Role of the ligand density in cation exchange materials for the purification of proteins

Journal of Chromatography A

Volumn 1217, Issue 15, 2010, Pages 2216-2225

  Franke, Agnes ^a   Forrer, Nicola ^a   Butté, Alessandro ^b   Cvijetić, Božidar ^a   Morbidelli, Massimo ^a   Jöhnck, Matthias ^c   Schulte, Michael ^c  

^a ETH ZURICH   (Switzerland)

^b LONZA AG   (Switzerland)

^c MERCK KGAA   (Germany)

Author keywords

Dynamic binding capacity; General rate model; Ion exchange chromatography; Ligand density; Mass transfer resistances; Polyclonal antibody; Pore accessibility

Indexed keywords

DYNAMIC BINDING CAPACITY; GENERAL RATE MODEL; ION EXCHANGE CHROMATOGRAPHY; LIGAND DENSITY; MASS TRANSFER RESISTANCES; POLYCLONAL ANTIBODY;

ACTINIDES; ANTIBODIES; CHROMATOGRAPHIC ANALYSIS; CHROMATOGRAPHY; FUNCTIONAL POLYMERS; ION CHROMATOGRAPHY; ION EXCHANGE; ION EXCHANGE RESINS; MASS TRANSFER; MATERIALS; MOLECULES; PORE SIZE; POSITIVE IONS; PURIFICATION;

LIGANDS;

CATION EXCHANGE RESIN; IMMUNOGLOBULIN G;

ARTICLE; BINDING KINETICS; BINDING SITE; CALCULATION; CATION EXCHANGE; CHEMICAL ANALYSIS; CONTROLLED STUDY; DENSITY; DYNAMIC BINDING CAPACITY; GEOMETRY; INTERMETHOD COMPARISON; LIGAND DENSITY; MATERIAL STATE; MOLECULAR WEIGHT; PARTICLE SIZE; PH; POROSITY; PRIORITY JOURNAL; PROTEIN PURIFICATION; SIMULATION; STATIC BINDING CAPACITY;

ADSORPTION; CATION EXCHANGE RESINS; CHROMATOGRAPHY, GEL; COMPUTER SIMULATION; IMMUNOGLOBULIN G; KINETICS; LIGANDS; PARTICLE SIZE; POROSITY; PROTEINS;

EID: 77950690143     PISSN: 00219673     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chroma.2010.02.002     Document Type: Article

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