TLR4 is a negative regulator in noninfectious lung inflammation

Journal of Immunology

Volumn 184, Issue 9, 2010, Pages 5308-5314

  Zhao, Hang ^a,b   Leu, Shaw Wei ^a,b,e   Shi, Liyun ^a,b,f   Dedaj, Rejmon ^a,b   Zhao, Gaofeng ^a,b   Garg, Hari G ^a,b   Shen, Lianjun ^c   Lien, Egil ^c   Fitzgerald, Katherine A ^c   Shiedlin, Aviva ^d   Shen, Huahao ^g   Quinn, Deborah A ^a,b   Hales, Charles A ^a,b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^d GENZYME CORPORATION   (United States)

^e CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^f HANGZHOU NORMAL UNIVERSITY   (China)

^g THE SECOND AFFILIATED HOSPITAL OF ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

HYALURONIC ACID DERIVATIVE; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; LOW MOLECULAR WEIGHT HYALURONIC ACID; MYELOID DIFFERENTIATION FACTOR 88; TOLL LIKE RECEPTOR 4; UNCLASSIFIED DRUG; AUTACOID; HYALURONIC ACID; INTERLEUKIN 1BETA; TLR4 PROTEIN, MOUSE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; IMMUNE RESPONSE; LUNG INJURY; MOUSE; NEUTROPHIL COUNT; NONHUMAN; PNEUMONIA; PRIORITY JOURNAL; PROTEIN FUNCTION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; ACUTE LUNG INJURY; ANIMAL; BIOSYNTHESIS; C3H MOUSE; C57BL MOUSE; CELL CULTURE; CELL MEMBRANE PERMEABILITY; CHEMICALLY INDUCED DISORDER; CHEMISTRY; DOWN REGULATION; DRUG ANTAGONISM; GENETICS; IMMUNOLOGY; LUNG; LUNG ALVEOLUS; LUNG LAVAGE; METABOLISM; MOLECULAR WEIGHT; MOUSE MUTANT; PATHOLOGY; PHYSIOLOGY;

ACUTE LUNG INJURY; ANIMALS; BRONCHOALVEOLAR LAVAGE FLUID; CELL MEMBRANE PERMEABILITY; CELLS, CULTURED; DOWN-REGULATION; HYALURONIC ACID; INFLAMMATION MEDIATORS; INTERLEUKIN 1 RECEPTOR ANTAGONIST PROTEIN; INTERLEUKIN-1BETA; LUNG; MICE; MICE, INBRED C3H; MICE, INBRED C57BL; MICE, KNOCKOUT; MOLECULAR WEIGHT; PULMONARY ALVEOLI; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 4;

EID: 77954477105     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1000009     Document Type: Article

References (36)

