MicroRNA in lung cancer diagnostics and treatment

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 717, Issue 1-2, 2011, Pages 25-31

  Skrzypski, Marcin ^a   Dziadziuszko, Rafał ^a   Jassem, Jacek ^a  

^a MEDICAL UNIVERSITY OF GDANSK   (Poland)

Author keywords

Early detection; MicroRNA; Non small cell lung cancer; Predictive factors; Prognosis

Indexed keywords

CETUXIMAB; CISPLATIN; DOXORUBICIN; ETOPOSIDE; LET 7; MICRORNA; MICRORNA 123; MICRORNA 126; MICRORNA 155; MICRORNA 17; MICRORNA 182; MICRORNA 205; MICRORNA 21; MICRORNA 221; MICRORNA 25; MICRORNA 294; MICRORNA 29B; MICRORNA 30; MICRORNA 32; MICRORNA 34B; MICRORNA 34C; MICRORNA 372; MIRAVIRSEN; UNCLASSIFIED DRUG;

CANCER CHEMOTHERAPY; CANCER RECURRENCE; CANCER RELAPSE; CANCER RESISTANCE; CANCER STAGING; CANCER SURVIVAL; DISTANT METASTASIS; DRUG RESPONSE; EARLY DIAGNOSIS; GENE EXPRESSION PROFILING; HEPATITIS C; HUMAN; LUNG ADENOCARCINOMA; LUNG CANCER; LUNG CARCINOGENESIS; LUNG NON SMALL CELL CANCER; LUNG SQUAMOUS CELL CARCINOMA; NONHUMAN; OVERALL SURVIVAL; PHARMACOGENETICS; PREDICTIVE VALUE; PRIORITY JOURNAL; PROGNOSIS; PROGRESSION FREE SURVIVAL; REVIEW;

ANIMALS; ANTINEOPLASTIC AGENTS; BIOLOGICAL MARKERS; CLINICAL TRIALS AS TOPIC; EARLY DETECTION OF CANCER; HUMANS; LUNG NEOPLASMS; MICRORNAS; PROGNOSIS;

EID: 82755187248     PISSN: 00275107     EISSN: 09218262     Source Type: Journal    
DOI: 10.1016/j.mrfmmm.2011.04.002     Document Type: Review

References (70)

