Enhancing the permeation of marker compounds and enaminone anticonvulsants across Caco-2 monolayers by modulating tight junctions using zonula occludens toxin

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 52, Issue 2, 2001, Pages 145-150

  Cox, Donna S ^a   Gao, Huanglin ^a   Raje, Sangeeta ^a   Scott, Kenneth R ^b   Eddington, Natalie D ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF PHARMACY   (United States)

^b HOWARD UNIVERSITY   (United States)

Author keywords

Bioavailability; Enaminones; Paracellular transport; Tight junctions; Zonula occludens toxin

Indexed keywords

ANTICONVULSIVE AGENT; BACTERIAL TOXIN; BUFFER; CARBON 14; ENAMINONE; ENAMINONE DERIVATIVE; INULIN; MANNITOL; MARKER; PENETRATION ENHANCING AGENT; PHOSPHATE; SODIUM CHLORIDE; UNCLASSIFIED DRUG; ZONULA OCCLUDENS TOXIN;

ARTICLE; CELL STRAIN CACO 2; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG TRANSPORT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; INTESTINE ABSORPTION; INTESTINE CELL; MONOLAYER CULTURE; TIGHT JUNCTION; VIBRIO CHOLERAE;

ANTICONVULSANTS; CACO-2 CELLS; CELL CULTURE TECHNIQUES; CHOLERA TOXIN; DIURETICS, OSMOTIC; HUMANS; INTESTINAL ABSORPTION; INULIN; MANNITOL; MOLECULAR WEIGHT; TIGHT JUNCTIONS;

EID: 0034880291     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0939-6411(01)00172-2     Document Type: Article

References (21)

1. Epithelial transport of drugs in cell culture I: a model for studying the passive diffusion of drugs over intestinal absorptive (Caco-2) cells
2. Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells
3. Paracellular diffusion in Caco-2 cell monolayers: effect of perturbation on the transport of hydrophilic compounds that vary in charge and size
4. Mucoadhesive polymers in peroral peptide drug delivery. IV. Polycarbophil and chitosan are potent enhancers of peptide transport across intestinal mucosae in vitro
5. Effect of chitosan on the permeability of monolayers of intestinal epithelial cells (Caco-2)
6. Physiological mechanism for enhancement of paracellular drug transport
7. Chitosan as a novel nasal delivery system for peptide drugs
8. Chitosan as a nasal delivery system: evaluation of insulin absorption enhancement and effect on nasal membrane integrity using rat models
9. Effect of degree of quanternization of N-trimethyl chitosan chloride for enhanced transport of hydrophilic compounds across intestinal Caco-2 cell monolayers
10. Vibrio cholerae produces a second enterotoxin, which affects intestinal tight junctions
11. Zonula occludens toxin modulates tight junctions through protein kinase C-dependent actin reorganization, in vitro
12. The enterotoxic effect of zonula occludens toxin on rabbit small intestine involves the paracellular pathway
13. Modulation of intestinal tight junctions by zonula occludens toxin permits enteral administration of insulin and other macromolecules in an animal model
14. Synthesis and anticonvulsant activity of enaminones. 2. Further structure activity correlations
15. Synthesis and anticonvulsant activity of enaminones. 3. Investigations on 4′-, 3′-, and 2′-substituted polysubstituted anilino compounds, sodium channel binding studies, and toxicity evaluations
16. Synthesis and anticonvulsant activity of enaminones
17. The profile of anticonvulsant activity and minimal toxicity of methyl 4-[(p-chlorophenyl) amino]-6-methyl-2-oxocyclohex-3-en-1-oate and some prototype antiepileptic drugs in mice and rats
18. Determination of the enaminone, DM5, an anti-epileptic agent in plasma and mouse tissue by high performance liquid chromatography with ultraviolet detection
19. Mucosal penetration enhancers for facilitation of peptide and protein drug absorption
20. Enaminones - versatile therapeutic pharmacophores. Further advances