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Volumn 113, Issue 7, 2009, Pages 1598-1607

Heme oxygenase-1 expression enhances vascular endothelial resistance to complement-mediated injury through induction of decay-accelerating factor: A role for increased bilirubin and ferritin

Author keywords

[No Author keywords available]

Indexed keywords

BILIRUBIN; COMPLEMENT; DECAY ACCELERATING FACTOR; FERRITIN; HEME OXYGENASE 1; HEMIN; IRON; MESSENGER RNA; MONOCLONAL ANTIBODY; PROTOPORPHYRIN COBALT; SMALL INTERFERING RNA;

EID: 61849124659     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2008-04-152934     Document Type: Article
Times cited : (80)

References (50)
  • 1
    • 0030921166 scopus 로고    scopus 로고
    • Protective genes expressed in endothelial cells: A regulatory response to injury
    • Bach FH, Hancock WW, Ferran C. Protective genes expressed in endothelial cells: a regulatory response to injury. Immunol Today. 1997;18:483-486.
    • (1997) Immunol Today , vol.18 , pp. 483-486
    • Bach, F.H.1    Hancock, W.W.2    Ferran, C.3
  • 2
    • 0034979275 scopus 로고    scopus 로고
    • Signaling mechanisms mediating vascular protective actions of vascular endothelial growth factor
    • Zachary I. Signaling mechanisms mediating vascular protective actions of vascular endothelial growth factor. Am J Physiol Cell Physiol. 2001; 280:C1375-C1386.
    • (2001) Am J Physiol Cell Physiol , vol.280
    • Zachary, I.1
  • 3
    • 1642581763 scopus 로고    scopus 로고
    • Bifunctional role for VEGF-induced heme oxygenase-1 in vivo: Induction of angiogenesis and inhibition of leukocytic infiltration
    • Bussolati B, Ahmed A, Pemberton H, et al. Bifunctional role for VEGF-induced heme oxygenase-1 in vivo: induction of angiogenesis and inhibition of leukocytic infiltration. Blood. 2004;103: 761-766.
    • (2004) Blood , vol.103 , pp. 761-766
    • Bussolati, B.1    Ahmed, A.2    Pemberton, H.3
  • 4
    • 4744342973 scopus 로고    scopus 로고
    • Decay-accelerating factor induction on vascular endothelium by VEGF is mediated via a VEGF-R2 and PKCα/ε-dependent cytoprotective signaling pathway and is inhibited by cyclosporin A
    • Mason JC, Steinberg R, Lidington EA, Kinderlerer AR, Ohba M, Haskard DO. Decay-accelerating factor induction on vascular endothelium by VEGF is mediated via a VEGF-R2 and PKCα/ε-dependent cytoprotective signaling pathway and is inhibited by cyclosporin A. J Biol Chem. 2004; 279:41611-41618.
    • (2004) J Biol Chem , vol.279 , pp. 41611-41618
    • Mason, J.C.1    Steinberg, R.2    Lidington, E.A.3    Kinderlerer, A.R.4    Ohba, M.5    Haskard, D.O.6
  • 5
    • 0014348401 scopus 로고
    • The enzymatic conversion of heme to bilirubin by microsomal heme oxygenase
    • Tenhunen R, Marver HS, Schmid R. The enzymatic conversion of heme to bilirubin by microsomal heme oxygenase. Proc Natl Acad Sci U S A. 1968;61:748-755.
    • (1968) Proc Natl Acad Sci U S A , vol.61 , pp. 748-755
    • Tenhunen, R.1    Marver, H.S.2    Schmid, R.3
  • 6
    • 0025969686 scopus 로고
    • Regulation of ferritin and heme oxygenase synthesis in rat fibroblasts by different forms of iron
    • Eisenstein RS, Garcia-Mayol D, Pettingell W, Munro HN. Regulation of ferritin and heme oxygenase synthesis in rat fibroblasts by different forms of iron. Proc Natl Acad Sci U S A. 1991;88: 688-692.
    • (1991) Proc Natl Acad Sci U S A , vol.88 , pp. 688-692
    • Eisenstein, R.S.1    Garcia-Mayol, D.2    Pettingell, W.3    Munro, H.N.4
  • 7
    • 0033161957 scopus 로고    scopus 로고
    • Haem oxygenase-1 prevents cell death by regulating cellular iron
    • Ferris CD, Jaffrey SR, Sawa A, et al. Haem oxygenase-1 prevents cell death by regulating cellular iron. Nat Cell Biol. 1999;1:152-157.
