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Volumn 199, Issue , 2011, Pages 86-102

Intermittent noxious stimulation following spinal cord contusion injury impairs locomotor recovery and reduces spinal brain-derived neurotrophic factor-tropomyosin-receptor kinase signaling in adult rats

Author keywords

BDNF; Functional recovery; Nociceptive stimulation; Spinal cord injury; Spinal plasticity

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN C FOS;

EID: 83055186552     PISSN: 03064522     EISSN: 18737544     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2011.10.007     Document Type: Article
Times cited : (41)

References (76)
  • 3
    • 0028919411 scopus 로고
    • A sensitive and reliable locomotor rating scale for open field testing in rats
    • Basso D.M., Beattie M.S., Bresnahan J.C. A sensitive and reliable locomotor rating scale for open field testing in rats. J Neurotrauma 1995, 12:1-21.
    • (1995) J Neurotrauma , vol.12 , pp. 1-21
    • Basso, D.M.1    Beattie, M.S.2    Bresnahan, J.C.3
  • 4
    • 0030157694 scopus 로고    scopus 로고
    • Graded histological and locomotor outcomes after spinal cord contusion using the NYU weight-drop device versus transection
    • Basso D.M., Beattie M.S., Bresnahan J.C. Graded histological and locomotor outcomes after spinal cord contusion using the NYU weight-drop device versus transection. Exp Neurol 1996, 139:244-256.
    • (1996) Exp Neurol , vol.139 , pp. 244-256
    • Basso, D.M.1    Beattie, M.S.2    Bresnahan, J.C.3
  • 6
    • 0034589060 scopus 로고    scopus 로고
    • Cell death and plasticity after experimental spinal cord injury
    • Beattie M.S., Li Q., Bresnahan J.C. Cell death and plasticity after experimental spinal cord injury. Prog Brain Res 2000, 128:9-21.
    • (2000) Prog Brain Res , vol.128 , pp. 9-21
    • Beattie, M.S.1    Li, Q.2    Bresnahan, J.C.3
  • 7
    • 35348921741 scopus 로고    scopus 로고
    • Neurotrophic factors promote and enhance locomotor recovery in untrained spinalized cats
    • Boyce V.S., Tumolo M., Fischer I., Murray M., Lemay M.A. Neurotrophic factors promote and enhance locomotor recovery in untrained spinalized cats. J Neurophysiol 2007, 98:1988-1996.
    • (2007) J Neurophysiol , vol.98 , pp. 1988-1996
    • Boyce, V.S.1    Tumolo, M.2    Fischer, I.3    Murray, M.4    Lemay, M.A.5
  • 8
    • 0024385554 scopus 로고
    • Induction of c-fos-like protein within the lumbar spinal cord and thalamus of the rat following peripheral stimulation
    • Bullitt E. Induction of c-fos-like protein within the lumbar spinal cord and thalamus of the rat following peripheral stimulation. Brain Res 1989, 493:391-397.
    • (1989) Brain Res , vol.493 , pp. 391-397
    • Bullitt, E.1
  • 9
    • 0027954265 scopus 로고
    • The effects of methylprednisolone and the ganglioside GM1 on acute spinal cord injury in rats
    • Constantini S., Young W. The effects of methylprednisolone and the ganglioside GM1 on acute spinal cord injury in rats. J Neurosurg 1994, 80:97-111.
    • (1994) J Neurosurg , vol.80 , pp. 97-111
    • Constantini, S.1    Young, W.2
  • 11
    • 0035576371 scopus 로고    scopus 로고
    • Axonal regeneration and functional recovery after complete spinal cord transection in rats by delayed treatment with transplants and neurotrophins
    • Coumans J.V., Lin T.T., Dai H.N., MacArthur L., McAtee M., Nash C., Bregman B.S. Axonal regeneration and functional recovery after complete spinal cord transection in rats by delayed treatment with transplants and neurotrophins. J Neurosci 2001, 21:9334-9344.
    • (2001) J Neurosci , vol.21 , pp. 9334-9344
    • Coumans, J.V.1    Lin, T.T.2    Dai, H.N.3    MacArthur, L.4    McAtee, M.5    Nash, C.6    Bregman, B.S.7
  • 12
    • 0036896864 scopus 로고    scopus 로고
    • Instrumental learning within the spinal cord: IV. Induction and retention of the behavioral deficit observed after noncontingent shock
    • Crown E.D., Ferguson A.R., Joynes R.L., Grau J.W. Instrumental learning within the spinal cord: IV. Induction and retention of the behavioral deficit observed after noncontingent shock. Behav Neurosci 2002, 116:1032-1051.
