-
1
-
-
1842633680
-
Gefitinib, a novel, orally administered agent for the treatment of cancer
-
Ranson M, Wardell S. Gefitinib, a novel, orally administered agent for the treatment of cancer. J Clin Pharm Ther 2004; 29: 95-103
-
(2004)
J Clin Pharm Ther
, vol.29
, pp. 95-103
-
-
Ranson, M.1
Wardell, S.2
-
2
-
-
4143076078
-
Targetting the epidermal growth factor receptor
-
El-Reyes BF, LoRusso PM. Targetting the epidermal growth factor receptor. Br J Cancer 2004; 91: 418-24
-
(2004)
Br J Cancer
, vol.91
, pp. 418-424
-
-
El-Reyes, B.F.1
LoRusso, P.M.2
-
3
-
-
0035884231
-
The epidermal growth factor receptor: From mutant oncogene in nonhuman cancers to therapeutic target in human neoplasia
-
Sep 15
-
Arteaga CL. The epidermal growth factor receptor: from mutant oncogene in nonhuman cancers to therapeutic target in human neoplasia. J Clin Oncol 2001 Sep 15; 19 (18 Suppl.): 32S-40S
-
(2001)
J Clin Oncol
, vol.19
, Issue.18 SUPPL.
-
-
Arteaga, C.L.1
-
4
-
-
0036032582
-
Gefitinib
-
Culy CR, Faulds D. Gefitinib. Drugs 2002; 62 (15): 2237-48
-
(2002)
Drugs
, vol.62
, Issue.15
, pp. 2237-2248
-
-
Culy, C.R.1
Faulds, D.2
-
6
-
-
0036569870
-
ZD1839, a selective oral epidermal growth factor receptor-tyrosine kinase inhibitor, is well tolerated and active in patients with solid, malignant tumors: Results of a phase I trial
-
May 1
-
Ranson M, Hammond LA, Ferry D, et al. ZD1839, a selective oral epidermal growth factor receptor-tyrosine kinase inhibitor, is well tolerated and active in patients with solid, malignant tumors: results of a phase I trial. J Clin Oncol 2002 May 1; 20 (9): 2240-50
-
(2002)
J Clin Oncol
, vol.20
, Issue.9
, pp. 2240-2250
-
-
Ranson, M.1
Hammond, L.A.2
Ferry, D.3
-
7
-
-
0012381722
-
Multi-institutional randomized phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer
-
Jun 15
-
Fukuoka M, Yano S, Giaccone G, et al. Multi-institutional randomized phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer. J Clin Oncol 2003 Jun 15; 21 (12): 2237-46
-
(2003)
J Clin Oncol
, vol.21
, Issue.12
, pp. 2237-2246
-
-
Fukuoka, M.1
Yano, S.2
Giaccone, G.3
-
8
-
-
0142055937
-
Efficacy of gefitinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in symptomatic patients with non-small cell lung cancer: A randomized trial
-
Oct 22
-
Kris MG, Natale RB, Herbst RS, et al. Efficacy of gefitinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in symptomatic patients with non-small cell lung cancer: a randomized trial. JAMA 2003 Oct 22; 290 (16): 2149-58
-
(2003)
JAMA
, vol.290
, Issue.16
, pp. 2149-2158
-
-
Kris, M.G.1
Natale, R.B.2
Herbst, R.S.3
-
9
-
-
2442451710
-
Rapid and durable objective responses in patients with advanced non-small-cell lung cancer in phase II trials (IDEAL 1 and IDEAL 2) treated with gefitinib
-
abstract no. 52. Sep
-
Gatzemeier U, Douillard JY, Kris M, et al. Rapid and durable objective responses in patients with advanced non-small-cell lung cancer in phase II trials (IDEAL 1 and IDEAL 2) treated with gefitinib [abstract no. 52]. EJC Supplements 2003 Sep; 1 (5): 20
-
(2003)
EJC Supplements
, vol.1
, Issue.5
, pp. 20
-
-
Gatzemeier, U.1
Douillard, J.Y.2
Kris, M.3
-
10
-
-
17844404190
-
-
Improvement in symptoms and quality of life for advanced non-small-cell lung cancer patients receiving ZD1839 ('Iressa') in IDEAL 2. 38th Proc Am Soc Clin Oncol 2002 May; 21 (Pt 1 of 2): 292 plus poster presented; May 18-21, Orl
-
Natale RB, Skarin A, Maddox A-M, et al. Improvement in symptoms and quality of life for advanced non-small-cell lung cancer patients receiving ZD1839 ('Iressa') in IDEAL 2. 38th Proc Am Soc Clin Oncol 2002 May; 21 (Pt 1 of 2): 292 plus poster presented at the 38th Annual Meeting of the American Society of Clinical Oncology; May 18-21, 2002; Orl
-
(2002)
38th Annual Meeting of the American Society of Clinical Oncology
