Hypermorphic mutation of the voltage-gated sodium channel encoding gene Scn10a causes a dramatic stimulus-dependent neurobehavioral phenotype

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 48, 2011, Pages 19413-19418

  Blasius, Amanda L ^a   Dubin, Adrienne E ^a   Petrus, Matt J ^b   Lim, Byung Kwan ^c   Narezkina, Anna ^c   Criado, José R ^a   Wills, Derek N ^a   Xia, Yu ^a   Moresco, Eva Marie Y ^a   Ehlers, Cindy ^a   Knowlton, Kirk U ^c   Patapoutian, Ardem ^a,b   Beutler, Bruce ^a,d  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b GENOMICS INSTITUTE OF THE NOVARTIS RESEARCH FOUNDATION   (United States)

^c UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^d UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Cold sensitivity; EEG; Scruffing

Indexed keywords

ATROPINE; ETHYLNITROSOUREA; SODIUM CHANNEL NAV1.8;

ALLELE; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BEHAVIOR CHANGE; BRAIN ELECTROPHYSIOLOGY; CATATONIA; COGNITION; COLD; COLD EXPOSURE; COLD SENSITIVITY; CONTROLLED STUDY; ELECTROCARDIOGRAPHY; ELECTROENCEPHALOGRAPHY; FEAR; FEMALE; GENE MUTATION; GENETIC IDENTIFICATION; HEART RATE VARIABILITY; HOMOZYGOTE; HYPERMORPHIC MUTATION; MALE; MOUSE; NECK; NERVE CELL EXCITABILITY; NERVE STIMULATION; NONHUMAN; PAIN; PHENOTYPE; POSSUM PHENOTYP; PRIORITY JOURNAL; SENSORY STIMULATION; SINUS BRADYCARDIA; SODIUM CURRENT; TONIC IMMOBILITY; UPREGULATION;

ANIMALS; ATROPINE; BRADYCARDIA; ELECTROCARDIOGRAPHY; ELECTROENCEPHALOGRAPHY; IMMOBILITY RESPONSE, TONIC; MICE; MUTATION; PHENOTYPE; SODIUM CHANNELS;

EID: 82755190552     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1117020108     Document Type: Article

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