Impact of exercise on mitochondrial transcription factor expression and damage in the striatum of a chronic mouse model of Parkinson's disease

Neuroscience Letters

Volumn 505, Issue 3, 2011, Pages 268-272

  Patki, Gaurav ^a   Lau, Yuen Sum ^a  

^a UNIVERSITY OF HOUSTON   (United States)

Author keywords

Chronic MPTP model; Cytochrome c; Mitochondrial DNA defect; Neurodegeneration; P53; Parkinson's disease; PGC 1 ; TFAM; Treadmill exercise

Indexed keywords

CYTOCHROME C; MITOCHONDRIAL TRANSCRIPTION FACTOR A; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PROTEIN P53;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CORPUS STRIATUM; DISORDERS OF MITOCHONDRIAL FUNCTIONS; EXERCISE; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN EXPRESSION; UPREGULATION;

ADJUVANTS, PHARMACEUTIC; ANALYSIS OF VARIANCE; ANIMALS; CHRONIC DISEASE; CORPUS STRIATUM; CYTOCHROMES C; DISEASE MODELS, ANIMAL; DNA-BINDING PROTEINS; EXERCISE TEST; HIGH MOBILITY GROUP PROTEINS; MALE; MICE; MICE, INBRED C57BL; MPTP POISONING; PHYSICAL CONDITIONING, ANIMAL; PROBENECID; RNA, MESSENGER; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS;

EID: 83555173195     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2011.10.036     Document Type: Article

References (30)

