Enhanced screening of glutathione-trapped reactive metabolites by in-source collision-induced dissociation and extraction of product ion using UHPLC-high resolution mass spectrometry

Analytical Chemistry

Volumn 83, Issue 24, 2011, Pages 9516-9523

  Zhu, Xiaochun ^a   Kalyanaraman, Nataraj ^a   Subramanian, Raju ^a  

^a AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CLOZAPINE; COLLISION-INDUCED DISSOCIATION; DICLOFENAC; FILTER METHOD; FRAGMENTATION PATTERNS; HIGH RESOLUTION; HUMAN LIVER MICROSOMES; IN-VITRO; ION CHROMATOGRAM; L-GLUTATHIONE; LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY; MASS DEFECT; MODEL COMPOUND; NICOTINAMIDE ADENINE DINUCLEOTIDES; ORBITRAP; PARENT IONS; PRECURSOR-ION SCAN; REACTIVE METABOLITES;

AMIDES; AMINO ACIDS; CHROMATOGRAPHIC ANALYSIS; DISSOCIATION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLISM; METABOLITES; NEGATIVE IONS; PEPTIDES;

BIOMOLECULES;

AMODIAQUINE; CLOZAPINE; DICLOFENAC; FIPEXIDE; GLUTATHIONE; ION; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; PIPERAZINE DERIVATIVE;

ARTICLE; CHEMISTRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; LIVER MICROSOME; MASS SPECTROMETRY; METABOLISM;

AMODIAQUINE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CLOZAPINE; DICLOFENAC; GLUTATHIONE; HUMANS; IONS; MASS SPECTROMETRY; MICROSOMES, LIVER; NADP; PIPERAZINES;

EID: 83655164516     PISSN: 00032700     EISSN: None     Source Type: Journal    
DOI: 10.1021/ac202280f     Document Type: Article

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