Hirsutism, virilism, polycystic ovarian disease, and the steroid-gonadotropin-feedback system: A career retrospective

American Journal of Physiology - Endocrinology and Metabolism

Volumn 302, Issue 1, 2012, Pages

  Mahesh, Virendra B ^a  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

Androgens; Estrogens; Progesterone

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; FOLLITROPIN; GLUTAMIC ACID; GONADORELIN; LUTEINIZING HORMONE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 1; NITRIC OXIDE; PEPTIDASE; PROGESTERONE;

ANDROGEN RELEASE; ARTICLE; ENZYME INHIBITION; ENZYME REGULATION; FEEDBACK SYSTEM; FOLLITROPIN RELEASE; GONADAL DISEASE; GONADORELIN RELEASE; HIRSUTISM; HORMONE ACTION; HORMONE SYNTHESIS; HUMAN; HYPOTHALAMUS; LUTEINIZING HORMONE RELEASE; MENSTRUAL CYCLE; NERVE CELL; NEUROPROTECTION; NONHUMAN; OVARY POLYCYSTIC DISEASE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PUBERTY;

ANDROGENS; ANIMALS; ASTROCYTES; ESTROGENS; EXCITATORY AMINO ACIDS; FEEDBACK, PHYSIOLOGICAL; FEMALE; FOLLICLE STIMULATING HORMONE; GONADOTROPINS; HIRSUTISM; HORMONE REPLACEMENT THERAPY; HORMONES; HUMANS; HYPOTHALAMUS; LUTEINIZING HORMONE; OVULATION INDUCTION; POLYCYSTIC OVARY SYNDROME; PROGESTERONE; VIRILISM;

EID: 83455198428     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00488.2011     Document Type: Article

References (225)

1. Aguan K, Mahesh VB, Ping L, Bhat G, Brann DW. Evidence for a physiological role for nitric oxide in the regulation of the LH surge: effect of central administration of antisense oligonucleotides to nitric oxide synthase. Neuroendocrinology 64: 449-455, 1996.
2. Bagnell CA, Mills TM, Costoff A, Mahesh VB. A model for the study of androgen effects on follicular atresia and ovulation. Biol Reprod 27: 903-914, 1982.
3. Bhat G, Mahesh VB, Aguan K, Brann DW. Evidence that brain-nitric oxide synthase is the major nitric oxide synthase isoform in the hypothalamus of the adult female rat and that nitric oxide potently regulates hypothalamic cGMP levels. Neuroendocrinology 64: 93-102, 1996.
4. Bhat GK, Mahesh VB, Lamar CA, Ping L, Aguan K, Brann DW. Histochemical localization of nitric oxide neurons in the hypothalamus: association with gonadotropin-releasing hormone neurons and co-localization with N-methyl-D-aspartate receptors. Neuroendocrinology 62: 187-197, 1995.
5. Bhat GK, Mahesh VB, Ping L, Chorich LP, Wiedmeier V, Brann DW. Opioid-glutamate-nitric oxide connection in the regulation of luteinizing hormone secretion in the rat. Endocrinology 139: 955-960, 1998.
6. Bhat GK, Mahesh VB, Zhen WC, Chorich LP, Zamorano PL, Brann DW. Localization of the N-methyl-D-aspartate R1 receptor subunit in specific anterior pituitary hormone cell types of the female rat. Neuroendocrinology 62: 178-186, 1995.
7. Brann DW, Bhat GK, Lamar CA, Mahesh VB. Gaseous transmitters and neuroendocrine regulation. Neuroendocrinology 65: 385-395, 1997.
8. Brann DW, Chorich LP, Mahesh VB. Effect of progesterone on galanin mRNA levels in the hypothalamus and the pituitary: correlation with the gonadotropin surge. Neuroendocrinology 58: 531-538, 1993.
9. Brann DW, Chorich LP, Zamorano PL, Mahesh VB. Presence of NMDA receptor mRNA in the anterior pituitary of the female rat: steroid modulation and changes during gonadotropin surge induction. Mol Cell Neurosci 4: 571-575, 1993.
10. Brann DW, De Sevilla L, Zamorano PL, Mahesh VB. Regulation of leptin gene expression and secretion by steroid hormones. Steroids 64: 659-663, 1999.
11. Brann DW, Dhandapani K, Wakade C, Mahesh VB, Khan MM. Neurotrophic and neuroprotective actions of estrogen: basic mechanisms and clinical implications. Steroids 72: 381-405, 2007.
12. Brann DW, Greenbaum L, Mahesh Gao X VB. Changes in kininogens and kallikrein in the plasma, brain and uterus during pregnancy in the rat. Endocrinology 136: 46-51, 1995.
13. Brann DW, Hendry LB, Mahesh VB. Emerging diversities in the mechanism of action of steroid hormones. J Steroid Biochem Mol Biol 52: 113-133, 1995.
14. Brann DW, Mahesh VB. The role of corticosteroids in reproduction. FASEB J 5: 2691-2698, 1991.
15. Brann DW, Mahesh VB. Detailed examination of the mechanism and site of action of progesterone and corticosteroids in the regulation of gonadotropin secretion: hypothalamic gonadotropin releasing hormone and catecolamine involvement. Biol Reprod 44: 1005-1015, 1991.
16. Brann DW, Mahesh VB. Validation of the mechanisms proposed for the stimulatory and inhibitory effects of progesterone on gonadotropin secretion in the estrogen-primed rat. A possible role for adrenal steroids. Steroids 56: 103-111, 1991.
17. Brann DW, Mahesh VB. Regulation of gonadotropin secretion by steroid hormones. Front Neuroendocrinol 12: 165-207, 1991.
18. Brann DW, Mahesh VB. Endogenous excitatory amino acid regulation of the progesterone-induced LH and FSH surge in estrogen-primed ovariectomized rats. Neuroendocrinology 53: 107-110, 1991.
19. Brann DW, Mahesh VB. Endogenous excitatory amino acid involvement in the preovulatory and steroid-induced surge of gonadotropins in the female rat. Endocrinology 128: 1541-1547, 1991.
20. Brann DW, Mahesh VB. Excitatory amino acid regulation of gonadotropin secretion: modulation by steroid hormones. J Steroid Biochem Mol Biol 41: 847-850, 1992.
21. Brann DW, Mahesh VB. Excitatory amino acid neurotransmission: evidence for a role in neuroendocrine regulation. Trends Endocrinol Metab 3: 120-124, 1992.