1. Al-Jarrah M., Pothakos K., Novikova L., Smirnova I.V., Kurz M.J., Stehno-Bittel L., Lau Y.S. Endurance exercise promotes cardiorespiratory rehabilitation without neurorestoration in the chronic mouse model of parkinsonism with severe neurodegeneration. Neuroscience 2007, 149:28-37.
2. Beal M.F. Therapeutic approaches to mitochondrial dysfunction in Parkinson's disease. Parkinsonism Relat. Disord. 2009, 15(Suppl. 3):S189-S194.
3. Bender A., Krishnan K.J., Morris C.M., Taylor G.A., Reeve A.K., Perry R.H., Jaros E., Hersheson J.S., Betts J., Klopstock T., Taylor R.W., Turnbull D.M. High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease. Nat. Genet. 2006, 38:515-517.
4. Betarbet R., Sherer T.B., MacKenzie G., Garcia-Osuna M., Panov A.V., Greenamyre J.T. Chronic systemic pesticide exposure reproduces features of Parkinson's disease. Nat. Neurosci. 2000, 3:1301-1306.
5. Culmsee C., Mattson M.P. p53 in neuronal apoptosis. Biochem. Biophys. Res. Commun. 2005, 331:761-777.
6. Duan W., Zhu X., Ladenheim B., Yu Q.S., Guo Z., Oyler J., Cutler R.G., Cadet J.L., Greig N.H., Mattson M.P. p53 inhibitors preserve dopamine neurons and motor function in experimental parkinsonism. Ann. Neurol. 2002, 52:597-606.
7. Ekstrand M.I., Terzioglu M., Galter D., Zhu S., Hofstetter C., Lindqvist E., Thams S., Bergstrand A., Hansson F.S., Trifunovic A., Hoffer B., Cullheim S., Mohammed A.H., Olson L., Larsson N.G. Progressive parkinsonism in mice with respiratory-chain-deficient dopamine neurons. Proc. Natl. Acad. Sci. U.S.A. 2007, 104:1325-1330.
8. Gorman A.M., Ceccatelli S., Orrenius S. Role of mitochondria in neuronal apoptosis. Dev. Neurosci. 2000, 22:348-358.
9. Hood D.A. Mechanisms of exercise-induced mitochondrial biogenesis in skeletal muscle. Appl. Physiol. Nutr. Metab. 2009, 34:465-472.
10. Keeney P.M., Dunham L.D., Quigley C.K., Morton S.L., Bergquist K.E., Bennett J.P. Cybrid models of Parkinson's disease show variable mitochondrial biogenesis and genotype-respiration relationships. Exp. Neurol. 2009, 220:374-382.
11. Kraytsberg Y., Kudryavtseva E., McKee A.C., Geula C., Kowall N.W., Khrapko K. Mitochondrial DNA deletions are abundant and cause functional impairment in aged human substantia nigra neurons. Nat. Genet. 2006, 38:518-520.
12. Krueger M.J., Singer T.P., Casida J.E., Ramsay R.R. Evidence that the blockade of mitochondrial respiration by the neurotoxin 1-methyl-4-phenylpyridinium (MPP+) involves binding at the same site as the respiratory inhibitor, rotenone. Biochem. Biophys. Res. Commun. 1990, 169:123-128.
13. Lau Y.S. Progressive neurodegeneration in the MPTP/probenecid model of Parkinson's disease. Parkinson's disease 2005, 109-115. CRC Press, Boca Raton, FL. M. Ebadi, R. Pfeiffer (Eds.).
14. Lau Y.S., Patki G., Das-Panja K., Le W.D., Ahmad S.O. Neuroprotective effects and mechanisms of exercise in a chronic mouse model of Parkinson's disease with moderate neurodegeneration. Eur. J. Neurosci. 2011, 33:1264-1274.
15. Lau Y.S., Trobough K.L., Crampton J.M., Wilson J.A. Effects of probenecid on striatal dopamine depletion in acute and long-term 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated mice. Gen. Pharmacol. 1990, 21:181-187.
16. Leick L., Wojtaszewski J.F., Johansen S.T., Kiilerich K., Comes G., Hellsten Y., Hidalgo J., Pilegaard H. PGC-1alpha is not mandatory for exercise- and training-induced adaptive gene responses in mouse skeletal muscle. Am. J. Physiol. Endocrinol. Metab. 2008, 294:E463-E474.
17. Meredith G.E., Totterdell S., Petroske E., Santa Cruz K., Callison R.C., Lau Y.S. Lysosomal malfunction accompanies alpha-synuclein aggregation in a progressive mouse model of Parkinson's disease. Brain Res. 2002, 956:156-165.
18. Mihara M., Erster S., Zaika A., Petrenko O., Chittenden T., Pancoska P., Moll U.M. p53 has a direct apoptogenic role at the mitochondria. Mol. Cell 2003, 11:577-590.
19. Miyai I., Fujimoto Y., Ueda Y., Yamamoto H., Nozaki S., Saito T., Kang J. Treadmill training with body weight support: its effect on Parkinson's disease. Arch. Phys. Med. Rehabil. 2000, 81:849-852.
20. Nair V.D. Activation of p53 signaling initiates apoptotic death in a cellular model of Parkinson's disease. Apoptosis 2006, 11:955-966.
21. Novikova L., Garris B.L., Garris D.R., Lau Y.S. Early signs of neuronal apoptosis in the substantia nigra pars compacta of the progressive neurodegenerative mouse 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine/probenecid model of Parkinson's disease. Neuroscience 2006, 140:67-76.
22. Patki G., Che Y., Lau Y.S. Mitochondrial dysfunction in the striatum of aged chronic mouse model of Parkinson's disease. Front. Aging Neurosci. 2009, 1:3.
23. Patki G., Lau Y.S. Melatonin protects against neurobehavioral and mitochondrial deficits in a chronic mouse model of Parkinson's disease. Pharmacology, Biochem. Behav. 2011, 99:704-711.
24. Petroske E., Meredith G.E., Callen S., Totterdell S., Lau Y.S. Mouse model of Parkinsonism: a comparison between subacute MPTP and chronic MPTP/probenecid treatment. Neuroscience 2001, 106:589-601.
25. Pilegaard H., Saltin B., Neufer P.D. Exercise induces transient transcriptional activation of the PGC-1alpha gene in human skeletal muscle. J. Physiol. 2003, 546:851-858.
26. Pothakos K., Kurz M.J., Lau Y.S. Restorative effect of endurance exercise on behavioral deficits in the chronic mouse model of Parkinson's disease with severe neurodegeneration. BMC Neurosci. 2009, 10:6.
27. Scarpulla R.C. Nuclear control of respiratory gene expression in mammalian cells. J. Cell Biochem. 2006, 97:673-683.
28. Schapira A.H., Cooper J.M., Dexter D., Clark J.B., Jenner P., Marsden C.D. Mitochondrial complex I deficiency in Parkinson's disease. J. Neurochem. 1990, 54:823-827.
29. Smith A.D., Zigmond M.J. Can the brain be protected through exercise? Lessons from an animal model of parkinsonism. Exp. Neurol. 2003, 184:31-39.
30. St-Pierre J., Drori S., Uldry M., Silvaggi J.M., Rhee J., Jager S., Handschin C., Zheng K., Lin J., Yang W., Simon D.K., Bachoo R., Spiegelman B.M. Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators. Cell 2006, 127:397-408.