Residue threonine 350 confers steroid hormone responsiveness to the mouse nuclear orphan receptor CAR

Molecular Pharmacology

Volumn 61, Issue 6, 2002, Pages 1284-1288

  Ueda, Akiko ^a   Kakizaki, Satoru ^a   Negishi, Masahiko ^a   Sueyoshi, Tatsuya ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL NUCLEUS RECEPTOR; CHIMERIC PROTEIN; CONSTITUTIVE ACTIVE RECEPTOR; MUTANT PROTEIN; PROGESTERONE; STEROID HORMONE; STEROID RECEPTOR COACTIVATOR 1; TESTOSTERONE; THREONINE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GENETIC TRANSFECTION; HORMONE RECEPTOR INTERACTION; HORMONE RESPONSE; HUMAN; HUMAN CELL; LIVER; MOUSE; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN;

AMINO ACID SUBSTITUTION; ANIMALS; ESTROGENS; HUMANS; MICE; MUTAGENESIS, SITE-DIRECTED; PROGESTERONE; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECOMBINANT FUSION PROTEINS; STEROIDS; TESTOSTERONE; THREONINE; TRANSCRIPTION FACTORS; TUMOR CELLS, CULTURED;

EID: 0036259008     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.61.6.1284     Document Type: Article

References (20)

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3. The coregulator exchange in transcriptional functions of nuclear receptors
4. Activation by diverse xenochemicals of the 51-base pair phenobarbital-responsive enhancer module in the CYP2B10 gene
5. The nuclear orphan receptor CAR-retinoid X receptor heterodimer activates the phenobarbital-responsive enhancer module of the CYP2B gene
6. Estrogen activation of the nuclear orphan receptor CAR (constitutive active receptor) in induction of the mouse Cyp2b1O gene
7. Phenobarbital-responsive nuclear translocation of the receptor CAR in induction of the CYP2B gene
8. Alteration of mouse cytochrome P450coh substrate specificity by mutation of a single amino-acid residue
9. Xenobiotic induction of cytochrome P450 2B1 (CYP2B1) is mediated by the orphan nuclear receptor constitutive androstane receptor (CAR) and requires steroid co-activator 1 (SRC-1) and the transcription factor Sp1
10. Structural flexibility and functional versatility of mammalian P450 enzymes
11. Phenobarbital induction mediated by a distal CYP2B2 sequence in rat liver transiently transfected in situ
12. Phenobarbital responsiveness conferred by the 5′-flanking region of the rat CYP2B2 gene in transgenic mice
13. The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 gene
14. Phenobarbital response elements of cytochrome P450 genes and nuclear receptors
15. The phenobarbital response enhancer module in the human bilirubin UDP-glucuronosyltransferase UGT1A1 gene and regulation by the nuclear receptor CAR
16. Localization of a phenobarbital-responsive element (pbre) in the 5′-flanking region of the rat CYP2B2 gene
17. Diverse roles of the nuclear orphan receptor CAR in regulating hepatic genes in response to phenobarbital
18. The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism
19. Phenobarbital-elicited activation of nuclear receptor CAR in induction of cytochrome P450 genes
20. The peptide near the C terminus regulates receptor CAR nuclear translocation induced by xenochemicals in mouse liver