    • (1999) Nat Cell Biol , vol.1 , pp. 152-157
    • Ferris, C.D.1    Jaffrey, S.R.2    Sawa, A.3
  • 8
    • 0032893958 scopus 로고    scopus 로고
    • Oxidative stress causes enhanced endothelial cell injury in human heme oxygenase-1 deficiency
    • Yachie A, Niida Y, Wada T, et al. Oxidative stress causes enhanced endothelial cell injury in human heme oxygenase-1 deficiency. J Clin Invest. 1999;103:129-135.
    • (1999) J Clin Invest , vol.103 , pp. 129-135
    • Yachie, A.1    Niida, Y.2    Wada, T.3
  • 9
    • 0030886381 scopus 로고    scopus 로고
    • Heme oxygenase 1 is required for mammalian iron reutilization
    • Poss KD, Tonegawa S. Heme oxygenase 1 is required for mammalian iron reutilization. Proc Natl Acad Sci U S A. 1997;94:10919-10924.
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 10919-10924
    • Poss, K.D.1    Tonegawa, S.2
  • 10
    • 0035896220 scopus 로고    scopus 로고
    • Heme oxygenase-1 inhibits atherosclerotic lesion formation in LDL-receptor knockout mice
    • Ishikawa K, Sugawara D, Wang Xp, et al. Heme oxygenase-1 inhibits atherosclerotic lesion formation in LDL-receptor knockout mice. Circ Res. 2001;88:506-512.
    • (2001) Circ Res , vol.88 , pp. 506-512
    • Ishikawa, K.1    Sugawara, D.2    Wang, X.3
  • 11
    • 0035920256 scopus 로고    scopus 로고
    • Cardiac-specific expression of heme oxygenase-1 protects against ischemia and reperfusion injury in transgenic mice
    • Yet S-F, Tian R, Layne MD, et al. Cardiac-specific expression of heme oxygenase-1 protects against ischemia and reperfusion injury in transgenic mice. Circ Res. 2001;89:168-173.
    • (2001) Circ Res , vol.89 , pp. 168-173
    • Yet, S.-F.1    Tian, R.2    Layne, M.D.3
  • 12
    • 0031757984 scopus 로고    scopus 로고
    • Antibody-induced transplant arteriosclerosis is prevented by graft expression of anti-oxidant and anti-apoptotic genes
    • Hancock WW, Buelow R, Sayegh MH, Turka LA. Antibody-induced transplant arteriosclerosis is prevented by graft expression of anti-oxidant and anti-apoptotic genes. Nat Med. 1998;4:1392-1396.
    • (1998) Nat Med , vol.4 , pp. 1392-1396
    • Hancock, W.W.1    Buelow, R.2    Sayegh, M.H.3    Turka, L.A.4
  • 13
    • 0031697123 scopus 로고    scopus 로고
    • Expression of heme oxygenase-1 can determine cardiac xenograft survival
    • Soares MP, Lin Y, Anrather J, et al. Expression of heme oxygenase-1 can determine cardiac xenograft survival. Nat Med. 1998;4:1073-1077.
    • (1998) Nat Med , vol.4 , pp. 1073-1077
    • Soares, M.P.1    Lin, Y.2    Anrather, J.3
  • 14
    • 0344284580 scopus 로고    scopus 로고
    • Carbon monoxide suppresses arteriosclerotic lesions associated with chronic graft rejection and with balloon injury
    • Otterbein LE, Zuckerbraun BS, Haga M, et al. Carbon monoxide suppresses arteriosclerotic lesions associated with chronic graft rejection and with balloon injury. Nat Med. 2003;9:183-190.
    • (2003) Nat Med , vol.9 , pp. 183-190
    • Otterbein, L.E.1    Zuckerbraun, B.S.2    Haga, M.3
  • 15
    • 0028881851 scopus 로고
    • Complement-mediated regulation of tissue factor activity in endothelium
    • Saadi S, Holzknecht RA, Patte CP, Stern DM, Platt JL. Complement-mediated regulation of tissue factor activity in endothelium. J Exp Med. 1995;182:1807-1814.
