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Volumn 48, Issue 6, 2007, Pages 1280-1292

Involvement of ACSL in local synthesis of neutral lipids in cytoplasmic lipid droplets in human hepatocyte HuH7

Author keywords

Acyl coenzyme A; Triacsin C; Triacylglycerol

Indexed keywords

ACYL COENZYME A SYNTHETASE 3; CHOLESTEROL ESTER; ENZYME INHIBITOR; FAT DROPLET; LONG CHAIN FATTY ACID COENZYME A LIGASE; OLEIC ACID; PALMITIC ACID; TRIACSIN C; TRIACYLGLYCEROL; TROGLITAZONE; UNCLASSIFIED DRUG;

EID: 34548162204     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.M700050-JLR200     Document Type: Article
Times cited : (144)

References (42)
  • 1
    • 0034684048 scopus 로고    scopus 로고
    • Intracellular lipid particles of eukaryotic cells
    • Zweytick, D., K. Athenstaedt, and G. Daum. 2000. Intracellular lipid particles of eukaryotic cells. Biochim. Biophys. Acta. 1469: 101-120.
    • (2000) Biochim. Biophys. Acta , vol.1469 , pp. 101-120
    • Zweytick, D.1    Athenstaedt, K.2    Daum, G.3
  • 2
    • 0037113954 scopus 로고    scopus 로고
    • The surface of lipid droplets is a phospholipid monolayer with a unique fatty acid composition
    • Tauchi-Sato, K., S. Ozeki, T. Houjou, R. Taguchi, and T. Fujimoto. 2002. The surface of lipid droplets is a phospholipid monolayer with a unique fatty acid composition. J. Biol. Chem. 277: 44507-44512.
    • (2002) J. Biol. Chem , vol.277 , pp. 44507-44512
    • Tauchi-Sato, K.1    Ozeki, S.2    Houjou, T.3    Taguchi, R.4    Fujimoto, T.5
  • 3
    • 4344644928 scopus 로고    scopus 로고
    • Obesity and the metabolic syndrome
    • Vega, G. L. 2004. Obesity and the metabolic syndrome. Minerva Endocrinol. 29: 47-54.
    • (2004) Minerva Endocrinol , vol.29 , pp. 47-54
    • Vega, G.L.1
  • 4
    • 1642565185 scopus 로고    scopus 로고
    • Identification of major proteins in the lipid droplet-enriched fraction isolated from the human hepatocyte cell line HuH7
    • Fujimoto, Y., H. Itabe, J. Sakai, M. Makita, J. Noda, M. Mori, Y. Higashi, S. Kojima, and T. Takano. 2004. Identification of major proteins in the lipid droplet-enriched fraction isolated from the human hepatocyte cell line HuH7. Biochim. Biophys. Acta. 1644: 47-59.
    • (2004) Biochim. Biophys. Acta , vol.1644 , pp. 47-59
    • Fujimoto, Y.1    Itabe, H.2    Sakai, J.3    Makita, M.4    Noda, J.5    Mori, M.6    Higashi, Y.7    Kojima, S.8    Takano, T.9
  • 6
    • 0035816532 scopus 로고    scopus 로고
    • Acyl-CoA synthetase isoforms 1, 4, and 5 are present in different subcellular membranes in rat liver and can be inhibited independently
    • Lewin, T. M., J. H. Kim, D. A. Granger, J. E. Vance, and R. A. Coleman. 2001. Acyl-CoA synthetase isoforms 1, 4, and 5 are present in different subcellular membranes in rat liver and can be inhibited independently. J. Biol. Chem. 276: 24674-24679.
    • (2001) J. Biol. Chem , vol.276 , pp. 24674-24679
    • Lewin, T.M.1    Kim, J.H.2    Granger, D.A.3    Vance, J.E.4    Coleman, R.A.5
  • 7
    • 0942287191 scopus 로고    scopus 로고
    • Chinese hamster ovary K2 cell lipid droplets appear to be metabolic organelles involved in membrane traffic
    • Liu, P., Y. Ying, Y. Zhao, D. I. Mundy, M. Zhu, and R. G. Anderson. 2004. Chinese hamster ovary K2 cell lipid droplets appear to be metabolic organelles involved in membrane traffic. J. Biol. Chem. 279: 3787-3792.
