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Volumn 9, Issue 1, 2012, Pages 40-52

Stable angina pectoris: Antianginal therapies and future directions

Author keywords

[No Author keywords available]

Indexed keywords

ACETYL COENZYME A ACYLTRANSFERASE; ALLOPURINOL; AMLODIPINE; ANTIANGINA PECTORIS AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM CHANNEL BLOCKING AGENT; CARVEDILOL; CYTOCHROME P450 3A4; DILTIAZEM; FELODIPINE; IVABRADINE; LABETALOL; NICARDIPINE; NICORANDIL; NIFEDIPINE; NITRATE; RANOLAZINE; TRIMETAZIDINE; VASCULOTROPIN; VASOPEPTIDASE INHIBITOR; VERAPAMIL;

EID: 83655167300     PISSN: 17595002     EISSN: 17595010     Source Type: Journal    
DOI: 10.1038/nrcardio.2011.129     Document Type: Review
Times cited : (16)

References (111)
  • 2
    • 37349031812 scopus 로고    scopus 로고
    • 2007 Chronic angina focused update of the ACC/AHA 2002 guidelines for the management of patients with chronic stable angina: A report of the American college of cardiology/American heart association task force on practice guidelines writing group to develop the focused update of the 2002 guidelines for the management of patients with chronic stable angina
    • DOI 10.1161/CIRCULATIONAHA.107.187930
    • Fraker, T. D. Jr et al. 2007 chronic angina focused update of the ACC/AHA 2002 Guidelines for the management of patients with chronic stable angina: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines Writing Group to develop the focused update of the 2002 Guidelines for the management of patients with chronic stable angina. Circulation 116, 2762-2772 (2007). (Pubitemid 350291248)
    • (2007) Circulation , vol.116 , Issue.23 , pp. 2762-2772
    • Fraker Jr., T.D.1    Fihn, S.D.2
  • 4
    • 33744982042 scopus 로고    scopus 로고
    • AHA/ACC guidelines for secondary prevention for patients with coronary and other atherosclerotic vascular disease: 2006 update. Endorsed by the National Heart, Lung, and Blood Institute
    • Smith, S. C. et al. AHA/ACC guidelines for secondary prevention for patients with coronary and other atherosclerotic vascular disease: 2006 update. Endorsed by the National Heart, Lung, and Blood Institute. Circulation 113, 2363-2372 (2006).
    • (2006) Circulation , vol.113 , pp. 2363-2372
    • Smith, S.C.1
  • 6
    • 77949562278 scopus 로고    scopus 로고
    • Intensive multifactorial intervention for stable coronary artery disease: Optimal medical therapy in the COURAGE trial
    • Maron, D. J. et al. Intensive multifactorial intervention for stable coronary artery disease: optimal medical therapy in the COURAGE trial. J. Am. Coll. Cardiol. 55, 1348-1358 (2010).
    • (2010) J. Am. Coll. Cardiol. , vol.55 , pp. 1348-1358
    • Maron, D.J.1
  • 7
    • 67149142042 scopus 로고    scopus 로고
    • A randomized trial of therapy for type 2 diabetes and coronary artery disease
    • The BARI 2D Study Group
    • The BARI 2D Study Group. A randomized trial of therapy for type 2 diabetes and coronary artery disease. N. Engl. J. Med. 360, 2503-2515 (2009).
    • (2009) N. Engl. J. Med. , vol.360 , pp. 2503-2515
  • 8
    • 73949143669 scopus 로고    scopus 로고
    • The Bypass Angioplasty Revascularization Investigation 2 Diabetes randomized trial of different treatment strategies in type 2 diabetes mellitus with stable ischemic heart disease. Impact of treatment strategy on cardiac mortality and myocardial infarction
    • Chaitman, B. R. et al. The Bypass Angioplasty Revascularization Investigation 2 Diabetes randomized trial of different treatment strategies in type 2 diabetes mellitus with stable ischemic heart disease. Impact of treatment strategy on cardiac mortality and myocardial infarction. Circulation 120, 2529-2540 (2009).
    • (2009) Circulation , vol.120 , pp. 2529-2540
    • Chaitman, B.R.1
  • 9
    • 77958530594 scopus 로고    scopus 로고
    • Choice of initial medical therapy vs. prompt coronary revascularization in patients with type 2 diabetes and stable ischemic coronary disease with special emphasis on the BARI 2D trial results
    • Chaitman, B. R., Hadid, M. & Laddu, A. A. Choice of initial medical therapy vs. prompt coronary revascularization in patients with type 2 diabetes and stable ischemic coronary disease with special emphasis on the BARI 2D trial results. Curr. Opin. Cardiol. 25, 597-602 (2010).
    • (2010) Curr. Opin. Cardiol. , vol.25 , pp. 597-602
    • Chaitman, B.R.1    Hadid, M.2    Laddu, A.A.3
  • 10
    • 77749264545 scopus 로고    scopus 로고
    • Chronic stable coronary artery disease: Drugs vs. revascularization
    • Simoons, M. L. & Windecker, S. Chronic stable coronary artery disease: drugs vs. revascularization. Eur. Heart J. 31, 530-541 (2010).