    • (2002) Behav Neurosci , vol.116 , pp. 1032-1051
    • Crown, E.D.1    Ferguson, A.R.2    Joynes, R.L.3    Grau, J.W.4
  • 13
    • 0036854665 scopus 로고    scopus 로고
    • Instrumental learning within the spinal cord: II. Evidence for central mediation
    • Crown E.D., Ferguson A.R., Joynes R.L., Grau J.W. Instrumental learning within the spinal cord: II. Evidence for central mediation. Physiol Behav 2002, 77:259-267.
    • (2002) Physiol Behav , vol.77 , pp. 259-267
    • Crown, E.D.1    Ferguson, A.R.2    Joynes, R.L.3    Grau, J.W.4
  • 14
    • 0034895864 scopus 로고    scopus 로고
    • Preserving and restoring behavioral potential within the spinal cord using an instrumental training paradigm
    • Crown E.D., Grau J.W. Preserving and restoring behavioral potential within the spinal cord using an instrumental training paradigm. J Neurophysiol 2001, 86:845-855.
    • (2001) J Neurophysiol , vol.86 , pp. 845-855
    • Crown, E.D.1    Grau, J.W.2
  • 15
    • 47349092661 scopus 로고    scopus 로고
    • Remote activation of microglia and pro-inflammatory cytokines predict the onset and severity of below-level neuropathic pain after spinal cord injury in rats
    • Detloff M.R., Fisher L.C., McGaughy V., Longbrake E.E., Popovich P.G., Basso D.M. Remote activation of microglia and pro-inflammatory cytokines predict the onset and severity of below-level neuropathic pain after spinal cord injury in rats. Exp Neurol 2008, 212:337-347.
    • (2008) Exp Neurol , vol.212 , pp. 337-347
    • Detloff, M.R.1    Fisher, L.C.2    McGaughy, V.3    Longbrake, E.E.4    Popovich, P.G.5    Basso, D.M.6
  • 16
    • 0037095759 scopus 로고    scopus 로고
    • Calcium-calmodulin-dependent protein kinase II contributes to spinal cord central sensitization
    • Fang L., Wu J., Lin Q., Willis W.D. Calcium-calmodulin-dependent protein kinase II contributes to spinal cord central sensitization. J Neurosci 2002, 22:4196-4204.
    • (2002) J Neurosci , vol.22 , pp. 4196-4204
    • Fang, L.1    Wu, J.2    Lin, Q.3    Willis, W.D.4
  • 17
    • 54949157325 scopus 로고    scopus 로고
    • Chronic pain after spinal cord injury: what characteristics make some pains more disturbing than others?
    • Felix E.R., Cruz-Almeida Y., Widerström-Noga E.G. Chronic pain after spinal cord injury: what characteristics make some pains more disturbing than others?. J Rehabil Res Dev 2007, 44:703-715.
    • (2007) J Rehabil Res Dev , vol.44 , pp. 703-715
    • Felix, E.R.1    Cruz-Almeida, Y.2    Widerström-Noga, E.G.3
  • 18
    • 33646782907 scopus 로고    scopus 로고
    • Nociceptive plasticity inhibits adaptive learning in the spinal cord
    • Ferguson A.R., Crown E.D., Grau J.W. Nociceptive plasticity inhibits adaptive learning in the spinal cord. Neuroscience 2006, 141:421-431.
    • (2006) Neuroscience , vol.141 , pp. 421-431
    • Ferguson, A.R.1    Crown, E.D.2    Grau, J.W.3
  • 19
    • 0034084290 scopus 로고    scopus 로고
    • Reactions of oligodendrocytes to spinal cord injury: cell survival and myelin repair
    • Frei E., Klusman I., Schnell L., Schwab M.E. Reactions of oligodendrocytes to spinal cord injury: cell survival and myelin repair. Exp Neurol 2000, 163:373-380.
    • (2000) Exp Neurol , vol.163 , pp. 373-380
    • Frei, E.1    Klusman, I.2    Schnell, L.3    Schwab, M.E.4
  • 20
    • 0344874610 scopus 로고    scopus 로고
    • BDNF sensitizes the response of lamina II neurons to high threshold primary afferent inputs
    • Garraway S.M., Petruska J.C., Mendell L.M. BDNF sensitizes the response of lamina II neurons to high threshold primary afferent inputs. Eur J Neurosci 2003, 18:2467-2476.
    • (2003) Eur J Neurosci , vol.18 , pp. 2467-2476
    • Garraway, S.M.1    Petruska, J.C.2    Mendell, L.M.3
  • 21
    • 34548677266 scopus 로고    scopus 로고
    • BDNF and learning: evidence that instrumental training promotes learning within the spinal cord by up-regulating BDNF expression
    • Gómez-Pinilla F., Huie J.R., Ying Z., Ferguson A.R., Crown E.D., Baumbauer K.M., Edgerton V.R., Grau J.W. BDNF and learning: evidence that instrumental training promotes learning within the spinal cord by up-regulating BDNF expression. Neuroscience 2007, 148:893-906.