1. Fabian M., Sonenberg N., Filipowicz W. Regulation of mRNA translation and stability by microRNAs. Annu. Rev. Biochem. 2010, 79:351-379.
2. Xi Y., Nakajima G., Gavin E., Morris C., Kudo K., Hayashi K., Ju J. Systematic analysis of microRNA expression of RNA extracted from fresh frozen and formalin-fixed paraffin-embedded samples. RNA 2007, 13:1668-1674.
3. Chen X., Ba Y., Ma L., Cai X., Yin Y., Wang K., Guo J., Zhang Y., Chen J., Guo X., Li Q., Li X., Wang W., Wang J., Jiang X., Xiang Y., Xu C., Zheng P., Zhang J., Li R., Zhang H., Shang X., Gong T., Ning G., Zen K., Zhang C.Y. Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases. Cell Res. 2008, 18:997-1006.
4. Lewis B., Burge C., Bartel D. Conserved seed pairing often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell 2005, 120:15-20.
5. Miranda K., Huynh T., Tay Y., Ang Y., Tam W., Thomson A., Lim B., Rigoutsos I. A pattern-based method for the identification of MicroRNA binding sites and their corresponding heteroduplexes. Cell 2006, 126:1203-1217.
6. Fabbri M., Garzon R., Cimmino A., Liu Z., Zanesi N., Callegari E., Liu S., Alder H., Costinean S., Fernandez-Cymering C., Volinia S., Guler G., Morrison C., Chan K., Marcucci G., Calin G., Huebner K., Croce C. MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B. Proc. Natl. Acad. Sci. U.S.A. 2007, 104:15805-15810.
7. Bandi N., Zbinden S., Gugger M., Arnold M., Kocher V., Hasan L., Kappeler A., Brunner T., Vassella E. miR-15a and miR-16 are implicated in cell cycle regulation in a Rb-dependent manner and are frequently deleted or down-regulated in non-small cell lung cancer. Cancer Res. 2009, 69:5553-5559.
8. Bartlett J., Going J., Mallon E., Watters A., Reeves J., Stanton P., Richmond J., Donald B., Ferrier R., Cooke T. Evaluating HER2 amplification and overexpression in breast cancer. J. Pathol. 2001, 195:422-428.
9. Xing L., Todd N., Yu L., Fang H., Jiang F. Early detection of squamous cell lung cancer in sputum by a panel of microRNA markers. Mod. Pathol. 2010, 23:1157-1164.
10. Lodes M., Caraballo M., Suciu D., Munro S., Kumar A., Anderson B. Detection of cancer with serum miRNAs on an oligonucleotide microarray. PLoS One 2009, 4:e6229.
11. Yanaihara N., Caplen N., Bowman E., Seike M., Kumamoto K., Yi M., Stephens R., Okamoto A., Yokota J., Tanaka T., Calin G., Liu C., Croce C., Harris C. Unique microRNA molecular profiles in lung cancer diagnosis and prognosis. Cancer Cell 2006, 9:189-198.
12. Yang Y., Li X.F., Yang Q., Wang X.P., Zhou Y.G., Jiang T., Ma Q.F., Wang Y.J. The role of microRNA in human lung squamous cell carcinoma. Cancer Genet. Cytogenet. 2010, 200:127-133.
13. Volinia S., Calin G., Liu C., Ambs S., Cimmino A., Petrocca F., Visone R., Iorio M., Roldo C., Ferracin M., Prueitt R., Yanaihara N., Lanza G., Scarpa A., Vecchione A., Negrini M., Harris C., Croce C. A microRNA expression signature of human solid tumors defines cancer gene targets. Proc. Natl. Acad. Sci. U.S.A. 2006, 103:2257-2261.
14. Raponi M., Dossey L., Jatkoe T., Wu X., Chen G., Fan H., Beer D. MicroRNA classifiers for predicting prognosis of squamous cell lung cancer. Cancer Res. 2009, 69:5776-5783.
15. Crawford M., Brawner E., Batte K., Yu L., Hunter M., Otterson G., Nuovo G., Marsh C., Nana-Sinkam S. MicroRNA-126 inhibits invasion in non-small cell lung carcinoma cell lines. Biochem. Biophys. Res. Commun. 2008, 373:607-612.
16. Kumar M., Erkeland S., Pester R., Chen C., Ebert M., Sharp P., Jacks T. Suppression of non-small cell lung tumor development by the let-7 microRNA family. Proc. Natl. Acad. Sci. U.S.A. 2008, 105:3903-3908.
17. Johnson S., Grosshans H., Shingara J., Byrom M., Jarvis R., Cheng A., Labourier E., Reinert K., Brown D., Slack F. RAS is regulated by the let-7 microRNA family. Cell 2005, 120:635-647.