    • (2010) Eur. Heart J. , vol.31 , pp. 530-541
    • Simoons, M.L.1    Windecker, S.2
  • 15
    • 34848874507 scopus 로고    scopus 로고
    • A meta-analysis of 94,492 patients with hypertension treated with beta blockers to determine the risk of new-onset diabetes mellitus
    • DOI 10.1016/j.amjcard.2007.05.057, PII S000291490701332X
    • Bangalore, S., Parkar, S., Grossman, E. & Messerli, F. H. A meta-analysis of 94,492 patients with hypertension treated with beta blockers to determine the risk of new-onset diabetes mellitus. Am. J. Cardiol. 100, 1254-1262 (2007). (Pubitemid 47498283)
    • (2007) American Journal of Cardiology , vol.100 , Issue.8 , pp. 1254-1262
    • Bangalore, S.1    Parkar, S.2    Grossman, E.3    Messerli, F.H.4
  • 16
    • 33846294746 scopus 로고    scopus 로고
    • Incident diabetes in clinical trials of antihypertensive drugs: A network meta-analysis
    • DOI 10.1016/S0140-6736(07)60108-1, PII S0140673607601081
    • Elliott, W. J. & Meyer, P. M. Incident diabetes in clinical trials of antihypertensive drugs: a network meta-analysis. Lancet 269, 201-207 (2007). (Pubitemid 46111014)
    • (2007) Lancet , vol.369 , Issue.9557 , pp. 201-207
    • Elliott, W.J.1    Meyer, P.M.2
  • 17
    • 44249083511 scopus 로고    scopus 로고
    • Impact of nebivolol on levels of serum nitric oxide, plasma von Willebrand factor and exercise stress testing parameters in hypertensive and ischemic heart disease patients
    • Kobusiak-Prokopowicz, M. et al. Impact of nebivolol on levels of serum nitric oxide, plasma von Willebrand factor and exercise stress testing parameters in hypertensive and ischemic heart disease patients. Cardiol. J. 15, 162-168 (2008). (Pubitemid 351721978)
    • (2008) Cardiology Journal , vol.15 , Issue.2 , pp. 162-168
    • Kobusiak-Prokopowicz, M.1    Jolda-Mydlowska, B.2    Zubkiewicz, A.3    Szymczak, M.4    Mysiak, A.5    Skalik, R.6
  • 18
    • 0026550074 scopus 로고
    • Efficacy, safety and duration of nitrate-free interval to prevent tolerance to transdermal nitroglycerin in effort angina
    • Gumbrielle, T. et al. Efficacy, safety and duration of nitrate-free interval to prevent tolerance to transdermal nitroglycerin in effort angina. Eur. Heart J. 13, 671-678 (1992).
    • (1992) Eur. Heart J. , vol.13 , pp. 671-678
    • Gumbrielle, T.1
  • 19
    • 33847041037 scopus 로고    scopus 로고
    • Novel therapeutic approaches to treating chronic angina in the setting of chronic ischemic heart disease
    • Chaitman, B. R. & Sano, J. Novel therapeutic approaches to treating chronic angina in the setting of chronic ischemic heart disease. Clin. Cardiol. 30 (Suppl. 1), I25-I30 (2007).
    • (2007) Clin. Cardiol. , vol.30 , Issue.SUPPL. 1
    • Chaitman, B.R.1    Sano, J.2
  • 20
    • 33644877646 scopus 로고    scopus 로고
    • Trimetazidine for stable angina
    • Art. No.: CD003614. doi:10.1002/14651858.CD003614.pub2
    • Ciapponi, A., Pizzarro, R. & Harrison, J. Trimetazidine for stable angina. Cochrane Database of Systematic Reviews, Issue 4, Art. No.: CD003614. doi:10.1002/14651858.CD003614.pub2 (2005).
    • (2005) Cochrane Database of Systematic Reviews , Issue.4
    • Ciapponi, A.1    Pizzarro, R.2    Harrison, J.3
  • 21
    • 34250306338 scopus 로고    scopus 로고
    • Trimetazidine added to combined hemodynamic antianginal therapy in patients with type 2 diabetes: A randomized crossover trial
    • Ribeiro, L. W., Ribeiro, J. P., Stein, R., Leitao, C. & Polanczyk, C. A. Trimetazidine added to combined hemodynamic antianginal therapy in patients with type 2 diabetes: a randomized crossover trial. Am. Heart J. 154, 78.e1-78.e7 (2007).
    • (2007) Am. Heart J. , vol.154
    • Ribeiro, L.W.1    Ribeiro, J.P.2    Stein, R.3    Leitao, C.4    Polanczyk, C.A.5
  • 22
    • 0141723313 scopus 로고    scopus 로고
    • The antianginal agent trimetazidine does not exert its functional benefit via inhibition of mitochondrial long-chain 3-ketoacyl coenzyme A thiolase
    • MacInnes, A. et al. The antianginal agent trimetazidine does not exert its functional benefit via inhibition of mitochondrial long-chain 3-ketoacyl coenzyme A thiolase. Circ. Res. 93, e26-e32 (2003).
    • (2003) Circ. Res. , vol.93
    • MacInnes, A.1
  • 24
    • 0037070736 scopus 로고    scopus 로고
    • Effect of nicorandil on coronary events in patients with stable angina: The Impact of Nicorandil of Angina (IONA) randomised trial
    • IONA Study Group
    • IONA Study Group. Effect of nicorandil on coronary events in patients with stable angina: the Impact of Nicorandil of Angina (IONA) randomised trial. Lancet 359, 1269-1275 (2002).
    • (2002) Lancet , vol.359 , pp. 1269-1275
  • 25
    • 25844446036 scopus 로고    scopus 로고
    • Determinants of coronary events in patients with stable angina: Results from the Impact of Nicorandil in Angina Study
    • IONA Study Group
    • IONA Study Group. Determinants of coronary events in patients with stable angina: results from the Impact of Nicorandil in Angina Study. Am. Heart J. 150, 689.e1-689.e9 (2005).
    • (2005) Am. Heart J. , vol.150
  • 26
    • 4644356399 scopus 로고    scopus 로고
    • Nicorandil: A review of its use in the management of stable angina pectoris, including high-risk patients
    • DOI 10.2165/00003495-200464170-00012
    • Simpson, D. & Wellington, K. Nicorandil: a review of its use in the management of stable angina pectoris, including high-risk patients. Drugs 64, 1941-1955 (2004). (Pubitemid 39263662)
    • (2004) Drugs , vol.64 , Issue.17 , pp. 1941-1955
    • Simpson, D.1    Wellington, K.2
  • 27
    • 78349260910 scopus 로고    scopus 로고
    • Systematic review on the short-term efficacy and safety of nicorandil for stable angina pectoris in comparison with those of β-blockers, nitrates and calcium antagonists
    • Hanai, Y., Mita, M., Hishinuma, S. & Shoji, M. Systematic review on the short-term efficacy and safety of nicorandil for stable angina pectoris in comparison with those of β-blockers, nitrates and calcium antagonists. J. Pharmaceut. Soc. Japan 130, 1549-1563 (2010).