-
-
Natale, R.B.1
Skarin, A.2
Maddox, A.-M.3
-
11
-
-
17844403172
-
-
ZD1839 improves disease-related symptoms and quality of life of patients with locally advanced or metastatic non-small-cell lung cancer in two randomized, double-blind studies (IDEAL-1 and IDEAL-2) [abstract no. P367]. 2002 Oct; 122 Suppl.: 166 plus poster presented; Nov 2
-
Herbst R, Natale R, Giaccone G, et al. ZD1839 improves disease-related symptoms and quality of life of patients with locally advanced or metastatic non-small-cell lung cancer in two randomized, double-blind studies (IDEAL-1 and IDEAL-2) [abstract no. P367]. 2002 Oct; 122 Suppl.: 166 plus poster presented at the 68th Annual International Scientific Assembley of the American College of Chest Physicians; 2002 Nov 2-
-
(2002)
68th Annual International Scientific Assembley of the American College of Chest Physicians
-
-
Herbst, R.1
Natale, R.2
Giaccone, G.3
-
12
-
-
8344281238
-
Clinically meaningful improvement in disease-related symptoms by gefitinib (Iressa, ZD1839) in patients with advanced non-small-cell lung cancer: Relationship between lung cancer subscale scores and radiographic response and survival
-
Sep
-
Douillard JY, Cella D, Natale RB, et al. Clinically meaningful improvement in disease-related symptoms by gefitinib (Iressa, ZD1839) in patients with advanced non-small-cell lung cancer: relationship between lung cancer subscale scores and radiographic response and survival. EJC Supplements 2003 Sep; 1 (5): 276-7
-
(2003)
EJC Supplements
, vol.1
, Issue.5
, pp. 276-277
-
-
Douillard, J.Y.1
Cella, D.2
Natale, R.B.3
-
13
-
-
10244265781
-
Final survival and safety results for 21,064 non-small-cell lung cancer (NSCLC) patients who received compassionate use gefitinib in a US expanded access program (EAP)
-
abstract no. 7060. Jun 5; New Orleans
-
Ochs J, Grous JJ, Warner KL, et al. Final survival and safety results for 21,064 non-small-cell lung cancer (NSCLC) patients who received compassionate use gefitinib in a US expanded access program (EAP) [abstract no. 7060]. 40th Annual Meeting of the American Society of Clinical Oncology; 2004 Jun 5; New Orleans: 628
-
(2004)
40th Annual Meeting of the American Society of Clinical Oncology
, pp. 628
-
-
Ochs, J.1
Grous, J.J.2
Warner, K.L.3
-
14
-
-
10744220834
-
Efficacy and tolerability of gefitinib in pretreated elderly patients with advanced non-small-cell lung cancer (NSCLC)
-
Jan 12
-
Cappuzzo F, Bartolini S, Ceresoli GL, et al. Efficacy and tolerability of gefitinib in pretreated elderly patients with advanced non-small-cell lung cancer (NSCLC). Br J Cancer 2004 Jan 12; 90 (1): 82-6
-
(2004)
Br J Cancer
, vol.90
, Issue.1
, pp. 82-86
-
-
Cappuzzo, F.1
Bartolini, S.2
Ceresoli, G.L.3
-
15
-
-
9144244180
-
Activity of a specific inhibitor, gefitinib (Iressa TM, ZD1839), of epidermal growth factor receptor in refractory non-small-cell lung cancer
-
Jan
-
Santoro A, Cavina R, Latteri F, et al. Activity of a specific inhibitor, gefitinib (Iressa TM, ZD1839), of epidermal growth factor receptor in refractory non-small-cell lung cancer. Ann Oncol 2004 Jan; 15 (1): 33-7
-
(2004)
Ann Oncol
, vol.15
, Issue.1
, pp. 33-37
-
-
Santoro, A.1
Cavina, R.2
Latteri, F.3
-
16
-
-
2642561372
-
Gefitinib as a last treatment option for non-small-cell lung cancer: Durable disease control in a subset of patients
-
May
-
Haringhuizen A, van Tinteren H, Vaessen HFR, et al. Gefitinib as a last treatment option for non-small-cell lung cancer: durable disease control in a subset of patients. Ann Oncol 2004 May; 15 (5): 786-92
-
(2004)
Ann Oncol
, vol.15
, Issue.5
, pp. 786-792
-
-
Haringhuizen, A.1
Van Tinteren, H.2
Vaessen, H.F.R.3
-
17
-
-
8344278420
-
Gefitinib in heavily pretreated non small cell lung cancer: Results of the expanded access program in Eastern France
-
