메뉴 건너뛰기




Volumn 64, Issue 1, 2012, Pages 30-39

The influence of AT1002 on the nasal absorption of molecular weight markers and therapeutic agents when co-administered with bioadhesive polymers and an AT1002 antagonist, AT1001

Author keywords

AT1001; AT1002; carrageenan; Na CMC

Indexed keywords

AT 1002; CALCITONIN; INULIN; LARAZOTIDE; MOLECULAR MARKER; PENETRATION ENHANCING AGENT; POLYMER; PROTEINASE ACTIVATED RECEPTOR 2; RECEPTOR PROTEIN; SAQUINAVIR; UNCLASSIFIED DRUG; ZONULIN RECEPTOR;

EID: 83555160922     PISSN: 00223573     EISSN: 20427158     Source Type: Journal    
DOI: 10.1111/j.2042-7158.2011.01381.x     Document Type: Article
Times cited : (7)

References (42)
  • 1
    • 0141816588 scopus 로고    scopus 로고
    • HIV-1 Tat protein alters tight junction protein expression and distribution in cultured brain endothelial cells
    • DOI 10.1002/jnr.10762
    • Andras IE, et al,. HIV-1 Tat protein alters tight junction protein expression and distribution in cultured brain endothelial cells. J Neurosci Res 2003; 74: 255-265. (Pubitemid 37193712)
    • (2003) Journal of Neuroscience Research , vol.74 , Issue.2 , pp. 255-265
    • Andras, I.E.1    Pu, H.2    Deli, M.A.3    Nath, A.4    Hennig, B.5    Toborek, M.6
  • 2
    • 23644435437 scopus 로고    scopus 로고
    • Advances in nasal drug delivery through tight junction technology
    • DOI 10.1517/17425247.2.2.281
    • Johnson PH, Quay SC,. Advances in nasal drug delivery through tight junction technology. Expert Opin Drug Deliv 2005; 2: 281-298. (Pubitemid 41130883)
    • (2005) Expert Opinion on Drug Delivery , vol.2 , Issue.2 , pp. 281-298
    • Johnson, P.H.1    Quay, S.C.2
  • 3
    • 52649172841 scopus 로고    scopus 로고
    • Endothelial EphA receptor stimulation increases lung vascular permeability
    • Larson J, et al,. Endothelial EphA receptor stimulation increases lung vascular permeability. Am J Physiol Lung Cell Mol Physiol 2008; 295: L431-L439.
    • (2008) Am J Physiol Lung Cell Mol Physiol , vol.295
    • Larson, J.1
  • 4
    • 0034880291 scopus 로고    scopus 로고
    • Enhancing the permeation of marker compounds and enaminone anticonvulsants across Caco-2 monolayers by modulating tight junctions using zonula occludens toxin
    • DOI 10.1016/S0939-6411(01)00172-2, PII S0939641101001722
    • Cox DS, et al,. Enhancing the permeation of marker compounds and enaminone anticonvulsants across Caco-2 monolayers by modulating tight junctions using zonula occludens toxin. Eur J Pharm Biopharm 2001; 52: 145-150. (Pubitemid 32755892)
    • (2001) European Journal of Pharmaceutics and Biopharmaceutics , vol.52 , Issue.2 , pp. 145-150
    • Cox, D.S.1    Gao, H.2    Raje, S.3    Scott, K.R.4    Eddington, N.D.5
  • 5
    • 0036846813 scopus 로고    scopus 로고
    • Enhanced permeability of molecular weight markers and poorly bioavailable compounds across Caco-2 cell monolayers using the absorption enhancer, zonula occludens toxin
    • DOI 10.1023/A:1020709513562
    • Cox DS, et al,. Enhanced permeability of molecular weight markers and poorly bioavailable compounds across Caco-2 cell monolayers using the absorption enhancer, zonula occludens toxin. Pharm Res 2002; 19: 1680-1688. (Pubitemid 35305520)
    • (2002) Pharmaceutical Research , vol.19 , Issue.11 , pp. 1680-1688
    • Cox, D.S.1    Raje, S.2    Gao, H.3    Salama, N.N.4    Eddington, N.D.5
  • 6
    • 12244281485 scopus 로고    scopus 로고
    • Zonula occludens toxin increases the permeability of molecular weight markers and chemotherapeutic agents across the bovine brain microvessel endothelial cells
    • DOI 10.1002/jps.10310
    • Karyekar CS, et al,. Zonula occludens toxin increases the permeability of molecular weight markers and chemotherapeutic agents across the bovine brain microvessel endothelial cells. J Pharm Sci 2003; 92: 414-423. (Pubitemid 36169314)
    • (2003) Journal of Pharmaceutical Sciences , vol.92 , Issue.2 , pp. 414-423
    • Karyekar, C.S.1    Fasano, A.2    Raje, S.3    Lu, R.4    Dowling, T.C.5    Eddington, N.D.6
  • 7
    • 0035374570 scopus 로고    scopus 로고