22. Brann DW, Mahesh VB. Excitatory amino acids: function and significance in reproduction and neuroendocrine regulation. Front Neuroendocrinol 15: 3-49, 1994.
23. Brann DW, Mahesh VB. Glutamate: a major neuroendocrine excitatory signal mediating steroid effects on gonadotropin secretion. J Steroid Biochem Mol Biol 53: 325-329, 1995.
24. Brann DW, Mahesh VB. Excitatory amino acids: evidence for a role in the control of reproduction and anterior pituitary hormone secretion. Endoc Rev 18: 678-700, 1997.
25. Brann DW, Mahesh VB. The aging reproductive neuroendocrine axis. Steroids 70: 273-283, 2005.
26. Brann DW, McDonald JK, Putnam CD, Mahesh VB. Regulation of hypothalamic gonadotropin-releasing hormone and neuropeptide Y concentrations by progesterone and corticosteroids in immature rats: correlation with Luteinizing hormone and follicle-stimulating hormone release. Neuroendocrinology 54: 425-432, 1991.
27. Brann DW, O'Conner JL, Wade M, Mahesh VB. LH and FSH subunit mRNA concentrations during the progesterone-induced gonadotropin surge in ovariectomized estrogen-primed immature rats. Mol Cell Neurosci 3: 171-178, 1992.
28. Brann DW, O'Conner JL, Wade MF, Zamorano PL, Mahesh VB. Regulation of anterior pituitary gonadotropin subunit mRNA levels during the preovulatory gonadotropin surge: a physiological role of progesterone in regulating LH-β and FSH-β mRNA levels. J Steroid Biochem Mol Biol 46: 427-437, 1993.
29. Brann DW, Ping L, Mahesh VB. Possible role of non-NMDA receptormediated neurotransmission in steroid-induced and preovulatory gonadotropin surges in the rat. Mol Cell Neurosci 4: 292-297, 1993.
30. Brann DW, Putnam CD, Mahesh VB. Antagonism of estrogen-induced prolactin release by dihydrotesterone. Biol Reprod 40: 1201-1208, 1989.
31. Brann DW, Putnam CD, Mahesh VB. Dose-related effects of progesterone and 5alpha-dihydroprogesterone upon estrogen-induced prolactin release. J Neuroendocrinol 2: 341-345, 1990.
32. Brann DW, Putnam CD, Mahesh VB. Similarities and differences in progesterone and androgens in modulation of LH, FSH and PRL release: unexpected properties of flutamide. J Steroid Biochem Mol Biol 36: 287-294, 1990.
33. Brann DW, Putnam CD, Mahesh VB. GABAA receptor mediate 3α-hydroxy-5α-pregnan-20-one induced gonadotropin secretion. Endocrinology 126: 1854-1859, 1990.
34. Brann DW, Putnam CD, Mahesh VB. Dose-related effects of progesterone and 5alpha-dihydroprogesterone upon estrogen-induced prolactin release. J Neuroendocrinol 2: 341-345, 1990.
35. Brann DW, Putnam CD, Mahesh VB. Corticosteroid regulation of gonadotropin secretion and induction of ovulation in the rat. Proc Soc Expt Biol Med 193: 176-180, 1990.
36. Brann DW, Putnam CD, Mahesh VB. Corticosteroid regulation of gonadotropin and prolactin secretion in the rat. Endocrinology 126: 159-166, 1990.
37. Brann DW, Putnam-Roberts CD, Mahesh VB. Progesterone and corticosteroid regulation of hypothalamic and pituitary opioid content during LH surge induction. Mol Cell Neurosci 3: 191-198, 1992.
38. Brann DW, Rao IM, Mahesh VB. Antagonism of estrogen-induced prolactin release by progesterone. Biol Reprod 39: 1067-1073, 1988.
39. Brann DW, Unda R, Mahesh VB. Role of progesterone receptor in restrained glutamic acid decarboxylase gene expression in the hypothalamus during the preovultory luteinizing hormone surge. Neuroendocrinology 76: 283-289, 2002.
40. Brann DW, Wade MF, Dhandapani KM, Mahesh VB, Buchanan CD. Leptin and reproduction. Steroids 67: 95-104, 2002.
41. Brann DW, Zamorano PL, Chorich LP, Mahesh VB. Steroid hormone effects on NMDA receptor binding and NMDA receptor mRNA levels in the hypothalamus and cerebral cortex of the adult rat. Neuroendocrinology 58: 666-672, 1993.
42. Brann DW, Zamorano PL, DeSevilla L, Mahesh VB. Expression of glutamate receptor subunits in the hypothalamus of the female rat during the afternoon of the proestrous LH surge and effects of antiprogestin treatment and aging. Neuroendocrinology 81: 120-128, 2005.
43. Brann DW, Zamorano PL, Ping L, Mahesh VB. Role of excitatory amino acid neurotransmission during puberty in the female rat. Mol Cell Neurosci 4: 107-112, 1993.
44. Brann DW, Zamorano PL, Putnam-Roberts CD, Mahesh VB. Gamma aminobutyric acid-opioid interactions in the regulation of gonadotropin secretion in the immature female rat. Neuroendocrinology 56: 445-452, 1992.
45. Brann DW, Zhang QG, Wang RM, Mahesh VB, Vadlamudi RK. PELP1-a novel estrogen receptor-interacting protein in the brain. Mol Cell Endocrinol 290: 2-7, 2008.
46. Bransome ED Jr, Hendry LB, Muldoon TG, Mahesh VB, Hutson MS, Campbell LK. Apparent stereochemical complementarity of estrogens and helical cavities between DNA base pairs: implications for the mechanism of action of steroids. J Theoret Biol 112: 97-108, 1985.
47. Braselton WE, Lin TJ, Mills TM, Ellegood JO, Mahesh VB. Identification and measurement by gas chromatography-mass spectrometry of Norethindrone and metabolites in human urine and blood. J Steroid Biochem Mol Biol 8: 9-18, 1977.
48. Braselton WE Jr, Lin TJ, Ellegood JO, Mills TM, Mahesh VB. Accumulation of Norethindrone and idividual metabolites in human plasma during short- and long-term administration of a contraceptive dosage. Am J Obstet Gynecol 133: 154-160, 1979.
49. Buchanan CD, Mahesh VB, Brann DW. Estrogen-astrocyte-luteinizing hormone releasing hormone signaling: a role for transforming growth factor-beta-1. Biol Reprod 62: 1710-1721, 2000.
