. H., Delmeire L., Van Gastel A., Kenis G., De Jongh R., and, Bosmans E., (1999) Elevated serum interleukin-6 (IL-6) and IL-6 receptor concentrations in posttraumatic stress disorder following accidental man-made traumatic events. Biol. Psychiatry 45, 833-839. (Pubitemid 29185473)
49. McAllister T. W., (2009) Psychopharmacological issues in the treatment of TBI and PTSD. Clin. Neuropsychol. 23, 1338-1367.
50. McEwen B. S., (1997) Possible mechanisms for atrophy of the human hippocampus. Mol. Psychiatry 2, 255-262. (Pubitemid 27217691)
51. McEwen B. S., (2001) Plasticity of the hippocampus: adaptation to chronic stress and allostatic load. Ann. N Y Acad. Sci. 933, 265-277. (Pubitemid 32390122)
52. Mommersteeg P. M., Vermetten E., Kavelaars A., Geuze E., and, Heijnen C. J., (2008) Hostility is related to clusters of T-cell cytokines and chemokines in healthy men. Psychoneuroendocrinology 33, 1041-1050.
53. Moochhala S. M., Md S., Lu J., Teng C. H., and, Greengrass C., (2004) Neuroprotective role of aminoguanidine in behavioral changes after blast injury. J. Trauma 56, 393-403. (Pubitemid 38295386)
54. Morgan C. A. 3rd, Rasmusson A. M., Wang S., Hoyt G., Hauger R. L., and, Hazlett G., (2002) Neuropeptide-Y, cortisol, and subjective distress in humans exposed to acute stress: replication and extension of previous report. Biol. Psychiatry 52, 136-142. (Pubitemid 34759984)
55. de Pablos R. M., Villaran R. F., Arguelles S., Herrera A. J., Venero J. L., Ayala A., Cano J., and, Machado A., (2006) Stress increases vulnerability to inflammation in the rat prefrontal cortex. J. Neurosci. 26, 5709-5719. (Pubitemid 44315262)
56. Park E., Bell J. D., and, Baker A. J., (2008) Traumatic Brain Injury: Can the consequences be stopped? Canadian Med. Assoc. J. 178, 1163-1170. (Pubitemid 351596226)
57. Pennica D., Nedwin G. E., Hayflick J. S., Seeburg P. H., Derynck R., Palladino M. A., Kohr W. J., Aggarwal B. B., and, Goeddel D. V., (1984) Human tumour necrosis factor: precursor structure, expression and homology to lymphotoxin. Nature 312, 724-729. (Pubitemid 15195918)
58. Potter E. K., and, Tripovic D., (2006) Modulation of sympathetic neurotransmission by neuropeptide Y Y2 receptors in rats and guinea pigs. Exp. Brain Res. 173, 346-352. (Pubitemid 44264899)
59. Raivich G., Jones L. L., Werner A., Bluthmann H., Doetschmann T., and, Kreutzberg G. W., (1999) Molecular signals for glial activation: pro- and anti-inflammatory cytokines in the injured brain. Acta Neurochir. Suppl. 73, 21-30.
60. Rosenberg G. A., (2009) Matrix metalloproteinases and their multiple roles in neurodegenerative diseases. Lancet Neurol. 8, 205-216.
61. Roy M., and, Sapolsky R. M., (2003) The exacerbation of hippocampal excitotoxicity by glucocorticoids is not mediated by apoptosis. Neuroendocrinology 77, 24-31. (Pubitemid 36302419)
62. Santarelli L., Saxe M., Gross C., et al. (2003) Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants. Science 301, 805-809. (Pubitemid 36962615)
63. Sapolsky R. M., (2000) Glucocorticoids and hippocampal atrophy in neuropsychiatric disorders. Arch. Gen. Psychiatry 57, 925-935.