    • (2010) J. Pharmaceut. Soc. Japan , vol.130 , pp. 1549-1563
    • Hanai, Y.1    Mita, M.2    Hishinuma, S.3    Shoji, M.4
  • 28
    • 33744455453 scopus 로고    scopus 로고
    • Ranolazine for the treatment of chronic angina and potential use in other cardiovascular conditions
    • DOI 10.1161/CIRCULATIONAHA.105.597500, PII 0000301720060523000015
    • Chaitman, B. R. Ranolazine for the treatment of chronic angina and potential use in other cardiovascular conditions. Circulation 113, 2462-2472 (2006). (Pubitemid 43948054)
    • (2006) Circulation , vol.113 , Issue.20 , pp. 2462-2472
    • Chaitman, B.R.1
  • 30
    • 33646432742 scopus 로고    scopus 로고
    • Ranolazine and late cardiac sodium current - A therapeutic target for angina, arrhythmia and more?
    • DOI 10.1038/sj.bjp.0706713, PII 0706713
    • Makielski, J. C. & Valdivia, C. R. Ranolazine and late cardiac sodium current-a therapeutic target for angina, arrhythmia and more? Br. J. Pharmacol. 148, 4-6 (2006). (Pubitemid 43675594)
    • (2006) British Journal of Pharmacology , vol.148 , Issue.1 , pp. 4-6
    • Makielski, J.C.1    Valdivia, C.R.2
  • 33
    • 33746192571 scopus 로고    scopus 로고
    • Antianginal efficacy of ranolazine when added to treatment with amlodipine: The ERICA (Efficacy of Ranolazine in Chronic Angina) trial
    • Stone, P. H., Gratsiansky, N. A., Blokhin, A., Huang, I. Z. & Meng, L. Antianginal efficacy of ranolazine when added to treatment with amlodipine: the ERICA (Efficacy of Ranolazine in Chronic Angina) trial. J. Am. Coll. Cardiol. 48, 566-755 (2006).
    • (2006) J. Am. Coll. Cardiol. , vol.48 , pp. 566-755
    • Stone, P.H.1    Gratsiansky, N.A.2    Blokhin, A.3    Huang, I.Z.4    Meng, L.5
  • 34
    • 77956535593 scopus 로고    scopus 로고
    • The anti-ischemic mechanism of action of ranolazine in stable ischemic heart disease
    • Stone, P. H. et al. The anti-ischemic mechanism of action of ranolazine in stable ischemic heart disease. J. Am. Coll. Cardiol. 56, 934-942 (2010).
    • (2010) J. Am. Coll. Cardiol. , vol.56 , pp. 934-942
    • Stone, P.H.1
  • 36
    • 84867911904 scopus 로고    scopus 로고
    • US National Library of Medicine. Study the Effects of Ranolazine on Myocardial Perfusion Assessed by Serial Quantitative Exercise SPECT Imaging
    • US National Library of Medicine. Study the Effects of Ranolazine on Myocardial Perfusion Assessed by Serial Quantitative Exercise SPECT Imaging. ClinicalTrials.gov [online], http://clinicaltrials.gov/ct2/show/NCT01221272 (2011).
    • (2011) ClinicalTrials.gov [Online]
  • 37
    • 28944448286 scopus 로고    scopus 로고
    • 1c in patients with chronic angina and diabetes
    • DOI 10.1093/eurheartj/ehi495
    • Timmis, A. D., Chaitman, B. R. & Crager, M. Effects of ranolazine on exercise tolerance and HbA1c in patients with chronic angina and diabetes. Eur. Heart J. 27, 42-48 (2006). (Pubitemid 41785931)
    • (2006) European Heart Journal , vol.27 , Issue.1 , pp. 42-48
    • Timmis, A.D.1    Chaitman, B.R.2    Crager, M.3
  • 38
    • 65449149816 scopus 로고    scopus 로고
    • Evaluation of the glycometabolic effects of ranolazine in patients with and without diabetes mellitus in the MERLIN-TIMI 36 randomized controlled trial
    • Morrow, D. A. et al. Evaluation of the glycometabolic effects of ranolazine in patients with and without diabetes mellitus in the MERLIN-TIMI 36 randomized controlled trial. Circulation 119, 2032-2039 (2009).
    • (2009) Circulation , vol.119 , pp. 2032-2039
    • Morrow, D.A.1
  • 39
    • 77956075888 scopus 로고    scopus 로고
    • Effect of ranolazine on A1C and glucose levels in hyperglycemic patients with non-ST elevation acute coronary syndrome
    • Chisholm, J. W. et al. Effect of ranolazine on A1C and glucose levels in hyperglycemic patients with non-ST elevation acute coronary syndrome. Diabetes Care 33, 1163-1168 (2010).
    • (2010) Diabetes Care , vol.33 , pp. 1163-1168
    • Chisholm, J.W.1
  • 40
    • 79953014923 scopus 로고    scopus 로고
    • Ranolazine increases β-cell survival and improves glucose homeostasis in low dose STZ-induced diabetes in mice
    • Ning, Y. et al. Ranolazine increases β-cell survival and improves glucose homeostasis in low dose STZ-induced diabetes in mice. J. Pharmacol. Exp. Ther. 337, 50-58 (2011).
    • (2011) J. Pharmacol. Exp. Ther. , vol.337 , pp. 50-58
    • Ning, Y.1
  • 42
    • 77951766402 scopus 로고    scopus 로고
    • Clinical features and outcomes of women with unstable ischemic heart disease. Observations from Metabolic Efficiency with Ranolazine for Less Ischemia in Non-ST-Elevation Acute Coronary Syndrome-Thrombolysis in Myocardial Infarction 36 (MERLIN-TIMI 36)
    • Mega J. L. et al. Clinical features and outcomes of women with unstable ischemic heart disease. Observations from Metabolic Efficiency with Ranolazine for Less Ischemia in Non-ST-Elevation Acute Coronary Syndrome-Thrombolysis in Myocardial Infarction 36 (MERLIN-TIMI 36). Circulation 121 1809-1817 (2010).
    • (2010) Circulation , vol.121 , pp. 1809-1817
    • Mega, J.L.1
  • 43
    • 77949286901 scopus 로고    scopus 로고
    • B-type natriuretic peptide and the effect of ranolazine in patients with non-ST-segment elevation acute coronary syndromes. Observations from the MERLIN-TIMI 36 (Metabolic Efficiency with Ranolazine for Less Ischemia in Non-ST-Elevation Acute Coronary Syndrome-Thrombolysis in Myocardial Infarction 36) trial
    • Morrow, D. A. et al. B-type natriuretic peptide and the effect of ranolazine in patients with non-ST-segment elevation acute coronary syndromes. Observations from the MERLIN-TIMI 36 (Metabolic Efficiency with Ranolazine for Less Ischemia in Non-ST-Elevation Acute Coronary Syndrome-Thrombolysis in Myocardial Infarction 36) trial. J. Am. Coll. Cardiol. 55, 1189-1196 (2010).