    • (1995) J Exp Med , vol.182 , pp. 1807-1814
    • Saadi, S.1    Holzknecht, R.A.2    Patte, C.P.3    Stern, D.M.4    Platt, J.L.5
  • 16
    • 0031010642 scopus 로고    scopus 로고
    • The cytolytically inactive terminal complement complex activates endothelial cells to express adhesion molecules and tissue factor procoagulant activity
    • Tedesco F, Pausa M, Nardon E, Introna M, Mantovani A, Dobrina A. The cytolytically inactive terminal complement complex activates endothelial cells to express adhesion molecules and tissue factor procoagulant activity. J Exp Med. 1997; 185:1619-1627.
    • (1997) J Exp Med , vol.185 , pp. 1619-1627
    • Tedesco, F.1    Pausa, M.2    Nardon, E.3    Introna, M.4    Mantovani, A.5    Dobrina, A.6
  • 17
    • 0024334289 scopus 로고
    • Decay-accelerating factor: Biochemistry, molecular biology and function
    • Lublin DM, Atkinson JP. Decay-accelerating factor: biochemistry, molecular biology and function. Annu Rev Immunol. 1989;7:35-58.
    • (1989) Annu Rev Immunol , vol.7 , pp. 35-58
    • Lublin, D.M.1    Atkinson, J.P.2
  • 18
    • 0033198618 scopus 로고    scopus 로고
    • Induction of decay-accelerating factor by cytokines or the membrane-attack complex protects vascular endothelial cells against complement deposition
    • Mason JC, Yarwood H, Sugars K, Morgan BP, Davies KA, Haskard DO. Induction of decay-accelerating factor by cytokines or the membrane-attack complex protects vascular endothelial cells against complement deposition. Blood. 1999;94: 1673-1682.
    • (1999) Blood , vol.94 , pp. 1673-1682
    • Mason, J.C.1    Yarwood, H.2    Sugars, K.3    Morgan, B.P.4    Davies, K.A.5    Haskard, D.O.6
  • 19
    • 1542619241 scopus 로고    scopus 로고
    • Critical protection from renal ischemia reperfusion injury by CD55 and CD59
    • Yamada K, Miwa T, Liu J, Nangaku M, Song W-C. Critical protection from renal ischemia reperfusion injury by CD55 and CD59. J Immunol. 2004;172: 3869-3875.
    • (2004) J Immunol , vol.172 , pp. 3869-3875
    • Yamada, K.1    Miwa, T.2    Liu, J.3    Nangaku, M.4    Song, W.-C.5
  • 20
    • 0036127426 scopus 로고    scopus 로고
    • Heme oxygenase-1 mediates the anti-inflammatory effect of interleukin-10 in mice
    • Lee TS, Chau LY. Heme oxygenase-1 mediates the anti-inflammatory effect of interleukin-10 in mice. Nat Med. 2002;8:240-246.
    • (2002) Nat Med , vol.8 , pp. 240-246
    • Lee, T.S.1    Chau, L.Y.2
  • 21
    • 0037448802 scopus 로고    scopus 로고
    • Rapamycin induces heme oxygenase-1 in human pulmonary vascular cells: Implications in the antiproliferative response to rapamycin
    • Visner GA, Lu F, Zhou H, Liu J, Kazemfar K, Agarwal A. Rapamycin induces heme oxygenase-1 in human pulmonary vascular cells: implications in the antiproliferative response to rapamycin. Circulation. 2003;107:911-916.
    • (2003) Circulation , vol.107 , pp. 911-916
    • Visner, G.A.1    Lu, F.2    Zhou, H.3    Liu, J.4    Kazemfar, K.5    Agarwal, A.6
  • 22
    • 23444454955 scopus 로고    scopus 로고
    • Heme oxygenase-1: A therapeutic amplification funnel
    • Bach FH. Heme oxygenase-1: a therapeutic amplification funnel. FASEB J. 2005;19:1216-1219.
    • (2005) FASEB J , vol.19 , pp. 1216-1219
    • Bach, F.H.1
  • 23
    • 0036090780 scopus 로고    scopus 로고
    • Heme oxygenase activity modulates vascular endothelial growth factor synthesis in vascular smooth muscle cells
    • Dulak J, Jozkowicz A, Foresti R, et al. Heme oxygenase activity modulates vascular endothelial growth factor synthesis in vascular smooth muscle cells. Antioxid Redox Signal. 2002;4:229-240.