18. Lee Y., Dutta A. The tumor suppressor microRNA let-7 represses the HMGA2 oncogene. Genes Dev. 2007, 21:1025-1030.
19. Young A., Narita M. Oncogenic HMGA2: Short or small?. Genes Dev. 2007, 21:1005-1009.
20. Yu F., Deng H., Yao H., Liu Q., Su F., Song E. Mir-30 reduction maintains self-renewal and inhibits apoptosis in breast tumor-initiating cells. Oncogene 2010, 29:4194-4204.
21. Mascaux C., Laes J., Anthoine G., Haller A., Ninane V., Burny A., Sculier J. Evolution of microRNA expression during human bronchial squamous carcinogenesis. Eur. Respir. J. 2009, 33:352-359.
22. Izzotti A., Calin G., Arrigo P., Steele V., Croce C., De Flora S. Downregulation of microRNA expression in the lungs of rats exposed to cigarette smoke. FASEB J. 2009, 23:806-812.
23. Izzotti A., Bagnasco M., Cartiglia C., Longobardi M., Balansky R., Merello A., Lubet R., De Flora S. Chemoprevention of genome transcriptome, and proteome alterations induced by cigarette smoke in rat lung. Eur. J. Cancer 2005, 41:1864-1874.
24. He L., He X., Lim L., de Stanchina E., Xuan Z., Liang Y., Xue W., Zender L., Magnus J., Ridzon D., Jackson A., Linsley P., Chen C., Lowe S., Cleary M., Hannon G. A microRNA component of the p53 tumour suppressor network. Nature 2007, 447:1130-1134.
25. Izzotti A., Calin G., Steele V., Cartiglia C., Longobardi M., Croce C., De Flora S. Chemoprevention of cigarette smoke-induced alterations of MicroRNA expression in rat lungs. Cancer Prev. Res. (Phila, PA) 2010, 3:62-72.
26. Izzotti A., Larghero P., Cartiglia C., Longobardi M., Pfeffer U., Steele V., De Flora S. Modulation of microRNA expression by budesonide phenethyl isothiocyanate and cigarette smoke in mouse liver and lung. Carcinogenesis 2010, 31:894-901.
27. Lebanony D., Benjamin H., Gilad S., Ezagouri M., Dov A., Ashkenazi K., Gefen N., Izraeli S., Rechavi G., Pass H., Nonaka D., Li J., Spector Y., Rosenfeld N., Chajut A., Cohen D., Aharonov R., Mansukhani M. Diagnostic assay based on hsa-miR-205 expression distinguishes squamous from nonsquamous non-small-cell lung carcinoma. J. Clin. Oncol. 2009, 27:2030-2037.
28. Du L., Schageman J., Irnov, Girard L., Hammond S., Minna J., Gazdar A., Pertsemlidis A. MicroRNA expression distinguishes SCLC from NSCLC lung tumor cells and suggests a possible pathological relationship between SCLCs and NSCLCs. J. Exp. Clin. Cancer Res. 2010, 29:75.
29. Henschke C., Yankelevitz D., Libby D., Pasmantier M., Smith J., Miettinen O., Investigators I.E.L.C.A.P. Survival of patients with stage I lung cancer detected on CT screening. N. Engl. J. Med. 2006, 355:1763-1771.
30. Rabinowits G., Gerçel-Taylor C., Day J., Taylor D., Kloecker G. Exosomal microRNA: a diagnostic marker for lung cancer. Clin. Lung Cancer 2009, 10:42-46.
31. Silva J., García V., Zaballos A., Provencio M., Lombardía L., Almonacid L., García J., Domínguez G., Peña C., Diaz R., Herrera M., Varela A., Bonilla F. Vesicle-related microRNAs in plasma of NSCLC patients correlation with survival. Eur. Respir. J. 2010.
32. Heneghan H.M., Miller N., Lowery A.J., Sweeney K.J., Kerin M.J. Systemic miRNA levels as novel breast cancer biomarkers. Cancer Res. 2009, 492. (Abstract 432).
33. Boeri M., Verri C., Conte D., Roz L., Modena P., Facchinetti F., Calabrò E., Croce C.M., Pastorino U., Sozzi G. MicroRNA signatures in tissues and plasma predict development and prognosis of computed tomography detected lung cancer. Proc. Natl. Acad. Sci. U.S.A. 2011, 108:3713-3718.
34. Yu L., Todd N., Xing L., Xie Y., Zhang H., Liu Z., Fang H., Zhang J., Katz R., Jiang F. Early detection of lung adenocarcinoma in sputum by a panel of microRNA markers. Int. J. Cancer 2010.
