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Volumn 5, Issue 20, 2011, Pages 2247-2254

Zerumbone protects HEK 293 cells from irradiation-induced DNA damage via activating Keap1/Nrf2/ARE pathway

Author keywords

H2AX; Antioxidant response element; DNA double strand break; HEK 293 cell; HO 1; NQO1; Zerumbone

Indexed keywords

BETA ACTIN; HEME OXYGENASE 1; HISTONE H2AX; KELCH LIKE ECH ASSOCIATED PROTEIN 1; TRANSCRIPTION FACTOR NRF2; ZERUMBONE;

EID: 82755192631     PISSN: None     EISSN: 19960816     Source Type: Journal    
DOI: 10.5897/AJPP11.464     Document Type: Article
Times cited : (6)

References (32)
  • 2
    • 4544384318 scopus 로고    scopus 로고
    • Radiation oncology: A century of achievements
    • Bernier J, Hall EJ, Giaccia A (2004). Radiation oncology: a century of achievements. Nat. Rev. Cancer. 4: 737-747.
    • (2004) Nat. Rev. Cancer , vol.4 , pp. 737-747
    • Bernier, J.1    Hall, E.J.2    Giaccia, A.3
  • 3
    • 0028139014 scopus 로고
    • The thioredoxin and glutaredoxin systems are efficient electron donors to human plasma glutathione peroxidase
    • Bjornstedt M, Xue J, Huang W, Akesson B, Holmgren A (1994). The thioredoxin and glutaredoxin systems are efficient electron donors to human plasma glutathione peroxidase. J. Biol. Chem., 269: 29382-29384.
    • (1994) J. Biol. Chem , vol.269 , pp. 29382-29384
    • Bjornstedt, M.1    Xue, J.2    Huang, W.3    Akesson, B.4    Holmgren, A.5
  • 7
    • 34247547489 scopus 로고    scopus 로고
    • Zerumbone suppresses phorbol ester-induced expression of multiple scavenger receptor genes in THP-1 human monocytic cells
    • Eguchi A, Kaneko Y, Murakami A, Ohigashi H (2007). Zerumbone suppresses phorbol ester-induced expression of multiple scavenger receptor genes in THP-1 human monocytic cells. Biosci. Biotechnol. Biochem., 71: 935-945.
    • (2007) Biosci. Biotechnol. Biochem , vol.71 , pp. 935-945
    • Eguchi, A.1    Kaneko, Y.2    Murakami, A.3    Ohigashi, H.4
  • 12
    • 79251487517 scopus 로고    scopus 로고
    • Inhibition of Gama-H2AX after Ionizing Radiation as a Biological Surrogate of Impaired Upstream DNA Damage Signaling and Radiosensitivity
    • Johnny Kao, Amir Lavaf, Chao-Hua Lan, Fu S (2010). Inhibition of Gama-H2AX after Ionizing Radiation as a Biological Surrogate of Impaired Upstream DNA Damage Signaling and Radiosensitivity. J. Cancer Mol., 5: 49-54.
    • (2010) J. Cancer Mol , vol.5 , pp. 49-54
    • Kao, J.1    Lavaf, A.2    Lan, C.-H.3    Fu, S.4
  • 13
    • 48749112811 scopus 로고    scopus 로고
    • Oxidative stress and thioredoxin system
    • Koharyova M, Kolarova M (2008). Oxidative stress and thioredoxin system. Gen Physiol. Biophys. 27: 71-84.
    • (2008) Gen Physiol. Biophys , vol.27 , pp. 71-84
    • Koharyova, M.1    Kolarova, M.2
  • 14
    • 33845221922 scopus 로고    scopus 로고
    • Protective effect of paeoniflorin on irradiation-induced cell damage involved in modulation of reactive oxygen species and the mitogen-activated protein kinases
    • Li CR, Zhou Z, Zhu D, Sun YN, Dai JM, Wang SQ (2007). Protective effect of paeoniflorin on irradiation-induced cell damage involved in modulation of reactive oxygen species and the mitogen-activated protein kinases. Int J. Biochem. Cell. Biol., 39: 426-38.
    • (2007) Int J. Biochem. Cell. Biol , vol.39 , pp. 426-438
    • Li, C.R.1    Zhou, Z.2    Zhu, D.3    Sun, Y.N.4    Dai, J.M.5    Wang, S.Q.6
  • 15
    • 59849113546 scopus 로고    scopus 로고
