A two-step binding model of PCSK9 interaction with the low density lipoprotein receptor

Journal of Biological Chemistry

Volumn 286, Issue 7, 2011, Pages 5464-5470

  Yamamoto, Taichi ^a   Lu, Christine ^a   Ryan, Robert O ^a  

^a CHILDREN S HOSPITAL OAKLAND RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ASSAYS; BINDING INTERACTION; BINDING MODELS; C-TERMINAL DOMAINS; CATALYTIC DOMAINS; ENDOSOMAL PH; HEK293 CELLS; HOMOLOGY DOMAIN; LIGAND BINDING DOMAIN; LOW DENSITY LIPOPROTEIN RECEPTORS; MULTIDOMAIN PROTEINS; N-TERMINAL DOMAINS; PLASMA CHOLESTEROL; RECEPTOR BINDING; SUBTILISIN;

BINDING ENERGY; DEGRADATION;

ASSAYS;

APOLIPOPROTEIN E; HIGH DENSITY LIPOPROTEIN RECEPTOR; LOW DENSITY LIPOPROTEIN RECEPTOR; MEMBRANE PROTEIN; PROPROTEIN CONVERTASE SUBTILISIN LIKE KEXIN TYPE 9; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BINDING ASSAY; CONTROLLED STUDY; HUMAN; HUMAN CELL; LIGAND BINDING; PH; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; RECEPTOR BINDING;

CALCIUM; ENDOSOMES; HEK293 CELLS; HUMANS; HYDROGEN-ION CONCENTRATION; MODELS, CHEMICAL; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, LDL; SERINE ENDOPEPTIDASES;

EID: 79953136043     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.199042     Document Type: Article

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