Gefitinib induces apoptosis in human glioma cells by targeting Bad phosphorylation

Journal of Neuro-Oncology

Volumn 105, Issue 3, 2011, Pages 507-522

  Chang, Cheng Yi ^a,b,c   Shen, Chiung Chyi ^c   Su, Hong Lin ^a,e   Chen, Chun Jung ^c,d  

^a NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

^b FENG YUAN HOSPITAL   (Taiwan)

^c TAICHUNG VETERANS GENERAL HOSPITAL   (Taiwan)

^d TUNGHAI UNIVERSITY   (Taiwan)

^e CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Bad; EGFR; Gefitinib; Glioma

Indexed keywords

CASPASE 12; CASPASE 3; CASPASE 8; CASPASE 9; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYTOCHROME C; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; FOCAL ADHESION KINASE; GEFITINIB; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; PROTEIN BAD; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL XL;

APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL DAMAGE; CELL FRACTIONATION; CELL PROLIFERATION; CELL STRUCTURE; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOSTASIS; DRUG CYTOTOXICITY; DRUG MECHANISM; DRUG TARGETING; ENZYME ACTIVATION; ENZYME INACTIVATION; ENZYME RELEASE; GLIOMA CELL; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL PERMEABILITY; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN DEPHOSPHORYLATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BCL-ASSOCIATED DEATH PROTEIN; BLOTTING, WESTERN; BRAIN NEOPLASMS; CELL LINE, TUMOR; CELL SURVIVAL; CYCLIC AMP-DEPENDENT PROTEIN KINASES; GLIOMA; HUMANS; IMMUNOPRECIPITATION; MEMBRANE POTENTIAL, MITOCHONDRIAL; PHOSPHORYLATION; QUINAZOLINES; RNA, SMALL INTERFERING; TRANSFECTION;

EID: 82955212778     PISSN: 0167594X     EISSN: 15737373     Source Type: Journal    
DOI: 10.1007/s11060-011-0632-3     Document Type: Article

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