Small interfering RNA targeting focal adhesion kinase prevents cardiac dysfunction in endotoxemia

Shock

Volumn 37, Issue 1, 2012, Pages 77-84

  Guido, Maria C ^a   Clemente, Carolina F ^b   Moretti, Ana I ^a   Barbeiro, Hermes V ^a   Debbas, Victor ^a   Caldini, Elia G ^a   Franchini, Kleber G ^b   Soriano, Francisco G ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b UNIVERSITY OF CAMPINAS   (Brazil)

Author keywords

cytokines; Focal adhesion protein tyrosine kinases; inflammation; sepsis; shock septic

Indexed keywords

COLLAGEN; FOCAL ADHESION KINASE; GELATINASE A; LIPOPOLYSACCHARIDE; SMALL INTERFERING RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENDOTOXEMIA; ENZYME ACTIVITY; GENE SILENCING; HEART; HEART CATHETERIZATION; HEART DISEASE; HEART HYPERTROPHY; HEART LEFT VENTRICLE; HEART LEFT VENTRICLE ENDDIASTOLIC PRESSURE; HEART MUSCLE CELL; HEART MUSCLE CONTRACTILITY; HISTOLOGY; HYPOTENSION; IN VIVO STUDY; MALE; MORPHOMETRICS; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT;

ANIMALS; COLLAGEN; ENDOTOXEMIA; ENZYME ACTIVATION; FOCAL ADHESION KINASE 1; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE SILENCING; HUMANS; LIPOPOLYSACCHARIDES; MALE; MATRIX METALLOPROTEINASE 2; MUSCLE PROTEINS; MYOCARDIAL CONTRACTION; MYOCARDIUM; PHOSPHORYLATION; RATS; RATS, WISTAR; RNA, SMALL INTERFERING;

EID: 83655191975     PISSN: 10732322     EISSN: 15400514     Source Type: Journal    
DOI: 10.1097/SHK.0b013e31823532ec     Document Type: Article

References (36)

