Engineered allosteric mutants of the integrin αMβ2 I domain: Structural and functional studies

Biochemical Journal

Volumn 372, Issue 1, 2003, Pages 121-127

  McCleverty, Clare J ^a   Liddington, Robert C ^a  

^a BURNHAM INSTITUTE   (United States)

Author keywords

A domain; Allostery; Gain of function; I domain; Integrin

Indexed keywords

ADHESION; CELLS; CHEMICAL BONDS; CONFORMATIONS; CRYSTAL STRUCTURE; SURFACE PLASMON RESONANCE;

ALLOSTERIC MUTANTS;

BIOCHEMISTRY;

FIBRINOGEN; INTEGRIN; INTERCELLULAR ADHESION MOLECULE 1;

ALLOSTERISM; ARTICLE; BINDING AFFINITY; CELL ADHESION; CELL MIGRATION; CRYSTAL STRUCTURE; DISULFIDE BOND; EQUILIBRIUM CONSTANT; HUMAN; LIGAND BINDING; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN ENGINEERING; PROTEIN FUNCTION; PROTEIN STRUCTURE; SURFACE PLASMON RESONANCE;

ALLOSTERIC REGULATION; ALLOSTERIC SITE; ANIMALS; CRYSTALLOGRAPHY, X-RAY; MACROPHAGE-1 ANTIGEN; PROTEIN CONFORMATION; PROTEIN ENGINEERING; PROTEIN STRUCTURE, TERTIARY;

EID: 0037616465     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20021273     Document Type: Article

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