메뉴 건너뛰기




Volumn 359, Issue 1-2, 2012, Pages 399-407

The intact strontium ranelate complex stimulates osteoblastogenesis and suppresses osteoclastogenesis by antagonizing NF-κB activation

Author keywords

Bone formation; Bone resorption; Nuclear factor kappa B; Osteoblast; Osteoclast; Strontium ranelate

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; SODIUM; SODIUM RANELATE; STRONTIUM; STRONTIUM CHLORIDE; STRONTIUM RANELATE; UNCLASSIFIED DRUG;

EID: 83555164882     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-011-1034-8     Document Type: Article
Times cited : (64)

References (30)
  • 1
    • 0030176233 scopus 로고    scopus 로고
    • The divalent strontium salt S12911 enhances bone cell replication and bone formation in vitro
    • DOI 10.1016/8756-3282(96)00080-4
    • E Canalis M Hott P Deloffre Y Tsouderos PJ Marie 1996 The divalent strontium salt S12911 enhances bone cell replication and bone formation in vitro Bone 18 517 523 8805991 10.1016/8756-3282(96)00080-4 1:CAS:528: DyaK28Xkslagu7k%3D (Pubitemid 26257871)
    • (1996) Bone , vol.18 , Issue.6 , pp. 517-523
    • Canalis, E.1    Hott, M.2    Deloffre, P.3    Tsouderos, Y.4    Marie, P.J.5
  • 2
    • 0037118899 scopus 로고    scopus 로고
    • In vitro effects of S12911-2 on osteoclast function and bone marrow macrophage differentiation
    • 12176103 10.1016/S0014-2999(02)02040-X 1:CAS:528:DC%2BD38XmtlKjsb8%3D
    • R Baron Y Tsouderos 2002 In vitro effects of S12911-2 on osteoclast function and bone marrow macrophage differentiation Eur J Pharmacol 450 11 17 12176103 10.1016/S0014-2999(02)02040-X 1:CAS:528:DC%2BD38XmtlKjsb8%3D
    • (2002) Eur J Pharmacol , vol.450 , pp. 11-17
    • Baron, R.1    Tsouderos, Y.2
  • 6
    • 77955028665 scopus 로고    scopus 로고
    • The calcium-sensing receptor (CaR) is involved in strontium ranelate-induced osteoblast differentiation and mineralization
    • 20560105 10.1055/s-0030-1255091 1:CAS:528:DC%2BC3cXhtFygsr7L
    • S Takaoka T Yamaguchi S Yano M Yamauchi T Sugimoto 2010 The calcium-sensing receptor (CaR) is involved in strontium ranelate-induced osteoblast differentiation and mineralization Horm Metab Res 42 627 631 20560105 10.1055/s-0030-1255091 1:CAS:528:DC%2BC3cXhtFygsr7L
    • (2010) Horm Metab Res , vol.42 , pp. 627-631
    • Takaoka, S.1    Yamaguchi, T.2    Yano, S.3    Yamauchi, M.4    Sugimoto, T.5
  • 8
    • 58649120832 scopus 로고    scopus 로고
    • The calcium-sensing receptor is involved in strontium ranelate-induced osteoclast apoptosis. New insights into the associated signaling pathways
    • 18927086 10.1074/jbc.M801668200 1:CAS:528:DC%2BD1cXhsFCjtLjM
    • AS Hurtel-Lemaire R Mentaverri A Caudrillier F Cournarie A Wattel S Kamel EF Terwilliger EM Brown M Brazier 2009 The calcium-sensing receptor is involved in strontium ranelate-induced osteoclast apoptosis. New insights into the associated signaling pathways J Biol Chem 284 575 584 18927086 10.1074/jbc.M801668200 1:CAS:528:DC%2BD1cXhsFCjtLjM
    • (2009) J Biol Chem , vol.284 , pp. 575-584