1. Barbeiro DF, Barbeiro HV, Faintuch J, Ariga SK, Mariano M, Popi AF, de Souz HP, Velasco IT, Soriano FG: B-1 cells temper endotoxemic inflammatory responses. Immunobiology 216:302-308, 2011.
2. Lorigados CB, Soriano FG, Szabo C: Pathomechanisms of myocardial dysfunction in sepsis. Endocr Metab Immune Disord Drug Targets 10:274-284, 2011.
3. Melo ES, Barbeiro DF, Gorjao R, Rios EC, Vasconcelos D, Velasco IT, Szabo C, Curi R, de Lima-Salgado TM, Soriano FG: Gene expression reprogramming protects macrophage from septic-induced cell death. Mol Immunol 47:2587-2593, 2011.
4. Melo ES, Goloubkova T, Barbeiro DF, Gorjao R, Vasconcelos D, Szabo C, Curi R, de Lima Salgado TM, Velasco IT, Soriano FG: Endotoxin tolerance: selective alterations in gene expression and protection against lymphocyte death. Immunobiology 215:435-442, 2011.
5. Seki E, De Minicis S, Osterreicher CH, Kluwe J, Osawa Y, Brenner DA, Schwabe RF: TLR4 enhances TGF-beta signaling and hepatic fibrosis. Nat Med 13:1324-1332, 2007. (Pubitemid 350073596)
6. Kluwe J, Mencin A, Schwabe RF: Toll-like receptors, wound healing, and carcinogenesis. J Mol Med 87:125-138, 2009.
7. Otte JM, Rosenberg IM, Podolsky DK: Intestinal myofibroblasts in innate immune responses of the intestine. Gastroenterology 124:1866-1878, 2003. (Pubitemid 36666782)
8. Aoyama T, Paik YH, Seki E: Toll-like receptor signaling and liver fibrosis [published online ahead of print]. Gastroenterol Res Pract Epub 2010 Jul 25.
9. Rojas M, Woods CR, Mora AL, Xu J, Brigham KL: Endotoxin-induced lung injury in mice: structural, functional, and biochemical responses. Am J Physiol Lung Cell Mol Physiol 288:L333-L341, 2005. (Pubitemid 40105372)
10. He Z, Zhu Y, Jiang H: Toll-like receptor 4 mediates lipopolysaccharideinduced collagen secretion by phosphoinositide 3-kinase-Akt pathway in fibroblasts during acute lung injury. J Recept Signal Transduct Res 29:119-125, 2009.
11. Clemente CF, Tornatore TF, Theizen TH, Deckmann AC, Pereira TC, Lopes-Cendes I, Souza JR, Franchini KG: Targeting focal adhesion kinase with small interfering RNA prevents and reverses load-induced cardiac hypertrophy in mice. Circ Res 101:1339-1348, 2007. (Pubitemid 350294651)
12. Hutchinson KR, Stewart JA Jr, Lucchesi PA: Extracellular matrix remodeling during the progression of volume overload-induced heart failure. J Mol Cell Cardiol 48:564-569, 2010.
13. Negri EM, Montes GS, Saldiva PH, Capelozzi VL: Architectural remodelling in acute and chronic interstitial lung disease: fibrosis or fibroelastosis? Histopathology 37:393-401, 2000.
14. Saldiva PH, Delmonte VC, de Carvalho CR, Kairalla RA, Auler Junior JO: Histochemical evaluation of lung collagen content in acute and chronic interstitial diseases. Chest 95:953-957, 1989. (Pubitemid 19136979)
15. Gaddnas F, Koskela M, Koivukangas V, Risteli J, Oikarinen A, Laurila J, Saarnio J, Ala-Kokko T: Markers of collagen synthesis and degradation are increased in serum in severe sepsis: a longitudinal study of 44 patients. Crit Care 13:R53, 2009.
16. Soriano FG, Nogueira AC, Caldini EG, Lins MH, Teixeira AC, Cappi SB, Lotufo PA, Bernik MM, Zsengeller Z, Chen M, et al.: Potential role of poly(adenosine 5¶-diphosphate-ribose) polymerase activation in the pathogenesis of myocardial contractile dysfunction associated with human septic shock. Crit Care Med 34:1073-1079, 2006.
17. Nogueira AC, Kawabata V, Biselli P, Lins MH, Valeri C, Seckler M, Hoshino W, Junior LG, Bernik MM, de Andrade Machado JB, et al.: Changes in plasma free fatty acid levels in septic patients are associated with cardiac damage and reduction in heart rate variability. Shock 29:342-348, 2008. (Pubitemid 351271705)
18. Jones AE, Puskarich MA: Sepsis-induced tissue hypoperfusion. Crit Care Clin 25:769-779, ix, 2009.
19. Natanson C, Eichenholz PW, Danner RL, Eichacker PQ, Hoffman WD, Kuo GC, Banks SM, MacVittie TJ, Parrillo JE: Endotoxin and tumor necrosis factor challenges in dogs simulate the cardiovascular profile of human septic shock. J Exp Med 169:823-832, 1989. (Pubitemid 19085823)
20. Parker MM, McCarthy KE, Ognibene FP, Parrillo JE: Right ventricular dysfunction and dilatation, similar to left ventricular changes, characterize the cardiac depression of septic shock in humans. Chest 97:126-131, 1990. (Pubitemid 20023505)
21. Zanotti-Cavazzoni SL, Hollenberg SM: Cardiac dysfunction in severe sepsis and septic shock. Curr Opin Crit Care 15:392-397, 2009.
22. Fallach R, Shainberg A, Avlas O, Fainblut M, Chepurko Y, Porat E, Hochhauser E: Cardiomyocyte Toll-like receptor 4 is involved in heart dysfunction following septic shock or myocardial ischemia. J Mol Cell Cardiol 48:1236-1244, 2011.
23. Nadruz W Jr, Corat MA, Marin TM, Guimaraes Pereira GA, Franchini KG: Focal adhesion kinase mediates MEF2 and c-Jun activation by stretch: role in the activation of the cardiac hypertrophic genetic program. Cardiovasc Res 68:87-97, 2005. (Pubitemid 41253559)
24. Taylor JM, Rovin JD, Parsons JT: A role for focal adhesion kinase in phenylephrine-induced hypertrophy of rat ventricular cardiomyocytes. J Biol Chem 275:19250-19257, 2000. (Pubitemid 30422897)
25. Dykxhoorn DM, Lieberman J: Knocking down disease with siRNAs. Cell 126:231-235, 2006. (Pubitemid 44092975)
26. ZeiselMB, Druet VA, Sibilia J, Klein JP, Quesniaux V,Wachsmann D: Cross talk between MyD88 and focal adhesion kinase pathways. J Immunol 174:7393-7397, 2005. (Pubitemid 40705710)
27. Guido MC, de Carvalho Frimm C, Koike MK, Cordeiro FF, Moretti AI, Godoy LC: Low coronary driving pressure is associated with subendocardial remodelling and left ventricular dysfunction in aortocaval fistula. Clin Exp Pharmacol Physiol 34:1165-1172, 2007. (Pubitemid 47416349)
28. Soriano FG, Liaudet L, Szabo E, Virag L, Mabley JG, Pacher P, Szabo C: Resistance to acute septic peritonitis in poly(ADP-ribose) polymerase-1- deficient mice. Shock 17:286-292, 2002.
29. Cinel I, Dellinger RP: Advances in pathogenesis and management of sepsis. Curr Opin Infect Dis 20:345-352, 2007. (Pubitemid 47026230)
30. Vincent JL, Sun Q, Dubois MJ: Clinical trials of immunomodulatory therapies in severe sepsis and septic shock. Clin Infect Dis 34:1084-1093, 2002. (Pubitemid 34289681)
31. Hamar P, Song E, Kokeny G, Chen A, Ouyang N, Lieberman J: Small interfering RNA targeting Fas protects mice against renal ischemia-reperfusion injury. Proc Natl Acad Sci USA 101:14883-14888, 2004. (Pubitemid 39410769)
32. Sorensen DR, Leirdal M, Sioud M: Gene silencing by systemic delivery of synthetic siRNAs in adult mice. J Mol Biol 327:761-766, 2003. (Pubitemid 36315917)
33. Eble DM, Strait JB, Govindarajan G, Lou J, Byron KL, Samarel AM: Endothelininduced cardiac myocyte hypertrophy: role for focal adhesion kinase. Am J Physiol Heart Circ Physiol 278:H1695-H1707, 2000. (Pubitemid 30395584)
34. Katz AM: The cardiomyopathy of overload: an unnatural growth response in the hypertrophied heart. Ann Intern Med 121:363-371, 1994.
35. Cazita PM, Barbeiro DF, Moretti AI, Quintao EC, Soriano FG: Human cholesteryl ester transfer protein expression enhances the mouse survival rate in an experimental systemic inflammation model: a novel role for CETP. Shock 30:590-595, 2008.
36. Bergman MR, Teerlink JR, Mahimkar R, Li L, Zhu BQ, Nguyen A, Dahi S, Karliner JS, Lovett DH: Cardiac matrix metalloproteinase-2 expression independently induces marked ventricular remodeling and systolic dysfunction. Am J Physiol Heart Circ Physiol 292:H1847-H1860, 2007. (Pubitemid 46572408)