    • Zonula occludens toxin structure-function analysis. Identification of the fragment biologically active on tight junctions and of the zonulin receptor binding domain
    • Di Pierro M, et al,. Zonula occludens toxin structure-function analysis. Identification of the fragment biologically active on tight junctions and of the zonulin receptor binding domain. J Biol Chem 2001; 276: 19160-19165.
    • (2001) J Biol Chem , vol.276 , pp. 19160-19165
    • Di Pierro, M.1
  • 8
    • 12244273009 scopus 로고    scopus 로고
    • Effect of the biologically active fragment of zonula occludens toxin, ΔG, on the intestinal paracellular transport and oral absorption of mannitol
    • DOI 10.1016/S0378-5173(02)00589-6, PII S0378517302005896
    • Salama NN, et al,. Effect of the biologically active fragment of zonula occludens toxin, delta G, on the intestinal paracellular transport and oral absorption of mannitol. Int J Pharm 2003; 251: 113-121. (Pubitemid 36071466)
    • (2003) International Journal of Pharmaceutics , vol.251 , Issue.1-2 , pp. 113-121
    • Salama, N.N.1    Fasano, A.2    Lu, R.3    Eddington, N.D.4
  • 11
    • 38849207768 scopus 로고    scopus 로고
    • Effect of the six-mer synthetic peptide (AT1002) fragment of zonula occludens toxin on the intestinal absorption of cyclosporin A
    • Song KH, et al,. Effect of the six-mer synthetic peptide (AT1002) fragment of zonula occludens toxin on the intestinal absorption of cyclosporin A. Int J Pharm 2008; 351: 8-14.
    • (2008) Int J Pharm , vol.351 , pp. 8-14
    • Song, K.H.1
  • 12
    • 41549090387 scopus 로고    scopus 로고
    • Enhanced nasal absorption of hydrophilic markers after dosing with AT1002, a tight junction modulator
    • Song KH, et al,. Enhanced nasal absorption of hydrophilic markers after dosing with AT1002, a tight junction modulator. Eur J Pharm Biopharm 2008; 69: 231-237.
    • (2008) Eur J Pharm Biopharm , vol.69 , pp. 231-237
    • Song, K.H.1
  • 13
    • 57049114897 scopus 로고    scopus 로고
    • Mechanism of action of Zot-derived peptide AT-1002, a tight junction regulator and absorption enhancer
    • Gopalakrishnan S, et al,. Mechanism of action of Zot-derived peptide AT-1002, a tight junction regulator and absorption enhancer. Int J Pharm 2009; 365: 121-130.
    • (2009) Int J Pharm , vol.365 , pp. 121-130
    • Gopalakrishnan, S.1
  • 15
    • 0029161839 scopus 로고
    • Zonula occludens toxin modulates tight junctions through protein kinase C-dependent actin reorganization, in vitro
    • Fasano A, et al,. Zonula occludens toxin modulates tight junctions through protein kinase C-dependent actin reorganization, in vitro. J Clin Invest 1995; 96: 710-720.
    • (1995) J Clin Invest , vol.96 , pp. 710-720
    • Fasano, A.1
  • 16
    • 0031051849 scopus 로고    scopus 로고
    • The enterotoxic effect of zonula occludens toxin on rabbit small intestine involves the paracellular pathway
    • DOI 10.1053/gast.1997.v112.pm9041245
    • Fasano A, et al,. The enterotoxic effect of zonula occludens toxin on rabbit small intestine involves the paracellular pathway. Gastroenterology 1997; 112: 839-846. (Pubitemid 27113809)
    • (1997) Gastroenterology , vol.112 , Issue.3 , pp. 839-846
    • Fasano, A.1    Uzzau, S.2    Fiore, C.3    Margaretten, K.4
  • 17
    • 0030938926 scopus 로고    scopus 로고
    • Modulation of intestinal tight junctions by zonula occludens toxin permits enteral administration of insulin and other macromolecules in an animal model
    • Fasano A, Uzzau S,. Modulation of intestinal tight junctions by zonula occludens toxin permits enteral administration of insulin and other macromolecules in an animal model. J Clin Invest 1997; 99: 1158-1164. (Pubitemid 27142750)
    • (1997) Journal of Clinical Investigation , vol.99 , Issue.6 , pp. 1158-1164
    • Fasano, A.1    Uzzau, S.2
  • 20
    • 83555163248 scopus 로고    scopus 로고
    • P0517 Zot/Zonulin-mediated regulation of intestinal tight junctions involves the proteinase-activated receptor 2 (Par-2)
