A proprotein convertase subtilisin-like/kexin type 9 (PCSK9) C-terminal domain antibody antigen-binding fragment inhibits PCSK9 internalization and restores low density lipoprotein uptake

Journal of Biological Chemistry

Volumn 285, Issue 17, 2010, Pages 12882-12891

  Ni, Yan G ^a,d   Condra, Jon H ^a   Orsatti, Laura ^b   Shen, Xun ^a   Di Marco, Stefania ^b   Pandit, Shilpa ^a   Bottomley, Matthew J ^b   Ruggeri, Lionello ^b   Cummings, Richard T ^a   Cubbon, Rose M ^a   Santoro, Joseph C ^a   Ehrhardt, Anka ^a   Lewis, Dale ^a   Fisher, Timothy S ^a   Ha, Sookhee ^a   Njimoluh, Leila ^a   Wood, Dana D ^a   Hammond, Holly A ^a   Wisniewski, Douglas ^a   Volpari, Cinzia ^b   Noto, Alessia ^b   Lo Surdo, Paola ^b   Hubbard, Brian ^a   Carfí, Andrea ^b,c   Sitlani, Ayesha ^a,d   more..

^a MERCK RESEARCH LABORATORIES   (United States)

^b IRBM   (Italy)

^c Clinical Research and Development   (United States)

^d NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY-ANTIGEN; ANTIGEN BINDING; C-TERMINAL DOMAINS; CELLULAR UPTAKE; CORONARY HEART DISEASE; HEK-293; HEPG2 CELLS; HYPERCHOLESTEROLEMIA; INHIBITORY EFFECT; LDL CHOLESTEROL; LOW DENSITY LIPOPROTEIN RECEPTORS; LOW DENSITY LIPOPROTEINS; NATURALLY OCCURRING; NEW TOOLS; PHAGE DISPLAY LIBRARIES; SITE DIRECTED MUTAGENESIS; SUBTILISIN; THERAPEUTIC TARGETS;

ANTIGENS; COMPLEXATION; DEGRADATION;

ANTIBODIES;

ARGININE; GLUTAMIC ACID; LOW DENSITY LIPOPROTEIN; LYSINE; PROPROTEIN CONVERTASE SUBTILISIN LIKE KEXIN TYPE 9; REGULATOR PROTEIN; UNCLASSIFIED DRUG;

ANTIGEN ANTIBODY COMPLEX; ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CELL STRAIN HEK293; CELL STRAIN HEPG2; CONTROLLED STUDY; ENZYME MECHANISM; HUMAN; HUMAN CELL; INTERNALIZATION; PHAGE DISPLAY; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN TRANSPORT; RECEPTOR BINDING; SITE DIRECTED MUTAGENESIS;

AMINO ACID SUBSTITUTION; ANTIBODIES, MONOCLONAL; HEP G2 CELLS; HUMANS; HYPERCHOLESTEROLEMIA; IMMUNOGLOBULIN FAB FRAGMENTS; LIPOPROTEINS, LDL; MUTAGENESIS, SITE-DIRECTED; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, LDL; SERINE ENDOPEPTIDASES;

EID: 77951224306     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.113035     Document Type: Article

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