    • (2004) J. Biol. Chem , vol.279 , pp. 3787-3792
    • Liu, P.1    Ying, Y.2    Zhao, Y.3    Mundy, D.I.4    Zhu, M.5    Anderson, R.G.6
  • 9
    • 8744267532 scopus 로고    scopus 로고
    • Proteomic analysis of proteins associated with lipid droplets of basal and lipolytically stimulated 3T3-L1 adipocytes
    • Brasaemle, D. L., G. Dolios, L. Shapiro, and R. Wang. 2004. Proteomic analysis of proteins associated with lipid droplets of basal and lipolytically stimulated 3T3-L1 adipocytes. J. Biol. Chem. 279: 46835-46842.
    • (2004) J. Biol. Chem , vol.279 , pp. 46835-46842
    • Brasaemle, D.L.1    Dolios, G.2    Shapiro, L.3    Wang, R.4
  • 10
    • 0025772167 scopus 로고
    • Perilipin, a major hormonally regulated adipocyte-specific phosphoprotein associated with the periphery of lipid storage droplets
    • Greenberg, A. S., J. J. Egan, S. A. Wek, N. B. Garty, E. J. Blanchette-Mackie, and C. Londos. 1991. Perilipin, a major hormonally regulated adipocyte-specific phosphoprotein associated with the periphery of lipid storage droplets. J. Biol. Chem. 266: 11341-11346.
    • (1991) J. Biol. Chem , vol.266 , pp. 11341-11346
    • Greenberg, A.S.1    Egan, J.J.2    Wek, S.A.3    Garty, N.B.4    Blanchette-Mackie, E.J.5    Londos, C.6
  • 11
    • 0026668669 scopus 로고
    • Isolation and characterization of a full-length cDNA coding for an adipose differentiation-related protein
    • Jiang, H. P., and G. Serrero. 1992. Isolation and characterization of a full-length cDNA coding for an adipose differentiation-related protein. Proc. Natl. Acad. Sci. USA. 89: 7856-7860.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 7856-7860
    • Jiang, H.P.1    Serrero, G.2
  • 12
    • 0033071156 scopus 로고    scopus 로고
    • Perilipins, ADRP, and other proteins that associate with intracellular neutral lipid droplets in animal cells
    • Londos, C., D. L. Brasaemle, C. J. Schultz, J. P. Segrest, and A. R. Kimmel. 1999. Perilipins, ADRP, and other proteins that associate with intracellular neutral lipid droplets in animal cells. Semin. Cell Dev. Biol. 10: 51-58.
    • (1999) Semin. Cell Dev. Biol , vol.10 , pp. 51-58
    • Londos, C.1    Brasaemle, D.L.2    Schultz, C.J.3    Segrest, J.P.4    Kimmel, A.R.5
  • 13
    • 0035895982 scopus 로고    scopus 로고
    • TIP47 associates with lipid droplets
    • Wolins, N. E., B. Rubin, and D. L. Brasaemle. 2001. TIP47 associates with lipid droplets. J. Biol. Chem. 276: 5101-5108.
    • (2001) J. Biol. Chem , vol.276 , pp. 5101-5108
    • Wolins, N.E.1    Rubin, B.2    Brasaemle, D.L.3
  • 14
    • 0035809923 scopus 로고    scopus 로고
    • Accumulation of caveolin in the endoplasmic reticulum redirects the protein to lipid storage droplets
    • Ostermeyer, A. G., J. M. Paci, Y. Zeng, D. M. Lublin, S. Munro, and D. A. Brown. 2001. Accumulation of caveolin in the endoplasmic reticulum redirects the protein to lipid storage droplets. J. Cell Biol. 152: 1071-1078.
    • (2001) J. Cell Biol , vol.152 , pp. 1071-1078
    • Ostermeyer, A.G.1    Paci, J.M.2    Zeng, Y.3    Lublin, D.M.4    Munro, S.5    Brown, D.A.6
  • 15
    • 0035809931 scopus 로고    scopus 로고
    • Caveolin-2 is targeted to lipid droplets, a new "membrane domain" in the cell
    • Fujimoto, T., H. Kogo, K. Ishiguro, K. Tauchi, and R. Nomura. 2001. Caveolin-2 is targeted to lipid droplets, a new "membrane domain" in the cell. J. Cell Biol. 152: 1079-1085.
    • (2001) J. Cell Biol , vol.152 , pp. 1079-1085
    • Fujimoto, T.1    Kogo, H.2    Ishiguro, K.3    Tauchi, K.4    Nomura, R.5
  • 16
    • 21644459401 scopus 로고    scopus 로고
    • Rab18 localizes to lipid droplets and induces their close apposition to the endoplasmic reticulum-derived membrane
    • Ozeki, S., J. Cheng, K. Tauchi-Sato, N. Hatano, H. Taniguchi, and T. Fujimoto. 2005. Rab18 localizes to lipid droplets and induces their close apposition to the endoplasmic reticulum-derived membrane. J. Cell Sci. 118: 2601-2611.