    • (2007) Neuroscience , vol.148 , pp. 893-906
    • Gómez-Pinilla, F.1    Huie, J.R.2    Ying, Z.3    Ferguson, A.R.4    Crown, E.D.5    Baumbauer, K.M.6    Edgerton, V.R.7    Grau, J.W.8
  • 22
    • 0036850342 scopus 로고    scopus 로고
    • Voluntary exercise induces a BDNF-mediated mechanism that promotes neuroplasticity
    • Gómez-Pinilla F., Ying Z., Roy R.R., Molteni R., Edgerton V.R. Voluntary exercise induces a BDNF-mediated mechanism that promotes neuroplasticity. J Neurophysiol 2002, 88:2187-2195.
    • (2002) J Neurophysiol , vol.88 , pp. 2187-2195
    • Gómez-Pinilla, F.1    Ying, Z.2    Roy, R.R.3    Molteni, R.4    Edgerton, V.R.5
  • 23
    • 0032442183 scopus 로고    scopus 로고
    • Instrumental learning within the spinal cord: I. Behavioral properties
    • Grau J.W., Barstow D.G., Joynes R.L. Instrumental learning within the spinal cord: I. Behavioral properties. Behav Neurosci 1998, 112:1366-1386.
    • (1998) Behav Neurosci , vol.112 , pp. 1366-1386
    • Grau, J.W.1    Barstow, D.G.2    Joynes, R.L.3
  • 25
    • 0026802223 scopus 로고
    • A monitored contusion model of spinal cord injury in the rat
    • discussion 126-128
    • Gruner J.A. A monitored contusion model of spinal cord injury in the rat. J Neurotrauma 1992, 9:123-126. discussion 126-128.
    • (1992) J Neurotrauma , vol.9 , pp. 123-126
    • Gruner, J.A.1
  • 26
    • 0141529982 scopus 로고    scopus 로고
    • Upregulation of sodium channel Nav1.3 and functional involvement in neuronal hyperexcitability associated with central neuropathic pain after spinal cord injury
    • Hains B.C., Klein J.P., Saab C.Y., Craner M.J., Black J.A., Waxman S.G. Upregulation of sodium channel Nav1.3 and functional involvement in neuronal hyperexcitability associated with central neuropathic pain after spinal cord injury. J Neurosci 2003, 23:8881-8892.
    • (2003) J Neurosci , vol.23 , pp. 8881-8892
    • Hains, B.C.1    Klein, J.P.2    Saab, C.Y.3    Craner, M.J.4    Black, J.A.5    Waxman, S.G.6
  • 27
    • 33646439133 scopus 로고    scopus 로고
    • Activated microglia contribute to the maintenance of chronic pain after spinal cord injury
    • Hains B.C., Waxman S.G. Activated microglia contribute to the maintenance of chronic pain after spinal cord injury. J Neurosci 2006, 26:4308-4317.
    • (2006) J Neurosci , vol.26 , pp. 4308-4317
    • Hains, B.C.1    Waxman, S.G.2
  • 28
    • 47249139020 scopus 로고    scopus 로고
    • Gene expression alterations of neurotrophins, their receptors and prohormone convertases in a rat model of spinal cord contusion
    • Hajebrahimi Z., Mowla S.J., Movahedin M., Tavallaei M. Gene expression alterations of neurotrophins, their receptors and prohormone convertases in a rat model of spinal cord contusion. Neurosci Lett 2008, 441:261-266.
    • (2008) Neurosci Lett , vol.441 , pp. 261-266
    • Hajebrahimi, Z.1    Mowla, S.J.2    Movahedin, M.3    Tavallaei, M.4
  • 29
    • 67349233866 scopus 로고    scopus 로고
    • Brief, low frequency stimulation of rat peripheral C-fibres evokes prolonged microglial-induced central sensitization in adults but not in neonates
    • Hathway G.J., Vega-Avelaira D., Moss A., Ingram R., Fitzgerald M. Brief, low frequency stimulation of rat peripheral C-fibres evokes prolonged microglial-induced central sensitization in adults but not in neonates. Pain 2009, 144:110-118.
    • (2009) Pain , vol.144 , pp. 110-118
    • Hathway, G.J.1    Vega-Avelaira, D.2    Moss, A.3    Ingram, R.4    Fitzgerald, M.5
  • 31
    • 40749097184 scopus 로고    scopus 로고
    • Peripheral inflammation undermines the plasticity of the isolated spinal cord
    • Hook M.A., Huie J.R., Grau J.W. Peripheral inflammation undermines the plasticity of the isolated spinal cord. Behav Neurosci 2008, 122:233-249.
