Endotoxin tolerance: Selective alterations in gene expression and protection against lymphocyte death

Immunobiology

Volumn 215, Issue 6, 2010, Pages 435-442

  Melo, Edielle S ^a   Goloubkova, Tatiana ^a   Barbeiro, Denise F ^a   Gorjão, Renata ^a   Vasconcelos, Dewton ^a   Szabo, Csaba ^b   Curi, Rui ^a   de Lima Salgado, Thais Martins ^a   Velasco, Irineu T ^a   Soriano, Francisco G ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b University of Texas Medical Branch School of Medicine   (United States)

Author keywords

Apoptosis; Cytokines; Inflammation; Necrosis; Sepsis; Shock; T cells

Indexed keywords

APOPTOSIS PROTEIN 3 INHIBITOR; APOPTOTIC PROTEASE ACTIVATING FACTOR 1; CASPASE; CASPASE 11; CASPASE 2; CASPASE 3; CASPASE 7; CATHEPSIN B; ENDOTOXIN; EPHRIN RECEPTOR A3; ESCHERICHIA COLI LIPOPOLYSACCHARIDE; FAS LIGAND; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 1BETA CONVERTING ENZYME; INTERLEUKIN 4; MESSENGER RNA; PROGRAMMED CELL DEATH 1 PROTEIN PRECURSOR; PROTEIN BID; PROTEIN INHIBITOR; PROTEIN PRECURSOR; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CD4+ T LYMPHOCYTE; CELL PROTECTION; CELL SURVIVAL; CLONAL ANERGY; CONTROLLED STUDY; EXPERIMENTAL MODEL; GENE EXPRESSION; GENE MUTATION; IMMUNOGENETICS; IMMUNOLOGICAL TOLERANCE; IN VIVO STUDY; LYMPHOCYTE ACTIVATION; LYMPHOCYTE DIFFERENTIATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SEPSIS; SIGNAL TRANSDUCTION; TH1 CELL; TH2 CELL;

ANIMALS; APOPTOSIS; CD4-POSITIVE T-LYMPHOCYTES; CELL SURVIVAL; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; IMMUNE TOLERANCE; LIPOPOLYSACCHARIDES; MICE; MICE, INBRED BALB C; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RNA, MESSENGER; SEPSIS;

EID: 77952554085     PISSN: 01712985     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.imbio.2009.09.002     Document Type: Article

References (48)