    • (2005) J. Cell Sci , vol.118 , pp. 2601-2611
    • Ozeki, S.1    Cheng, J.2    Tauchi-Sato, K.3    Hatano, N.4    Taniguchi, H.5    Fujimoto, T.6
  • 17
    • 29644442801 scopus 로고    scopus 로고
    • Regulated localization of Rab18 to lipid droplets: Effects of lipolytic stimulation and inhibition of lipid droplet catabolism
    • Martin, S., K. Driessen, S. J. Nixon, M. Zerial, and R. G. Parton. 2005. Regulated localization of Rab18 to lipid droplets: effects of lipolytic stimulation and inhibition of lipid droplet catabolism. J. Biol. Chem. 280: 42325-42335.
    • (2005) J. Biol. Chem , vol.280 , pp. 42325-42335
    • Martin, S.1    Driessen, K.2    Nixon, S.J.3    Zerial, M.4    Parton, R.G.5
  • 18
    • 0033546310 scopus 로고    scopus 로고
    • Adipose differentiation related protein (ADRP) expressed in transfected COS-7 cells selectively stimulates long chain fatty acid uptake
    • Gao, J., and G. Serrero. 1999. Adipose differentiation related protein (ADRP) expressed in transfected COS-7 cells selectively stimulates long chain fatty acid uptake. J. Biol. Chem. 274: 16825-16830.
    • (1999) J. Biol. Chem , vol.274 , pp. 16825-16830
    • Gao, J.1    Serrero, G.2
  • 19
    • 0034623950 scopus 로고    scopus 로고
    • Perilipin A increases triacylglycerol storage by decreasing the rate of triacylglycerol hydrolysis
    • Brasaemle, D. L., B. Rubin, I. A. Harten, J. Gruia-Gray, A. R. Kimmel, and C. Londos. 2000. Perilipin A increases triacylglycerol storage by decreasing the rate of triacylglycerol hydrolysis. J. Biol. Chem. 275: 38486-38493.
    • (2000) J. Biol. Chem , vol.275 , pp. 38486-38493
    • Brasaemle, D.L.1    Rubin, B.2    Harten, I.A.3    Gruia-Gray, J.4    Kimmel, A.R.5    Londos, C.6
  • 21
    • 0141814912 scopus 로고    scopus 로고
    • Localization of mammalian NAD(P)H steroid dehydrogenase-like protein on lipid droplets
    • Ohashi, M., N. Mizushima, Y. Kabeya, and T. Yoshimori. 2003. Localization of mammalian NAD(P)H steroid dehydrogenase-like protein on lipid droplets. J. Biol. Chem. 278: 36819-36829.
    • (2003) J. Biol. Chem , vol.278 , pp. 36819-36829
    • Ohashi, M.1    Mizushima, N.2    Kabeya, Y.3    Yoshimori, T.4
  • 22
    • 0035199303 scopus 로고    scopus 로고
    • Foam cell formation containing lipid droplets enriched with free cholesterol by hyperlipidemic serum
    • Mori, M., H. Itabe, Y. Higashi, Y. Fujimoto, M. Shiomi, M. Yoshizumi, Y. Ouchi, and T. Takano. 2001. Foam cell formation containing lipid droplets enriched with free cholesterol by hyperlipidemic serum. J. Lipid Res. 42: 1771-1781.
    • (2001) J. Lipid Res , vol.42 , pp. 1771-1781
    • Mori, M.1    Itabe, H.2    Higashi, Y.3    Fujimoto, Y.4    Shiomi, M.5    Yoshizumi, M.6    Ouchi, Y.7    Takano, T.8
  • 23
    • 0014514052 scopus 로고
    • Preparative thin-layer and column chromatography of prostaglandin
    • Andersen, N. H. 1969. Preparative thin-layer and column chromatography of prostaglandin. J. Lipid Res. 10: 316-319.
    • (1969) J. Lipid Res , vol.10 , pp. 316-319
    • Andersen, N.H.1
  • 24
    • 0023629778 scopus 로고
    • Inhibition of acyl-CoA synthetase by triacsins
    • Tomoda, H., K. Igarashi, and S. Omura. 1987. Inhibition of acyl-CoA synthetase by triacsins. Biochim. Biophys. Acta. 921: 595-598.