1. O'Neill, L. A. 2008. The interleukin-1 receptor/Toll-like receptor superfamily: 10 years of progress. Immunol. Rev. 226: 10-18.
2. Miyake, K. 2007. Innate immune sensing of pathogens and danger signals by cell surface Toll-like receptors. Semin. Immunol. 19: 3-10.
3. Termeer, C., F. Benedix, J. Sleeman, C. Fieber, U. Voith, T. Ahrens, K. Miyake, M. Freudenberg, C. Galanos, and J. C. Simon. 2002. Oligosaccharides of Hyaluronan activate dendritic cells via toll-like receptor 4. J. Exp. Med. 195: 99-111.
4. Taylor, K. R., J. M. Trowbridge, J. A. Rudisill, C. C. Termeer, J. C. Simon, and R. L. Gallo. 2004. Hyaluronan fragments stimulate endothelial recognition of injury through TLR4. J. Biol. Chem. 279: 17079-17084.
5. Akira, S., S. Uematsu, and O. Takeuchi. 2006. Pathogen recognition and innate immunity. Cell 124: 783-801.
6. Georgel, P., Z. Jiang, S. Kunz, E. Janssen, J. Mols, K. Hoebe, S. Bahram, M. B. Oldstone, and B. Beutler. 2007. Vesicular stomatitis virus glycoprotein G activates a specific antiviral Toll-like receptor 4-dependent pathway. Virology 362: 304-313.
7. Dinarello, C. A. 1996. Biologic basis for interleukin-1 in disease. Blood 87: 2095-2147.
8. Lee, Y. M., B. M. Hybertson, H. G. Cho, L. S. Terada, O. Cho, A. J. Repine, and J. E. Repine. 2000. Platelet-activating factor contributes to acute lung leak in rats given interleukin-1 intratracheally. Am. J. Physiol. Lung Cell Mol. Physiol. 279: L75-L80.
9. Gasse, P., C. Mary, I. Guenon, N. Noulin, S. Charron, S. Schnyder-Candrian, B. Schnyder, S. Akira, V. F. Quesniaux, V. Lagente, et al. 2007. IL-1R1/MyD88 signaling and the inflammasome are essential in pulmonary inflammation and fibrosis in mice. J. Clin. Invest. 117: 3786-3799.
10. Gasse, P., N. Riteau, S. Charron, S. Girre, L. Fick, V. Pétrilli, J. Tschopp, V. Lagente, V. F. Quesniaux, B. Ryffel, and I. Couillin. 2009. Uric acid is a danger signal activating NALP3 inflammasome in lung injury inflammation and fibrosis. Am. J. Respir. Crit. Care Med. 179: 903-913.
11. Fraser, J. R., T. C. Laurent, and U. B. Laurent. 1997. Hyaluronan: its nature, distribution, functions and turnover. J. Intern. Med. 242: 27-33.
12. Jiang, D., J. Liang, J. Fan, S. Yu, S. Chen, Y. Luo, G. D. Prestwich, M. M. Mascarenhas, H. G. Garg, D. A. Quinn, et al. 2005. Regulation of lung injury and repair by Toll-like receptors and hyaluronan. Nat. Med. 11: 1173-1179.
13. Hällgren, R., T. Samuelsson, T. C. Laurent, and J. Modig. 1989. Accumulation of hyaluronan (hyaluronic acid) in the lung in adult respiratory distress syndrome. Am. Rev. Respir. Dis. 139: 682-687.
14. Scheibner, K. A., M. A. Lutz, S. Boodoo, M. J. Fenton, J. D. Powell, and M. R. Horton. 2006. Hyaluronan fragments act as an endogenous danger signal by engaging TLR2. J. Immunol. 177: 1272-1281.
15. Noble, P. W., F. R. Lake, P. M. Henson, and D. W. Riches. 1993. Hyaluronate activation of CD44 induces insulin-like growth factor-1 expression by a tumor necrosis factor-alpha-dependent mechanism in murine macrophages. J. Clin. Invest. 91: 2368-2377.
16. Hoshino, K., O. Takeuchi, T. Kawai, H. Sanjo, T. Ogawa, Y. Takeda, K. Takeda, and S. Akira. 1999. Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product. J. Immunol. 162: 3749-3752.
17. Adachi, O., T. Kawai, K. Takeda, M. Matsumoto, H. Tsutsui, M. Sakagami, K. Nakanishi, and S. Akira. 1998. Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function. Immunity 9: 143-150.
18. Sato, M., H. Suemori, N. Hata, M. Asagiri, K. Ogasawara, K. Nakao, T. Nakaya, M. Katsuki, S. Noguchi, N. Tanaka, and T. Taniguchi. 2000. Distinct and essential roles of transcription factors IRF-3 and IRF-7 in response to viruses for IFN-alpha/beta gene induction. Immunity 13: 539-548.