50. Buchanan CL, Mahesh VB, Zamorano PL, Brann DW. Central nervous system effects of leptin. Trends Endocrinol Metab 9: 146-150, 1998.
51. Bush IE. The 11-oxygen function in steroid metabolism. Experientia 12: 325-331, 1956.
52. Bush IE, Mahesh VB. Metabolism of 11-oxygenated steroids. 1. Influence of the A/B ring junction on the reduction of 11-oxo groups. Biochem J 71: 705-717, 1959.
53. Bush IE, Mahesh VB. Metabolism of 11-oxygenated steroids. 2. 2-Methyl steroids. Biochem J 71: 718-742, 1959.
54. Bush IE, Mahesh VB. Adrenocortical hyperfunction with sudden onset of hirsutism. J Endocrinol 18: 1-25, 1959.
55. Bush IE, Mahesh VB. Metabolism of 11-oxygenated steroids. 3. Some 1-dehydro and 9alpha-fluoro steroids. Biochem J 93: 236-255, 1964.
56. Byrd JR, Mahesh VB, Greenblatt RB. Chromosomal studies in the Stein-Leventhal Syndrome. J Clin Endocrinol Metab 24: 939-940, 1964.
57. Calderon JJ, Muldoon TG, Mahesh VB. Receptor mediated interrelationship between progesterone and estradiol action on the anterior pituitary- hypothalamic axis of the ovariectomized Immature rat. Endocrinology 120: 2428-2435, 1987.
58. Cannady WE, Brann DW, Mahesh VB. The potential role of periovarian fat and leptin the initiation of puberty. Int J Obes Relat Metab Dis Suppl 12: S146-S147, 2000.
59. Chakravorty A, Mahesh VB, Mills TM. Regulation of follicular development by diethylstilboestrol in the immature rat ovary. J Reprod Fertil 92: 307-321, 1991.
60. Chakravorty A, Mahesh VB, Mills TM. Inhibition of proliferative potential of specific-sized follicles in the rat ovary by diethylstilboestrol. J Reprod Fertil 92: 323-332, 1991.
61. Chorich L, Rosser M, Howard E, Zamorano P, Mahesh VB. Rat anterior pituitary estrogen receptor mRNA levels after estrogen and progesterone treatment. Mol Cell Neurosci 3: 487-496, 1992.
62. Conway BA, Mahesh VB, Mills TM. Effect of dihydrotestosterone on the growth and function of ovarian follicles in intact immature female rats primed with PMSG. J Reprod Fertil 90: 267-277, 1990.
63. Costoff A, Eldridge JC, Mahesh VB. Pituitary ultrastructure and serum gonadotropin levels in the PMS-primed immature rat. Cell Tissue Res 151: 79-92, 1974.
64. Costoff A, Knudsen JF, Mahesh VB. Correlation of serum gonadotropins, ovarian and uterine histology in immature and prepubertal rats. Anat Rec 180: 497-507, 1974.
65. Dalla Pria S, Greenblatt RB, Mahesh VB. An antiandrogen in acne and idiopathic hirsutism. Invest Dermatol 52: 348-350, 1969.
66. Dhandapani KM, Hadman M, De Seville L, Wade MF, Mahesh VB, Brann DW. Astrocyte protection of neurons: role of transforming growth factor-beta signaling via c-Jun-AP-1 protective pathway. J Biol Chem 278: 44329-44339, 2003.
67. Dhandapani KM, Wade MF, Mahesh VB, Brann DW. Basic fibroblast growth factor induces TGF-beta release in an isoform and gliomaspecific manner. Neuroreport 13: 239-41, 2002.
68. Dhandapani KM, Wade MF, Mahesh VB, Brann DW. Astrocyte derived transforming growth factor-β mediates the neuroprotective effects of 17β-estradiol: involvement of non-classical genomic signaling pathways. Endocrinology 146: 2749-2759, 2005.
69. Dhandapani KM, Wade MF, Mahesh VB, Brann DW. Neuroprotection by stem cell factor in rat cortical neurons involves Akt and NFκB. J Neurochem 95: 9-19, 2005.
70. Dulin WE, Bowman BJ, Stafford RO. Effects of 2-methylation on glucocorticoid activity of various C-21. Proc Soc Exp Biol Med 94: 303-305, 1957.
71. El Ayat AAB, Mahesh VB. Stimulation of 17β-hydroxy steroid dehydrogenase in the rat anterior pituitary gland by progesterone. J Steroid Biochem Mol Biol 20: 1141-1145, 1984.
72. Eldridge JC, Dmowski WP, Mahesh VB. Effects of castration of immature rats on serum FSH and LH, and of various steroid treatments after castration. Biol Reprod 10: 438-446, 1974.
73. Eldridge JC, Mahesh VB. The pituitary-gonadal axis before puberty: evaluation of testicular steroids in the male rat. Biol Reprod 11: 385-397, 1974.
74. Eldridge JC, McPherson JC, Mahesh VB. Maturation of the negative feedback control of gonadotropin secretion in the female rat. Endocrinology 94: 1536-1540, 1974.
75. Fuentes MA, Muldoon TG, Mahesh VB. Inhibitory effect of progesterone on occupied estrogen receptors of anterior pituitary and uterus in adult rats. J Neuroendocrinol 2: 517-522, 1990.
76. Fuentes MA, Muldoon TG, Mahesh VB. Role of 17β-hydroxysteroid dehydrogenase in the modulation of nuclear estradiol receptor binding by progesterone in the rat anterior pituitary gland and the uterus. J Steroid Biochem Mol Biol 37: 57-63, 1990.
77. Fuentes MA, Muldoon TG, Mahesh VB. Inhibitory effect of 5-alphadihydroprogesterone on nuclear estrogen receptor binding of the anterior pituitary and uterus in the rat. Neuroendocrinology 52: 213-220, 1990.
78. Gambrell RD, Greenblatt RB, Mahesh VB. Serum gonadotropins levels and ancillary studies in Stein-Leventhal syndrome treated with Clomiphene Citrate. Obstet Gynecol 38: 850-862, 1971.
79. Gambrell RD, Greenblatt RB, Mahesh VB. Serum gonadotropins in a variety of anovulatory women treated with Clomiphene Citrate. Int J Gynecol Obstet 11: 90-95, 1973.
80. Gambrell RD, Greenblatt RB, Mahesh VB. Inappropriate secretion of LH in the Stein-Leventhal syndrome. Obstet Gynecol 42: 429-440, 1973.
