Importin β1 protein-mediated nuclear localization of Death Receptor 5 (DR5) limits DR5/Tumor Necrosis Factor (TNF)-related apoptosis-inducing ligand (TRAIL)-induced cell death of human tumor cells

Journal of Biological Chemistry

Volumn 286, Issue 50, 2011, Pages 43383-43393

  Kojima, Yuko ^a   Nakayama, Masafumi ^a,b   Nishina, Takashi ^a   Nakano, Hiroyasu ^a   Koyanagi, Makoto ^a   Takeda, Kazuyoshi ^a   Okumura, Ko ^a   Yagita, Hideo ^a  

^a JUNTENDO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b TOHOKU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CANCER THERAPY; CELL SURFACES; DEATH-RECEPTOR; HELA CELL; HEPG2 CELLS; HIGHLY SENSITIVE; HUMAN TUMOR CELLS; IMMUNOPRECIPITATIONS; NECROSIS FACTORS; NUCLEAR IMPORT; NUCLEAR LOCALIZATION; NUCLEAR LOCALIZATION SIGNAL; NUCLEAR TRANSPORT; TUMOR CELLS; TUMOR NECROSIS FACTOR-RELATED APOPTOSIS-INDUCING LIGANDS; UP-REGULATION; WESTERN-BLOT ANALYSIS;

CELL MEMBRANES; CONFOCAL MICROSCOPY; DISEASES; LIGANDS; MONOCLONAL ANTIBODIES; ONCOLOGY; TUMORS;

CELL DEATH;

DEATH RECEPTOR 5; DEATH RECEPTOR 5 MONOCLONAL ANTIBODY; KARYOPHERIN BETA1; MONOCLONAL ANTIBODY; NUCLEAR PROTEIN; RECOMBINANT TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ARTICLE; CELL DEATH; CELL NUCLEUS; CELL SURFACE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DRUG RESISTANCE; DRUG SENSITIVITY; GENE MUTATION; HUMAN; HUMAN CELL; NUCLEAR IMPORT; NUCLEAR LOCALIZATION SIGNAL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN TRANSPORT; TUMOR CELL; UPREGULATION;

BETA KARYOPHERINS; BLOTTING, WESTERN; CELL DEATH; CELL LINE, TUMOR; CELL NUCLEUS; FLOW CYTOMETRY; HELA CELLS; HEP G2 CELLS; HUMANS; MICROSCOPY, CONFOCAL; PROTEIN BINDING; PROTEIN TRANSPORT; RECEPTORS, TNF-RELATED APOPTOSIS-INDUCING LIGAND; RNA, SMALL INTERFERING; TNF-RELATED APOPTOSIS-INDUCING LIGAND;

EID: 83355163382     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.309377     Document Type: Article

References (44)

