Influence of the pathogenic mutations T188K/R/A on the structural stability and misfolding of human prion protein: Insight from molecular dynamics simulations

Biochimica et Biophysica Acta - General Subjects

Volumn 1820, Issue 2, 2012, Pages 116-123

  Guo, Jingjing ^a   Ning, Lulu ^a   Ren, Hui ^b   Liu, Huanxiang ^a,b   Yao, Xiaojun ^a  

^a LANZHOU UNIVERSITY   (China)

^b LANZHOU UNIVERSITY   (China)

Author keywords

Familial Creutzfeldt Jakob disease; Familial prion disease; Molecular dynamics simulation; T188K R A mutant

Indexed keywords

PRION PROTEIN;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; GENE CONVERSION; GENE MUTATION; HUMAN; HYDROPHOBICITY; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN POLYMORPHISM; PROTEIN SECONDARY STRUCTURE; PROTEIN STABILITY; PROTEIN STRUCTURE; SIMULATION;

HUMANS; HYDROGEN BONDING; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR DYNAMICS SIMULATION; MUTANT PROTEINS; MUTATION; PRIONS; PROTEIN FOLDING; PROTEIN STABILITY; PROTEIN STRUCTURE, SECONDARY; SOLVENTS;

EID: 83655169803     PISSN: 03044165     EISSN: 18728006     Source Type: Journal    
DOI: 10.1016/j.bbagen.2011.11.013     Document Type: Article

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