1. Coopersmith C.M., Stromberg P.E., Davis C.G., Dunne W.M., Amiot D.M., Karl I.E., Hotchkiss R.S., Buchman T.G. Sepsis from Pseudomonas aeruginosa pneumonia decreases intestinal proliferation and induces gut epithelial cell cycle arrest. Crit. Care Med. 2003, 31:1630.
2. Texereau J., Pene F., Chiche J.D., Rousseau C., Mira J.P. Importance of hemostatic gene polymorphisms for susceptibility to and outcome of severe sepsis. Crit. Care Med. 2004, 32:S313.
3. Clark S.R., Ma A.C., Tavener S.A., McDonald B., Goodarzi Z., Kelly M.M., Patel K.D., Chakrabarti S., McAvoy E., Sinclair G.D., Keys E.M., Allen-Vercoe E., Devinney R., Doig C.J., Green F.H., Kubes P. Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood. Nat. Med. 2007, 13:463.
4. Foster S.L., Hargreaves D.C., Medzhitov R. Gene-specific control of inflammation by TLR-induced chromatin modifications. Nature 2007, 447:972.
5. Hotchkiss R.S., Tinsley K.W., Swanson P.E., Schmieg R.E., Hui J.J., Chang K.C., Osborne D.F., Freeman B.D., Cobb J.P., Buchman T.G., Karl I.E. Sepsis-induced apoptosis causes progressive profound depletion of B and CD4+ T lymphocytes in humans. J. Immunol. 2001, 166:6952.
6. Hotchkiss R.S., Coopersmith C.M., Karl I.E. Prevention of lymphocyte apoptosis - a potential treatment of sepsis?. Clin. Infect. Dis. 2005, 41(Suppl. 7):S465.
7. Kusuda T., Shigemasa K., Arihiro K., Fujii T., Nagai N., Ohama K. Relative expression levels of Th1 and Th2 cytokine mRNA are independent prognostic factors in patients with ovarian cancer. Oncol. Rep. 2005, 13:1153.
8. Pinheiro-da-Silva F., Chiamolera M., Charles N., Kanamaru Y., Velasco I.T., Benhamou M., Monteiro R.C. B lymphocytes undergo apoptosis because of FcgammaRIIb stress response to infection: a novel mechanism of cell death in sepsis. Shock 2006, 25:61.
9. Hoffmann J.A., Kafatos F.C., Janeway C.A., Ezekowitz R.A. Phylogenetic perspectives in innate immunity. Science 1999, 284:1313.
10. Hotchkiss R.S., Swanson P.E., Freeman B.D., Tinsley K.W., Cobb J.P., Matuschak G.M., Buchman T.G., Karl I.E. Apoptotic cell death in patients with sepsis, shock, and multiple organ dysfunction. Crit. Care Med. 1999, 27:1230.
11. Hotchkiss R.S., Tinsley K.W., Swanson P.E., Grayson M.H., Osborne D.F., Wagner T.H., Cobb J.P., Coopersmith C., Karl I.E. Depletion of dendritic cells, but not macrophages, in patients with sepsis. J. Immunol. 2002, 168:2493.
12. Hotchkiss R.S., Karl I.E. The pathophysiology and treatment of sepsis. N. Engl. J. Med. 2003, 348:138.
13. Fan H., Cook J.A. Molecular mechanisms of endotoxin tolerance. J. Endotoxin Res. 2004, 10:71.
14. Cavaillon J.M., Adrie C., Fitting C., Adib-Conquy M. Endotoxin tolerance: is there a clinical relevance?. J. Endotoxin Res. 2003, 9:101.
15. Cavaillon J.M., Adib-Conquy M. Bench-to-bedside review: endotoxin tolerance as a model of leukocyte reprogramming in sepsis. Crit. Care 2006, 10:233.
16. Van Epps H.L. Ignoring endotoxin. J. Exp. Med. 2006, 203:1137.
17. Wheeler D.S., Lahni P.M., Denenberg A.G., Poynter S.E., Wong H.R., Cook J.A., Zingarelli B. Induction of endotoxin tolerance enhances bacterial clearance and survival in murine polymicrobial sepsis. Shock 2008, 30:267.
18. Flohe S., Dominguez Fernandez E., Ackermann M., Hirsch T., Borgermann J., Schade F.U. Endotoxin tolerance in rats: expression of TNF-alpha, IL-6, IL-10, VCAM-1 AND HSP 70 in lung and liver during endotoxin shock. Cytokine 1999, 11:796.
19. Soriano F.G., Liaudet L., Szabo E., Virag L., Mabley J.G., Pacher P., Szabo C. Resistance to acute septic peritonitis in poly(ADP-ribose) polymerase-1-deficient mice. Shock 2002, 17:286.
20. West M.A., Heagy W. Endotoxin tolerance: a review. Crit. Care Med. 2002, 30:S64.
21. Sly L.M., Rauh M.J., Kalesnikoff J., Song C.H., Krystal G. LPS-induced upregulation of SHIP is essential for endotoxin tolerance. Immunity 2004, 21:227.
22. Fink S.L., Cookson B.T. Apoptosis, pyroptosis, and necrosis: mechanistic description of dead and dying eukaryotic cells. Infect. Immun. 2005, 73:1907.
23. Lamkanfi M., Festjens N., Declercq W., Vanden Berghe T., Vandenabeele P. Caspases in cell survival, proliferation and differentiation. Cell Death Differ. 2007, 14:44.
24. Ivanov V.N., Nikolic-Zugic J. Biochemical and kinetic characterization of the glucocorticoid-induced apoptosis of immature CD4+CD8+ thymocytes. Int. Immunol. 1998, 10:1807.
25. Benjamim C.F., Ferreira S.H., Cunha F.Q. Role of nitric oxide in the failure of neutrophil migration in sepsis. J. Infect. Dis. 2000, 182:214.
26. Rios-Santos F., Alves-Filho J.C., Souto F.O., Spiller F., Freitas A., Lotufo C.M., Soares M.B., Dos Santos R.R., Teixeira M.M., Cunha F.Q. Down-regulation of CXCR2 on neutrophils in severe sepsis is mediated by inducible nitric oxide synthase-derived nitric oxide. Am. J. Respir. Crit. Care Med. 2007, 175:490.