81. Gao X, Greenbaum L, Mahesh VB, Brann DW. Characterization of the kinin system in the ovary during ovulation in the rat. Biol Reprod 47: 945-951, 1992.
82. Glenn EM, Stafford RO, Lyster SC, Bowman BJ. Relationship between biological activity of hydrocortisone analogues and their rates of inactivation by rat liver enzymes. Endocrinology 61: 128-142, 1957.
83. Goldman BD, Kamberi IA, Siiteri K, Porter JC. Temporal relationship of progesterone secretion, LH release and ovulation in rats. Endocrinology 85: 1137-1143, 1979.
84. Goldman BD, Mahesh VB. Fluctuations in pituitary FSH during the ovulatory cycle in the rat and a possible role of FSH in the induction of ovulation. Endocrinology 83: 97-106, 1968.
85. Goldman BD, Mahesh VB. A possible role of acute FSH-release in ovulation in the hamster, as demonstrated by utilization of antibodies to LH and FSH. Endocrinology 84: 236-243, 1969.
86. Goldman BD, Mahesh VB, Porter JC. The role of the ovary in control of cyclic LH release in the hamster, Mesocricetus auratus. Biol Reprod 4: 57-65, 1971.
87. Greeley GH Jr, Allen MB, Mahesh VB. FSH and LH rsponse in the rat after intravenous, intracarotid or subcutaneous administration of LH-RH. Proc Soc Expl Biol Med 147: 859-862, 1974.
88. Greeley GH Jr, Allen MB, Mahesh VB. Potentiation of luteinizing hormone release by estradiol at the level of the pituitary. Neuroendocrinology 18: 233-241, 1975.
89. Greeley GH Jr, Muldoon TG, Mahesh VB. Correlative aspects of luteinizing hormone-releasing hormone sensitivity and cytoplasmic estrogen receptor concentration in the anterior pituitary and hypothalmus of the cycling rat. Biol Reprod 13: 505-512, 1975.
90. Greenblatt RB, Byrd JR, McDonough PG, Mahesh VB. The spectrum of gonadal dysgenesis: a clinical, cytogenetic and pathologic study. Am J Obstet Gynecol 98: 151-172, 1967.
91. Greenblatt RB, Dominquez H, Mahesh VB, Demos RJ. Gondal dysgenesis intersex with X0/XY mosaicism. J Am Med Assoc 188: 221-224, 1964.
92. Greenblatt RB, Faucher G, Mahesh VB, Lunenfeld B, Rabau E, David A, Insler V. Ovulation and pregnancy in the Chiari-Frommel syndrome: report of 10 cases. Fertil Steril 17: 742-756, 1966.
93. Greenblatt RB, Mahesh VB, Gambrell RD. Arrhenoblastoma-three case reports. Obstet Gynecol 39: 567-576, 1972.
94. Greenblatt RB, Roy S, Mahesh VB, Barfield WE, Jungck EC. Induction of ovulation. Am J Obstet Gynecol 84: 900-912, 1962.
95. Greenblatt RB, Zarate A, Mahesh VB. Methods available for the induction of ovulation. Proc VI Pan American Cong Endocrinol Excerpta Med Int Congr Ser 112: 129-133, 1965.
96. Hendry LB, Bransome ED, Lehner AF, Muldoon TG, Hutson MS, Mahesh VB. The stereochemical complementarity of DNA and reproductive steroid hormones correlates with biological activity. J Steroid Biochem Mol Biol 24: 843-852, 1986.
97. Hendry LB, Bransome ED, Mahesh VB. The ligand insertion hypothesis in the genomic action of steroid hormones. J Steroid Biochem Mol Biol 65: 75-89, 1998.
98. Hendry LB, Mahesh VB. Stereochemical complementarity of progesterone and cavities between base pairs in partially unwound double stranded DNA using computer modeling and energy calculations to determine degree of fit. J Steroid Biochem Mol Biol 39: 133-146, 1991.
99. Hendry LB, Mahesh VB. A putative step in steroid hormone action involves insertion of steroid ligands into DNA facilitated by receptor proteins. J Steroid Biochem Mol Biol 55: 173-183, 1995.
100. Herbison AE, Robinson JE, Skinner DC. Distribution of estrogenimmunoreactive cells in the preoptic area of the ewe: co-localization with glutamic acid decarboxylase but not luteinizing hormone-releasing hormone. Neuroendocrinology 57: 751-759, 1993.
101. Hoff JD, Quigley ME, Yen SSC. Hormonal dynamics in mid cycle: a reevaluation. J Clin Endocrinol Metab 57: 792-796, 1983.
102. Jensen EV. On the mechanism of estrogen action. Perspect Biol Med 6: 47-59, 1962.
103. Jungck EC, Roy S, Greenblatt RB, Mahesh VB. Effect of Clomiphene Citrate on spermatogenesis in the human. Fertil Steril 15: 40-43, 1964.
104. Khan MM, De Sevilla L, Mahesh VB, Brann DW. Enhanced glutamatergic and decreased GABAergic synaptic appositions to GnRH neurons on proestrus in the rat: modulatory effect of aging. PLoS One 5: e10172, 2010.
105. Khan MM, Hadman M, Wakade C, DeSevilla L, Dhandapani KM, Mahesh VB, Vadlamudi RK, Brann DW. Cloning, expression and localization of MNAR/PELP1 in rodent brain: colocalization in estrogen receptor-α but not in gonadotropin-releasing hormone-positive neurons. Endocrinology 146: 5215-5227, 2005.
106. Knudsen JF, Costoff A, Mahesh VB. Dehydroepiandrosterone-induced polycystic ovaries and acyclicity in the rat. Fertil Steril 26: 807-817, 1975.
107. Knudsen JF, Mahesh VB. Initiation of precocious sexual maturation in the immature rat treated with dehydroepiandrosterone. Endocrinology 97: 458-468, 1975.
108. Lamar CA, Bhat GK, Mahesh VB, Brann DW. Evidence that neuronal nitric oxide synthase but not heme oxygenase increases in the hypothalamus on proestrus afternoon. Neuroendocrinology 70: 360-367, 1999.
109. Lamar CA, Mahesh VB, Brann DW. Regulation of gonadotropinreleasing hormone (GnRH) secretion by heme molecules: a regulatory role for carbon monoxide? Endocrinology 137: 790-793, 1996.
