Human intestinal acyl-CoA synthetase 5 is sensitive to the inhibitor triacsin C

World Journal of Gastroenterology

Volumn 17, Issue 44, 2011, Pages 4883-4889

  Kaemmerer, Elke ^a   Peuscher, Anne ^b   Reinartz, Andrea ^a   Liedtke, Christian ^a   Weiskirchen, Ralf ^a   Kopitz, Jürgen ^c   Gassler, Nikolaus ^a  

^a RWTH AACHEN UNIVERSITY   (Germany)

^b FRAUNHOFER INSTITUTE FOR MOLECULAR BIOLOGY AND APPLIED ECOLOGY IME   (Germany)

^c UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Acyl CoA synthetase 5; Fatty acid metabolism; Mitochondria; Triacsin C

Indexed keywords

ENZYME INHIBITOR; HUMAN ACYL COENZYME A SYNTHETASE 5; ISOENZYME; ISOPROPYL THIOGALACTOSIDE; LONG CHAIN FATTY ACID COENZYME A LIGASE; NICKEL; PALMITIC ACID; RECOMBINANT ENZYME; TRIACSIN C; TRITON X 100; UNCLASSIFIED DRUG;

AFFINITY CHROMATOGRAPHY; AMINO TERMINAL SEQUENCE; ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CELL LYSATE; CELL STRAIN CACO 2; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; GENETIC TRANSFECTION; HUMAN; HUMAN TISSUE; IC 50; IMMUNOFLUORESCENCE; INTESTINE MUCOSA; MOLECULAR CLONING; NUCLEOTIDE SEQUENCE; PH; PROTEIN EXPRESSION; ULTRACENTRIFUGATION; WESTERN BLOTTING;

EID: 83155187282     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.v17.i44.4883     Document Type: Article

References (26)