    • (2008) Behav Neurosci , vol.122 , pp. 233-249
    • Hook, M.A.1    Huie, J.R.2    Grau, J.W.3
  • 32
    • 0019423594 scopus 로고
    • Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures
    • Hsu S.M., Raine L., Fanger H. Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures. J Histochem Cytochem 1981, 29:577-580.
    • (1981) J Histochem Cytochem , vol.29 , pp. 577-580
    • Hsu, S.M.1    Raine, L.2    Fanger, H.3
  • 33
    • 2942596238 scopus 로고    scopus 로고
    • Three exercise paradigms differentially improve sensory recovery after spinal cord contusion in rats
    • Hutchinson K.J., Gómez-Pinilla F., Crowe M.J., Ying Z., Basso D.M. Three exercise paradigms differentially improve sensory recovery after spinal cord contusion in rats. Brain 2004, 127:1403-1414.
    • (2004) Brain , vol.127 , pp. 1403-1414
    • Hutchinson, K.J.1    Gómez-Pinilla, F.2    Crowe, M.J.3    Ying, Z.4    Basso, D.M.5
  • 34
    • 0033490464 scopus 로고    scopus 로고
    • Nociceptive-specific activation of ERK in spinal neurons contributes to pain hypersensitivity
    • Ji R.R., Baba H., Brenner G.J., Woolf C.J. Nociceptive-specific activation of ERK in spinal neurons contributes to pain hypersensitivity. Nat Neurosci 1999, 2:1114-1119.
    • (1999) Nat Neurosci , vol.2 , pp. 1114-1119
    • Ji, R.R.1    Baba, H.2    Brenner, G.J.3    Woolf, C.J.4
  • 35
    • 0037080003 scopus 로고    scopus 로고
    • ERK MAP kinase activation in superficial spinal cord neurons induces prodynorphin and NK-1 upregulation and contributes to persistent inflammatory pain hypersensitivity
    • Ji R.R., Befort K., Brenner G.J., Woolf C.J. ERK MAP kinase activation in superficial spinal cord neurons induces prodynorphin and NK-1 upregulation and contributes to persistent inflammatory pain hypersensitivity. J Neurosci 2002, 22:478-485.
    • (2002) J Neurosci , vol.22 , pp. 478-485
    • Ji, R.R.1    Befort, K.2    Brenner, G.J.3    Woolf, C.J.4
  • 36
    • 0036434324 scopus 로고    scopus 로고
    • Transplants of fibroblasts genetically modified to express BDNF promote axonal regeneration from supraspinal neurons following chronic spinal cord injury
    • Jin Y., Fischer I., Tessler A., Houle J.D. Transplants of fibroblasts genetically modified to express BDNF promote axonal regeneration from supraspinal neurons following chronic spinal cord injury. Exp Neurol 2002, 177:265-275.
    • (2002) Exp Neurol , vol.177 , pp. 265-275
    • Jin, Y.1    Fischer, I.2    Tessler, A.3    Houle, J.D.4
  • 38
    • 0033798313 scopus 로고    scopus 로고
    • Changes in truncated trkB and p75 receptor expression in the rat spinal cord following spinal cord hemisection and spinal cord hemisection plus neurotrophin treatment
    • King V.R., Bradbury E.J., McMahon S.B., Priestley J.V. Changes in truncated trkB and p75 receptor expression in the rat spinal cord following spinal cord hemisection and spinal cord hemisection plus neurotrophin treatment. Exp Neurol 2000, 165:327-341.
    • (2000) Exp Neurol , vol.165 , pp. 327-341
    • King, V.R.1    Bradbury, E.J.2    McMahon, S.B.3    Priestley, J.V.4
  • 40
    • 7444243313 scopus 로고    scopus 로고
    • Overexpression of the full-length neurotrophin receptor trkB regulates the expression of plasticity-related genes in mouse brain
    • Koponen E., Lakso M., Castrén E. Overexpression of the full-length neurotrophin receptor trkB regulates the expression of plasticity-related genes in mouse brain. Brain Res Mol Brain Res 2004, 130:81-94.
    • (2004) Brain Res Mol Brain Res , vol.130 , pp. 81-94
    • Koponen, E.1    Lakso, M.2    Castrén, E.3
  • 41
    • 83055163963 scopus 로고    scopus 로고
    • Molecular mechanisms underlying cell death in spinal networks in relation to locomotor activity after acute injury in vitro
    • Kuzhandaivel A., Nistri A., Mazzone G.L., Mladinic M. Molecular mechanisms underlying cell death in spinal networks in relation to locomotor activity after acute injury in vitro. Front Cell Neurosci 2011, 5:9.