1. Gonzalvez, F., and Ashkenazi, A. (2010) Oncogene 29, 4752-4765
2. Falschlehner, C., Schaefer, U., and Walczak, H. (2009) Immunology 127, 145-154
3. Kayagaki, N., Yamaguchi, N., Nakayama, M., Eto, H., Okumura, K., and Yagita, H. (1999) J. Exp. Med. 189, 1451-1460
4. Kayagaki, N., Yamaguchi, N., Nakayama, M., Takeda, K., Akiba, H., Tsutsui, H., Okamura, H., Nakanishi, K., Okumura, K., and Yagita, H. (1999) J. Immunol. 163, 1906-1913
5. Walczak, H., Degli-Esposti, M. A., Johnson, R. S., Smolak, P. J., Waugh, J. Y., Boiani, N., Timour, M. S., Gerhart, M. J., Schooley, K. A., Smith, C. A., Goodwin, R. G., and Rauch, C. T. (1997) EMBO J. 16, 5386-5397
6. Elrod, H. A., and Sun, S. Y. (2008) Cancer Biol. Ther. 7, 163-173
7. Johnstone, R. W., Frew, A. J., and Smyth, M. J. (2008) Nat. Rev. Cancer 8, 782-798
8. Bridgham, J. T., Wilder, J. A., Hollocher, H., and Johnson, A. L. (2003) Cell Death Differ. 10, 19-25
9. McDonald, E. R., 3rd, Chui, P. C., Martelli, P. F., Dicker, D. T., and El- Deiry, W. S. (2001) J. Biol. Chem. 276, 14939-14945
10. Tait, S. W., and Green, D. R. (2010) Nat. Rev. Mol. Cell Biol. 11, 621-632
11. Zhang, L., and Fang, B. (2005) Cancer Gene Ther. 12, 228-237
12. Takeda, K., Yamaguchi, N., Akiba, H., Kojima, Y., Hayakawa, Y., Tanner, J. E., Sayers, T. J., Seki, N., Okumura, K., Yagita, H., and Smyth, M. J. (2004) J. Exp. Med. 199, 437-448
13. Uno, T., Takeda, K., Kojima, Y., Yoshizawa, H., Akiba, H., Mittler, R. S., Gejyo, F., Okumura, K., Yagita, H., and Smyth, M. J. (2006) Nat. Med. 12, 693-698
14. Yagita, H., Takeda, K., Hayakawa, Y., Smyth, M. J., and Okumura, K. (2004) Cancer Sci. 95, 777-783
15. Takeda, K., Stagg, J., Yagita, H., Okumura, K., and Smyth, M. J. (2007) Oncogene 26, 3745-3757
16. Ashkenazi, A. (2008) Nat. Rev. Drug Discov. 7, 1001-1012
17. Ullman, K. S., Powers, M. A., and Forbes, D. J. (1997) Cell 90, 967-970
18. Sorokin, A. V., Kim, E. R., and Ovchinnikov, L. P. (2007) Biochemistry 72, 1439-1457
19. Jazirehi, A. R., Ng, C. P., Gan, X. H., Schiller, G., and Bonavida, B. (2001) Clin. Cancer Res. 7, 3874-3883
20. Lanza, F., Latorraca, A., Moretti, S., Castagnari, B., Ferrari, L., and Castoldi, G. (1997) Cytometry 30, 134-144
21. Akiba, H., Nakano, H., Nishinaka, S., Shindo, M., Kobata, T., Atsuta, M., Morimoto, C., Ware, C. F., Malinin, N. L., Wallach, D., Yagita, H., and Okumura, K. (1998) J. Biol. Chem. 273, 13353-13358
22. Kanazawa, T., Takematsu, H., Yamamoto, A., Yamamoto, H., and Kozutsumi, Y. (2008) J. Cell. Physiol. 215, 517-525
23. Chen, H. C., and Reich, N. C. (2010) J. Immunol. 185, 64-70
24. Baake, M., Bäuerle, M., Doenecke, D., and Albig, W. (2001) Eur. J. Cell Biol. 80, 669-677
25. Zhang, X. D., Franco, A. V., Nguyen, T., Gray, C. P., and Hersey, P. (2000) J. Immunol. 164, 3961-3970
26. Zhang, X. D., Nguyen, T., Thomas, W. D., Sanders, J. E., and Hersey, P. (2000) FEBS Lett. 482, 193-199
27. Leithner, K., Stacher, E., Wurm, R., Ploner, F., Quehenberger, F., Wohlkoenig, C., Bálint, Z., Polachova, J., Olschewski, A., Samonigg, H., Popper, H. H., and Olschewski, H. (2009) Lung Cancer 65, 98-104
28. Austin, C. D., Lawrence, D. A., Peden, A. A., Varfolomeev, E. E., Totpal, K., De Mazière, A. M., Klumperman, J., Arnott, D., Pham, V., Scheller, R. H., and Ashkenazi, A. (2006) Proc. Natl. Acad. Sci. U.S.A. 103, 10283-10288
29. Kohlhaas, S. L., Craxton, A., Sun, X. M., Pinkoski, M. J., and Cohen, G. M. (2007) J. Biol. Chem. 282, 12831-12841
30. Akazawa, Y., Mott, J. L., Bronk, S. F., Werneburg, N. W., Kahraman, A., Guicciardi, M. E., Meng, X. W., Kohno, S., Shah, V. H., Kaufmann, S. H., McNiven, M. A., and Gores, G. J. (2009) Gastroenterology 136, 2365-2376
31. Sanders, S. L., and Schekman, R. (1992) J. Biol. Chem. 267, 13791-13794
32. von Heijne, G. (1981) Eur. J. Biochem. 116, 419-422
33. Miyakawa, K., Hatsuzawa, K., Kurokawa, T., Asada, M., Kuroiwa, T., and Imamura, T. (1999) J. Biol. Chem. 274, 29352-29357
34. Miyakawa, K., and Imamura, T. (2003) J. Biol. Chem. 278, 35718-35724
35. Lin-Lee, Y. C., Pham, L. V., Tamayo, A. T., Fu, L., Zhou, H. J., Yoshimura, L. C., Decker, G. L., and Ford, R. J. (2006) J. Biol. Chem. 281, 18878-18887
36. Carpenter, G. (2003) Curr. Opin. Cell Biol. 15, 143-148
37. Wagner, K. W., Punnoose, E. A., Januario, T., Lawrence, D. A., Pitti, R. M., Lancaster, K., Lee, D., von Goetz, M., Yee, S. F., Totpal, K., Huw, L., Katta, V., Cavet, G., Hymowitz, S. G., Amler, L., and Ashkenazi, A. (2007) Nat. Med. 13, 1070-1077
38. West, C. M., van der Wel, H., and Gaucher, E. A. (2002) Glycobiology 12, 17R-27R
39. Kau, T. R., Way, J. C., and Silver, P. A. (2004) Nat. Rev. Cancer 4, 106-117
40. Sheridan, J. P., Marsters, S. A., Pitti, R. M., Gurney, A., Skubatch, M., Baldwin, D., Ramakrishnan, L., Gray, C. L., Baker, K., Wood, W. I., Goddard, A. D., Godowski, P., and Ashkenazi, A. (1997) Science 277, 818-821
41. Marsters, S. A., Sheridan, J. P., Pitti, R. M., Huang, A., Skubatch, M., Baldwin, D., Yuan, J., Gurney, A., Goddard, A. D., Godowski, P., and Ashkenazi, A. (1997) Curr. Biol. 7, 1003-1006
42. MacFarlane, M. (2003) Toxicol. Lett. 139, 89-97
43. Petrocca, F., and Lieberman, J. (2011) J. Clin. Oncol. 29, 747-754
44. Hintersteiner, M., Ambrus, G., Bednenko, J., Schmied, M., Knox, A. J., Meisner, N. C., Gstach, H., Seifert, J. M., Singer, E. L., Gerace, L., and Auer, M. (2010) ACS Chem. Biol. 5, 967-979