Novel domain interaction regulates secretion of proprotein convertase subtilisin/kexin type 9 (PCSK9) protein

Journal of Biological Chemistry

Volumn 286, Issue 50, 2011, Pages 43054-43061

  Du, Fen ^a   Hui, Yvonne ^a   Zhang, Michelle ^a   Linton, MacRae F ^b,c   Fazio, Sergio ^b   Fan, Daping ^a  

^a UNIVERSITY OF SOUTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^c VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

C-TERMINAL DOMAINS; CO-TRANSFECTIONS; CRITICAL DETERMINANT; DELETION MUTANTS; HYPERCHOLESTEROLEMIA; IN-VITRO; NOVEL DOMAIN; PROTEIN FRAGMENTS; REDUCING ACTIVITY; SELF-CLEAVAGE; SMALL MOLECULE INHIBITOR; STRUCTURE-FUNCTION RELATION; SUBTILISIN; THERAPEUTIC TARGETS;

PROTEINS;

PHYSIOLOGY;

LOW DENSITY LIPOPROTEIN RECEPTOR; PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9; SERINE PROTEINASE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; C TERMINAL DOMAIN; CONTROLLED STUDY; EMBRYO; ENZYMATIC DEGRADATION; ENZYME ACTIVITY; ENZYME BINDING; ENZYME RELEASE; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HYPERCHOLESTEROLEMIA; IN VITRO STUDY; MOUSE; MUTAGENESIS; MUTANT; NONHUMAN; PRIORITY JOURNAL; PRODOMAIN; PROTEIN CLEAVAGE; PROTEIN DOMAIN; REGULATORY MECHANISM; STRUCTURE ACTIVITY RELATION;

ANIMALS; BLOTTING, WESTERN; CELL LINE; HEP G2 CELLS; HUMANS; MICE; MUTAGENESIS; MUTATION; PROPROTEIN CONVERTASES; PROTEIN STRUCTURE, TERTIARY; SERINE ENDOPEPTIDASES;

EID: 83355169698     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.273474     Document Type: Article

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