abstract no. 7323. Jun 5; New Orleans
-
Spaeth D, Deplanque G, Favrot N, et al. Gefitinib in heavily pretreated non small cell lung cancer: results of the expanded access program in Eastern France [abstract no. 7323]. 40th Annual Meeting of the American Society of Clinical Oncology; 2004 Jun 5; New Orleans: 693
-
(2004)
40th Annual Meeting of the American Society of Clinical Oncology
, pp. 693
-
-
Spaeth, D.1
Deplanque, G.2
Favrot, N.3
-
18
-
-
8344270623
-
Gefitinib in patients with non-small-cell lung cancer (NSCLC): The Royal Marsden Experience
-
abstract no. 7099. Jun 5; New Orleans
-
Parton M, Maisey N, Banerjee S, et al. Gefitinib in patients with non-small-cell lung cancer (NSCLC): The Royal Marsden Experience [abstract no. 7099]. 40th Annual Meeting of the American Society of Clinical Oncology; 2004 Jun 5; New Orleans: 638
-
(2004)
40th Annual Meeting of the American Society of Clinical Oncology
, pp. 638
-
-
Parton, M.1
Maisey, N.2
Banerjee, S.3
-
19
-
-
1542713370
-
Gefitinib in combination with paclitaxel and carboplatin in advanced non-small-cell lung cancer: A phase III trial - INTACT 2
-
Herbst RS, Giaccone G, Schiller JH, et al. Gefitinib in combination with paclitaxel and carboplatin in advanced non-small-cell lung cancer: a phase III trial - INTACT 2. J Clin Oncol 2004; 22: 785-94
-
(2004)
J Clin Oncol
, vol.22
, pp. 785-794
-
-
Herbst, R.S.1
Giaccone, G.2
Schiller, J.H.3
-
20
-
-
1542503746
-
Gefitinib in combination with gemcitabine and cisplatin in advanced non-small-cell lung cancer: A phase III trial - INTACT 1
-
Giaccone G, Herbst RS, Manegold C, et al. Gefitinib in combination with gemcitabine and cisplatin in advanced non-small-cell lung cancer: a phase III trial - INTACT 1. J Clin Oncol 2004; 22: 777-84
-
(2004)
J Clin Oncol
, vol.22
, pp. 777-784
-
-
Giaccone, G.1
Herbst, R.S.2
Manegold, C.3
-
21
-
-
8344289512
-
Gefitinib (ZD1839) therapy for advanced bronchioloalveolar lung cancer (BAC): Southwest Oncology Group Study (SWOG) S0126
-
abstract no. 7014, Jun 5; New Orleans
-
West H, Franklin WA, Gumerlock PH. Gefitinib (ZD1839) therapy for advanced bronchioloalveolar lung cancer (BAC): Southwest Oncology Group Study (SWOG) S0126 [abstract no. 7014], 40th Annual Meeting of the American Society of Clinical Oncology; 2004 Jun 5; New Orleans: 618
-
(2004)
40th Annual Meeting of the American Society of Clinical Oncology
, pp. 618
-
-
West, H.1
Franklin, W.A.2
Gumerlock, P.H.3
-
22
-
-
1242283946
-
Gefitinib as first-line, compassionate use therapy in patients with advanced non-small-cell lung cancer
-
Argiris A, Mittal N. Gefitinib as first-line, compassionate use therapy in patients with advanced non-small-cell lung cancer. Lung Cancer 2004; 43: 317-22
-
(2004)
Lung Cancer
, vol.43
, pp. 317-322
-
-
Argiris, A.1
Mittal, N.2
-
23
-
-
3042747669
-
Single-agent gefitinib as first line therapy in patients with advanced non-small cell lung cancer; Washington University experience
-
Aug
-
Kommareddy A, Coplin M, Gao F, et al. Single-agent gefitinib as first line therapy in patients with advanced non-small cell lung cancer; Washington University experience. Lung Cancer 2004 Aug; 45 (2): 221-5
-
(2004)
Lung Cancer
, vol.45
, Issue.2
, pp. 221-225
-
-
Kommareddy, A.1
Coplin, M.2
Gao, F.3
-
24
-
-
1142293600
-
-
Safety and tolerability of gefitinib in advanced NSCLC: overview of clinical experience [abstract no. P327]. Sep; plus poster presented at the European Respiratory Society 13th Annual Congress, Vienna, Austria, Sept 27-Oct
-
Forsythe B, Faulkner K. Safety and tolerability of gefitinib in advanced NSCLC: overview of clinical experience [abstract no. P327]. Eur Respir J 2003 Sep; 22 (Suppl. 45): 32s plus poster presented at the European Respiratory Society 13th Annual Congress, Vienna, Austria, Sept 27-Oct
-
(2003)
Eur Respir J
, vol.22
, Issue.45 SUPPL.