    • Fasano A, et al,. P0517 Zot/Zonulin-mediated regulation of intestinal tight junctions involves the proteinase-activated receptor 2 (Par-2). J Pediatr Gastroenterol Nutr 2004; 39: S253-S254.
    • (2004) J Pediatr Gastroenterol Nutr , vol.39
    • Fasano, A.1
  • 21
    • 70349736175 scopus 로고    scopus 로고
    • Identification of human zonulin, a physiological modulator of tight junctions, as prehaptoglobin-2
    • Tripathi A, et al,. Identification of human zonulin, a physiological modulator of tight junctions, as prehaptoglobin-2. Proc Natl Acad Sci USA 2009; 106: 16799-16804.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 16799-16804
    • Tripathi, A.1
  • 23
    • 0025851808 scopus 로고
    • The nasal mucociliary clearance: Relevance to nasal drug delivery
    • Schipper NG, et al,. The nasal mucociliary clearance: relevance to nasal drug delivery. Pharm Res 1991; 8: 807-814.
    • (1991) Pharm Res , vol.8 , pp. 807-814
    • Schipper, N.G.1
  • 25
    • 0032472335 scopus 로고    scopus 로고
    • A rheological examination of the mucoadhesive/mucus interaction: The effect of mucoadhesive type and concentration
    • DOI 10.1016/S0168-3659(97)00138-7, PII S0168365997001387
    • Madsen F, et al,. A rheological examination of the mucoadhesive/mucus interaction: the effect of mucoadhesive type and concentration. J Control Release 1998; 50: 167-178. (Pubitemid 28044111)
    • (1998) Journal of Controlled Release , vol.50 , Issue.1-3 , pp. 167-178
    • Madsen, F.1    Eberth, K.2    Smart, J.D.3
  • 26
    • 28444463645 scopus 로고    scopus 로고
    • In situ gelling, bioadhesive nasal inserts for extended drug delivery: In vitro characterization of a new nasal dosage form
    • DOI 10.1016/j.ejps.2005.08.005, PII S0928098705002514
    • Bertram U, Bodmeier R,. In situ gelling, bioadhesive nasal inserts for extended drug delivery: in vitro characterization of a new nasal dosage form. Eur J Pharm Sci 2006; 27: 62-71. (Pubitemid 41728256)
    • (2006) European Journal of Pharmaceutical Sciences , vol.27 , Issue.1 , pp. 62-71
    • Bertram, U.1    Bodmeier, R.2
  • 27
    • 65449149831 scopus 로고    scopus 로고
    • Development of novel mucoadhesive pellets of metformin hydrochloride
    • Piao J, et al,. Development of novel mucoadhesive pellets of metformin hydrochloride. Arch Pharm Res 2009; 32: 391-397.
    • (2009) Arch Pharm Res , vol.32 , pp. 391-397
    • Piao, J.1
  • 28
    • 34547852241 scopus 로고    scopus 로고
    • The safety, tolerance, pharmacokinetic and pharmacodynamic effects of single doses of AT-1001 in coeliac disease subjects: A proof of concept study
    • DOI 10.1111/j.1365-2036.2007.03413.x
    • Paterson BM, et al,. The safety, tolerance, pharmacokinetic and pharmacodynamic effects of single doses of AT-1001 in coeliac disease subjects: a proof of concept study. Aliment Pharmacol Ther 2007; 26: 757-766. (Pubitemid 47246202)
    • (2007) Alimentary Pharmacology and Therapeutics , vol.26 , Issue.5 , pp. 757-766
    • Paterson, B.M.1    Lammers, K.M.2    Arrieta, M.C.3    Fasano, A.4    Meddings, J.B.5
  • 30
    • 77956682296 scopus 로고    scopus 로고
    • Efficacy and safety of an antiviral iota-carrageenan nasal spray: A randomized, double-blind, placebo-controlled exploratory study in volunteers with early symptoms of the common cold
    • Eccles R, et al,. Efficacy and safety of an antiviral iota-carrageenan nasal spray: a randomized, double-blind, placebo-controlled exploratory study in volunteers with early symptoms of the common cold. Respir Res 2010; 11: 108.
    • (2010) Respir Res , vol.11 , pp. 108
    • Eccles, R.1
  • 31
    • 23944494896 scopus 로고    scopus 로고
    • Enhanced intestinal absorption of salmon calcitonin (sCT) from proliposomes containing bile salts
    • Song KH, et al,. Enhanced intestinal absorption of salmon calcitonin (sCT) from proliposomes containing bile salts. J Control Release 2005; 106: 298-308.
    • (2005) J Control Release , vol.106 , pp. 298-308
    • Song, K.H.1
  • 32
    • 0029689063 scopus 로고    scopus 로고
    • Changes in Nasal Cavity Volume and Target Area of Exposure to Nasal Drops with Age in Rats