    • (2010) J. Am. Coll. Cardiol. , vol.55 , pp. 1189-1196
    • Morrow, D.A.1
  • 44
    • 64649089888 scopus 로고    scopus 로고
    • Efficacy of ranolazine in patients with chronic angina. Observations from the randomized, double-blind, placebo-controlled MERLIN-TIMI (Metabolic Efficiency with Ranolazine for Less Ischemia in Non-ST-Segment Elevation Acute Coronary Syndromes) 36 trial
    • Wilson, S. R. et al. Efficacy of ranolazine in patients with chronic angina. Observations from the randomized, double-blind, placebo-controlled MERLIN-TIMI (Metabolic Efficiency with Ranolazine for Less Ischemia in Non-ST-Segment Elevation Acute Coronary Syndromes) 36 trial. J. Am. Coll. Cardiol. 53, 1510-1516 (2009).
    • (2009) J. Am. Coll. Cardiol. , vol.53 , pp. 1510-1516
    • Wilson, S.R.1
  • 45
    • 35148850168 scopus 로고    scopus 로고
    • Effect of ranolazine, an antianginal agent with novel electrophysiological properties, on the incidence of arrhythmias in patients with non-ST-segment-elevation acute coronary syndrome: Results from the metabolic efficiency with ranolazine for less ischemia in non-ST-elevation acute coronary syndrome-thrombolysis in myocardial infarction 36 (MERLIN-TIMI 36) randomized controlled trial
    • DOI 10.1161/CIRCULATIONAHA.107.724880
    • Scirica, B. M. et al. Effect of ranolazine, an antianginal agent with novel electrophysiological properties, on the incidence of arrhythmias in patients with non-ST-segment-elevation acute coronary syndrome. Results from the Metabolic Efficiency with Ranolazine for Less Ischemia in Non-ST-Elevation Acute Coronary Syndrome-Thrombolysis in Myocardial Infarction 36 (MERLIN-TIMI 36) randomized controlled trial. Circulation 116, 1647-1652 (2007). (Pubitemid 47537839)
    • (2007) Circulation , vol.116 , Issue.15 , pp. 1647-1652
    • Scirica, B.M.1    Morrow, D.A.2    Hod, H.3    Murphy, S.A.4    Belardinelli, L.5    Hedgepeth, C.M.6    Molhoek, P.7    Verheugt, F.W.A.8    Gersh, B.J.9    McCabe, C.H.10    Braunwald, E.11
  • 46
    • 77955422004 scopus 로고    scopus 로고
    • Relationship between nonsustained ventricular tachycardia after non-ST-elevation acute coronary syndrome and sudden cardiac death. Observations from the Metabolic Efficiency with Ranolazine for Less Ischemia in Non-ST-Elevation Acute Coronary Syndrome-Thrombolysis in Myocardial Infarction 36 (MERLIN-TIMI 36) randomized controlled trial
    • Scirica, B. M. et al. Relationship between nonsustained ventricular tachycardia after non-ST-elevation acute coronary syndrome and sudden cardiac death. Observations from the Metabolic Efficiency with Ranolazine for Less Ischemia in Non-ST-Elevation Acute Coronary Syndrome-Thrombolysis in Myocardial Infarction 36 (MERLIN-TIMI 36) randomized controlled trial. Circulation 122, 455-462 (2010).
    • (2010) Circulation , vol.122 , pp. 455-462
    • Scirica, B.M.1
  • 47
    • 64049099187 scopus 로고    scopus 로고
    • Ischemia detected on continuous electrocardiography after acute coronary syndrome. Observations from the MERLIN-TIMI 36 (Metabolic Efficiency with Ranolazine for Less Ischemia in Non-ST-Elevation Acute Coronary Syndrome-Thrombolysis in Myocardial Infarction 36) trial
    • Scirica, B. M. et al. Ischemia detected on continuous electrocardiography after acute coronary syndrome. Observations from the MERLIN-TIMI 36 (Metabolic Efficiency with Ranolazine for Less Ischemia in Non-ST-Elevation Acute Coronary Syndrome-Thrombolysis in Myocardial Infarction 36) trial. J. Am. Coll. Cardiol. 53, 1411-1421 (2009).
    • (2009) J. Am. Coll. Cardiol. , vol.53 , pp. 1411-1421
    • Scirica, B.M.1
  • 48
    • 84867911904 scopus 로고    scopus 로고
    • US National Library of Medicine. Ranolazine Implantable Cardioverter-Defibrillator Trial (RAID)
    • US National Library of Medicine. Ranolazine Implantable Cardioverter-Defibrillator Trial (RAID). ClinicalTrials.gov [online], http://clinicaltrials.gov/ct2/show/NCT01215253 (2010).
    • (2010) ClinicalTrials.gov [Online]
  • 49
    • 34748873780 scopus 로고    scopus 로고
    • Atrium-selective sodium channel block as a strategy for suppression of atrial fibrillation: Differences in sodium channel inactivation between atria and ventricles and the role of ranolazine
    • DOI 10.1161/CIRCULATIONAHA.107.704890
    • Burashnikov, A., Di Diego, J. M., Zygmunt, A. C., Belardinelli, L. & Antzelevitch, C. Atrium-selective sodium channel block as a strategy for suppression of atrial fibrillation. Differences in sodium channel inactivation between atria and ventricles and the role of ranolazine. Circulation 116, 1449-1457 (2007). (Pubitemid 47480635)
    • (2007) Circulation , vol.116 , Issue.13 , pp. 1449-1457
    • Burashnikov, A.1    Di Diego, J.M.2    Zygmunt, A.C.3    Belardinelli, L.4    Antzelevitch, C.5
  • 50
    • 77952165183 scopus 로고    scopus 로고
    • Altered Na+ currents in atrial fibrillation. Effects of ranolazine on arrhythmias and contractility in human atrial myocardium
    • Sossalla, S. et al. Altered Na+ currents in atrial fibrillation. Effects of ranolazine on arrhythmias and contractility in human atrial myocardium. J. Am. Coll. Cardiol. 55, 2330-2342 (2010).
