ONIOM study on a missing piece in our understanding of heme chemistry: Bacterial tryptophan 2,3-dioxygenase with dual oxidants

Journal of the American Chemical Society

Volumn 132, Issue 34, 2010, Pages 11993-12005

  Chung, Lung Wa ^a   Li, Xin ^a   Sugimoto, Hiroshi ^b   Shiro, Yoshitsugu ^b   Morokuma, Keiji ^a  

^a KYOTO UNIVERSITY   (Japan)

^b Harima Institute ^*  (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

C-C BONDS; DIOXETANES; DIOXYGEN ACTIVATION; DIOXYGENASES; L-TRYPTOPHAN; MECHANISTIC PATHWAYS; NON-HEME OXYGENASES; OXIDATIVE CLEAVAGES; PYRROLE RING; RADICAL ADDITION; REACTION MECHANISM; REGIOSPECIFIC; RING OPENING; RING-CLOSURE; SUPEROXIDES; X RAY CRYSTAL STRUCTURES; XANTHOMONAS CAMPESTRIS;

AMINO ACIDS; BACTERIOLOGY; CHEMICAL BONDS; OXIDANTS; OXYGEN;

PORPHYRINS;

BACTERIAL ENZYME; HEME; HORSERADISH PEROXIDASE; HYDROGEN; INDOLE; INDOLEAMINE 2,3 DIOXYGENASE; MYOGLOBIN; OXIDIZING AGENT; OXYGEN; PROTON; TRYPTOPHAN; TRYPTOPHAN 2,3 DIOXYGENASE;

ARTICLE; CATALYSIS; CHEMICAL REACTION; CRYSTAL STRUCTURE; ELECTRON TRANSPORT; ENERGY; ENZYME ACTIVITY; ENZYME SPECIFICITY; ENZYME SUBSTRATE; EPOXIDATION; MOLECULAR DYNAMICS; MOSSBAUER SPECTROSCOPY; NONHUMAN; OXIDATION; PROTON TRANSPORT; QUANTUM MECHANICS; XANTHOMONAS CAMPESTRIS;

CARRIER PROTEINS; CATALYSIS; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; FERROUS COMPOUNDS; HEMEPROTEINS; INDOLEAMINE-PYRROLE 2,3,-DIOXYGENASE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; OXIDATION-REDUCTION; TRYPTOPHAN; TRYPTOPHAN OXYGENASE; XANTHOMONAS CAMPESTRIS;

EID: 77956092331     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja103530v     Document Type: Article

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