64. Sapolsky R. M., Romero L. M., and, Munck A. U., (2000) How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions. Endocr. Rev. 21, 55-89. (Pubitemid 32266068)
65. Segman R. H., Shefi N., Goltser-Dubner T., Friedman N., Kaminski N., and, Shalev A. Y., (2005) Peripheral blood mononuclear cell gene expression profiles identify emergent post-traumatic stress disorder among trauma survivors. Mol. Psychiatry 10, 500-513. (Pubitemid 40646438)
66. Shirai T., Yamaguchi H., Ito H., Todd C. W., and, Wallace R. B., (1985) Cloning and expression in Escherichia coli of the gene for human tumour necrosis factor. Nature 313, 803-806. (Pubitemid 15130832)
67. Smith M. E., (2005) Bilateral hippocampal volume reduction in adults with post-traumatic stress disorder: a meta-analysis of structural MRI studies. Hippocampus 15, 798-807. (Pubitemid 41300829)
68. Spivak B., Shohat B., Mester R., Avraham S., Gil-Ad I., Bleich A., Valevski A., and, Weizman A., (1997) Elevated levels of serum interleukin-1 beta in combat-related posttraumatic stress disorder. Biol. Psychiatry 42, 345-348. (Pubitemid 27380968)
69. Stein M. B., Koverola C., Hanna C., Torchia M. G., and, McClarty B., (1997) Hippocampal volume in women victimized by childhood sexual abuse. Psychol. Med. 27, 951-959. (Pubitemid 27332181)
70. Stoll G., Jander S., and, Schroeter M., (2000) Cytokines in CNS disorders: neurotoxicity versus neuroprotection. J. Neural Transm. Suppl. 59, 81-89. (Pubitemid 30479409)
71. Stolp H. B., and, Dziegielewska K. M., (2009) Review: Role of developmental inflammation and blood-brain barrier dysfunction in neurodevelopmental and neurodegenerative diseases. Neuropathol. Appl. Neurobiol. 35, 132-146.
72. Su T. P., Zhang L., Chung M. Y., et al. (2009) Levels of the potential biomarker p11 in peripheral blood cells distinguish patients with PTSD from those with other major psychiatric disorders. J. Psychiatr. Res. 43, 1078-1085.
73. Svenningsson P., Chergui K., Rachleff I., Flajolet M., Zhang X., El Yacoubi. M., Vaugeois J. M., Nomikos G. G., and, Greengard P., (2006) Alterations in 5-HT1B receptor function by p11 in depression-like states. Science 311, 77-80. (Pubitemid 43063061)
74. Tilg H., Dinarello C. A., and, Mier J. W., (1997) IL-6 and APPs: anti-inflammatory and immunosuppressive mediators. Immunol. Today 18, 428-432. (Pubitemid 27381984)
75. Tucker P., Ruwe W. D., Masters B., Parker D. E., Hossain A., Trautman R. P., and, Wyatt D. B., (2004) Neuroimmune and cortisol changes in selective serotonin reuptake inhibitor and placebo treatment of chronic posttraumatic stress disorder. Biol. Psychiatry 56, 121-128. (Pubitemid 38844787)
76. Vidovic A., Vilibic M., Sabioncello A., Gotovac K., Rabatic S., Folnegovic-Smalc V., and, Dekaris D., (2007) Circulating lymphocyte subsets, natural killer cell cytotoxicity, and components of hypothalamic-pituitary- adrenal axis in Croatian war veterans with posttraumatic stress disorder: cross-sectional study. Croat. Med. J. 48, 198-206. (Pubitemid 46651026)
77. Walczak P., Chen N., Hudson J. E., Willing A. E., Garbuzova-Davis S. N., Song S., Sanberg P. R., Sanchez-Ramos J., Bickford P. C., and, Zigova T., (2004) Do hematopoietic cells exposed to a neurogenic environment mimic properties of endogenous neural precursors? J. Neurosci. Res. 76, 244-254. (Pubitemid 38451212)
78. Wheway J., Mackay C. R., Newton R. A., Sainsbury A., Boey D., Herzog H., and, Mackay F., (2005) A fundamental bimodal role for neuropeptide Y1 receptor in the immune system. J. Exp. Med. 202, 1527-1538. (Pubitemid 41746599)
79. Wunder A., Klohs J., and, Dirnagl U., (2009) Non-invasive visualization of CNS inflammation with nuclear and optical imaging. Neuroscience 158, 1161-1173.
80. Xydakis M. S., Bebarta V. S., Harrison C. D., Conner J. C., Grant G. A., and, Robbins A. S., (2007) Tympanic-membrane perforation as a marker of concussive brain injury in Iraq. N. Engl. J. Med. 357, 830-831. (Pubitemid 47295664)
81. Zukowska-Grojec Z., (1995) Neuropeptide Y. A novel sympathetic stress hormone and more. Ann. N Y Acad. Sci. 771, 219-233. (Pubitemid 26077409)