    • Molecular mechanisms of Nrf2-mediated antioxidant response
    • Li W, Kong AN (2009). Molecular mechanisms of Nrf2-mediated antioxidant response. Mol. Carcinog., 48: 91-104.
    • (2009) Mol Carcinog , vol.48 , pp. 91-104
    • Li, W.1    Kong, A.N.2
  • 16
    • 0042198801 scopus 로고    scopus 로고
    • Redox regulation in the lens
    • Lou MF (2003). Redox regulation in the lens. Prog. Retin. Eye Res., 22: 657-682.
    • (2003) Prog. Retin. Eye Res , vol.22 , pp. 657-682
    • Lou, M.F.1
  • 17
    • 67650252237 scopus 로고    scopus 로고
    • Chemoprevention with phytochemicals targeting inducible nitric oxide synthase
    • Murakami A (2009). Chemoprevention with phytochemicals targeting inducible nitric oxide synthase. Forum Nutr., 61: 193-203.
    • (2009) Forum Nutr , vol.61 , pp. 193-203
    • Murakami, A.1
  • 18
    • 33745482597 scopus 로고    scopus 로고
    • Cancer-preventive anti-oxidants that attenuate free radical generation by inflammatory cells
    • Murakami A, Ohigashi H (2006). Cancer-preventive anti-oxidants that attenuate free radical generation by inflammatory cells. Biol Chem. 387: 387-392.
    • (2006) Biol Chem , vol.387 , pp. 387-392
    • Murakami, A.1    Ohigashi, H.2
  • 19
    • 0036258778 scopus 로고    scopus 로고
    • Zerumbone, a Southeast Asian ginger sesquiterpene, markedly suppresses free radical generation, proinflammatory protein production, and cancer cell proliferation accompanied by apoptosis: The alpha, beta-unsaturated carbonyl group is a prerequisite
    • Murakami A, Takahashi D, Kinoshita T, Koshimizu K, Kim HW, Yoshihiro A, Nakamura Y, Jiwajinda S, Terao J, Ohigashi H (2002). Zerumbone, a Southeast Asian ginger sesquiterpene, markedly suppresses free radical generation, proinflammatory protein production, and cancer cell proliferation accompanied by apoptosis: the alpha, beta-unsaturated carbonyl group is a prerequisite. Carcinogenesis, 23: 795-802.
    • (2002) Carcinogenesis , vol.23 , pp. 795-802
    • Murakami, A.1    Takahashi, D.2    Kinoshita, T.3    Koshimizu, K.4    Kim, H.W.5    Yoshihiro, A.6    Nakamura, Y.7    Jiwajinda, S.8    Terao, J.9    Ohigashi, H.10
  • 20
    • 4143081630 scopus 로고    scopus 로고
    • Zerumbone, a tropical ginger sesquiterpene, activates phase II drug metabolizing enzymes
    • Nakamura Y, Yoshida C, Murakami A, Ohigashi H, Osawa T, Uchida K (2004). Zerumbone, a tropical ginger sesquiterpene, activates phase II drug metabolizing enzymes. FEBS Lett., 572: 245-250.
    • (2004) FEBS Lett , vol.572 , pp. 245-250
    • Nakamura, Y.1    Yoshida, C.2    Murakami, A.3    Ohigashi, H.4    Osawa, T.5    Uchida, K.6
  • 22
    • 34247218059 scopus 로고    scopus 로고
    • Zerumbone induced apoptosis in liver cancer cells via modulation of Bax/Bcl-2 ratio
    • Sakinah SA, Handayani ST, Hawariah LP (2007). Zerumbone induced apoptosis in liver cancer cells via modulation of Bax/Bcl-2 ratio. Cancer Cell Int., 7: 4.
    • (2007) Cancer Cell Int , vol.7 , pp. 4
    • Sakinah, S.A.1    Handayani, S.T.2    Hawariah, L.P.3
  • 25
    • 60549113238 scopus 로고    scopus 로고
    • Zerumbone abolishes RANKL-induced NF-kappaB activation, inhibits osteoclastogenesis, and suppresses human breast cancer-induced bone loss in athymic nude mice
    • Sung B, Murakami A, Oyajobi BO, Aggarwal BB (2009). Zerumbone abolishes RANKL-induced NF-kappaB activation, inhibits osteoclastogenesis, and suppresses human breast cancer-induced bone loss in athymic nude mice. Cancer Res., 69: 1477-1484.