    • Kuboyama Y, et al,. Changes in nasal cavity volume and target area of exposure to nasal drops with age in rats. Exp Anim 1996; 45: 15-22. (Pubitemid 126419604)
    • (1996) Experimental Animals , vol.45 , Issue.1 , pp. 15-22
    • Kuboyama, Y.1    Mori, K.2    Suzuki, K.3    Ishii, A.4    Shuto, K.5
  • 33
    • 0037025842 scopus 로고    scopus 로고
    • Simple liquid chromatography-electrospray ionization mass spectrometry method for the routine determination of salmon calcitonin in serum
    • Song KH, et al,. Simple liquid chromatography-electrospray ionization mass spectrometry method for the routine determination of salmon calcitonin in serum. J Chromatogr B Analyt Technol Biomed Life Sci 2002; 775: 247-255.
    • (2002) J Chromatogr B Analyt Technol Biomed Life Sci , vol.775 , pp. 247-255
    • Song, K.H.1
  • 35
    • 0003351764 scopus 로고    scopus 로고
    • Multifunctional polymers for the peroral delivery of peptide drugs
    • Mathiowitz E. et al., ed. New York: Marcel Dekker.
    • Luessen HL, et al,. Multifunctional polymers for the peroral delivery of peptide drugs. In:, Mathiowitz E, et al., ed. Bioadhesive Drug Delivery Systems. Fundamentals, Novel Approaches, and Development. New York: Marcel Dekker, 1999: 299-339.
    • (1999) Bioadhesive Drug Delivery Systems. Fundamentals, Novel Approaches, and Development , pp. 299-339
    • Luessen, H.L.1
  • 36
    • 0036896831 scopus 로고    scopus 로고
    • Nasal drug delivery: New developments and strategies
    • DOI 10.1016/S1359-6446(02)02529-1, PII S1359644602025291
    • Illum L,. Nasal drug delivery: new developments and strategies. Drug Discov Today 2002; 7: 1184-1189. (Pubitemid 35430155)
    • (2002) Drug Discovery Today , vol.7 , Issue.23 , pp. 1184-1189
    • Illum, L.1
  • 37
    • 0037459005 scopus 로고    scopus 로고
    • Nasal drug delivery - Possibilities, problems and solutions
    • DOI 10.1016/S0168-3659(02)00363-2, PII S0168365902003632
    • Illum L,. Nasal drug delivery-possibilities problems and solutions. J Control Release 2003; 87: 187-198. (Pubitemid 36255456)
    • (2003) Journal of Controlled Release , vol.87 , Issue.1-3 , pp. 187-198
    • Illum, L.1
  • 38
    • 77958580026 scopus 로고    scopus 로고
    • US Food and Drug Administration [Online] Available at
    • US Food and Drug Administration. Generally Recognized as Safe (GRAS). [Online] Available at:.
    • Generally Recognized As Safe (GRAS)
  • 39
    • 0034665269 scopus 로고    scopus 로고
    • Toxicological investigations of the effects carboxymethylcellulose on ciliary beat frequency of human nasal epithelial cells in primary suspension culture and in vivo on rabbit nasal mucosa
    • Ugwoke MI, et al,. Toxicological investigations of the effects carboxymethylcellulose on ciliary beat frequency of human nasal epithelial cells in primary suspension culture and in vivo on rabbit nasal mucosa. Int J Pharm 2000; 205: 43-51.
    • (2000) Int J Pharm , vol.205 , pp. 43-51
    • Ugwoke, M.I.1
  • 40
    • 0026290528 scopus 로고
    • Enhanced rectal and nasal absorption of human epidermal growth factor by combined use of the absorption promoter and the synthetic polymer in rats
    • Spec.
    • Murakami T, et al,. Enhanced rectal and nasal absorption of human epidermal growth factor by combined use of the absorption promoter and the synthetic polymer in rats. Eur J Drug Metab Pharmacokinet 1991; Spec 3: 125-131.
    • (1991) Eur J Drug Metab Pharmacokinet , vol.3 , pp. 125-131
    • Murakami, T.1
  • 42
    • 0345268671 scopus 로고    scopus 로고
    • Zonula occludens toxin acts as an adjuvant through different mucosal routes and induces protective immune responses
    • DOI 10.1128/IAI.71.4.1897-1902.2003
    • Marinaro M, et al,. Zonula occludens toxin acts as an adjuvant through different mucosal routes and induces protective immune responses. Infect Immun 2003; 71: 1897-1902. (Pubitemid 36368721)
    • (2003) Infection and Immunity , vol.71 , Issue.4 , pp. 1897-1902
    • Marinaro, M.1    Fasano, A.2    De Magistris, M.T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.