    • Hurtel-Lemaire, A.S.1    Mentaverri, R.2    Caudrillier, A.3    Cournarie, F.4    Wattel, A.5    Kamel, S.6    Terwilliger, E.F.7    Brown, E.M.8    Brazier, M.9
  • 9
    • 77955501594 scopus 로고    scopus 로고
    • Essential role of nuclear factor of activated T cells (NFAT)-mediated Wnt signaling in osteoblast differentiation induced by strontium ranelate
    • 20554534 10.1074/jbc.M110.110502 1:CAS:528:DC%2BC3cXpslKjsbc%3D
    • O Fromigue E Hay A Barbara PJ Marie 2010 Essential role of nuclear factor of activated T cells (NFAT)-mediated Wnt signaling in osteoblast differentiation induced by strontium ranelate J Biol Chem 285 25251 25258 20554534 10.1074/jbc.M110.110502 1:CAS:528:DC%2BC3cXpslKjsbc%3D
    • (2010) J Biol Chem , vol.285 , pp. 25251-25258
    • Fromigue, O.1    Hay, E.2    Barbara, A.3    Marie, P.J.4
  • 10
    • 0032991354 scopus 로고    scopus 로고
    • Required and nonessential functions of nuclear factor-kappa B in bone cells
    • DOI 10.1016/S8756-3282(99)00105-2, PII S8756328299001052
    • BF Boyce L Xing G Franzoso U Siebenlist 1999 Required and nonessential functions of nuclear factor-kappa B in bone cells Bone 25 137 149 10423039 10.1016/S8756-3282(99)00105-2 1:CAS:528:DyaK1MXkvV2qsr4%3D (Pubitemid 29322078)
    • (1999) Bone , vol.25 , Issue.1 , pp. 137-139
    • Boyce, B.F.1    Xing, L.2    Franzoso, G.3    Siebenlist, U.4
  • 11
    • 0028906402 scopus 로고
    • The role of reactive oxygen intermediates in osteoclastic bone resorption
    • 7857277 10.1006/bbrc.1995.1184 1:CAS:528:DyaK2MXjsFKhsbw%3D
    • TJ Hall M Schaeublin H Jeker K Fuller TJ Chambers 1995 The role of reactive oxygen intermediates in osteoclastic bone resorption Biochem Biophys Res Commun 207 280 287 7857277 10.1006/bbrc.1995.1184 1:CAS:528: DyaK2MXjsFKhsbw%3D
    • (1995) Biochem Biophys Res Commun , vol.207 , pp. 280-287
    • Hall, T.J.1    Schaeublin, M.2    Jeker, H.3    Fuller, K.4    Chambers, T.J.5
  • 12
    • 45749124735 scopus 로고    scopus 로고
    • RelA/p65 promotes osteoclast differentiation by blocking a RANKL-induced apoptotic JNK pathway in mice
    • DOI 10.1172/JCI33392
    • S Vaira M Alhawagri I Anwisye H Kitaura R Faccio DV Novack 2008 RelA/p65 promotes osteoclast differentiation by blocking a RANKL-induced apoptotic JNK pathway in mice J Clin Invest 118 2088 2097 18464930 1:CAS:528: DC%2BD1cXntVCmtL0%3D (Pubitemid 351872328)
    • (2008) Journal of Clinical Investigation , vol.118 , Issue.6 , pp. 2088-2097
    • Vaira, S.1    Alhawagri, M.2    Anwisye, I.3    Kitaura, H.4    Faccio, R.5    Novack, D.V.6
  • 14
    • 66449130502 scopus 로고    scopus 로고
    • Molecular mechanism of the bifunctional role of lipopolysaccharide in osteoclastogenesis
    • 19258321 10.1074/jbc.M809789200 1:CAS:528:DC%2BD1MXltVCls7Y%3D
    • J Liu S Wang P Zhang N Said-Al-Naief SM Michalek X Feng 2009 Molecular mechanism of the bifunctional role of lipopolysaccharide in osteoclastogenesis J Biol Chem 284 12512 12523 19258321 10.1074/jbc.M809789200 1:CAS:528: DC%2BD1MXltVCls7Y%3D
    • (2009) J Biol Chem , vol.284 , pp. 12512-12523