1. Shrago E. Long-chain acyl-CoA as a multi-effector ligand in cellular metabolism. J Nutr 2000; 130: 290S-293S
2. Bar-Tana J, Rose G, Brandes R, Shapiro B. Palmitoyl-coenzyme A synthetase. Mechanism of reaction. Biochem J 1973; 131: 199-209
3. Mashek DG, Bornfeldt KE, Coleman RA, Berger J, Bernlohr DA, Black P, DiRusso CC, Farber SA, Guo W, Hashimoto N, Khodiyar V, Kuypers FA, Maltais LJ, Nebert DW, Renieri A, Schaffer JE, Stahl A, Watkins PA, Vasiliou V, Yamamoto TT. Revised nomenclature for the mammalian long-chain acyl-CoA synthetase gene family. J Lipid Res 2004; 45: 1958-1961
4. Yamashita Y, Kumabe T, Cho YY, Watanabe M, Kawagishi J, Yoshimoto T, Fujino T, Kang MJ, Yamamoto TT. Fatty acid induced glioma cell growth is mediated by the acyl-CoA synthetase 5 gene located on chromosome 10q25.1-q25.2, a region frequently deleted in malignant gliomas. Oncogene 2000; 19: 5919-5925
5. Gassler N, Kopitz J, Tehrani A, Ottenwälder B, Schnölzer M, Kartenbeck J, Lyer S, Autschbach F, Poustka A, Otto HF, Mollenhauer J. Expression of acyl-CoA synthetase 5 reflects the state of villus architecture in human small intestine. J Pathol 2004; 202: 188-196
6. Gassler N, Roth W, Funke B, Schneider A, Herzog F, Tischendorf JJ, Grund K, Penzel R, Bravo IG, Mariadason J, Ehemann V, Sykora J, Haas TL, Walczak H, Ganten T, Zentgraf H, Erb P, Alonso A, Autschbach F, Schirmacher P, Knüchel R, Kopitz J. Regulation of enterocyte apoptosis by acyl-CoA synthetase 5 splicing. Gastroenterology 2007; 133: 587-598
7. Gassler N, Herr I, Schneider A, Penzel R, Langbein L, Schirmacher P, Kopitz J. Impaired expression of acyl-CoA synthetase 5 in sporadic colorectal adenocarcinomas. J Pathol 2005; 207: 295-300
8. Coleman RA, Lewin TM, Van Horn CG, Gonzalez-Baró MR. Do long-chain acyl-CoA synthetases regulate fatty acid entry into synthetic versus degradative pathways? J Nutr 2002; 132: 2123-2126
9. Caviglia JM, Li LO, Wang S, DiRusso CC, Coleman RA, Lewin TM. Rat long chain acyl-CoA synthetase 5, but not 1, 2, 3, or 4, complements Escherichia coli fadD. J Biol Chem 2004; 279: 11163-11169
10. Tomoda H, Igarashi K, Omura S. Inhibition of acyl-CoA synthetase by triacsins. Biochim Biophys Acta 1987; 921: 595-598
11. Namatame I, Tomoda H, Arai H, Inoue K, Omura S. Complete inhibition of mouse macrophage-derived foam cell formation by triacsin C. J Biochem 1999; 125: 319-327
12. Oh-ishi S, Yamaki K, Abe M, Tomoda H, Omura S. The acyl-CoA synthetase inhibitor triacsin C enhanced eicosanoid release in leukocytes. Jpn J Pharmacol 1992; 59: 417-418
13. Weis MT, Brady M, Moore M, Crumley J, Stallone JN. Inhibiting long-chain fatty acyl CoA synthetase does not increase agonist-induced release of arachidonate metabolites from human endothelial cells. J Vasc Res 2005; 42: 275-283
14. Tomoda H, Igarashi K, Cyong JC, Omura S. Evidence for an essential role of long chain acyl-CoA synthetase in animal cell proliferation. Inhibition of long chain acyl-CoA synthetase by triacsins caused inhibition of Raji cell proliferation. J Biol Chem 1991; 266: 4214-4219
15. Mashima T, Oh-hara T, Sato S, Mochizuki M, Sugimoto Y, Yamazaki K, Hamada J, Tada M, Moriuchi T, Ishikawa Y, Kato Y, Tomoda H, Yamori T, Tsuruo T. p53-defective tumors with a functional apoptosome-mediated pathway: a new therapeutic target. J Natl Cancer Inst 2005; 97: 765-777
16. Kim JH, Lewin TM, Coleman RA. Expression and characterization of recombinant rat Acyl-CoA synthetases 1, 4, and 5. Selective inhibition by triacsin C and thiazolidinediones. J Biol Chem 2001; 276: 24667-24673
17. Van Horn CG, Caviglia JM, Li LO, Wang S, Granger DA, Coleman RA. Characterization of recombinant long-chain rat acyl-CoA synthetase isoforms 3 and 6: identification of a novel variant of isoform 6. Biochemistry 2005; 44: 1635-1642
18. Gassler N, Klaus C, Kaemmerer E, Reinartz A. Modifier-concept of colorectal carcinogenesis: lipidomics as a technical tool in pathway analysis. World J Gastroenterol 2010; 16: 1820-1827
19. Resh MD. Palmitoylation of ligands, receptors, and intracellular signaling molecules. Sci STKE 2006; 2006: re14
20. Lewin TM, Kim JH, Granger DA, Vance JE, Coleman RA. Acyl-CoA synthetase isoforms 1, 4, and 5 are present in different subcellular membranes in rat liver and can be inhibited independently. J Biol Chem 2001; 276: 24674-24679
21. Ellis JM, Frahm JL, Li LO, Coleman RA. Acyl-coenzyme A synthetases in metabolic control. Curr Opin Lipidol 2010; 21: 212-217
22. Fujimoto Y, Onoduka J, Homma KJ, Yamaguchi S, Mori M, Higashi Y, Makita M, Kinoshita T, Noda J, Itabe H, Takanoa T. Long-chain fatty acids induce lipid droplet formation in a cultured human hepatocyte in a manner dependent of Acyl-CoA synthetase. Biol Pharm Bull 2006; 29: 2174-2180
23. Fujimoto Y, Itabe H, Kinoshita T, Homma KJ, Onoduka J, Mori M, Yamaguchi S, Makita M, Higashi Y, Yamashita A, Takano T. Involvement of ACSL in local synthesis of neutral lipids in cytoplasmic lipid droplets in human hepatocyte HuH7. J Lipid Res 2007; 48: 1280-1292
24. Mashima T, Sato S, Okabe S, Miyata S, Matsuura M, Sugimoto Y, Tsuruo T, Seimiya H. Acyl-CoA synthetase as a cancer survival factor: its inhibition enhances the efficacy of etoposide. Cancer Sci 2009; 100: 1556-1562
25. Mashek DG, McKenzie MA, Van Horn CG, Coleman RA. Rat long chain acyl-CoA synthetase 5 increases fatty acid uptake and partitioning to cellular triacylglycerol in McArdle-RH7777 cells. J Biol Chem 2006; 281: 945-950
26. Zhou Y, Abidi P, Kim A, Chen W, Huang TT, Kraemer FB, Liu J. Transcriptional activation of hepatic ACSL3 and ACSL5 by oncostatin m reduces hypertriglyceridemia through enhanced beta-oxidation. Arterioscler Thromb Vasc Biol 2007; 27: 2198-2205