    • (2010) J. Am. Coll. Cardiol. , vol.55 , pp. 2330-2342
    • Sossalla, S.1
  • 51
    • 77649299995 scopus 로고    scopus 로고
    • Synergistic electrophysiologic and antiarrhythmic effects of the combination of ranolazine and chronic amiodarone in canine atria
    • Sicouri, S., Burashnikov, A., Belardinelli, L. & Antzelevitch, C. Synergistic electrophysiologic and antiarrhythmic effects of the combination of ranolazine and chronic amiodarone in canine atria. Circ. Arrhythm. Electrophysiol. 3, 88-95 (2010).
    • (2010) Circ. Arrhythm. Electrophysiol. , vol.3 , pp. 88-95
    • Sicouri, S.1    Burashnikov, A.2    Belardinelli, L.3    Antzelevitch, C.4
  • 52
    • 53049104215 scopus 로고    scopus 로고
    • Ranolazine shortens repolarization in patients with sustained inward sodium current due to type-3 long-QT syndrome
    • Moss, A. J. et al. Ranolazine shortens repolarization in patients with sustained inward sodium current due to type-3 long-QT syndrome. J. Cardiovasc. Electrophysiol. 19, 1289-1293 (2008).
    • (2008) J. Cardiovasc. Electrophysiol. , vol.19 , pp. 1289-1293
    • Moss, A.J.1
  • 53
    • 76449092876 scopus 로고    scopus 로고
    • Late Na+ current inhibition by ranolazine reduces torsades de pointes in the chronic atrioventricular block dog model
    • Antoons, G. et al. Late Na+ current inhibition by ranolazine reduces torsades de pointes in the chronic atrioventricular block dog model. J. Am. Coll. Cardiol. 55, 801-809 (2010).
    • (2010) J. Am. Coll. Cardiol. , vol.55 , pp. 801-809
    • Antoons, G.1
  • 54
    • 70449090162 scopus 로고    scopus 로고
    • Ranolazine, an antianginal agent, markedly reduces ventricular arrhythmias induced by ischemia and ischemia-reperfusion
    • Dhalla, A. K. et al. Ranolazine, an antianginal agent, markedly reduces ventricular arrhythmias induced by ischemia and ischemia-reperfusion. Am. J. Physiol. Heart Circ. Physiol. 297, H1923-H1929 (2009).
    • (2009) Am. J. Physiol. Heart Circ. Physiol. , vol.297
    • Dhalla, A.K.1
  • 55
    • 70349786605 scopus 로고    scopus 로고
    • Ranolazine as a cardioplegia additive improves recovery of diastolic function in isolated rat hearts
    • Hwang, H. et al. Ranolazine as a cardioplegia additive improves recovery of diastolic function in isolated rat hearts. Circulation 120, S16-S21 (2009).
    • (2009) Circulation , vol.120
    • Hwang, H.1
  • 56
    • 67649085854 scopus 로고    scopus 로고
    • Diastolic transient inward current in long QT syndrome type 3 is caused by Ca2+ overload and inhibited by ranolazine
    • Lindegger, N., Hagen, B., Marks, A. R., Lederer, W. J. & Kass, R. S. Diastolic transient inward current in long QT syndrome type 3 is caused by Ca2+ overload and inhibited by ranolazine. J. Mol. Cell. Cardiol. 47, 326-334 (2009).
    • (2009) J. Mol. Cell. Cardiol. , vol.47 , pp. 326-334
    • Lindegger, N.1    Hagen, B.2    Marks, A.R.3    Lederer, W.J.4    Kass, R.S.5
  • 58
    • 80051802104 scopus 로고    scopus 로고
    • Comparison of effectiveness and safety of ranolazine versus amiodarone for preventing atrial fibrillation after coronary artery bypass grafting
    • Miles, R. H., Passman, R. & Murdoch, D. K. Comparison of effectiveness and safety of ranolazine versus amiodarone for preventing atrial fibrillation after coronary artery bypass grafting. Am. J. Cardiol. 108, 673-676 (2011).
    • (2011) Am. J. Cardiol. , vol.108 , pp. 673-676
    • Miles, R.H.1    Passman, R.2    Murdoch, D.K.3
  • 59
    • 79960430593 scopus 로고    scopus 로고
    • Ranolazine for the treatment of heart failure with preserved ejection fraction: Background, aims and design of the RALI-DHF study
    • Jacobshagen, C., Belardinelli, L., Hasenfuss, G. & Maier, L. S. Ranolazine for the treatment of heart failure with preserved ejection fraction: background, aims and design of the RALI-DHF study. Clin. Card. 34, 426-432 (2011).
    • (2011) Clin. Card. , vol.34 , pp. 426-432
    • Jacobshagen, C.1    Belardinelli, L.2    Hasenfuss, G.3    Maier, L.S.4
  • 60
    • 35248835629 scopus 로고    scopus 로고
    • Safety and efficacy of extended-release ranolazine in patients aged 70 years or older with chronic stable angina pectoris
    • Rich, M. W., Crager, M. & McKay, C. R. Safety and efficacy of extended-release ranolazine in patients aged 70 years or older with chronic stable angina pectoris. Am. J. Geriatr. Cardiol. 16, 216-221 (2007).
    • (2007) Am. J. Geriatr. Cardiol. , vol.16 , pp. 216-221
    • Rich, M.W.1    Crager, M.2    McKay, C.R.3
  • 61
    • 77649123846 scopus 로고    scopus 로고
    • The role of the funny current in pacemaker activity
    • DiFrancesco, D. The role of the funny current in pacemaker activity. Circ. Res. 106, 434-446 (2010).
    • (2010) Circ. Res. , vol.106 , pp. 434-446
    • Difrancesco, D.1
  • 63
    • 38749094825 scopus 로고    scopus 로고
    • If inhibition with ivabradine: Electrophysiological effects and safety
    • Savelieva, I. & Camm, A. J. If inhibition with ivabradine: electrophysiological effects and safety. Drug Safety 31, 95-107 (2008). (Pubitemid 351175614)
    • (2008) Drug Safety , vol.31 , Issue.2 , pp. 95-107
    • Savelieva, I.1    Camm, A.J.2
  • 65
    • 63349103473 scopus 로고    scopus 로고
    • Efficacy of the if current inhibitor ivabradine in patients with chronic stable angina receiving beta-blocker therapy: A 4-month, randomized, placebo-controlled trial
    • Tardif, J. C. et al. Efficacy of the If current inhibitor ivabradine in patients with chronic stable angina receiving beta-blocker therapy: a 4-month, randomized, placebo-controlled trial. Eur. Heart J.30, 540-548 (2009).