    • (2011) Front Cell Neurosci , vol.5 , pp. 9
    • Kuzhandaivel, A.1    Nistri, A.2    Mazzone, G.L.3    Mladinic, M.4
  • 42
    • 33749326179 scopus 로고    scopus 로고
    • Upregulation of persistent and ramp sodium current in dorsal horn neurons after spinal cord injury
    • Lampert A., Hains B.C., Waxman S.G. Upregulation of persistent and ramp sodium current in dorsal horn neurons after spinal cord injury. Exp Brain Res 2006, 174:660-666.
    • (2006) Exp Brain Res , vol.174 , pp. 660-666
    • Lampert, A.1    Hains, B.C.2    Waxman, S.G.3
  • 43
    • 0035152176 scopus 로고    scopus 로고
    • Regulation of Trk receptors following contusion of the rat spinal cord
    • Liebl D.J., Huang W., Young W., Parada L.F. Regulation of Trk receptors following contusion of the rat spinal cord. Exp Neurol 2001, 167:15-26.
    • (2001) Exp Neurol , vol.167 , pp. 15-26
    • Liebl, D.J.1    Huang, W.2    Young, W.3    Parada, L.F.4
  • 44
    • 0036513485 scopus 로고    scopus 로고
    • The molecular basis of CaMKII function in synaptic and behavioural memory
    • Lisman J., Schulman H., Cline H. The molecular basis of CaMKII function in synaptic and behavioural memory. Nat Rev Neurosci 2002, 3:175-190.
    • (2002) Nat Rev Neurosci , vol.3 , pp. 175-190
    • Lisman, J.1    Schulman, H.2    Cline, H.3
  • 45
    • 0032791163 scopus 로고    scopus 로고
    • Neurotoxicity of glutamate at the concentration released upon spinal cord injury
    • Liu D., Xu G.Y., Pan E., McAdoo D.J. Neurotoxicity of glutamate at the concentration released upon spinal cord injury. Neuroscience 1999, 93:1383-1389.
    • (1999) Neuroscience , vol.93 , pp. 1383-1389
    • Liu, D.1    Xu, G.Y.2    Pan, E.3    McAdoo, D.J.4
  • 48
    • 0032528159 scopus 로고    scopus 로고
    • Neurotrophin-3 and brain-derived neurotrophic factor induce oligodendrocyte proliferation and myelination of regenerating axons in the contused adult rat spinal cord
    • McTigue D.M., Horner P.J., Stokes B.T., Gage F.H. Neurotrophin-3 and brain-derived neurotrophic factor induce oligodendrocyte proliferation and myelination of regenerating axons in the contused adult rat spinal cord. J Neurosci 1998, 18:5354-5365.
    • (1998) J Neurosci , vol.18 , pp. 5354-5365
    • McTigue, D.M.1    Horner, P.J.2    Stokes, B.T.3    Gage, F.H.4
  • 49
    • 0013970150 scopus 로고
    • Physiological properties of unmyelinated fiber projection to the spinal cord
    • Mendell L.M. Physiological properties of unmyelinated fiber projection to the spinal cord. Exp Neurol 1966, 16:316-332.
    • (1966) Exp Neurol , vol.16 , pp. 316-332
    • Mendell, L.M.1
  • 50
    • 0001895691 scopus 로고
    • Responses of single dorsal cord cells to peripheral cutaneous unmyelinated fibres
    • Mendell L.M., Wall P.D. Responses of single dorsal cord cells to peripheral cutaneous unmyelinated fibres. Nature 1965, 206:97-99.
    • (1965) Nature , vol.206 , pp. 97-99
    • Mendell, L.M.1    Wall, P.D.2
  • 51
    • 78649713359 scopus 로고    scopus 로고
    • Neurotrophin receptors TrkB.T1 and p75NTR cooperate in modulating both functional and structural plasticity in mature hippocampal neurons
    • Michaelsen K., Zagrebelsky M., Berndt-Huch J., Polack M., Buschler A., Sendtner M., Korte M. Neurotrophin receptors TrkB.T1 and p75NTR cooperate in modulating both functional and structural plasticity in mature hippocampal neurons. Eur J Neurosci 2010, 32:1854-1865.
    • (2010) Eur J Neurosci , vol.32 , pp. 1854-1865
    • Michaelsen, K.1    Zagrebelsky, M.2    Berndt-Huch, J.3    Polack, M.4    Buschler, A.5    Sendtner, M.6    Korte, M.7
  • 52
    • 0035369840 scopus 로고    scopus 로고
    • Trk receptors: mediators of neurotrophin action
    • Patapoutian A., Reichardt L.F. Trk receptors: mediators of neurotrophin action. Curr Opin Neurobiol 2001, 11:272-280.