110. Legan SJ, Karsch FJ. A daily signal for LH surge in the rat. Endocrinology 96: 57-62, 1975.
111. Lehman MN, Karsch FJ. Do gonadotropin-releasing hormone, tyrosine hydroxylase, and beta endorphin immunoreacive neurons contain estrogen receptors? A double-label immunocytochemical study in the Suffolk ewe. Endocrinology 133: 887-895, 1993.
112. Lesoon LA, Mahesh VB. Stimulatory and inhibitory effects of progesterone on FSH secretion by the anterior pituitary. J Steroid Biochem Mol Biol 42: 479-491, 1992.
113. Mahesh VB. The dynamic interaction between steroids and gonadotropins in the mammalian ovulatory cycle. Neurosci Biobehav Rev 9: 245-260, 1985.
114. Mahesh VB, Brann DW. Interaction between ovarian and adrenal steroids in the regulation of gonadotropin secretion. J Steroid Biochem Mol Biol 41: 495-513, 1992.
115. Mahesh VB, Brann DW. Neuroendocrine mechanisms underlying the control of gonadotropin secretion by steroids. Steroids 63: 252-256, 1998.
116. Mahesh VB, Dhandapani KM, Brann DW. Role of astrocytes in reproduction and neuroprotection. Mol Cell Endocrinol 246: 1-9, 2006.
117. Mahesh VB, Ewing DE, Hendry LB. Assessing activity and toxicity of drugs in silico based on DNA structure. Med Chem Res 17: 159-168, 2008.
118. Mahesh VB, Ewing DE, Sidell N, Bransome ED Jr, Hendry LB. New technology for drug discovery based upon insertion of ligands into gene sequences by nuclear receptor proteins. Med Chem Res 13: 497-508, 2004.
119. Mahesh VB, Greenblatt RB. Physiology and pathogenesis of the Stein-Leventhal syndrome. Nature 191: 888-890, 1961.
120. Mahesh VB, Greenblatt RB. Isolation of dehydroepiandrosterone and 17α-hydroxy-delta-5-pregnenolone from the polycystic ovaries of the Stein-Leventhal syndrome. J Clin Endocrinol Metab 22: 441-448, 1962.
121. Mahesh VB, Greenblatt RB. The in vivo conversion of dehydroepiandrosterone and androstenedione to testosterone in the human. Acta Endocrinol 41: 400-406, 1962.
122. Mahesh VB, Greenblatt RB. Steroid secretions of the normal and polycystic ovary. Recent Prog Horm Res 20: 341-394, 1964.
123. Mahesh VB, Greenblatt RB. Urinary steroid excretion patterns in hirsutism. II. Effect of ovarian stimulation with human pituitary FSH on urinary 17-ketosteroids. J Clin Endocrinol Metab 24: 1293-1302, 1964.
124. Mahesh VB, Greenblatt RB. Hormonal studies in females with virilizing adrenal tumors. Res Steroids 3: 221-231, 1967.
125. Mahesh VB, Greenblatt RB, Aydar CK, Roy S. Secretion of androgens by the polycystic ovary and its significance. Fertil Steril 13: 513-530, 1962.
126. Mahesh VB, Greenblatt RB, Aydar CK, Roy S, Puebla RA, Ellegood JO. Urinary steroid excretion patterns in hirsutism. I. Use of adrenal and ovarian suppression tests in the study of hirsutism. J Clin Endocrinol Metab 24: 1283-1292, 1964.
127. Mahesh VB, Greenblatt RB, Coniff RF. Urinary steroid excretion before and after dexamethasone administration and steroid content of adrenal tissue and venous blood in virilizing adrenal tumors. Am J Obstet Gynecol 100: 1043-1054, 1968.
128. Mahesh VB, Greenblatt RB, Coniff RF. Adrenal hyperplasia-a case report of delayed onset of the congential form or an acquired form. J Clin Endocrinol Metab 28: 619-623, 1968.
129. Mahesh VB, Goldman BD. Secretion of FSH and LH during the ovulatory cycle and their role in the induction of ovulation and corpus luteum function. In: Hormonal Steroids. Excerpta Med Int Congr Ser 219: 662-669, 1972.
130. Mahesh VB, Herrmann W. Isolation of estrone and 11-hydroxy estrone from a feminizing adrenal carcinoma. Steroids 1: 51-61, 1962.
131. Mahesh VB, McDonough PG. Urinary steroid excretion in a hirsute patient with ovarian cortical stromal hyperplasia and endometrial carcinoma. Am J Obstet Gynecol 104: 602-603, 1969.
132. Mahesh VB, McDonough PG, Deleo CA. Endocrine studies in the arrhenoblastoma. Am J Obstet Gynecol 107: 183-187, 1970.
133. Mahesh VB, McDonough PG, Greenblatt RB. Endocrine studies in a patient with virilism, ovarian stromal hyperplasia, and endometrial carcinoma. Obstet Gynecol 30: 584-590, 1967.
134. Mahesh VB, Muldoon TG. Integration of the effects of estradiol and progesterone in the modulation of gonadotropin secretion. J Steroid Biochem Mol Biol 27: 665-675, 1987.
135. Mahesh VB, Nazian SJ. Role of sex steroids in the initiation of puberty. J Steroid Biochem Mol Biol 11: 587-591, 1979.
136. Mahesh VB, Roach LW, Cannady WE, Ogle TF, Brann DW, Bransome ED Jr, Hendry LB. Gene based pharmacophores for drug design. Med Chem Res 10: 440-455, 2001.
137. Mahesh VB, Sidell N, Ewing DE, Bransome ED Jr, Hendry LB. A molecular guidance system based upon target genes, nuclear receptors and ligands applied to drug discovery and prediction of toxicity. Mini- Reviews Med Chem 8: 1252-1264, 2008.
138. Mahesh VB, Toledo SPA, Mattar E. Hormone levels following wedge resection in polycystic ovary syndrome. Obstet Gynecol 51: 64-69, 1978.
139. Mahesh VB, Ulrich F. Distribution of enzyme systems responsible for steroid metabolism in different tissues and subcellular particles. Nature 184, Suppl 15: 1147-1148, 1959.
140. Mahesh VB, Ulrich F. Metabolism of cortisol and cortisone by various tissues and subcellular particles. J Biol Chem 235: 356-360, 1960.
141. Mahesh VB, Zamorano P, De Sevilla L, Lewis D, Brann DW. Characterization of ionotropic glutamate receptors in rat hypothalamus, pituitary and immortalized gonadotropin-releasing hormone (GnRH) neurons (GT1-7 Cells). Neuroendocrinology 69: 397-407, 1999.
