Molecular basis for the substrate stereoselectivity in tryptophan dioxygenase

Biochemistry

Volumn 50, Issue 50, 2011, Pages 10910-10918

  Capece, Luciana ^a   Lewis Ballester, Ariel ^b   Marti, Marcelo A ^a   Estrin, Dario A ^a   Yeh, Syun Ru ^b  

^a UNIVERSIDAD DE BUENOS AIRES   (Argentina)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; AMMONIUM GROUPS; DIOXYGENASES; HEME PROTEINS; HYDROGEN BONDING INTERACTIONS; INDOLEAMINE 2 ,3-DIOXYGENASE; MOLECULAR BASIS; MOLECULAR DYNAMICS SIMULATIONS; OXIDATION REACTIONS; STEREOSTRUCTURE; STRUCTURAL ALTERATIONS; SUBSTRATE BINDING; XANTHOMONAS CAMPESTRIS;

AMINO ACIDS; AMMONIUM COMPOUNDS; DYNAMICS; ENZYMES; HYDROGEN BONDS; MOLECULAR DYNAMICS; MOLECULAR OXYGEN; PORPHYRINS; PROTEINS; REACTION KINETICS; STEREOSELECTIVITY;

SUBSTRATES;

ENZYME; FERRYL INDOLE 2,3 EPOXIDE; FORMYLKYNURENINE; INDOLEAMINE 2,3 DIOXYGENASE; TRYPTOPHAN 2,3 DIOXYGENASE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CONTROLLED STUDY; ENZYME BINDING; GENE MUTATION; HYDROGEN BOND; MOLECULAR DYNAMICS; NONHUMAN; OXIDATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN STRUCTURE; STEREOCHEMISTRY; XANTHOMONAS CAMPESTRIS;

AMINO ACID SUBSTITUTION; BINDING SITES; BIOCATALYSIS; HUMANS; HYDROGEN BONDING; KINETICS; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; MUTANT PROTEINS; OXIDATION-REDUCTION; PROTEIN BINDING; PROTEIN CONFORMATION; RECOMBINANT PROTEINS; SPECTROPHOTOMETRY; SPECTRUM ANALYSIS, RAMAN; STEREOISOMERISM; SUBSTRATE SPECIFICITY; THREONINE; TRYPTOPHAN; TRYPTOPHAN OXYGENASE;

EID: 83455262978     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi201439m     Document Type: Article

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