    • Liu, J.1    Wang, S.2    Zhang, P.3    Said-Al-Naief, N.4    Michalek, S.M.5    Feng, X.6
  • 15
    • 77950640257 scopus 로고    scopus 로고
    • Functions of nuclear factor kappaB in bone
    • 20392262 10.1111/j.1749-6632.2009.05315.x 1:CAS:528:DC%2BC3cXmsVSrurs%3D
    • BF Boyce Z Yao L Xing 2010 Functions of nuclear factor kappaB in bone Ann N Y Acad Sci 1192 367 375 20392262 10.1111/j.1749-6632.2009.05315.x 1:CAS:528:DC%2BC3cXmsVSrurs%3D
    • (2010) Ann N y Acad Sci , vol.1192 , pp. 367-375
    • Boyce, B.F.1    Yao, Z.2    Xing, L.3
  • 16
    • 0030715563 scopus 로고    scopus 로고
    • Osteopetrosis in mice lacking NF-κB1 and NF-κB2
    • V Iotsova J Caamano J Loy Y Yang A Lewin R Bravo 1997 Osteopetrosis in mice lacking NF-kappaB1 and NF-kappaB2 Nat Med 3 1285 1289 9359707 10.1038/nm1197-1285 1:CAS:528:DyaK2sXntFaktL4%3D (Pubitemid 27508833)
    • (1997) Nature Medicine , vol.3 , Issue.11 , pp. 1285-1289
    • Iotsova, V.1    Caamano, J.2    Loy, J.3    Yang, Y.4    Lewin, A.5    Bravo, R.6
  • 17
    • 44649160022 scopus 로고    scopus 로고
    • Suppression of NF-κB activation blocks osteoclastic bone resorption during estrogen deficiency
    • K Strait Y Li DL Dillehay MN Weitzmann 2008 Suppression of NF-kappaB activation blocks osteoclastic bone resorption during estrogen deficiency Int J Mol Med 21 521 525 18360699 1:CAS:528:DC%2BD1cXkslKqtrk%3D (Pubitemid 351802648)
    • (2008) International Journal of Molecular Medicine , vol.21 , Issue.4 , pp. 521-525
    • Strait, K.1    Li, Y.2    Dillehay, D.L.3    Weitzmann, M.N.4
  • 18
    • 33847364101 scopus 로고    scopus 로고
    • SDX-308, a nonsteroidal anti-inflammatory agent, inhibits NF-κB activity, resulting in strong inhibition of osteoclast formation/activity and multiple myeloma cell growth
    • DOI 10.1182/blood-2006-07-027458
    • R Feng G Anderson G Xiao G Elliott L Leoni MY Mapara GD Roodman S Lentzsch 2007 SDX-308, a nonsteroidal anti-inflammatory agent, inhibits NF-kappaB activity, resulting in strong inhibition of osteoclast formation/activity and multiple myeloma cell growth Blood 109 2130 2138 17095620 10.1182/blood-2006-07-027458 1:CAS:528:DC%2BD2sXjtFequ78%3D (Pubitemid 46348215)
    • (2007) Blood , vol.109 , Issue.5 , pp. 2130-2138
    • Feng, R.1    Anderson, G.2    Xiao, G.3    Elliott, G.4    Leoni, L.5    Mapara, M.Y.6    Roodman, G.D.7    Lentzsch, S.8
  • 19
    • 4444306858 scopus 로고    scopus 로고
    • The IκB kinase (IKK) inhibitor, NEMO-binding domain peptide, blocks osteoclastogenesis and bone erosion in inflammatory arthritis
    • DOI 10.1074/jbc.C400258200
    • S Dai T Hirayama S Abbas Y Abu-Amer 2004 The IkappaB kinase (IKK) inhibitor, NEMO-binding domain peptide, blocks osteoclastogenesis and bone erosion in inflammatory arthritis J Biol Chem 279 37219 37222 15252035 10.1074/jbc.C400258200 1:CAS:528:DC%2BD2cXntFSgtLw%3D (Pubitemid 39195425)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.36 , pp. 37219-37222
    • Dai, S.1    Hirayama, T.2    Abbas, S.3    Abu-Amer, Y.4
  • 20
    • 34447509873 scopus 로고    scopus 로고