    • (2001) Curr Opin Neurobiol , vol.11 , pp. 272-280
    • Patapoutian, A.1    Reichardt, L.F.2
  • 53
    • 0030176079 scopus 로고    scopus 로고
    • Recombinant BDNF rescues deficits in basal synaptic transmission and hippocampal LTP in BDNF knockout mice
    • Patterson S.L., Abel T., Deuel T.A., Martin K.C., Rose J.C., Kandel E.R. Recombinant BDNF rescues deficits in basal synaptic transmission and hippocampal LTP in BDNF knockout mice. Neuron 1996, 16:1137-1145.
    • (1996) Neuron , vol.16 , pp. 1137-1145
    • Patterson, S.L.1    Abel, T.2    Deuel, T.A.3    Martin, K.C.4    Rose, J.C.5    Kandel, E.R.6
  • 54
    • 15944418222 scopus 로고    scopus 로고
    • Induction of long-term potentiation in single nociceptive dorsal horn neurons is blocked by the CaMKII inhibitor AIP
    • Pedersen L.M., Lien G.F., Bollerud I., Gjerstad J. Induction of long-term potentiation in single nociceptive dorsal horn neurons is blocked by the CaMKII inhibitor AIP. Brain Res 2005, 1041:66-71.
    • (2005) Brain Res , vol.1041 , pp. 66-71
    • Pedersen, L.M.1    Lien, G.F.2    Bollerud, I.3    Gjerstad, J.4
  • 55
    • 0036298493 scopus 로고    scopus 로고
    • Downregulation of BDNF mRNA in the hippocampal dentate gyrus after re-exposure to cues previously associated with footshock
    • Rasmusson A.M., Shi L., Duman R. Downregulation of BDNF mRNA in the hippocampal dentate gyrus after re-exposure to cues previously associated with footshock. Neuropsychopharmacology 2002, 27:133-142.
    • (2002) Neuropsychopharmacology , vol.27 , pp. 133-142
    • Rasmusson, A.M.1    Shi, L.2    Duman, R.3
  • 57
    • 0032982565 scopus 로고    scopus 로고
    • Effects of BDNF and NT-3 on development of Ia/motoneuron functional connectivity in neonatal rats
    • Seebach B.S., Arvanov V., Mendell L.M. Effects of BDNF and NT-3 on development of Ia/motoneuron functional connectivity in neonatal rats. J Neurophysiol 1999, 81:2398-2405.
    • (1999) J Neurophysiol , vol.81 , pp. 2398-2405
    • Seebach, B.S.1    Arvanov, V.2    Mendell, L.M.3
  • 59
    • 0035090029 scopus 로고    scopus 로고
    • Pain following spinal cord injury
    • Siddall P.J., Loeser J.D. Pain following spinal cord injury. Spinal Cord 2001, 39:63-73.
    • (2001) Spinal Cord , vol.39 , pp. 63-73
    • Siddall, P.J.1    Loeser, J.D.2
  • 60
    • 0026742451 scopus 로고
    • Impaired spatial learning in alpha-calcium-calmodulin kinase II mutant mice
    • Silva A.J., Paylor R., Wehner J.M., Tonegawa S. Impaired spatial learning in alpha-calcium-calmodulin kinase II mutant mice. Science 1992, 257:206-211.
    • (1992) Science , vol.257 , pp. 206-211
    • Silva, A.J.1    Paylor, R.2    Wehner, J.M.3    Tonegawa, S.4
  • 61
    • 8144230420 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor induces NMDA receptor subunit one phosphorylation via ERK and PKC in the rat spinal cord
    • Slack S.E., Pezet S., McMahon S.B., Thompson S.W., Malcangio M. Brain-derived neurotrophic factor induces NMDA receptor subunit one phosphorylation via ERK and PKC in the rat spinal cord. Eur J Neurosci 2004, 20:1769-1778.
    • (2004) Eur J Neurosci , vol.20 , pp. 1769-1778
    • Slack, S.E.1    Pezet, S.2    McMahon, S.B.3    Thompson, S.W.4    Malcangio, M.5
  • 62
    • 0033529278 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor is an endogenous modulator of nociceptive responses in the spinal cord
    • Thompson S.W., Bennett D.L., Kerr B.J., Bradbury E.J., McMahon S.B. Brain-derived neurotrophic factor is an endogenous modulator of nociceptive responses in the spinal cord. Proc Natl Acad Sci U S A 1999, 96:7714-7718.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 7714-7718
    • Thompson, S.W.1    Bennett, D.L.2    Kerr, B.J.3    Bradbury, E.J.4    McMahon, S.B.5
  • 63
    • 0025354044 scopus 로고
    • Activity-dependent changes in rat ventral horn neurons in vitro; summation of prolonged afferent evoked postsynaptic depolarizations produce a d-2-amino-5-phosphonovaleric acid sensitive windup
    • Thompson S.W., King A.E., Woolf C.J. Activity-dependent changes in rat ventral horn neurons in vitro; summation of prolonged afferent evoked postsynaptic depolarizations produce a d-2-amino-5-phosphonovaleric acid sensitive windup. Eur J Neurosci 1990, 2:638-649.