    • (2009) Eur. Heart J. , vol.30 , pp. 540-548
    • Tardif, J.C.1
  • 66
    • 0037448788 scopus 로고    scopus 로고
    • f inhibitor, in stable angina: A randomized, double-blind, multicentered, placebo-controlled trial
    • DOI 10.1161/01.CIR.0000048143.25023.87
    • Borer, J. S., Fox, K., Jaillon, P. & Lerebours, G. Antianginal and antiischemic effects of ivabradine, an If inhibitor, in stable angina: a randomized, double-blind, multicentered, placebo-controlled trial. Circulation 107, 817-823 (2003). (Pubitemid 36241038)
    • (2003) Circulation , vol.107 , Issue.6 , pp. 817-823
    • Borer, J.S.1    Fox, K.2    Jaillon, P.3    Lerebours, G.4
  • 67
    • 27944492366 scopus 로고    scopus 로고
    • f inhibitor, compared with atenolol in patients with chronic stable angina
    • DOI 10.1093/eurheartj/ehi586
    • Tardif, J.-C. et al. Efficacy of ivabradine, a new selective If inhibitor, compared with atenolol in patients with chronic stable angina. Eur. Heart J. 26, 2529-2536 (2005). (Pubitemid 41677303)
    • (2005) European Heart Journal , vol.26 , Issue.23 , pp. 2529-2536
    • Tardif, J.-C.1    Ford, I.2    Tendera, M.3    Bourassa, M.G.4    Fox, K.5
  • 68
    • 66049159033 scopus 로고    scopus 로고
    • Efficacy of if inhibition with ivabradine in different subpopulations with stable angina pectoris
    • Tendera, M., Borer, J. S. & Tardif, J.-C. Efficacy of If inhibition with ivabradine in different subpopulations with stable angina pectoris. Cardiology 114, 116-125 (2009).
    • (2009) Cardiology , vol.114 , pp. 116-125
    • Tendera, M.1    Borer, J.S.2    Tardif, J.-C.3
  • 69
    • 64049101368 scopus 로고    scopus 로고
    • Selective Hcn1 channels inhibition by ivabradine in mouse rod photoreceptors
    • Demontis, G. C., Gargini, C., Paoli, T. G. & Cervetto, L. Selective Hcn1 channels inhibition by ivabradine in mouse rod photoreceptors. Invest. Ophthalmol. Vis. Sci. 50, 1948-1955 (2009).
    • (2009) Invest. Ophthalmol. Vis. Sci. , vol.50 , pp. 1948-1955
    • Demontis, G.C.1    Gargini, C.2    Paoli, T.G.3    Cervetto, L.4
  • 70
    • 50649089781 scopus 로고    scopus 로고
    • Heart rate as a prognostic risk factor in patients with coronary artery disease and left-ventricular systolic dysfunction (BEAUTIFUL): A subgroup analysis of a randomized controlled trial
    • Fox, K. et al. Heart rate as a prognostic risk factor in patients with coronary artery disease and left-ventricular systolic dysfunction (BEAUTIFUL): a subgroup analysis of a randomized controlled trial. Lancet 372, 817-821 (2008).
    • (2008) Lancet , vol.372 , pp. 817-821
    • Fox, K.1
  • 71
    • 50649109186 scopus 로고    scopus 로고
    • Ivabradine for patients with stable coronary artery disease and left-ventricular systolic dysfunction (BEAUTIFUL): A randomized, double-blind, placebo-controlled trial
    • Fox, K. et al. Ivabradine for patients with stable coronary artery disease and left-ventricular systolic dysfunction (BEAUTIFUL): a randomized, double-blind, placebo-controlled trial. Lancet 372, 807-816 (2008).
    • (2008) Lancet , vol.372 , pp. 807-816
    • Fox, K.1
  • 72
    • 70349669250 scopus 로고    scopus 로고
    • Relationship between ivabradine treatment and cardiovascular outcomes in patients with stable coronary artery disease and left ventricular systolic dysfunction with limiting angina: A subgroup analysis of the randomized, controlled BEAUTIFUL trial
    • Fox, K. et al. Relationship between ivabradine treatment and cardiovascular outcomes in patients with stable coronary artery disease and left ventricular systolic dysfunction with limiting angina: a subgroup analysis of the randomized, controlled BEAUTIFUL trial. Eur. Heart J. 30, 2337-2345 (2009).
    • (2009) Eur. Heart J. , vol.30 , pp. 2337-2345
    • Fox, K.1
  • 73
    • 77956612624 scopus 로고    scopus 로고
    • Ivabradine and outcomes in chronic heart failure (SHIFT): A randomised placebo-controlled study
    • Swedberg, K. et al. Ivabradine and outcomes in chronic heart failure (SHIFT): a randomised placebo-controlled study. Lancet 376, 875-885 (2010).
    • (2010) Lancet , vol.376 , pp. 875-885
    • Swedberg, K.1
  • 74
    • 77956618692 scopus 로고    scopus 로고
    • Heart rate as a risk factor in chronic heart failure (SHIFT): The association between heart rate and outcomes in a randomised placebo-controlled trial
    • Bohm, M. et al. Heart rate as a risk factor in chronic heart failure (SHIFT): the association between heart rate and outcomes in a randomised placebo-controlled trial. Lancet 376, 886-894 (2010).
    • (2010) Lancet , vol.376 , pp. 886-894
    • Bohm, M.1
  • 75
    • 77949379565 scopus 로고    scopus 로고
    • A step further with ivabradine: SIGNIfY (Study assessInG the morbidity-mortality beNefits of the if inhibitor ivabradine in patients with coronarY artery disease)
    • Ferrari, R. A step further with ivabradine: SIGNIfY (Study assessInG the morbidity-mortality beNefits of the If inhibitor ivabradine in patients with coronarY artery disease). Eur. Heart J. Suppl. 11 (Suppl. D), D19-D27 (2009).