    • (2002) Antioxid Redox Signal , vol.4 , pp. 229-240
    • Dulak, J.1    Jozkowicz, A.2    Foresti, R.3
  • 24
    • 0027452195 scopus 로고
    • A beneficial role of bile pigments as an endogenous tissue protector: Anti-complement effects of biliverdin and conjugated bilirubin
    • Nakagami T, Toyomura K, Kinoshita T, Morisawa S. A beneficial role of bile pigments as an endogenous tissue protector: anti-complement effects of biliverdin and conjugated bilirubin. Biochim Biophys Acta. 1993;1158:189-193.
    • (1993) Biochim Biophys Acta , vol.1158 , pp. 189-193
    • Nakagami, T.1    Toyomura, K.2    Kinoshita, T.3    Morisawa, S.4
  • 25
    • 0030045835 scopus 로고    scopus 로고
    • Heme oxygenase: A novel target for the modulation of the inflammatory response
    • Willis D, Moore AR, Frederick R, Willoughby DA. Heme oxygenase: a novel target for the modulation of the inflammatory response. Nat Med. 1996;2:87-90.
    • (1996) Nat Med , vol.2 , pp. 87-90
    • Willis, D.1    Moore, A.R.2    Frederick, R.3    Willoughby, D.A.4
  • 26
    • 0033561224 scopus 로고    scopus 로고
    • Hypoxia induces severe right ventricular dilatation and infarction in heme oxygenase-1 null mice
    • Yet SF, Perrella MA, Layne MD, et al. Hypoxia induces severe right ventricular dilatation and infarction in heme oxygenase-1 null mice. J Clin Invest. 1999;103:R23-R99.
    • (1999) J Clin Invest , vol.103
    • Yet, S.F.1    Perrella, M.A.2    Layne, M.D.3
  • 28
    • 38849203158 scopus 로고    scopus 로고
    • Heme oxygenase-1 inhibits the expression of adhesion molecules associated with endothelial cell activation via inhibition of NF-kappaB RelA phosphorylation at serine 276
    • Seldon MP, Silva G, Pejanovic N, et al. Heme oxygenase-1 inhibits the expression of adhesion molecules associated with endothelial cell activation via inhibition of NF-kappaB RelA phosphorylation at serine 276. J Immunol. 2007;179:7840-7851.
    • (2007) J Immunol , vol.179 , pp. 7840-7851
    • Seldon, M.P.1    Silva, G.2    Pejanovic, N.3
  • 29
    • 0034071424 scopus 로고    scopus 로고
    • Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway
    • Otterbein LE, Bach FH, Alam J, et al. Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway. Nat Med. 2000;6:422-428.
    • (2000) Nat Med , vol.6 , pp. 422-428
    • Otterbein, L.E.1    Bach, F.H.2    Alam, J.3
  • 30
    • 34250008488 scopus 로고    scopus 로고
    • Heme oxygenase-1 and carbon monoxide suppress the pathogenesis of experimental cerebral malaria
    • Pamplona A, Ferreira A, Balla J, et al. Heme oxygenase-1 and carbon monoxide suppress the pathogenesis of experimental cerebral malaria. Nat Med. 2007;13:703-710.
    • (2007) Nat Med , vol.13 , pp. 703-710
    • Pamplona, A.1    Ferreira, A.2    Balla, J.3
  • 31
    • 1542724430 scopus 로고    scopus 로고
    • Heme oxygenase-1 modulates the expression of adhesion molecules associated with endothelial cell activation
    • Soares MP, Seldon MP, Gregoire IP, et al. Heme oxygenase-1 modulates the expression of adhesion molecules associated with endothelial cell activation. J Immunol. 2004;172:3553-3563.
    • (2004) J Immunol , vol.172 , pp. 3553-3563
    • Soares, M.P.1    Seldon, M.P.2    Gregoire, I.P.3
  • 32
    • 36349008676 scopus 로고    scopus 로고
    • Statin-mediated cytoprotection of human vascular endothelial cells: A role for Kruppel-like factor 2-dependent induction of heme oxygenase-1
    • Ali F, Hamdulay SH, Kinderlerer AR, et al. Statin-mediated cytoprotection of human vascular endothelial cells: a role for Kruppel-like factor 2-dependent induction of heme oxygenase-1. J Thromb Haemost. 2007;5:2537-2546.
    • (2007) J Thromb Haemost , vol.5 , pp. 2537-2546
    • Ali, F.1    Hamdulay, S.H.2    Kinderlerer, A.R.3
  • 33
    • 12844255778 scopus 로고    scopus 로고
    • Prostaglandin E2 regulates the complement inhibitor CD55/decay-accelerating factor in colorectal cancer
    • Holla VR, Wang D, Brown JR, Mann JR, Katkuri S, DuBois RN. Prostaglandin E2 regulates the complement inhibitor CD55/decay-accelerating factor in colorectal cancer. J Biol Chem. 2005; 280:476-483.