27. Torres-Duenas D., Celes M.R., Freitas A., Alves-Filho J.C., Spiller F., Dal-Secco D., Dalto V.F., Rossi M.A., Ferreira S.H., Cunha F.Q. Peroxynitrite mediates the failure of neutrophil migration in severe polymicrobial sepsis in mice. Br. J. Pharmacol. 2007, 152:341.
28. Adib-Conquy M., Adrie C., Moine P., Asehnoune K., Fitting C., Pinsky M.R., Dhainaut J.F., Cavaillon J.M. NF-kappaB expression in mononuclear cells of patients with sepsis resembles that observed in lipopolysaccharide tolerance. Am. J. Respir. Crit. Care Med. 2000, 162:1877.
29. Deng J.C., Cheng G., Newstead M.W., Zeng X., Kobayashi K., Flavell R.A., Standiford T.J. Sepsis-induced suppression of lung innate immunity is mediated by IRAK-M. J. Clin. Invest. 2006, 116:2532.
30. Scumpia P.O., Delano M.J., Kelly-Scumpia K.M., Weinstein J.S., Wynn J.L., Winfield R.D., Xia C., Chung C.S., Ayala A., Atkinson M.A., Reeves W.H., Clare-Salzler M.J., Moldawer L.L. Treatment with GITR agonistic antibody corrects adaptive immune dysfunction in sepsis. Blood 2007, 110:3673.
31. Kim K.D., Zhao J., Auh S., Yang X., Du P., Tang H., Fu Y.X. Adaptive immune cells temper initial innate responses. Nat. Med. 2007, 13:1248.
32. Szabo C., Zingarelli B., O'Connor M., Salzman A.L. DNA strand breakage, activation of poly(ADP-ribose) synthetase, and cellular energy depletion are involved in the cytotoxicity of macrophages and smooth muscle cells exposed to peroxynitrite. Proc. Natl. Acad. Sci. USA 1996, 93:1753.
33. Kroemer G., Martin S.J. Caspase-independent cell death. Nat. Med. 2005, 11:725.
34. Krammer P.H., Arnold R., Lavrik I.N. Life and death in peripheral T cells. Nat. Rev. Immunol. 2007, 7:532.
35. Garcia Soriano F., Virag L., Jagtap P., Szabo E., Mabley J.G., Liaudet L., Marton A., Hoyt D.G., Murthy K.G., Salzman A.L., Southan G.J., Szabo C. Diabetic endothelial dysfunction: the role of poly(ADP-ribose) polymerase activation. Nat. Med. 2001, 7:108.
36. Aldinucci A., Gerlini G., Fossati S., Cipriani G., Ballerini C., Biagioli T., Pimpinelli N., Borgognoni L., Massacesi L., Moroni F., Chiarugi A. A key role for poly(ADP-ribose) polymerase-1 activity during human dendritic cell maturation. J. Immunol. 2007, 179:305.
37. Pacher P., Schulz R., Liaudet L., Szabo C. Nitrosative stress and pharmacological modulation of heart failure. Trends Pharmacol. Sci. 2005, 26:302.
38. Chen M., Zsengeller Z., Xiao C.Y., Szabo C. Mitochondrial-to-nuclear translocation of apoptosis-inducing factor in cardiac myocytes during oxidant stress: potential role of poly(ADP-ribose) polymerase-1. Cardiovasc. Res. 2004, 63:682.
39. Tyurina Y.Y., Basova L.V., Konduru N.V., Tyurin V.A., Potapovich A.I., Cai P., Bayir H., Stoyanovsky D., Pitt B.R., Shvedova A.A., Fadeel B., Kagan V.E. Nitrosative stress inhibits the aminophospholipid translocase resulting in phosphatidylserine externalization and macrophage engulfment: implications for the resolution of inflammation. J. Biol. Chem. 2007, 282:8498.
40. Hotchkiss R.S., Nicholson D.W. Apoptosis and caspases regulate death and inflammation in sepsis. Nat. Rev. Immunol. 2006, 6:813.
41. Chang K.C., Unsinger J., Davis C.G., Schwulst S.J., Muenzer J.T., Strasser A., Hotchkiss R.S. Multiple triggers of cell death in sepsis: death receptor and mitochondrial-mediated apoptosis. Faseb J. 2007, 21:708.
42. McDunn J.E., Muenzer J.T., Rachdi L., Chang K.C., Davis C.G., Dunne W.M., Piwnica-Worms D., Bernal-Mizrachi E., Hotchkiss R.S. Peptide-mediated activation of Akt and extracellular regulated kinase signaling prevents lymphocyte apoptosis. Faseb J 2007.
43. Rayhane N., Fitting C., Lortholary O., Dromer F., Cavaillon J.M. Administration of endotoxin associated with lipopolysaccharide tolerance protects mice against fungal infection. Infect. Immun. 2000, 68:3748.
44. Kobayashi K., Hernandez L.D., Galan J.E., Janeway C.A., Medzhitov R., Flavell R.A. IRAK-M is a negative regulator of Toll-like receptor signaling. Cell 2002, 110:191.
45. Bonig H., Packeisen J., Rohne B., Hempel L., Hannen M., Klein-Vehne A., Burdach S., Korholz D. Interaction between interleukin 10 and interleukin 6 in human B-cell differentiation. Immunol. Invest. 1998, 27:267.
46. Cerutti A., Zan H., Schaffer A., Bergsagel L., Harindranath N., Max E.E., Casali P. CD40 ligand and appropriate cytokines induce switching to IgG, IgA, and IgE and coordinated germinal center and plasmacytoid phenotypic differentiation in a human monoclonal IgM+IgD+ B cell line. J. Immunol. 1998, 160:2145.
47. Schultze J.L., Michalak S., Lowne J., Wong A., Gilleece M.H., Gribben J.G., Nadler L.M. Human non-germinal center B cell interleukin (IL)-12 production is primarily regulated by T cell signals CD40 ligand, interferon gamma, and IL-10: role of B cells in the maintenance of T cell responses. J. Exp. Med. 1999, 189:1.
48. Duddy M.E., Alter A., Bar-Or A. Distinct profiles of human B cell effector cytokines: a role in immune regulation?. J. Immunol. 2004, 172:3422.