    • (2009) Eur. Heart J. Suppl. , vol.11 , Issue.SUPPL. D
    • Ferrari, R.1
  • 76
    • 77949400234 scopus 로고    scopus 로고
    • Heart rate management in coronary artery disease: The CLARIFY registry
    • Steg, P. G. Heart rate management in coronary artery disease: the CLARIFY registry. Eur. Heart J. Suppl. 11 (Suppl. D), D13-D18 (2009).
    • (2009) Eur. Heart J. Suppl. , vol.11 , Issue.SUPPL. D
    • Steg, P.G.1
  • 77
    • 67649090226 scopus 로고    scopus 로고
    • Randomised, double-blind, placebo-controlled trial of ivabradine in patients with acute coronary syndrome: Effects of the if current inhibitor ivabradine on reduction of inflammation markers in patients with acute coronary syndrome-RIVIERA trial study design and rationale
    • Dominguez-Rodriguez, A. et al. Randomised, double-blind, placebo-controlled trial of ivabradine in patients with acute coronary syndrome: effects of the If current inhibitor ivabradine on reduction of inflammation markers in patients with acute coronary syndrome-RIVIERA trial study design and rationale. Cardiovasc. Drugs Ther. 23, 243-247 (2009).
    • (2009) Cardiovasc. Drugs Ther. , vol.23 , pp. 243-247
    • Dominguez-Rodriguez, A.1
  • 81
    • 77953615298 scopus 로고    scopus 로고
    • Effect of high-dose allopurinol on exercise in patients with chronic stable angina: A randomized, placebo controlled crossover trial
    • Noman, A., Ang, D. S., Ogston, S., Lang, C. C. & Struthers, A. D. Effect of high-dose allopurinol on exercise in patients with chronic stable angina: a randomized, placebo controlled crossover trial. Lancet 375, 2161-2167 (2010).
    • (2010) Lancet , vol.375 , pp. 2161-2167
    • Noman, A.1    Ang, D.S.2    Ogston, S.3    Lang, C.C.4    Struthers, A.D.5
  • 82
    • 0035263339 scopus 로고    scopus 로고
    • Allopurinol enhances adenine nucleotide levels and improves myocardial function in isolated hypoxic rat heart
    • DOI 10.1023/A:1010264216357
    • Khatib, S. Y, Farah, H. & El-Migdadi, F. Allopurinol enhances adenine nucleotide levels and improves myocardial function in isolated hypoxic rat heart. Biochemistry (Mosc.) 66, 328-333 (2001). (Pubitemid 32445803)
    • (2001) Biochemistry (Moscow) , vol.66 , Issue.3 , pp. 328-333
    • Khatib, S.Y.1    Farah, H.2    El-Migdadi, F.3
  • 85
    • 0037197740 scopus 로고    scopus 로고
    • Phase 1/2 placebo-controlled, double-blind, dose-escalating trial of myocardial vascular endothelial growth factor 2 gene transfer by catheter delivery in patients with chronic myocardial ischemia
    • DOI 10.1161/01.CIR.0000015982.70785.B7
    • Losordo, D. W. et al. Phase 1/2 placebo-controlled, double-blind, dose-escalating trial of myocardial vascular endothelial growth factor 2 gene transfer by catheter delivery in patients with chronic myocardial ischemia. Circulation 105, 2012-2018 (2002). (Pubitemid 34465261)
    • (2002) Circulation , vol.105 , Issue.17 , pp. 2012-2018
    • Losordo, D.W.1    Vale, P.R.2    Hendel, R.C.3    Milliken, C.E.4    Fortuin, F.D.5    Cummings, N.6    Schatz, R.A.7    Asahara, T.8    Isner, J.M.9    Kuntz, R.E.10
  • 87
    • 33846969572 scopus 로고    scopus 로고
    • Endothelial progenitor cells in cardiovascular disorders
    • Shantsila, E., Watson, T. & Lip, G. Y. Endothelial progenitor cells in cardiovascular disorders. J. Am. Coll. Cardiol. 49, 741-752 (2007).
    • (2007) J. Am. Coll. Cardiol. , vol.49 , pp. 741-752
    • Shantsila, E.1    Watson, T.2    Lip, G.Y.3
  • 89
    • 33847421319 scopus 로고    scopus 로고
    • Vascular endothelial growth factors: Biology and current status of clinical applications in cardiovascular medicine
    • DOI 10.1016/j.jacc.2006.09.053, PII S0735109706031147
    • Ylä-Herttuala, S., Rissanen, T. T., Vajanto, I. & Hartikainen, J. Vascular endothelial growth factors: biology and current status of clinical applications in cardiovascular medicine. J. Am. Coll. Cardiol. 49, 1015-1026 (2007). (Pubitemid 46349500)
    • (2007) Journal of the American College of Cardiology , vol.49 , Issue.10 , pp. 1015-1026
    • Yla-Herttuala, S.1    Rissanen, T.T.2    Vajanto, I.3    Hartikainen, J.4
  • 92
    • 82355172782 scopus 로고    scopus 로고
    • Therapeutic angiogenesis for the management of refractory angina: Current concepts
    • doi:10.1111/j.1755-59222010.00153.x
    • Attanasio, S. & Schaer, G. Therapeutic angiogenesis for the management of refractory angina: current concepts. Cardiovasc. Ther. doi:10.1111/j.1755-59222010.00153.x.
    • Cardiovasc. Ther.
    • Attanasio, S.1    Schaer, G.2
  • 95
    • 70350126601 scopus 로고    scopus 로고
    • Human studies of angiogenic gene therapy
    • Gupta, R., Tongers, J. & Losordo, D. W. Human studies of angiogenic gene therapy. Circ. Res. 105, 724-736 (2009).
    • (2009) Circ. Res. , vol.105 , pp. 724-736
    • Gupta, R.1    Tongers, J.2    Losordo, D.W.3
  • 96
    • 65649129319 scopus 로고    scopus 로고
    • Intramyocardial bone marrow cell injection for chronic myocardial ischemia: A randomized controlled trial
    • van Ramshorst, J. et al. Intramyocardial bone marrow cell injection for chronic myocardial ischemia: A randomized controlled trial. JAMA 301, 1997-2004 (2009).
    • (2009) JAMA , vol.301 , pp. 1997-2004
    • Van Ramshorst, J.1
  • 98
    • 80051748850 scopus 로고    scopus 로고
    • Intramyocardial, autologous CD34+ cell therapy for refractory angina
    • Losordo, D. W. et al. Intramyocardial, autologous CD34+ cell therapy for refractory angina. Circ. Res. 109, 428-436 (2011).
