Identification and analysis of functionally important amino acids in human purinergic 12 receptor using a Saccharomyces cerevisiae expression system

FEBS Journal

Volumn 279, Issue 1, 2012, Pages 180-191

  Ignatovica, Vita ^a   Megnis, Kaspars ^a   Lapins, Maris ^b   Schiöth, Helgi B ^b   Klovins, Janis ^a  

^a LATVIAN BIOMEDICAL RESEARCH AND STUDY CENTRE   (Latvia)

^b UPPSALA UNIVERSITY   (Sweden)

Author keywords

G protein coupled receptors; P2Y ligand binding pocket; P2Y receptor mutagenesis; P2Y receptors; Saccharomyces cerevisiae

Indexed keywords

ADENOSINE DIPHOSPHATE; AMINO ACID; PROTEIN VARIANT; PURINERGIC P2Y12 RECEPTOR;

AMINO ACID POSITION; AMINO ACID SUBSTITUTION; ARTICLE; CHEMICAL PHENOMENA; GENE EXPRESSION SYSTEM; HUMAN; LIGAND BINDING; MOLECULAR DOCKING; MOLECULAR LIBRARY; MUTAGENESIS; NONHUMAN; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN STRUCTURE; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RESIDUE ANALYSIS; SACCHAROMYCES CEREVISIAE; SEQUENCE HOMOLOGY;

AMINO ACID SEQUENCE; AMINO ACIDS; CLONING, MOLECULAR; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; MUTATION; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; RECEPTORS, PURINERGIC P2Y12; RECOMBINANT PROTEINS; SACCHAROMYCES CEREVISIAE;

SACCHAROMYCES CEREVISIAE;

EID: 83655184629     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2011.08410.x     Document Type: Article

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