    • (1990) Eur J Neurosci , vol.2 , pp. 638-649
    • Thompson, S.W.1    King, A.E.2    Woolf, C.J.3
  • 64
    • 0345227300 scopus 로고    scopus 로고
    • Delayed grafting of BDNF and NT-3 producing fibroblasts into the injured spinal cord stimulates sprouting, partially rescues axotomized red nucleus neurons from loss and atrophy, and provides limited regeneration
    • Tobias C.A., Shumsky J.S., Shibata M., Tuszynski M.H., Fischer I., Tessler A., Murray M. Delayed grafting of BDNF and NT-3 producing fibroblasts into the injured spinal cord stimulates sprouting, partially rescues axotomized red nucleus neurons from loss and atrophy, and provides limited regeneration. Exp Neurol 2003, 184:97-113.
    • (2003) Exp Neurol , vol.184 , pp. 97-113
    • Tobias, C.A.1    Shumsky, J.S.2    Shibata, M.3    Tuszynski, M.H.4    Fischer, I.5    Tessler, A.6    Murray, M.7
  • 66
    • 34247584175 scopus 로고    scopus 로고
    • Exposure to intermittent nociceptive stimulation under pentobarbital anesthesia disrupts spinal cord function in rats
    • Washburn S.N., Patton B.C., Ferguson A.R., Hudson K.L., Grau J.W. Exposure to intermittent nociceptive stimulation under pentobarbital anesthesia disrupts spinal cord function in rats. Psychopharmacology (Berl) 2007, 192:243-252.
    • (2007) Psychopharmacology (Berl) , vol.192 , pp. 243-252
    • Washburn, S.N.1    Patton, B.C.2    Ferguson, A.R.3    Hudson, K.L.4    Grau, J.W.5
  • 67
    • 0026339976 scopus 로고
    • Unbiased stereological estimation of the total number of neurons in the subdivisions of the rat hippocampus using the optical fractionator
    • West M.J., Slomianka L., Gundersen H.J. Unbiased stereological estimation of the total number of neurons in the subdivisions of the rat hippocampus using the optical fractionator. Anat Rec 1991, 231:482-497.
    • (1991) Anat Rec , vol.231 , pp. 482-497
    • West, M.J.1    Slomianka, L.2    Gundersen, H.J.3
  • 68
    • 0141705210 scopus 로고    scopus 로고
    • Blood-spinal cord barrier after spinal cord injury: relation to revascularization and wound healing
    • Whetstone W.D., Hsu J.Y., Eisenberg M., Werb Z., Noble-Haeusslein L.J. Blood-spinal cord barrier after spinal cord injury: relation to revascularization and wound healing. J Neurosci Res 2003, 74:227-239.
    • (2003) J Neurosci Res , vol.74 , pp. 227-239
    • Whetstone, W.D.1    Hsu, J.Y.2    Eisenberg, M.3    Werb, Z.4    Noble-Haeusslein, L.J.5
  • 69
    • 33749486775 scopus 로고    scopus 로고
    • Role of phosphorylation of ERK in induction and maintenance of LTP of the C-fiber evoked field potentials in spinal dorsal horn
    • Xin W.J., Gong Q.J., Xu J.T., Yang H.W., Zang Y., Zhang T., Li Y.Y., Liu X.G. Role of phosphorylation of ERK in induction and maintenance of LTP of the C-fiber evoked field potentials in spinal dorsal horn. J Neurosci Res 2006, 84:934-943.
    • (2006) J Neurosci Res , vol.84 , pp. 934-943
    • Xin, W.J.1    Gong, Q.J.2    Xu, J.T.3    Yang, H.W.4    Zang, Y.5    Zhang, T.6    Li, Y.Y.7    Liu, X.G.8
  • 70
    • 0034666105 scopus 로고    scopus 로고
    • The role of brain-derived neurotrophic factor receptors in the mature hippocampus: modulation of long-term potentiation through a presynaptic mechanism involving TrkB
    • Xu B., Gottschalk W., Chow A., Wilson R.I., Schnell E., Zang K., Wang D., Nicoll R.A., Lu B., Reichardt L.F. The role of brain-derived neurotrophic factor receptors in the mature hippocampus: modulation of long-term potentiation through a presynaptic mechanism involving TrkB. J Neurosci 2000, 20:6888-6897.