    • (2011) Circ. Res. , vol.109 , pp. 428-436
    • Losordo, D.W.1
  • 99
    • 79955512050 scopus 로고    scopus 로고
    • And progenitor cell-based therapy in ischaemic heart disease: Promise, uncertainties, and challenges
    • Tongers, J., Losordo, D. W. & Landmesser, U. Stem and progenitor cell-based therapy in ischaemic heart disease: promise, uncertainties, and challenges. Eur. Heart J. 32, 1197-1206 (2011).
    • (2011) Eur. Heart J. , vol.32 , pp. 1197-1206
    • Tongers, J.1    Losordo, D.W.2    Stem, L.U.3
  • 100
    • 49449114628 scopus 로고    scopus 로고
    • Effect of PCI on quality of life in patients with stable coronary disease
    • Weintraub, W. S. et al. Effect of PCI on quality of life in patients with stable coronary disease. N. Engl. J. Med. 359, 677-687 (2008).
    • (2008) N. Engl. J. Med. , vol.359 , pp. 677-687
    • Weintraub, W.S.1
  • 101
    • 73949135481 scopus 로고    scopus 로고
    • Economic outcomes of treatment strategies for type 2 diabetes mellitus and coronary artery disease in the Bypass Angioplasty Revascularization Investigation 2 Diabetes trial
    • Hlatky, M. A. et al. Economic outcomes of treatment strategies for type 2 diabetes mellitus and coronary artery disease in the Bypass Angioplasty Revascularization Investigation 2 Diabetes trial. Circulation 120, 2550-2558 (2009).
    • (2009) Circulation , vol.120 , pp. 2550-2558
    • Hlatky, M.A.1
  • 102
    • 78149279745 scopus 로고    scopus 로고
    • Health status after treatment for coronary artery disease and type 2 diabetes mellitus in the Bypass Angioplasty Revascularization Investigation 2 Diabetes trial
    • Brooks, M. M. et al. Health status after treatment for coronary artery disease and type 2 diabetes mellitus in the Bypass Angioplasty Revascularization Investigation 2 Diabetes trial. Circulation 122, 1690-1699 (2010).
    • (2010) Circulation , vol.122 , pp. 1690-1699
    • Brooks, M.M.1
  • 103
    • 79955494359 scopus 로고    scopus 로고
    • Coronary-artery bypass surgery in patients with left ventricular dysfunction
    • Velazquez, E. J. et al. Coronary-artery bypass surgery in patients with left ventricular dysfunction. N. Engl. J. Med. 364, 1607-1616 (2011).
    • (2011) N. Engl. J. Med. , vol.364 , pp. 1607-1616
    • Velazquez, E.J.1
  • 104
    • 79955486739 scopus 로고    scopus 로고
    • Myocardial viability and survival in ischemic left ventricular dysfunction
    • Bonow, R. O. et al. Myocardial viability and survival in ischemic left ventricular dysfunction. N. Engl. J. Med. 364, 1617-1625 (2011).
    • (2011) N. Engl. J. Med. , vol.364 , pp. 1617-1625
    • Bonow, R.O.1
  • 105
    • 79954843178 scopus 로고    scopus 로고
    • Effects of optimal medical treatment with or without coronary revascularization on angina and subsequent revascularization in patients with type 2 diabetes mellitus and stable ischemic heart disease
    • Dagenais, G. R. et al. Effects of optimal medical treatment with or without coronary revascularization on angina and subsequent revascularization in patients with type 2 diabetes mellitus and stable ischemic heart disease. Circulation 123, 1492-1500 (2011).
    • (2011) Circulation , vol.123 , pp. 1492-1500
    • Dagenais, G.R.1
  • 106
    • 77950881601 scopus 로고    scopus 로고
    • Meta-analysis: Effects of percutaneous coronary intervention versus medical therapy on angina relief
    • Wijeysundera, H. C., Nallamothu, B. K., Krumholz, H. M., Tu, J. V. & Ko, D. T. Meta-analysis: Effects of percutaneous coronary intervention versus medical therapy on angina relief. Ann. Intern. Med. 152, 370-379 (2010).
    • (2010) Ann. Intern. Med. , vol.152 , pp. 370-379
    • Wijeysundera, H.C.1    Nallamothu, B.K.2    Krumholz, H.M.3    Tu, J.V.4    Ko, D.T.5
  • 107
    • 67149142042 scopus 로고    scopus 로고
    • A randomized trial of therapies for type 2 diabetes and coronary artery disease
    • The BARI 2D Study Group et al.
    • The BARI 2D Study Group et al. A randomized trial of therapies for type 2 diabetes and coronary artery disease. N. Eng. J. Med. 360, 2503-2515 (2009).
    • (2009) N. Eng. J. Med. , vol.360 , pp. 2503-2515
  • 108
    • 38149112698 scopus 로고    scopus 로고
    • Design of the Future R Evascularization Evaluation in patients with Diabetes mellitus: Optimal management of Multivessel disease (FREEDOM) Trial
    • Farkouh, M. E. et al. Design of the Future R Evascularization Evaluation in patients with Diabetes mellitus: Optimal management of Multivessel disease (FREEDOM) Trial. Am. Heart J. 155, 215-223 (2008).
    • (2008) Am. Heart J. , vol.155 , pp. 215-223
    • Farkouh, M.E.1
  • 109
    • 84867911904 scopus 로고    scopus 로고
    • US National Institutes of Health. PROspective Multicenter Imaging Study for Evaluation of Chest Pain (PROMISE)
    • US National Institutes of Health. PROspective Multicenter Imaging Study for Evaluation of Chest Pain (PROMISE). ClinicalTrials.gov [online], http://clinicaltrials.gov/ct2/show/NCT01174550 (2010).
    • (2010) ClinicalTrials.gov [Online]
  • 110
    • 84867911904 scopus 로고    scopus 로고
    • US National Institutes of Health. Randomized Evaluation of Patients With Stable Angina Comparing Diagnostic Examinations (RESCUE)
    • US National Institutes of Health. Randomized Evaluation of Patients With Stable Angina Comparing Diagnostic Examinations (RESCUE). ClinicalTrials.gov [online], http://clinicaltrials.gov/ct2/show/NCT01262625 (2011).
    • (2011) ClinicalTrials.gov [Online]


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