19. Yamamoto, M., S. Sato, H. Hemmi, K. Hoshino, T. Kaisho, H. Sanjo, O. Takeuchi, M. Sugiyama, M. Okabe, K. Takeda, and S. Akira. 2003. Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway. Science 301: 640-643. (Pubitemid 36927946)
20. Yamamoto, M., S. Sato, H. Hemmi, S. Uematsu, K. Hoshino, T. Kaisho, O. Takeuchi, K. Takeda, and S. Akira. 2003. TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway. Nat. Immunol. 4: 1144-1150.
21. Mummert, M. E., M. Mohamadzadeh, D. I. Mummert, N. Mizumoto, and A. Takashima. 2000. Development of a peptide inhibitor of hyaluronan-mediated leukocyte trafficking. J. Exp. Med. 192: 769-779.
22. Matute-Bello, G., R. K. Winn, M. Jonas, E. Y. Chi, T. R. Martin, and W. C. Liles. 2001. Fas (CD95) induces alveolar epithelial cell apoptosis in vivo: implications for acute pulmonary inflammation. Am. J. Pathol. 158: 153-161.
23. Poltorak, A., X. He, I. Smirnova, M. Y. Liu, C. Van Huffel, X. Du, D. Birdwell, E. Alejos, M. Silva, C. Galanos, et al. 1998. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 282: 2085-2088.
24. Rubenfeld, G. D., E. Caldwell, E. Peabody, J. Weaver, D. P. Martin, M. Neff, E. J. Stern, and L. D. Hudson. 2005. Incidence and outcomes of acute lung injury. N. Engl. J. Med. 353: 1685-1693.
25. Kawai, T., and S. Akira. 2005. Pathogen recognition with Toll-like receptors. Curr. Opin. Immunol. 17: 338-344.
26. Kawai, T., O. Adachi, T. Ogawa, K. Takeda, and S. Akira. 1999. Unresponsiveness of MyD88-deficient mice to endotoxin. Immunity 11: 115-122.
27. Miller, L. C., E. A. Lynch, S. Isa, J. W. Logan, C. A. Dinarello, and A. C. Steere. 1993. Balance of synovial fluid IL-1 beta and IL-1 receptor antagonist and recovery from Lyme arthritis. Lancet 341: 146-148.
28. Nettelbladt, O., J. Bergh, M. Schenholm, A. Tengblad, and R. Hällgren. 1989. Accumulation of hyaluronic acid in the alveolar interstitial tissue in bleomycin-induced alveolitis. Am. Rev. Respir. Dis. 139: 759-762.
29. Teder, P., R. W. Vandivier, D. Jiang, J. Liang, L. Cohn, E. Puré, P. M. Henson, and P. W. Noble. 2002. Resolution of lung inflammation by CD44. Science 296: 155-158.
30. Nick, J. A., S. K. Young, K. K. Brown, N. J. Avdi, P. G. Arndt, B. T. Suratt, M. S. Janes, P. M. Henson, and G. S. Worthen. 2000. Role of p38 mitogen-activated protein kinase in a murine model of pulmonary inflammation. J. Immunol. 164: 2151-2159.
31. Hiro, D., A. Ito, K. Matsuta, and Y. Mori. 1986. Hyaluronic acid is an endogenous inducer of interleukin-1 production by human monocytes and rabbit macrophages. Biochem. Biophys. Res. Commun. 140: 715-722.
32. Arend, W. P. 2002. The balance between IL-1 and IL-1Ra in disease. Cytokine Growth Factor Rev. 13: 323-340.
33. Taylor, K. R., K. Yamasaki, K. A. Radek, A. Di Nardo, H. Goodarzi, D. Golenbock, B. Beutler, and R. L. Gallo. 2007. Recognition of hyaluronan released in sterile injury involves a unique receptor complex dependent on Toll-like receptor 4, CD44, and MD-2. J. Biol. Chem. 282: 18265-18275.
34. Thorn, J. 2001. The inflammatory response in humans after inhalation of bacterial endotoxin: a review. Inflamm. Res. 50: 254-261.
35. Leon, C. G., R. Tory, J. Jia, O. Sivak, and K. M. Wasan. 2008. Discovery and development of toll-like receptor 4 (TLR4) antagonists: a new paradigm for treating sepsis and other diseases. Pharm. Res. 25: 1751-1761.
36. Ware, L. B., and M. A. Matthay. 2000. The acute respiratory distress syndrome. N. Engl. J. Med. 342: 1334-1349.