    • (1987) Biochim. Biophys. Acta , vol.921 , pp. 595-598
    • Tomoda, H.1    Igarashi, K.2    Omura, S.3
  • 25
    • 2342491577 scopus 로고    scopus 로고
    • Characterization of triacsin C inhibition of short-, medium-, and long-chain fatty acid:CoA ligases of human liver
    • Vessey, D. A., M. Kelley, and R. S. Warren. 2004. Characterization of triacsin C inhibition of short-, medium-, and long-chain fatty acid:CoA ligases of human liver. J. Biochem. Mol. Toxicol. 18: 100-106.
    • (2004) J. Biochem. Mol. Toxicol , vol.18 , pp. 100-106
    • Vessey, D.A.1    Kelley, M.2    Warren, R.S.3
  • 26
    • 13444306413 scopus 로고    scopus 로고
    • Characterization of recombinant long-chain rat acyl-CoA synthetase isoforms 3 and 6: Identification of a novel variant of isoform 6
    • Van Horn, C. G., J. M. Caviglia, L. O. Li, S. Wang, D. A. Granger, and R. A. Coleman. 2005. Characterization of recombinant long-chain rat acyl-CoA synthetase isoforms 3 and 6: identification of a novel variant of isoform 6. Biochemistry. 44: 1635-1642.
    • (2005) Biochemistry , vol.44 , pp. 1635-1642
    • Van Horn, C.G.1    Caviglia, J.M.2    Li, L.O.3    Wang, S.4    Granger, D.A.5    Coleman, R.A.6
  • 27
    • 0029953175 scopus 로고    scopus 로고
    • Molecular characterization and expression of rat acyl-CoA synthetase 3
    • Fujino, T., M. J. Kang, H. Suzuki, H. Iijima, and T. Yamamoto. 1996. Molecular characterization and expression of rat acyl-CoA synthetase 3. J. Biol. Chem. 271: 16748-16752.
    • (1996) J. Biol. Chem , vol.271 , pp. 16748-16752
    • Fujino, T.1    Kang, M.J.2    Suzuki, H.3    Iijima, H.4    Yamamoto, T.5
  • 28
    • 0035816590 scopus 로고    scopus 로고
    • Expression and characterization of recombinant rat acyl-CoA synthetases 1, 4, and 5. Selective inhibition by triacsin C and thiazolidinediones
    • Kim, J. H., T. M. Lewin, and R. A. Coleman. 2001. Expression and characterization of recombinant rat acyl-CoA synthetases 1, 4, and 5. Selective inhibition by triacsin C and thiazolidinediones. J. Biol. Chem. 276: 24667-24673.
    • (2001) J. Biol. Chem , vol.276 , pp. 24667-24673
    • Kim, J.H.1    Lewin, T.M.2    Coleman, R.A.3
  • 29
    • 0018846846 scopus 로고
    • Enzymes of glycerolipid synthesis in eukaryotes
    • Bell, R. M., and R. A. Coleman. 1980. Enzymes of glycerolipid synthesis in eukaryotes. Annu. Rev. Biochem. 49: 459-487.
    • (1980) Annu. Rev. Biochem , vol.49 , pp. 459-487
    • Bell, R.M.1    Coleman, R.A.2
  • 31
    • 0031006469 scopus 로고    scopus 로고
    • A novel arachidonate-preferring acyl-CoA synthetase is present in steroidogenic cells of the rat adrenal, ovary, and testis
    • Kang, M. J., T. Fujino, H. Sasano, H. Minekura, N. Yabuki, H. Nagura, H. Iijima, and T. T. Yamamoto. 1997. A novel arachidonate-preferring acyl-CoA synthetase is present in steroidogenic cells of the rat adrenal, ovary, and testis. Proc. Natl. Acad. Sci. USA. 94: 2880-2884.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 2880-2884
    • Kang, M.J.1    Fujino, T.2    Sasano, H.3    Minekura, H.4    Yabuki, N.5    Nagura, H.6    Iijima, H.7    Yamamoto, T.T.8
  • 32
    • 0032693609 scopus 로고    scopus 로고
    • Identification and characterization of major lipid particle proteins of the yeast Saccharomyces cerevisiae
    • Athenstaedt, K., D. Zweytick, A. Jandrositz, S. D. Kohlwein, and G. Daum. 1999. Identification and characterization of major lipid particle proteins of the yeast Saccharomyces cerevisiae. J. Bacteriol. 181: 6441-6448.
