Exploring the nitric oxide detoxification mechanism of mycobacterium tuberculosis truncated haemoglobin N

NATO Security through Science Series C: Environmental Security

Volumn , Issue , 2009, Pages 33-47

  Bidon Chanal, A ^a   Marti M A ^b   Estrin D A ^b   Luque, F J ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

^b Instituto de Quimica Fisica de los Materiales Medio Ambiente y Energia   (Argentina)

Author keywords

Ligand migration; Molecular simulations; Mycobacterium tuberculosis; NO detoxification; Truncated haemoglobin N

Indexed keywords

MYCOBACTERIUM TUBERCULOSIS;

EID: 66249096026     PISSN: 18714668     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-90-481-2590-6_3     Document Type: Article

References (23)

1. Hussian T (2007) Leprosy and tuberculosis: an insight-review. Crit Rev Microbiol 33:15-66.
2. MacMicking JD, North RJ, LaCourse R, Mudgett JS, Shah SK, Nathan CF (1997) Identification of nitric oxide synthase as a protective locus against tuberculosis. Proc Natl Acad Sci USA 94:5243-5248.
3. Shiloh MU, Nathan CF (2000) Reactive nitrogen intermediates and the pathogenesis of Salmonella and Mycobacteria. Curr Opin Microbiol 3:35-42.
4. Couture M, Yeh SR, Wittenberg BA, Wittenberg JB, Ouellet Y, Rousseau DL, Guertin M (1999) A cooperative oxygen-binding hemoglobin from Mycobacterium tuberculosis. Proc Natl Acad Sci USA 96:11223-11228.
5. Ouellet H, Ouellet Y, Richard C, Labarre M, Wittenberg B, Wittenberg J, Guertin M (2002) Truncated hemoglobin HbN protects Mycobacterium bovis from nitric oxide. Proc Natl Acad Sci USA 99:5902-5907.
6. Pathania R, Navani NK, Gardner AM, Gardner PR, Dikshit KL (2002) Nitric oxide scavenging and detoxification by the Mycobacterium tuberculosis haemoglobin, HbN in Escherichia coli. Mol Microbiol, 45:1303-1314.
7. Nardini M, Pesce A, Milani M, Bolognesi M (2007) Protein fold and structure in the truncated (2/2) globin family. Gene 398:2-11.
8. Wittenberg JB, Bolognesi M, Wittenberg BA, Guertin M (2002) Truncated hemoglobins: a new family of hemoglobins widely distributed in bacteria, unicellular eukaryotes, and plants. J Biol Chem 277:871-874.
9. Vuletich DA, Lecomte JT (2006) A phylogenetic and structural analysis of truncated hemoglobins. J Mol Evol 62:196-210.
10. Pesce A, Couture M, Dewilde S, Guertin M, Yamauchi K, Ascenzi P, Moens L, Bolognesi M (2000) A novel two-over-two α-helical sandwich fold is characteristic of the truncated hemoglobin family. EMBO J. 19:2424-2434.
11. Milani M, Pesce A, Bolognesi M, Bocedi A, Ascenzi P (2003) Substrate channelling: molecular bases. Biochem Mol Biol Edu 31:228-233.
12. Vinogradov SN, Hoogewijs D, Bailly X, Arredondo-Peter R, Gough J, Dewilde S, Moens L, Vanfleteren JR (2006) A phylogenomic profile of globins. BMC Evol Biol 6:31-47.
13. Perutz MF (1979) Regulation of oxygen affinity of hemoglobin: influence of structure of the globin on the heme iron. Annu Rev Biochem 48:327-327.
14. Ascenzi A, Bolognesi M, Milani M, Guertin M, Visca P (2007) Mycobacterial truncated hemoglobins: from genes to functions. Gene 398:42-42.
15. Pawaria S, Rajamohan G, Gambhir V, Lama A, Varshney GC, Dikshit KL (2007) Intracellular growth and survival of Salmonella enterica serovar Typhimurium carrying truncated hemoglobins of Mycobacterium tuberculosis. Microb Pathog 42:119-128.
16. 2 diffusion to the heme. EMBO J 20:3902-3909.
17. Springer BA, Egeberg KD, Sligar SG, Rohlfs RJ, Mathews AJ, Olson JS (1989) Discrimination between oxygen and carbon monoxide and inhibition of autooxidation by myoglobin. Site-directed mutagenesis of the distal histidine. J Biol Chem 264:3057-3057.
18. Eich RF, Li T, Lemon DD, Doherty DH, Curry SR, Aitken JF, Mathews AJ, Johnson KA, Smith RD, Phillips GN Jr., Olson JS (1996) Mechanism of NO-induced oxidation of myoglobin and hemoglobin. Biochemistry-US 35:6976-6983.
19. Bidon-Chanal A, Marti MA, Crespo A, Milani M, Orozco M, Bolognesi M, Luque FJ, Estrin DA (2006) Ligand-induced dynamical regulation of NO conversion in Mycobacterium tuberculosis truncated hemoglobin-N. Proteins 64:457-464.
20. Ouellet Y, Milani M, Couture M, Bolognesi M, Guertin M (2006) Ligand interactions in the distal heme pocket of Mycobacterium tuberculosis truncated hemoglobin N: roles of TyrB10 and GlnE11 residues. Biochemistry-US 2006 45:8770-8781.
21. Bidon-Chanal A, Martí MA, Estrin DA, Luque FJ (2007) Dynamical regulation of ligand migration by a gate-opening molecular switch in truncated hemoglobin-N from Mycobacterium tuberculosis. J Am Chem Soc 129:6782-6788.
22. Crespo A, Marti MA, Kalko SG, Morreale A, Orozco M, Gelpi JL, Luque FJ, Estrin DA (2005) Theoretical study of the truncated hemoglobin HbN: exploring the molecular basis of the NO detoxification mechanism. J Am Chem Soc 127:4433-4444.
23. Marti MA, Bidon-Chanal A,Crespo A, Yeh SR, Guallar V, Luque FJ, Estrin DA (2008) Mechanism of product release in NO detoxification from Mycobacterium tuberculosis truncated hemoglobin N. J Am Chem Soc 130:1688-1693.