    • (2005) J Biol Chem , vol.280 , pp. 476-483
    • Holla, V.R.1    Wang, D.2    Brown, J.R.3    Mann, J.R.4    Katkuri, S.5    DuBois, R.N.6
  • 34
    • 0034596874 scopus 로고    scopus 로고
    • Carbon monoxide generated by heme oxygenase 1 suppresses endothelial cell apoptosis
    • Brouard S, Otterbein LE, Anrather J, et al. Carbon monoxide generated by heme oxygenase 1 suppresses endothelial cell apoptosis. J Exp Med. 2000;192:1015-1026.
    • (2000) J Exp Med , vol.192 , pp. 1015-1026
    • Brouard, S.1    Otterbein, L.E.2    Anrather, J.3
  • 35
    • 33645945014 scopus 로고    scopus 로고
    • Heme oxygenase-1/ carbon monoxide: From basic science to therapeutic applications
    • Ryter SW, Alam J, Choi AM. Heme oxygenase-1/ carbon monoxide: from basic science to therapeutic applications. Physiol Rev. 2006;86:583-650.
    • (2006) Physiol Rev , vol.86 , pp. 583-650
    • Ryter, S.W.1    Alam, J.2    Choi, A.M.3
  • 36
    • 0037208589 scopus 로고    scopus 로고
    • Phase II, randomized trial comparing bevaci-zumab plus fluorouracil (FU)/leucovorin (LV) with FU/LV alone in patients with metastatic colorectal cancer
    • Kabbinavar F, Hurwitz HI, Fehrenbacher L, et al. Phase II, randomized trial comparing bevaci-zumab plus fluorouracil (FU)/leucovorin (LV) with FU/LV alone in patients with metastatic colorectal cancer. J Clin Oncol. 2003;21:60-65.
    • (2003) J Clin Oncol , vol.21 , pp. 60-65
    • Kabbinavar, F.1    Hurwitz, H.I.2    Fehrenbacher, L.3
  • 37
    • 34547941252 scopus 로고    scopus 로고
    • Autocrine VEGF signaling is required for vascular homeostasis
    • Lee S, Chen TT, Barber CL, et al. Autocrine VEGF signaling is required for vascular homeostasis. Cell. 2007;130:691-703.
    • (2007) Cell , vol.130 , pp. 691-703
    • Lee, S.1    Chen, T.T.2    Barber, C.L.3
  • 38
    • 47249112564 scopus 로고    scopus 로고
    • KLF-2-dependent, shear stress-induced expression of CD59: A novel cytoprotective mechanism against complement-mediated injury in the vasculature
    • Kinderlerer AR, Ali F, Johns M, et al. KLF-2-dependent, shear stress-induced expression of CD59: a novel cytoprotective mechanism against complement-mediated injury in the vasculature. J Biol Chem. 2008;283:14636- 14644.
    • (2008) J Biol Chem , vol.283 , pp. 14636-14644
    • Kinderlerer, A.R.1    Ali, F.2    Johns, M.3
  • 39
    • 0026750782 scopus 로고
    • Superoxide responses of endothelial cells to C5a and TNF-α: Divergent signal transduction pathways
    • Murphy HS, Shayman JA, Till GO, et al. Superoxide responses of endothelial cells to C5a and TNF-α: divergent signal transduction pathways. Am J Physiol. 1992;263:L51-L59.
    • (1992) Am J Physiol , vol.263
    • Murphy, H.S.1    Shayman, J.A.2    Till, G.O.3
  • 40
    • 19944431852 scopus 로고    scopus 로고
    • Protection against ischemia/reperfusion injury in cardiac and renal transplantation with carbon monoxide, biliverdin and both
    • Nakao A, Neto JS, Kanno S, et al. Protection against ischemia/reperfusion injury in cardiac and renal transplantation with carbon monoxide, biliverdin and both. Am J Transplant. 2005;5:282-291.
    • (2005) Am J Transplant , vol.5 , pp. 282-291
    • Nakao, A.1    Neto, J.S.2    Kanno, S.3
  • 41
    • 0032760050 scopus 로고    scopus 로고
    • Inhibitory effect of bilirubin on complement-mediated hemolysis
    • ArriagaSM, Mottino AD, AlmaraAM. Inhibitory effect of bilirubin on complement-mediated hemolysis. Biochim BiophysActa. 1999;1473:329-336.
