Preparation, statistical optimization, and in vitro characterization of insulin nanoparticles composed of quaternized aromatic derivatives of chitosan

AAPS PharmSciTech

Volumn 12, Issue 4, 2011, Pages 1407-1419

  Mahjub, Reza ^a,c   Dorkoosh, Farid Abedin ^a   Amini, Mohsen ^a,e   Khoshayand, Mohammad Reza ^b   Rafiee Tehrani, Morteza ^a,d  

^a TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c HAMADAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^d TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^e TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

D optimal response surface experimental design methodology; insulin nanoparticles; methylated N (4 N,N dimethylaminobenzyl) chitosan; methylated N (4 pyridinyl) chitosan; methylated N (benzyl) chitosan

Indexed keywords

AMINOBENZYLCHITOSAN; AROMATIC COMPOUND; BENZYLCHITOSAN; CHITOSAN DERIVATIVE; INSULIN; NANOPARTICLE; POLYMER; PYRIDINYLCHITOSAN; SCHIFF BASE; UNCLASSIFIED DRUG;

ARTICLE; COMPLEX FORMATION; DRUG RELEASE; DRUG SYNTHESIS; IN VITRO STUDY; PARTICLE SIZE; PH; PRIORITY JOURNAL; TRANSMISSION ELECTRON MICROSCOPY; ZETA POTENTIAL;

CHEMISTRY, PHARMACEUTICAL; CHITOSAN; DRUG CARRIERS; DRUG COMPOUNDING; HYDROGEN-ION CONCENTRATION; HYPOGLYCEMIC AGENTS; INSULIN; KINETICS; METHYLATION; MICROSCOPY, ELECTRON, TRANSMISSION; MODELS, STATISTICAL; NANOPARTICLES; NANOTECHNOLOGY; PARTICLE SIZE; PYRIDINES; QUATERNARY AMMONIUM COMPOUNDS; SOLUBILITY; SURFACE PROPERTIES; TECHNOLOGY, PHARMACEUTICAL;

EID: 83555173378     PISSN: None     EISSN: 15309932     Source Type: Journal    
DOI: 10.1208/s12249-011-9716-9     Document Type: Article

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