142. Mahesh VB, Zarate A, Roper BK, Greenblatt RB. Studies on the action of 17α-methyl-B-nortestosterone as an antiandrogen. Steroids 8: 297-308, 1966.
143. McDonough PC, Ellegood JO, Byrd JR, Mahesh VB. Ovarian and peripheral venous steroids in XY gonadal dysgenesis and gonadoblastoma. Obstet Gynecol 47: 351-355, 1976.
144. McPherson JC III, Costoff A, Eldridge JC, Mahesh VB. Effect of various progestational preparations on gonadotropin secretion in ovariectomized immature female rats. Fertil Steril 25: 1063-1070, 1974.
145. McPherson JC III, Costoff A, Mahesh VB. The pituitary-gonadal axis before puberty: effects of various estrogenic steroids in the ovariectomized rat. Steroids 24: 41-56, 1974.
146. McPherson JC III, Costoff A, Mahesh VB. Influence of estrogenprogesterone combinations on gonadotropin secretion in castrate female rats. Endocrinology 97: 771-779, 1975.
147. McPherson JC III, Costoff A, Mahesh VB. Effects of aging on the hypothalamic-hypophyseal-gonadal axis in female rats. Fertil Steril 28: 1365-1370, 1977.
148. McPherson JC III, Mahesh VB. Dose related effect of a single injection of progesterone on gonadotropin secretion and pituitary sensitivity to LHRH in estrogen-primed castrate female rats. Biol Reprod 20: 763-772, 1979.
149. McPherson JC III, Mahesh VB. Induction of LH and FSH surge in the estrogen-primed castrated male rat by progesterone. Biol Reprod 27: 1222-1229, 1982.
150. Mehta SH, Dhandapani KM, De Seville LM, Webb RC, Mahesh VB, Brann DW. Tamoxifen, a selective estrogen receptor modulator, reduces ischemic damage caused by middle cerebral artery occlusion in the ovariectomized female rat. Neuroendocrinology 77: 44-50, 2003.
151. Mills TM, Lin TJ, Braselton WE Jr, Ellegood JO, Mahesh VB. Metabolism of oral contraceptive drugs. The formation and disappearance of metabolites of Norethindrone and Mestranol after intravenous and oral administration. Am J Obstet Gynecol 126: 987-992, 1976.
152. Mills TM, Lin TJ, Hernandez-Ayup S, Greenblatt RB, Ellegood JO, Mahesh VB. The metabolic clearance rate (MCR) and urinary excretion of oral contraceptive drugs. I. Norethindrone. Am J Obstet Gynecol 120: 764-772, 1974.
153. Mills TM, Lin TJ, Hernandez-Ayup S, Greenblatt RB, Ellegood JO, Mahesh VB. The metabolic clearance rate (MCR) and urinary excretion of oral contraceptive drugs. II. Mestranol. Am J Obstet Gynecol 120: 773-778, 1974.
154. Morris JM, Mahesh VB. Further observations on the syndrome, " Testicular Feminization." Am J Obstet Gynecol 87: 731-745, 1963.
155. Murphy LL, Mahesh VB. Selective release of FSH by 5α-dihydroprogesterone in immature ovariectomized estrogen-primed rats. Biol Reprod 30: 594-602, 1984.
156. Murphy LL, Mahesh VB. Selective release of luteinizing hormone by 3α-hydroxy-5α-pregnan-20-one in immature ovariectomized estrogenprimed rats. Biol Reprod 30: 795-803, 1984.
157. Murphy LL, Mahesh VB. Selective release of FSH and LH by 5α,dihydroprogesterone, and 3α, 5α-tetrahydroprogesterone in pregnant mare's serum gonadotropin-primed immature rats exposed to constant light. Biol Reprod 32: 795-803, 1985.
158. Natrajan PK, Muldoon TG, Greenblatt RB, Mahesh VB. Estradiol and progesterone receptors in estrogen-primed endometrium. Am J Obstet Gynecol 140: 387-392, 1981.
159. Natrajan PK. On estrogen and progesterone receptors of the human endometrium. J Reprod Med 27: 227-230, 1982.
160. Nazian SJ, Mahesh VB. Alterations in end organ responsiveness to testosterone during the sexual maturation of the male rat. Biol Reprod 21: 465-471, 1979.
161. Nazian SJ, Mahesh VB. Sexual maturation of the male rat. Influence of androgens on the pituitary response to single or multiple injections of LH-RH. Neuroendocrinology 29: 313-322, 1979.
162. Nazian SJ, Mahesh VB. Delay in some aspects of the sexual maturation of the male rat induced by androstenedione. Biol Reprod 22: 451-458, 1980.
163. Nazian SJ, Mahesh VB. Hypothalamic, pituitary, testicular, and secondary organ functions and interactions during the sexual maturation of the male rat. Arch Androl 4: 283-303, 1980.
164. Nazian SJ, Mahesh VB. LH-induced testicular steroid secretion after FSH treatment in immature and young adult hypophysectomized male rats. Arch Androl 6: 33-38, 1981.
165. Nequin LG, Alvarez J, Schwartz NB. Measurement of serum steroid and gonadotropin levels and uterine and ovarian variables throughout 4 day and 5 day estrus cycles in the rat. Biol Reprod 20: 659-670, 1979.
166. O'Conner JL, Lapp CA, Mahesh VB. Peptidase activity in the hypothalamus and pituitary of the rat: fluctuations and possible regulatory role of luteinizing hormone releasing hormone-degrading activity during the estrous cycle. Biol Reprod 30: 855-862, 1984.
167. O'Conner JL, Mahesh VB. A possible role for progesterone in the preovulatory gonadotropin surge through modulation of LHRH degrading activity. J Steroid Biochem Mol Biol 29: 257-264, 1988.
168. O'Conner JL, Wade MF, Brann DW, Mahesh VB. Direct anterior pituitary modulation of gonadotropin secretion by neuropeptide Y (NPY): role of gonadal steroids. Neuroendocrinology 58: 129-135, 1993.
169. O'Conner JL, Wade MF, Brann DW, Mahesh VB. Evidence that progesterone modulates anterior pituitary neuropeptide Y levels during the progesterone-induced gonadotropin surge in the estrogen-primed intact immature female rat. J Steroid Biochem Mol Biol 52: 497-504, 1995.
170. O'Conner JL, Wade MF, Edwards DP, Mahesh VB. Progesterone and regulation of the follicle-stimulating hormone (FSH-beta) gene. Steroids 64: 592-597, 1999.