    • Endogenous TNFα lowers maximum peak bone mass and inhibits osteoblastic smad activation through NF-κB
    • DOI 10.1359/jbmr.070121
    • Y Li A Li K Strait H Zhang MS Nanes MN Weitzmann 2007 Endogenous TNFalpha lowers maximum peak bone mass and inhibits osteoblastic smad activation, through NF-kappaB J Bone Miner Res 22 646 655 17266397 10.1359/jbmr.070121 1:CAS:528:DC%2BD2sXpt1yrt7w%3D (Pubitemid 351339092)
    • (2007) Journal of Bone and Mineral Research , vol.22 , Issue.5 , pp. 646-655
    • Li, Y.1    Li, A.2    Strait, K.3    Zhang, H.4    Nanes, M.S.5    Weitzmann, M.N.6
  • 21
    • 27944463205 scopus 로고    scopus 로고
    • Smad7 mediates inhibition of Saos2 osteosarcoma cell differentiation by NFκB
    • DOI 10.1016/j.yexcr.2005.09.016, PII S0014482705004386
    • RA Eliseev EM Schwarz MJ Zuscik RJ O'Keefe H Drissi RN Rosier 2006 Smad7 mediates inhibition of Saos2 osteosarcoma cell differentiation by NFkappaB Exp Cell Res 312 40 50 16259979 10.1016/j.yexcr.2005.09.016 1:CAS:528: DC%2BD2MXht1GhtLbJ (Pubitemid 41668590)
    • (2006) Experimental Cell Research , vol.312 , Issue.1 , pp. 40-50
    • Eliseev, R.A.1    Schwarz, E.M.2    Zuscik, M.J.3    O'Keefe, R.J.4    Drissi, H.5    Rosier, R.N.6
  • 22
    • 53149122891 scopus 로고    scopus 로고
    • Ubiquitin ligase Smurf1 mediates tumor necrosis factor-induced systemic bone loss by promoting proteasomal degradation of bone morphogenetic signaling proteins
    • 18567580 10.1074/jbc.M709848200 1:CAS:528:DC%2BD1cXpvFGgs7o%3D
    • R Guo M Yamashita Q Zhang Q Zhou D Chen DG Reynolds HA Awad L Yanoso L Zhao EM Schwarz YE Zhang BF Boyce L Xing 2008 Ubiquitin ligase Smurf1 mediates tumor necrosis factor-induced systemic bone loss by promoting proteasomal degradation of bone morphogenetic signaling proteins J Biol Chem 283 23084 23092 18567580 10.1074/jbc.M709848200 1:CAS:528:DC%2BD1cXpvFGgs7o%3D
    • (2008) J Biol Chem , vol.283 , pp. 23084-23092
    • Guo, R.1    Yamashita, M.2    Zhang, Q.3    Zhou, Q.4    Chen, D.5    Reynolds, D.G.6    Awad, H.A.7    Yanoso, L.8    Zhao, L.9    Schwarz, E.M.10    Zhang, Y.E.11    Boyce, B.F.12    Xing, L.13
  • 23
    • 67349238305 scopus 로고    scopus 로고
    • Inhibition of osteoblastic bone formation by nuclear factor-kappaB
    • 19448637 10.1038/nm.1954 1:CAS:528:DC%2BD1MXmtVOqsrk%3D
    • J Chang Z Wang E Tang Z Fan L McCauley R Franceschi K Guan PH Krebsbach CY Wang 2009 Inhibition of osteoblastic bone formation by nuclear factor-kappaB Nat Med 15 682 689 19448637 10.1038/nm.1954 1:CAS:528:DC%2BD1MXmtVOqsrk%3D
    • (2009) Nat Med , vol.15 , pp. 682-689
    • Chang, J.1    Wang, Z.2    Tang, E.3    Fan, Z.4    McCauley, L.5    Franceschi, R.6    Guan, K.7    Krebsbach, P.H.8    Wang, C.Y.9
  • 24
    • 0242409906 scopus 로고    scopus 로고
    • Tumor necrosis factor-α: Molecular and cellular mechanisms in skeletal pathology
    • DOI 10.1016/S0378-1119(03)00841-2
    • MS Nanes 2003 Tumor necrosis factor-alpha: molecular and cellular mechanisms in skeletal pathology Gene 321 1 15 14636987 10.1016/S0378-1119(03) 00841-2 1:CAS:528:DC%2BD3sXovFGhtro%3D (Pubitemid 37421390)