    • (1999) J. Bacteriol , vol.181 , pp. 6441-6448
    • Athenstaedt, K.1    Zweytick, D.2    Jandrositz, A.3    Kohlwein, S.D.4    Daum, G.5
  • 33
    • 0035798648 scopus 로고    scopus 로고
    • The enzymes of neutral lipid synthesis
    • Buhman, K. K., H. C. Chen, and R. V. Farese, Jr. 2001. The enzymes of neutral lipid synthesis. J. Biol. Chem. 276: 40369-40372.
    • (2001) J. Biol. Chem , vol.276 , pp. 40369-40372
    • Buhman, K.K.1    Chen, H.C.2    Farese Jr., R.V.3
  • 34
    • 0032911957 scopus 로고    scopus 로고
    • Mechanisms of lipid-body formation
    • Murphy, D. J., and J. Vance. 1999. Mechanisms of lipid-body formation. Trends Biochem. Sci. 24: 109-115.
    • (1999) Trends Biochem. Sci , vol.24 , pp. 109-115
    • Murphy, D.J.1    Vance, J.2
  • 35
    • 0023649685 scopus 로고
    • Rearrangement of the vimentin cytoskeleton during adipose conversion: Formation of an intermediate filament cage around lipid globules
    • Franke, W. W., M. Hergt, and C. Grund. 1987. Rearrangement of the vimentin cytoskeleton during adipose conversion: formation of an intermediate filament cage around lipid globules. Cell. 49: 131-141.
    • (1987) Cell , vol.49 , pp. 131-141
    • Franke, W.W.1    Hergt, M.2    Grund, C.3
  • 37
    • 0026627736 scopus 로고
    • The lipolysis/esterification cycle of hepatic triacylglycerol. Its role in the secretion of very-low-density lipoprotein and its response to hormones and sulphonylureas
    • Wiggins, D., and G. F. Gibbons. 1992. The lipolysis/esterification cycle of hepatic triacylglycerol. Its role in the secretion of very-low-density lipoprotein and its response to hormones and sulphonylureas. Biochem. J. 284: 457-462.
    • (1992) Biochem. J , vol.284 , pp. 457-462
    • Wiggins, D.1    Gibbons, G.F.2
  • 38
    • 0036193973 scopus 로고    scopus 로고
    • Triglyceride depletion in THP-1 cells alters cholesteryl ester physical state and cholesterol efflux
    • Lada, A. T., M. C. Willingham, and R. W. St Clair. 2002. Triglyceride depletion in THP-1 cells alters cholesteryl ester physical state and cholesterol efflux. J. Lipid Res. 43: 618-628.
    • (2002) J. Lipid Res , vol.43 , pp. 618-628
    • Lada, A.T.1    Willingham, M.C.2    St Clair, R.W.3
  • 40
    • 0014938130 scopus 로고
    • Subcellular distribution of acyl-CoA:cholesterol acyltransferase in rat liver cells
    • Stokke, K. T., and K. R. Norum. 1970. Subcellular distribution of acyl-CoA:cholesterol acyltransferase in rat liver cells. Biochim. Biophys. Acta. 210: 202-204.
    • (1970) Biochim. Biophys. Acta , vol.210 , pp. 202-204
    • Stokke, K.T.1    Norum, K.R.2
  • 41
    • 0035809929 scopus 로고    scopus 로고
    • Caveolin, cholesterol, and lipid droplets?
    • van Meer, G. 2001. Caveolin, cholesterol, and lipid droplets? J. Cell Biol. 152: F29-F34.
    • (2001) J. Cell Biol , vol.152
    • van Meer, G.1
  • 42
    • 0038711498 scopus 로고    scopus 로고
    • A phospholipase D-dependent process forms lipid droplets containing caveolin, adipocyte differentiation-related protein, and vimentin in a cell-free system
    • Marchesan, D., M. Rutberg, L. Andersson, L. Asp, T. Larsson, J. Boren, B. R. Johansson, and S. O. Olofsson. 2003. A phospholipase D-dependent process forms lipid droplets containing caveolin, adipocyte differentiation-related protein, and vimentin in a cell-free system. J. Biol. Chem. 278: 27293-27300.
    • (2003) J. Biol. Chem , vol.278 , pp. 27293-27300
    • Marchesan, D.1    Rutberg, M.2    Andersson, L.3    Asp, L.4    Larsson, T.5    Boren, J.6    Johansson, B.R.7    Olofsson, S.O.8


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