Recombinant viral protein promotes apoptosis and suppresses invasion of ovarian adenocarcinoma cells by targeting α5β1 integrin to down-regulate Akt and MMP-2

British Journal of Pharmacology

Volumn 165, Issue 2, 2012, Pages 479-493

  Peng, Jei Ming ^a,b,c   Chen, Yee Hsiung ^a,b   Hung, Shao Wen ^d   Chiu, Ching Feng ^d,e   Ho, Ming Yi ^c   Lee, Yi Jen ^f   Lai, Tsung Ching ^c   Hsiao, Michael ^c   Liang, Chi Ming ^b,c   Liang, Shu Mei ^d,e  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b INSTITUTE OF BIOLOGICAL CHEMISTRY   (Taiwan)

^c GENOMICS RESEARCH CENTER   (Taiwan)

^d AGRICULTURAL BIOTECHNOLOGY RESEARCH CENTER   (Taiwan)

^e NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^f TRI SERVICE GENERAL HOSPITAL   (Taiwan)

Author keywords

apoptosis; chemotherapeutic agent; integrin; metastasis; ovarian cancer

Indexed keywords

FOCAL ADHESION KINASE; GELATINASE A; GLYCOGEN SYNTHASE KINASE 3BETA; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; PROTEIN VP1; RECOMBINANT PROTEIN VP1; UNCLASSIFIED DRUG; VERY LATE ACTIVATION ANTIGEN 5;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BIOLUMINESCENCE; CANCER CELL; CANCER INHIBITION; CANCER INVASION; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; DOWN REGULATION; DRUG TARGETING; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; FEMALE; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; METASTASIS; MOUSE; NONHUMAN; OVARY ADENOCARCINOMA; PRIORITY JOURNAL; TUMOR XENOGRAFT;

ADENOCARCINOMA; ANIMALS; APOPTOSIS; CAPSID PROTEINS; CASPASE 3; CELL LINE, TUMOR; DNA FRAGMENTATION; FEMALE; HUMANS; INTEGRIN ALPHA5BETA1; MATRIX METALLOPROTEINASE 2; MICE; MICE, NUDE; NEOPLASM INVASIVENESS; OVARIAN NEOPLASMS; PROTO-ONCOGENE PROTEINS C-AKT; RECOMBINANT PROTEINS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 83755224349     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2011.01581.x     Document Type: Article

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