    • (2003) Gene , vol.321 , Issue.1-2 , pp. 1-15
    • Nanes, M.S.1
  • 25
    • 15444367188 scopus 로고    scopus 로고
    • Integration of the NfκB p65 subunit into the vitamin D receptor transcriptional complex: Identification of p65 domains that inhibit 1,25-dihydroxyvitamin D3-stimulated transcription
    • DOI 10.1002/jcb.20143
    • X Lu P Farmer J Rubin MS Nanes 2004 Integration of the NfkappaB p65 subunit into the vitamin D receptor transcriptional complex: identification of p65 domains that inhibit 1, 25-dihydroxyvitamin D3-stimulated transcription J Cell Biochem 92 833 848 15211579 10.1002/jcb.20143 1:CAS:528: DC%2BD2cXlslenu7s%3D (Pubitemid 44264272)
    • (2004) Journal of Cellular Biochemistry , vol.92 , Issue.4 , pp. 833-848
    • Lu, X.1    Farmer, P.2    Rubin, J.3    Nanes, M.S.4
  • 27
    • 70350761408 scopus 로고    scopus 로고
    • The bone anabolic carotenoid beta-cryptoxanthin enhances transforming growth factor-beta1-induced SMAD activation in MC3T3 preosteoblasts
    • 19787201 10.3892/ijmm-00000278 1:CAS:528:DC%2BD1MXhtlCgtb3E
    • M Yamaguchi MN Weitzmann 2009 The bone anabolic carotenoid beta-cryptoxanthin enhances transforming growth factor-beta1-induced SMAD activation in MC3T3 preosteoblasts Int J Mol Med 24 671 675 19787201 10.3892/ijmm-00000278 1:CAS:528:DC%2BD1MXhtlCgtb3E
    • (2009) Int J Mol Med , vol.24 , pp. 671-675
    • Yamaguchi, M.1    Weitzmann, M.N.2
  • 28
    • 0034183307 scopus 로고    scopus 로고
    • Anabolic effect of genistein in osteoblastic MC3T3-E1 cells
    • 10762655 1:CAS:528:DC%2BD3cXjtVOru7w%3D
    • E Sugimoto M Yamaguchi 2000 Anabolic effect of genistein in osteoblastic MC3T3-E1 cells Int J Mol Med 5 515 520 10762655 1:CAS:528:DC%2BD3cXjtVOru7w%3D
    • (2000) Int J Mol Med , vol.5 , pp. 515-520
    • Sugimoto, E.1    Yamaguchi, M.2
  • 29
    • 26444506000 scopus 로고    scopus 로고
    • Transforming growth factor-β1 to the bone
    • DOI 10.1210/er.2004-0001
    • K Janssens P Ten Dijke S Janssens W Van Hul 2005 Transforming growth factor-β1 to the bone Endocr Rev 26 743 774 15901668 10.1210/er.2004-0001 1:CAS:528:DC%2BD2MXhtFyitLjK (Pubitemid 41428537)
    • (2005) Endocrine Reviews , vol.26 , Issue.6 , pp. 743-774
    • Janssens, K.1    Ten Dijke, P.2    Janssens, S.3    Van Hul, W.4
  • 30
    • 67650506105 scopus 로고    scopus 로고
    • TGF-beta1-induced migration of bone mesenchymal stem cells couples bone resorption with formation
    • 19584867 10.1038/nm.1979 1:CAS:528:DC%2BD1MXotlSnsr0%3D
    • Y Tang X Wu W Lei L Pang C Wan Z Shi L Zhao TR Nagy X Peng J Hu X Feng W Van Hul M Wan X Cao 2009 TGF-beta1-induced migration of bone mesenchymal stem cells couples bone resorption with formation Nat Med 15 757 765 19584867 10.1038/nm.1979 1:CAS:528:DC%2BD1MXotlSnsr0%3D
    • (2009) Nat Med , vol.15 , pp. 757-765
    • Tang, Y.1    Wu, X.2    Lei, W.3    Pang, L.4    Wan, C.5    Shi, Z.6    Zhao, L.7    Nagy, T.R.8    Peng, X.9    Hu, J.10    Feng, X.11    Van Hul, W.12    Wan, M.13    Cao, X.14


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.