Validity of pharmacokinetic data of β-escin from horse chestnut semed extracts determined by radioimmunological methods;ZUR VALIDITAT RADIOIMMUNOLOGISCHE BESTIMMTER BIOVERFUGBARKEITSDATEN VON β-AESCIN IN ROSSKASTANIENSAMENEXTRAKTEN

Arzneimittel-Forschung/Drug Research

Volumn 48, Issue 9, 1998, Pages 905-910

  Schrödter, Andreas ^a   Loew, Dieter ^a   Schwankl, Walter ^b   Rietbrock, Norbert ^a  

^a GOETHE UNIVERSITY   (Germany)

^b Bionorica AG   (Germany)

Author keywords

Escin, bioavailability, extract composition, pharmacokinetics, radioimmunoassay (RIA); CAS 6805 41 0; Noricaven novo

Indexed keywords

AESCULUS HIPPOCASTANUM EXTRACT; ESCIN; NORICAVEN; UNCLASSIFIED DRUG; PLANT EXTRACT;

AREA UNDER THE CURVE; ARTICLE; BIOEQUIVALENCE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG QUALITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; RADIOIMMUNOASSAY; STEADY STATE; SUSTAINED RELEASE PREPARATION; ADULT; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CROSSOVER PROCEDURE; DELAYED RELEASE FORMULATION; DOUBLE BLIND PROCEDURE; FEMALE; MALE; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; REPRODUCIBILITY;

ADULT; AREA UNDER CURVE; CROSS-OVER STUDIES; DELAYED-ACTION PREPARATIONS; DOUBLE-BLIND METHOD; ESCIN; FEMALE; HUMANS; MALE; PLANT EXTRACTS; PROSPECTIVE STUDIES; RADIOIMMUNOASSAY; REPRODUCIBILITY OF RESULTS;

EID: 0031721036     PISSN: 00044172     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. DAB, 10 Bd. 4, Monographien P-Z, 2. Nachtrag (1993)
2. Monographie Hippocastani semen. BAnz. Nr. 71 vom 15. 4. 1994
3. BfArM, BAnz. Nr. 23 vom 2. 2. 96
4. Oschmann, R., Biber, A., Lang, F. et al., Pharmazie 51, 577 (1996)
5. Dittgen, M., Zimmermann, H., Wober, W. et al., Pharmazie 51, 608 (1996)
6. Schrader, E., Schwankl, W., Sieder, Ch. et al., Pharmazie 50, 623 (1995)
7. Kunz, K., Schaffler, K., Biber, A. et al., Pharmazie 46, 145 (1991)
8. Feiden, K., Addendum, 2, Chap. 2.66, Investigation of bioavailability and bioequivalence, in Arzneimittelprüfrichtlinien, Wiss. Verlagsges., Stuttgart (1992)
9. Denzel, K., Hofmann, A., Int. Abschlußbericht, Phytos GbRmbH, Neu-Ulm (1997)
10. Teuscher, E., Biogene Arzneimittel, Wissenschaftl. Verlagsges., Stuttgart (1997)
11. Reger, H., Dissertation, Fak. Chemie und Pharmazie, LMU München (1987)
12. Wagner, H., Reger, H., Bauer, R., DAZ 25, 1513 (1985)
13. Kunz, K., Validation Report, IBFR, München 1996
14. Sörgel, F., Kinzig-Schippers, M., Rüsing, G. et al., in: Phytopharmaka II, D. Loew, N. Rietbrock (Hrsg.), S. 15-48, Steinkopff Verlag, Darmstadt (1996)
15. Griffini, A., Lolla, E., Peterlongo, F., Fitoterapia, 68, 520 (1997)