The activation of the p53 pathway by the AMP mimetic AICAR is reduced by inhibitors of the ATM or mTOR kinases

Mechanisms of Ageing and Development

Volumn 132, Issue 11-12, 2011, Pages 543-551

  Zajkowicz, Artur ^a   Rusin, Marek ^a  

^a INSTITUTE OF ONCOLOGY   (Poland)

Author keywords

AMPK; ATM; Caloric restriction; P53; Senescence

Indexed keywords

5 AMINO 4 IMIDAZOLECARBOXAMIDE RIBOSIDE; ADENOSINE PHOSPHATE; ATM PROTEIN; MAMMALIAN TARGET OF RAPAMYCIN; PROTEIN MDM2; PROTEIN P53;

ARTICLE; CELL AGING; CONTROLLED STUDY; ENZYME ACTIVITY; HUMAN; HUMAN CELL; METABOLIC STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING;

ADENOSINE MONOPHOSPHATE; AMINOIMIDAZOLE CARBOXAMIDE; AMP-ACTIVATED PROTEIN KINASES; CAFFEINE; CELL AGING; CELL CYCLE PROTEINS; CELL LINE; DNA-BINDING PROTEINS; GENE KNOCKDOWN TECHNIQUES; HUMANS; MODELS, BIOLOGICAL; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; PROTEIN-SERINE-THREONINE KINASES; RIBONUCLEOTIDES; SIGNAL TRANSDUCTION; SIROLIMUS; STILBENES; STRESS, PHYSIOLOGICAL; TOR SERINE-THREONINE KINASES; TUMOR SUPPRESSOR PROTEIN P53; TUMOR SUPPRESSOR PROTEINS;

EID: 83755202384     PISSN: 00476374     EISSN: 18726216     Source Type: Journal    
DOI: 10.1016/j.mad.2011.09.002     Document Type: Article

References (34)