    • (2009) Cancer Res , vol.69 , pp. 1477-1484
    • Sung, B.1    Murakami, A.2    Oyajobi, B.O.3    Aggarwal, B.B.4
  • 26
    • 34748873851 scopus 로고    scopus 로고
    • Zerumbone exerts a beneficial effect on inflammatory parameters of cholecystokinin octapeptide-induced experimental pancreatitis but fails to improve histology
    • Szabolcs A, Tiszlavicz L, Kaszaki J, Posa A, Berko A, Varga IS, Boros I, Szuts V, Lonovics J, Takacs T (2007). Zerumbone exerts a beneficial effect on inflammatory parameters of cholecystokinin octapeptide-induced experimental pancreatitis but fails to improve histology. Pancreas, 35: 249-255.
    • (2007) Pancreas , vol.35 , pp. 249-255
    • Szabolcs, A.1    Tiszlavicz, L.2    Kaszaki, J.3    Posa, A.4    Berko, A.5    Varga, I.S.6    Boros, I.7    Szuts, V.8    Lonovics, J.9    Takacs, T.10
  • 27
    • 0014481378 scopus 로고
    • Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: Applications to mammalian blood and other tissues
    • Tietze F (1969). Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues. Anal. Biochem., 27: 502-522.
    • (1969) Anal. Biochem , vol.27 , pp. 502-522
    • Tietze, F.1
  • 28
    • 67349095790 scopus 로고    scopus 로고
    • Radiation-induced micronucleus formation and DNA damage in human lymphocytes and their prevention by antioxidant thiols
    • Tiwari P, Kumar A, Balakrishnan S, Kushwaha HS, Mishra KP (2009). Radiation-induced micronucleus formation and DNA damage in human lymphocytes and their prevention by antioxidant thiols. Mutat. Res., 676: 62-68.
    • (2009) Mutat. Res , vol.676 , pp. 62-68
    • Tiwari, P.1    Kumar, A.2    Balakrishnan, S.3    Kushwaha, H.S.4    Mishra, K.P.5
  • 30
    • 37649017714 scopus 로고    scopus 로고
    • Identification of retinoic acid as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha
    • Wang XJ, Hayes JD, Henderson CJ (2007). Identification of retinoic acid as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha. Proc. Natl. Acad. Sci. U S A., 104: 19589-19594.
    • (2007) Proc. Natl. Acad. Sci. U S A , vol.104 , pp. 19589-19594
    • Wang, X.J.1    Hayes, J.D.2    Henderson, C.J.3
  • 31
    • 33751332527 scopus 로고    scopus 로고
    • Zerumbone, a bioactive sesquiterpene, induces G2/M cell cycle arrest and apoptosis in leukemia cells via a Fas- and mitochondria-mediated pathway
    • Xian M, Ito K, Nakazato T, Shimizu T, Chen CK, Yamato K, Murakami A, Ohigashi H, Ikeda Y, Kizaki M (2007). Zerumbone, a bioactive sesquiterpene, induces G2/M cell cycle arrest and apoptosis in leukemia cells via a Fas- and mitochondria-mediated pathway. Cancer Sci., 98: 118-126.
    • (2007) Cancer Sci , vol.98 , pp. 118-126
    • Xian, M.1    Ito, K.2    Nakazato, T.3    Shimizu, T.4    Chen, C.K.5    Yamato, K.6    Murakami, A.7    Ohigashi, H.8    Ikeda, Y.9    Kizaki, M.10
  • 32
    • 69249083578 scopus 로고    scopus 로고
    • Zerumbone enhances TRAIL-induced apoptosis through the induction of death receptors in human colon cancer cells: Evidence for an essential role of reactive oxygen species
    • Yodkeeree S, Sung B, Limtrakul P, Aggarwal BB (2009). Zerumbone enhances TRAIL-induced apoptosis through the induction of death receptors in human colon cancer cells: Evidence for an essential role of reactive oxygen species. Cancer Res., 69: 6581-6589.
    • (2009) Cancer Res , vol.69 , pp. 6581-6589
    • Yodkeeree, S.1    Sung, B.2    Limtrakul, P.3    Aggarwal, B.B.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.