171. O'Conner JL, Wade MF, Prendergast P, Edwards DP, Boonyaratanakornkit V, Mahesh VB. A 361 base pair region of the rat FSH-b promoter contains multiple progesterone receptor binding sequences and confers progesterone responsiveness. Mol Cell Endocrinol 136: 67-78, 1997.
172. Ogle TF, Dai D, George P, Mahesh VB. Stromal cell progesterone and estrogen receptors during proliferation and regression of the decidua basalis in the pregnant rat. Biol Reprod 57: 495-506, 1997.
173. Ogle TF, Da D, George P, Mahesh VB. Regulation of the progesterone receptor and estrogen receptor in decidua basalis by progesterone and estradiol during pregnancy. Biol Reprod 58: 1188-1198, 1998.
174. Ogle TF, Soares MJ, Zhou Y, Chorich L, Mahesh VB. Regulation of the estrogen receptor and estrogen receptor mRNA in rat decidua basalis and placenta during pregnancy. Steroid Biochem (Life Sci Adv) 12: 1-12, 1993.
175. Ondo JG, Pass KA, Baldwin R. The effect of neurally active aminoacids on the pituitary gonadotropin secretion. Neuroendocrinology 21: 79-89, 1976.
176. Parker CR, Bruneteau DW, Greenblatt RB, Mahesh VB. Peripheral, ovarian, and adrenal vein steroids in hirsute women: acute effects of human chorionic gonadotropin and adrenocorticotrophic hormone. Fertil Steril 26: 877-888, 1975.
177. Parker CR, Costoff A, Muldoon TG, Mahesh VB. Actions of pregnant mare serum gonadotropin in the immature female rat: correlative changes in steroids, gonadotropins, and cytoplasmic estradiol receptors of the anterior pituitary and hypothalamus. Endocrinology 98: 129-138, 1976.
178. Parker CR, Mahesh VB. Interrelationship between excessive levels of circulating androgens in blood and ovulatory failure. J Reprod Med 17: 75-90, 1976.
179. Parker CR, Mahesh VB. Hormonal events surrounding the natural onset of puberty in female rats. Biol Reprod 14: 347-353, 1976.
180. Parker CR, Mahesh VB. Dehydroepiandrosterone (DHA) induced precocious ovulation: correlative changes in blood steroids, gonadotropins and cytosol estradiol receptors of anterior pituitary gland and hypothalamus. J Steroid Biochem Mol Biol 8: 173-177, 1977.
181. Parker CR, Servy E, McDonough PG, Mahesh VB. In vivo endocrine studies in adrenal rest tumor of ovary. Obstet Gynecol 44: 327-332, 1974.
182. Peduto JC, Mahesh VB. Effects of progesterone on hypothalamic and plasma LHRH. Neuroendocrinology 40: 238-245, 1985.
183. Peterson RE, Pierce CE, Wyngaarden JB, Bunim JJ, Brodie BB. The physiological disposition and metabolic fate of cortisone in man. J Clin Invest 36: 1301-1312, 1957.
184. Ping L, Mahesh VB, Bhat GK, Brann DW. Regulation of gonadotropin- releasing hormone and luteinizing hormone secretion by AMPA receptors. Neuroendocrinology 66: 246-253, 1997.
185. Ping L, Mahesh VB, Brann DW. A physiological role for NMDA and non-NMDA receptors in pulsatile gonadotropin secretion in the adult female rat. Endocrinology 135: 113-118, 1993.
186. Ping L, Mahesh VB, Brann DW. Effect of NMDA and non-NMDA recptor antagonists on pulsatile luteinizing hormone secretion in the adult male rat. Neuroendocrinology 61: 226-234, 1995.
187. Ping L, Mahesh VB, Wiedmeier VT, Brann DW. Release of glutamate and aspartate from the preoptic area during the progesterone-induced LH surge: in vivo microdialysis studies. Neuroendocrinology 59: 318-324, 1994.
188. Piva F, Maggi R, Limonta P, Motta M, Martini L. Effect of naloxone on luteinizing hormone, follicle stimulating hormone and prolactin sevretion in the different phases of the estrous cycle. Endocrinology 117: 766-772, 1985.
189. Putnam CD, Brann DW, Kolbeck RC, Mahesh VB. Inhibition of uterine contractility by progesterone and progesterone metabolites: mediation by progesterone and gamma amino butyric acid A receptor systems. Biol Reprod 45: 246-272, 1991.
190. Putnam CD, Brann DW, Mahesh VB. Acute activation of the ACTHadrenal axis: effect upon gonadotropin and prolactin secretion in the female rat. Endocrinology 128: 2558-2566, 1991.
191. Putnam-Roberts CD, Brann DW, Mahesh VB. Role of 5α-reduction in progesterone's ability to release FSH in estrogen-primed ovariectomized rats. J Steroid Biochem Mol Biol 42: 875-882, 1992.
192. Rao IM, Allsbrook WC Jr, Conway BA, Martinez JE, Beck JR, Pantazis CG, Mills TM, Anderson E, Mahesh VB. Flow cytometric analysis of granulosa cells from developing rat follicles. J Reprod Fertil 91: 521-530, 1991.
193. Rao IM, Mahesh VB. Role of progesterone in the modulation of the preovulatory surge of gonadotropins and ovulation in the pregnant mare's serum gonadotropin-primed immature rat and the adult rat. Biol Reprod 35: 1154-1161, 1986.
194. Rao IM, Mills TM, Anderson E, Mahesh VB. Heterogeneity in granulosa cells of developing rat follicles. Anat Rec 229: 177-185, 1991.
195. Rapkin AJ, Morgan M, Goldman L, Brann DW, Simone D, Mahesh VB. Progesterone metabolite allopregnanolone in women with premenstrual syndrome. Obstet Gynecol 90: 709-714, 1997.
196. Rapkin AJ, Shoupe D, Reading A, Bohn Y, Brann DW, Mahesh VB. Decreased central opioid activity in premenstrual syndrome: luteinizing hormone response to naloxone. J Soc Gynecol Invest 3: 93-98, 1996.
197. Rosser M, Chorich L, Howard E, Zamorano P, Mahesh VB. Changes in rat uterine estrogen receptor mRNA levels during estrogen and progesterone induced estrogen receptor depletion and subsequent replenishment. Biol Reprod 48: 89-98, 1993.