-
-
Forsythe, B.1
Faulkner, K.2
-
25
-
-
8344220853
-
ASCO conference highlights: EGFR mutations take centre stage
-
Belani CP. ASCO conference highlights: EGFR mutations take centre stage. Signal 2004; 5 (2): 18-22
-
(2004)
Signal
, vol.5
, Issue.2
, pp. 18-22
-
-
Belani, C.P.1
-
26
-
-
2342624080
-
EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy
-
Jun 4
-
Paez JG, Janne PA, Lee JC, et al. EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science 2004 Jun 4; 304: 1497-500
-
(2004)
Science
, vol.304
, pp. 1497-1500
-
-
Paez, J.G.1
Janne, P.A.2
Lee, J.C.3
-
27
-
-
2342471392
-
Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
-
Lynch TJ, Bell DW, Sordella R, et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. New Engl J Med 2004; 350 (21): 2129-39
-
(2004)
New Engl J Med
, vol.350
, Issue.21
, pp. 2129-2139
-
-
Lynch, T.J.1
Bell, D.W.2
Sordella, R.3
-
28
-
-
1842509828
-
Bronchioloalveolar pathologic subtype and smoking history predict sensitivity to gefitinib in advanced non-small-cell lung cancer
-
Mar 15
-
Miller VA, Kris MG, Shah N, et al. Bronchioloalveolar pathologic subtype and smoking history predict sensitivity to gefitinib in advanced non-small-cell lung cancer. J Clin Oncol 2004 Mar 15; 22 (6): 1103-9
-
(2004)
J Clin Oncol
, vol.22
, Issue.6
, pp. 1103-1109
-
-
Miller, V.A.1
Kris, M.G.2
Shah, N.3
-
29
-
-
0346649812
-
Targeting the epidermal growth factor receptor: Prognostic and clinical implications
-
Herbst R. Targeting the epidermal growth factor receptor: prognostic and clinical implications. EJC Supplements 2003; 1 (8): 9-15
-
(2003)
EJC Supplements
, vol.1
, Issue.8
, pp. 9-15
-
-
Herbst, R.1
-
30
-
-
4444332925
-
Akt phosphorylation and gefitinib efficacy in patients with advanced non-small-cell lung cancer
-
Cappuzzo F, Magrini E, Ceresoli GL, et al. Akt phosphorylation and gefitinib efficacy in patients with advanced non-small-cell lung cancer. J Natl Cancer Inst 2004; 96 (15): 1133-41
-
(2004)
J Natl Cancer Inst
, vol.96
, Issue.15
, pp. 1133-1141
-
-
Cappuzzo, F.1
Magrini, E.2
Ceresoli, G.L.3
-
31
-
-
3543122916
-
Predicting sensitivity of non-small-cell lung cancer to gefitinib: Is there a role for P-Akt?
-
Pao W, Miller VA, Venkatraman E, et al. Predicting sensitivity of non-small-cell lung cancer to gefitinib: is there a role for P-Akt? J Natl Cancer Inst 2004; 96 (15): 1117-9
-
(2004)
J Natl Cancer Inst
, vol.96
, Issue.15
, pp. 1117-1119
-
-
Pao, W.1
Miller, V.A.2
Venkatraman, E.3
-
32
-
-
4143066760
-
Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways
-
Aug 20
-
Sordella R, Bell DW, Haber DA, et al. Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways. Science 2004 Aug 20; 305 (5687): 1163-7
-
(2004)
Science
, vol.305
, Issue.5687
, pp. 1163-1167
-
-
Sordella, R.1
Bell, D.W.2
Haber, D.A.3
|