    • (2000) J Neurosci , vol.20 , pp. 6888-6897
    • Xu, B.1    Gottschalk, W.2    Chow, A.3    Wilson, R.I.4    Schnell, E.5    Zang, K.6    Wang, D.7    Nicoll, R.A.8    Lu, B.9    Reichardt, L.F.10
  • 71
    • 2342550091 scopus 로고    scopus 로고
    • Concentrations of glutamate released following spinal cord injury kill oligodendrocytes in the spinal cord
    • Xu G.Y., Hughes M.G., Ye Z., Hulsebosch C.E., McAdoo D.J. Concentrations of glutamate released following spinal cord injury kill oligodendrocytes in the spinal cord. Exp Neurol 2004, 187:329-336.
    • (2004) Exp Neurol , vol.187 , pp. 329-336
    • Xu, G.Y.1    Hughes, M.G.2    Ye, Z.3    Hulsebosch, C.E.4    McAdoo, D.J.5
  • 72
    • 58149391339 scopus 로고    scopus 로고
    • Activation of the neuronal extracellular signal-regulated kinase 2 in the spinal cord dorsal horn is required for complete Freund's adjuvant-induced pain hypersensitivity
    • Xu Q., Garraway S.M., Weyerbacher A.R., Shin S.J., Inturrisi C.E. Activation of the neuronal extracellular signal-regulated kinase 2 in the spinal cord dorsal horn is required for complete Freund's adjuvant-induced pain hypersensitivity. J Neurosci 2008, 28:14087-14096.
    • (2008) J Neurosci , vol.28 , pp. 14087-14096
    • Xu, Q.1    Garraway, S.M.2    Weyerbacher, A.R.3    Shin, S.J.4    Inturrisi, C.E.5
  • 73
    • 0028874907 scopus 로고
    • A combination of BDNF and NT-3 promotes supraspinal axonal regeneration into Schwann cell grafts in adult rat thoracic spinal cord
    • Xu X.M., Guénard V., Kleitman N., Aebischer P., Bunge M.B. A combination of BDNF and NT-3 promotes supraspinal axonal regeneration into Schwann cell grafts in adult rat thoracic spinal cord. Exp Neurol 1995, 134:261-272.
    • (1995) Exp Neurol , vol.134 , pp. 261-272
    • Xu, X.M.1    Guénard, V.2    Kleitman, N.3    Aebischer, P.4    Bunge, M.B.5
  • 74
    • 1342280526 scopus 로고    scopus 로고
    • Roles of CaMKII, PKA, and PKC in the induction and maintenance of LTP of C-fiber-evoked field potentials in rat spinal dorsal horn
    • Yang H.W., Hu X.D., Zhang H.M., Xin W.J., Li M.T., Zhang T., Zhou L.J., Liu X.G. Roles of CaMKII, PKA, and PKC in the induction and maintenance of LTP of C-fiber-evoked field potentials in rat spinal dorsal horn. J Neurophysiol 2004, 91:1122-1133.
    • (2004) J Neurophysiol , vol.91 , pp. 1122-1133
    • Yang, H.W.1    Hu, X.D.2    Zhang, H.M.3    Xin, W.J.4    Li, M.T.5    Zhang, T.6    Zhou, L.J.7    Liu, X.G.8
  • 75
    • 18244377125 scopus 로고    scopus 로고
    • Exercise restores levels of neurotrophins and synaptic plasticity following spinal cord injury
    • Ying Z., Roy R.R., Edgerton V.R., Gómez-Pinilla F. Exercise restores levels of neurotrophins and synaptic plasticity following spinal cord injury. Exp Neurol 2005, 193:411-419.
    • (2005) Exp Neurol , vol.193 , pp. 411-419
    • Ying, Z.1    Roy, R.R.2    Edgerton, V.R.3    Gómez-Pinilla, F.4
  • 76
    • 47349107138 scopus 로고    scopus 로고
    • BDNF induces late-phase LTP of C-fiber evoked field potentials in rat spinal dorsal horn
    • Zhou L.J., Zhong Y., Ren W.J., Li Y.Y., Zhang T., Liu X.G. BDNF induces late-phase LTP of C-fiber evoked field potentials in rat spinal dorsal horn. Exp Neurol 2008, 212:507-514.
    • (2008) Exp Neurol , vol.212 , pp. 507-514
    • Zhou, L.J.1    Zhong, Y.2    Ren, W.J.3    Li, Y.Y.4    Zhang, T.5    Liu, X.G.6


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