    • (1999) Biochim BiophysActa , vol.1473 , pp. 329-336
    • Arriaga, S.M.1    Mottino, A.D.2    Almara, A.M.3
  • 42
    • 0035884632 scopus 로고    scopus 로고
    • Qian Z, Hu W, Liu J, Sanfilippo F, Hruban RH, Baldwin WM 3rd. Accelerated graft arteriosclerosis in cardiac transplants: complement activation promotes progression of lesions from medium to large arteries. Transplantation. 2001;72:900-906.
    • Qian Z, Hu W, Liu J, Sanfilippo F, Hruban RH, Baldwin WM 3rd. Accelerated graft arteriosclerosis in cardiac transplants: complement activation promotes progression of lesions from medium to large arteries. Transplantation. 2001;72:900-906.
  • 43
    • 33845883789 scopus 로고    scopus 로고
    • Inhibition of complement component C3 reduces vein graft atherosclerosis in apolipoprotein E3-Leiden transgenic mice
    • Schepers A, de Vries MR, van Leuven CJ, et al. Inhibition of complement component C3 reduces vein graft atherosclerosis in apolipoprotein E3-Leiden transgenic mice. Circulation. 2006;114: 2831-2838.
    • (2006) Circulation , vol.114 , pp. 2831-2838
    • Schepers, A.1    de Vries, M.R.2    van Leuven, C.J.3
  • 44
    • 0027358877 scopus 로고
    • Endothelial-cell heme uptake from heme proteins: Induction of sensitization and desensitization to oxidant damage
    • Balla J, Jacob HS, Balla G, Nath K, Eaton JW, Vercellotti GM. Endothelial-cell heme uptake from heme proteins: induction of sensitization and desensitization to oxidant damage. Proc Natl Acad Sci USA. 1993;90:9285-9289.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 9285-9289
    • Balla, J.1    Jacob, H.S.2    Balla, G.3    Nath, K.4    Eaton, J.W.5    Vercellotti, G.M.6
  • 45
    • 33646238468 scopus 로고    scopus 로고
    • Heme oxygenase-1 is essential for and promotes tolerance to transplanted organs
    • YamashitaK, Ollinger R, McDaid J, et al. Heme oxygenase-1 is essential for and promotes tolerance to transplanted organs. FASEB J. 2006;20: 776-778.
    • (2006) FASEB J , vol.20 , pp. 776-778
    • Yamashita, K.1    Ollinger, R.2    McDaid, J.3
  • 46
    • 33846799062 scopus 로고    scopus 로고
    • Wehner J, Morrell CN, Reynolds T, Rodriguez ER, Baldwin WM 3rd. Antibody and complement in transplant vasculopathy. Circ Res. 2007;100: 191-203.
    • Wehner J, Morrell CN, Reynolds T, Rodriguez ER, Baldwin WM 3rd. Antibody and complement in transplant vasculopathy. Circ Res. 2007;100: 191-203.
  • 47
    • 34547686232 scopus 로고    scopus 로고
    • Heme oxygenase-1 in organ transplantation
    • Soares MP, Bach FH. Heme oxygenase-1 in organ transplantation. Front Biosci. 2007;12:4932-4945.
    • (2007) Front Biosci , vol.12 , pp. 4932-4945
    • Soares, M.P.1    Bach, F.H.2
  • 49
    • 0035039579 scopus 로고    scopus 로고
    • Paradoxical rescue from ischemic lung injury by inhaled carbon monoxide driven by derepression of fibrinolysis
    • FujitaT, Toda K, KarimovaA, et al. Paradoxical rescue from ischemic lung injury by inhaled carbon monoxide driven by derepression of fibrinolysis. Nat Med. 2001;7:598-604.
    • (2001) Nat Med , vol.7 , pp. 598-604
    • Fujita, T.1    Toda, K.2    Karimova, A.3
  • 50
    • 23844507814 scopus 로고    scopus 로고
    • Bilirubin: A natural inhibitor of vascular smooth muscle cell proliferation
    • Ollinger R, Bilban M, Erat A, et al. Bilirubin: a natural inhibitor of vascular smooth muscle cell proliferation. Circulation. 2005;112:1030-1039.
    • (2005) Circulation , vol.112 , pp. 1030-1039
    • Ollinger, R.1    Bilban, M.2    Erat, A.3


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