198. Roy S, Greenblatt RB, Mahesh VB. Effects of clomiphene on the physiology of reproduction in the rat. II. Its oestrogenic and antioestrogenic actions. Acta Endocrinol 47: 657-668, 1964.
199. Roy S, Greenblatt RB, Mahesh VB, Jungck EC. Clomiphene citrate: further observations on its use in induction of ovulation in the human and on its mode of action. Fertil Steril 14: 575-595, 1963.
200. Roy S, Mahesh VB, Greenblatt RB. Effects of clomiphene on the physiology of reproduction in the rat. I. Changes in the hypophysealgonadal axis. Acta Endocrinol 47: 645-656, 1964.
201. Roy S, Mahesh VB, Greenblatt RB. Effects of clomiphene on the physiology of reproduction in the rat. III. Inhibition of uptake of radioactive oestradiol by the uterus and the pituitary gland of immature rat. Acta Endocrinol 47: 669-675, 1964.
202. Roy S, Mahesh VB, Greenblatt RB. Effect of dehydroepiandrosterone and delta-4-androstenedione on the reproductive organs of female rats: production of cystic change in the ovary. Nature 196: 42-43, 1962.
203. Sato T, Greenblatt RB, Mahesh VB. Levels of luteinizing hormone during the menstrual cycle determined by immunologic techniques. Fertil Steril 16: 223-228, 1965.
204. Schenken RS, Werlin LB, Williams RF, Prihods TJ, Hodgen GD. Periovulatory hormonal dynamics: relationships of immunoassayable gonadotropins and ovarian steroids to the bioassayable LH surge in Rhesus monkey. J Clin Endocrinol Metab 60: 886-890, 1985.
205. Shi B, Bhat G, Mahesh VB, Brotto M, Nosek TM, Brann DW. Bradykinin receptor localization and cell signaling pathways used by bradykinin in the regulation of gonadotropin-releasing hormone secretion. Endocrinology 140: 4669-4676, 1999.
206. Shi B, Mahesh VB, Bhat GK, Ping L, Brann DW. Evidence for a role of bradykinin neurons in the control of gonadotropin-hormone releasing hormone secretion. Neuroendocrinology 67: 209-218, 1998.
207. Simone DA, Chorich LP, Mahesh VB. Mechanisms of action for an androgen-mediated autoregulatory process in rat thecal-interstitial cells. Biol Reprod 49: 1190-1201, 1993.
208. Simone DA, Mahesh VB. An autoregulatory process for androgen production in rat thecal-interstitial cells. Biol Reprod 48: 46-56, 1993.
209. Smanik E, Calderon J, Muldoon TG, Mahesh VB. Effect of progesterone on the activity of occupied nuclear estrogen receptor in vitro. Mol Cell Endocrinol 64: 111-117, 1989.
210. Smanik EJ, Young HK, Muldoon TG, Mahesh VB. Analysis of the effect of progesterone in vivo on estrogen receptor distribution in the rat anterior pituitary and hypothalamus. Endocrinology 113: 15-22, 1983.
211. Strott CA, Cargille CM, Ross GT, Lipsett MB. The short luteal phase. J Clin Endocrinol Metab 30: 246-251, 1970.
212. Talalay P, Williams-Ashman HG. Activation of hydrogen transfer between pyridine nucleotides by steroid hormones. Proc Natl Acad Sci USA 44: 15-26, 1958.
213. Trott EA, Plouffe L Jr, Hansen K, Hines R, Brann DW, Mahesh VB. Ovulation induction in clomiphene-resistant anovulatory women with normal dehydroepiandrosterone sulfate levels: beneficial effects of the addition of dexamethasone during the follicular phase. Fertil Steril 66: 484-486, 1996.
214. Uberoi NK, Mahesh VB, Black J, Meyer RK. Effect of 17α-methyl- B-nortestosterone on ovulation and ovarian weight in female rats. Steroids 9: 245-255, 1967.
215. Unda R, Brann DW, Mahesh VB. Progesterone suppression of glutamic acid decarboxylase (GAD67) mRNA levels in the preoptic area: correlation to the luteinizing hormone surge. Neuroendocrinology 62: 562-570, 1995.
216. Wakade C, Khan MM, DeSevilla LM, Zhang QG, Mahesh VB, Brann DW. Tamoxifen neuroprotection in cerebral ischemia involves attenuation of kinase activation and superoxide production and potentiation of mitochondrial superoxide dismutase. Endocrinology 149: 367-79, 2008.
217. Ward RC, Costoff A, Mahesh VB. The induction of polycystic ovaries in mature cycling rats by the administration of dehydroepiandrosterone (DHA). Biol Reprod 18: 614-623, 1978.
218. Zamorano PL, De Sevilla L, Mahesh VB, Brann DW. Production and refolding of recombinant leptin. BioTechniques 23, No.5, 1997.
219. Zamorano PL, Mahesh VB, De Sevilla L, Brann DW. Excitatory amino acid receptors and puberty. Steroids 63: 268-270, 1998.
220. Zamorano P, Mahesh VB, De Sevilla LM, Chorich LP, Bhat GK, Brann DW. Expression and localization of the leptin receptor in endocrine and neuroendocrine tissues of the rat. Neuroendocrinology 65: 223-228, 1997.
221. Zarate A, Mahesh VB, Greenblatt RB. Effect of an antiandrogen, 17α-methyl-B-nortestosterone, on acne and hirsutism. J Clin Endocrinol Metab 26: 1394-1398, 1966.
222. Zhang QG, Wang R, Khan MM, Mahesh VB, Brann DW. Role of Dickkopf-1 (Dkk1), an antagonist of the Wnt-β-catenin signaling pathway, in estrogen-induced neuroprotection and attenuation of Tau phosphorylation. J Neurosci 28: 8430-8441, 2008.
223. Zhou Y, Chorich LP, Mahesh VB, Ogle TF. Regulation of estrogen receptor protein and messenger ribonucleic acid by estradiol and progesterone in rat uterus. J Steroid Biochem Mol Biol 46: 687-698, 1993.
224. Zhou Y, Mahesh VB, Ogle TF. The role of rat uterine microsomal estrogen receptor in ovarian steroid hormone action. Endocr J 2: 53-62, 1994.
225. Zhou Z, Mahesh VB, Zamorano PL, Brann DW. Decreased gonadotropin- releasing hormone neurosecretory response to glutamate agonists in middle-aged female rats on proestrus afternoon: a possible role in reproductive aging. Endocrinology 137: 2334-2338, 1996.