1. Bakkenist C.J., Kastan M.B. DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature 2003, 421:499-506.
2. Boehme K.A., Blattner C. Regulation of p53 - insights into a complex process. Crit. Rev. Biochem. Mol. Biol. 2009, 44:367-392.
3. Cox M.L., Meek D.W. Phosphorylation of serine 392 in p53 is a common and integral event during p53 induction by diverse stimuli. Cell Signal. 2010, 22:564-571.
4. Dimri G.P., Lee X., Basile G., Acosta M., Scott G., Roskelley C., Medrano E.E., Linskens M., Rubelj I., Pereira-Smith O., et al. A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc. Natl. Acad. Sci. U. S. A. 1995, 92:9363-9367.
5. Duan X., Ponomareva L., Veeranki S., Choubey D. IFI16 induction by glucose restriction in human fibroblasts contributes to autophagy through activation of the ATM/AMPK/p53 pathway. PLoS One 2011, 6:e19532.
6. Gatz S.A., Wiesmüller L. Take a break - resveratrol in action on DNA. Carcinogenesis 2008, 29:321-332.
7. Goodrum F.D., Ornelles D.A. p53 status does not determine outcome of E1B 55-kilodalton mutant adenovirus lytic infection. J. Virol. 1998, 72:9479-9490.
8. Hickson I., Zhao Y., Richardson C.J., Green S.J., Martin N.M., Orr A.I., Reaper P.M., Jackson S.P., Curtin N.J., Smith G.C. Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM. Cancer Res. 2004, 64:9152-9159.
9. Jones R.G., Plas D.R., Kubek S., Buzzai M., Mu J., Xu Y., Birnbaum M.J., Thompson C.B. AMP-activated protein kinase induces a p53-dependent metabolic checkpoint. Mol. Cell 2005, 18:283-293.
10. Kruse J.P., Gu W. Modes of p53 regulation. Cell 2009, 137:609-622.
11. Kuo L.J., Yang L.X. Gamma-H2AX - a novel biomarker for DNA double-strand breaks. In Vivo 2008, 22:305-309.
12. Lee C.H., Inoki K., Karbowniczek M., Petroulakis E., Sonenberg N., Henske E.P., Guan K.L. Constitutive mTOR activation in TSC mutants sensitizes cells to energy starvation and genomic damage via p53. EMBO J. 2007, 26:4812-4823.
13. Lieberthal W., Levine J.S. The role of the mammalian target of rapamycin (mTOR) in renal disease. J. Am. Soc. Nephrol. 2009, 20:2493-2502.
14. Martin J.L., Avkiran M., Quinlan R.A., Cohen P., Marber M.S. Antiischemic effects of SB203580 are mediated through the inhibition of p38alpha mitogen-activated protein kinase: evidence from ectopic expression of an inhibition-resistant kinase. Circ. Res. 2001, 89:750-752.
15. Memmott R.M., Gills J.J., Hollingshead M., Powers M.C., Chen Z., Kemp B., Kozikowski A., Dennis P.A. Phosphatidylinositol ether lipid analogues induce AMP activated protein kinase-dependent death in LKB1-mutant non small cell lung cancer cells. Cancer Res. 2008, 68:580-588.
16. Mizuno S., Bogaard H.J., Voelkel N.F., Umeda Y., Kadowaki M., Ameshima S., Miyamori I., Ishizaki T. Hypoxia regulates human lung fibroblast proliferation via p53-dependent and -independent pathways. Respir. Res. 2009, 10:17-20.
17. Okoshi R., Ando K., Suenaga Y., Sang M., Kubo N., Kizaki H., Nakagawara A., Ozaki T. Transcriptional regulation of tumor suppressor p53 by cAMP-responsive element-binding protein/AMP-activated protein kinase complex in response to glucose deprivation. Genes Cells 2009, 14:1240-1429.
18. Pan S.Y., DesMeules M. Energy intake, physical activity, energy balance, and cancer: epidemiologic evidence. Methods Mol. Biol. 2009, 472:191-215.
19. Powers J.T., Hong S., Mayhew C.N., Rogers P.M., Knudsen E.S., Johnson D.G. E2F1 uses the ATM signaling pathway to induce p53 and Chk2 phosphorylation and apoptosis. Mol. Cancer Res. 2004, 2:203-214.
20. Richter K.H., Afshari C.A., Annab L.A., Burkhart B.A., Owen R.D., Boyd J., Barrett J.C. Down-regulation of cdc2 in senescent human and hamster cells. Cancer Res. 1991, 51:6010-6013.
21. Rusin M., Zajkowicz A., Butkiewicz D. Resveratrol induces senescence-like growth inhibition of U-2 OS cells associated with the instability of telomeric DNA and upregulation of BRCA1. Mech. Ageing Dev. 2009, 130:528-537.
22. Sanchez-Cespedes M., Parrella P., Esteller M., Nomoto S., Trink B., Engles J.M., Westra W.H., Herman J.G., Sidransky D. Inactivation of LKB1/STK11 is a common event in adenocarcinomas of the lung. Cancer Res. 2002, 62:3659-3662.
23. Sarkaria J.N., Busby E.C., Tibbetts R.S., Roos P., Taya Y., Karnisz L.M., Abraham R.T. Inhibition of ATM and ATR kinase activities by the radiosensitizing agent, caffeine. Cancer Res. 1999, 59:4375-4382.
24. Shackelford D.B., Shaw R.J. The LKB1-AMPK pathway: metabolism and growth control in tumour suppression. Nat. Rev. Cancer 2009, 9:563-575.
25. Stommel J.M., Wahl G.M. Accelerated MDM2 auto-degradation induced by DNA-damage kinases is required for p53 activation. EMBO J. 2004, 23:1547-1556.
26. Sun Y., Connors K.E., Yang D.Q. AICAR induces phosphorylation of AMPK in an ATM-dependent, LKB1-independent manner. Mol. Cell Biochem. 2007, 306:239-245.
27. Suzuki A., Kusakai G., Kishimoto A., Shimojo Y., Ogura T., Lavin M.F., Esumi H. IGF-1 phosphorylates AMPK-alpha subunit in ATM-dependent and LKB1-independent manner. Biochem. Biophys. Res. Commun. 2004, 324:986-992.
28. Tang Y., Zhao W., Chen Y., Zhao Y., Gu W. Acetylation is indispensable for p53 activation. Cell 2008, 133:612-626.
29. Tewari-Singh N., Gu M., Agarwal C., White C.W., Agarwal R. Biological and molecular mechanisms of sulfur mustard analogue-induced toxicity in JB6 and HaCaT cells: possible role of ataxia telangiectasia-mutated/ataxia telangiectasia-Rad3-related cell cycle checkpoint pathway. Chem. Res. Toxicol. 2010, 23:1034-1044.
30. Wade M., Wang Y.V., Wahl G.M. The p53 orchestra: Mdm2 and Mdmx set the tone. Trends Cell Biol. 2010, 20:299-309.
31. Wullschleger S., Loewith R., Hall M.N. TOR signaling in growth and metabolism. Cell 2006, 124:471-484.
32. Xi X., Han J., Zhang J.Z. Stimulation of glucose transport by AMP-activated protein kinase via activation of p38 mitogen-activated protein kinase. J. Biol. Chem. 2001, 276:41029-41034.
33. Yang D.Q., Halaby M.J., Li Y., Hibma J.C., Burn P. Cytoplasmic ATM protein kinase: an emerging therapeutic target for diabetes, cancer and neuronal degeneration. Drug Discov. Today 2011, 16:332-338.
34. Zeng P.Y., Berger S.L. LKB1 is recruited to the p21/WAF1 promoter by p53 to mediate transcriptional activation. Cancer Res. 2006, 66:10701-10708.