35. Martini N., Bains M., Burt M., Zakowski M., McCormack P., Rusch V., Ginsberg R. Incidence of local recurrence and second primary tumors in resected stage I lung cancer. J. Thorac. Cardiovasc. Surg. 1995, 109:120-129.
36. Pignon J., Tribodet H., Scagliotti G., Douillard J., Shepherd F., Stephens R., Dunant A., Torri V., Rosell R., Seymour L., Spiro S., Rolland E., Fossati R., Aubert D., Ding K., Waller D., Le Chevalier T., Group L.C. Lung adjuvant cisplatin evaluation: a pooled analysis by the LACE Collaborative Group. J. Clin. Oncol. 2008, 26:3552-3559.
37. Douillard J., Tribodet H., Aubert D., Shepherd F., Rosell R., Ding K., Veillard A., Seymour L., Le Chevalier T., Spiro S., Stephens R., Pignon J., Group L.C. Adjuvant cisplatin and vinorelbine for completely resected non-small cell lung cancer: subgroup analysis of the Lung Adjuvant Cisplatin Evaluation. J. Thorac. Oncol. 2010, 5:220-228.
38. Varlotto J., Recht A., Flickinger J., Medford-Davis L., Dyer A., Decamp M. Factors associated with local and distant recurrence and survival in patients with resected nonsmall cell lung cancer. Cancer 2009, 115:1059-1069.
39. Takamizawa J., Konishi H., Yanagisawa K., Tomida S., Osada H., Endoh H., Harano T., Yatabe Y., Nagino M., Nimura Y., Mitsudomi T., Takahashi T. Reduced expression of the let-7 microRNAs in human lung cancers in association with shortened postoperative survival. Cancer Res. 2004, 64:3753-3756.
40. Inamura K., Togashi Y., Nomura K., Ninomiya H., Hiramatsu M., Satoh Y., Okumura S., Nakagawa K., Ishikawa Y. let-7 microRNA expression is reduced in bronchioloalveolar carcinoma, a non-invasive carcinoma, and is not correlated with prognosis. Lung Cancer 2007, 58:392-396.
41. Yu S., Chen H., Chang G., Chen C., Chen H., Singh S., Cheng C., Yu C., Lee Y., Chen H., Su T., Chiang C., Li H., Hong Q., Su H., Chen C., Chen W., Liu C., Chan W., Li K., Chen J., Yang P. MicroRNA signature predicts survival and relapse in lung cancer. Cancer Cell 2008, 13:48-57.
42. Boyd J., Hubbs J., Kim D., Hollis D., Marks L., Kelsey C. Timing of local and distant failure in resected lung cancer: implications for reported rates of local failure. J. Thorac. Oncol. 2010, 5:211-214.
43. Pepek J.M., Chino J.P., Marks L.B., D'amico T.A., Yoo D.S., Onaitis M.W., Ready N.E., Hubbs J.L., Boyd J., Kelsey C.R. How well does the new lung cancer staging system predict for local/regional recurrence after surgery?: A comparison of the TNM 6 and 7 systems. J. Thorac. Oncol. 2011.
44. Landi M., Zhao Y., Rotunno M., Koshiol J., Liu H., Bergen A., Rubagotti M., Goldstein A., Linnoila I., Marincola F., Tucker M., Bertazzi P., Pesatori A., Caporaso N., McShane L., Wang E. MicroRNA expression differentiates histology and predicts survival of lung cancer. Clin. Cancer Res. 2010, 16:430-441.
45. Patnaik S., Kannisto E., Knudsen S., Yendamuri S. Evaluation of microRNA expression profiles that may predict recurrence of localized stage I non-small cell lung cancer after surgical resection. Cancer Res. 2010, 70:36-45.
46. Voortman J., Goto A., Mendiboure J., Sohn J.J., Schetter A.J., Saito M., Dunant A., Pham T.C., Petrini I., Lee A., Khan M.A., Hainaut P., Pignon J.P., Brambilla E., Popper H.H., Filipits M., Harris C.C., Giaccone G. MicroRNA expression and clinical outcomes in patients treated with adjuvant chemotherapy after complete resection of non-small cell lung carcinoma. Cancer Res. 2010, 70:8288-8298.
47. Saito M., Schetter A.J., Mollerup S., Kohno T., Skaug V., Bowman E.D., Mathé E.A., Takenoshita S., Yokota J., Haugen A., Harris C.C. The association of MicroRNA expression with prognosis and progression in early-stage non-small cell lung adenocarcinoma: a retrospective analysis of three cohorts. Clin. Cancer Res. 2011.
48. Berghmans T., Paesmans M., Meert A.P., Mascaux C., Lothaire P., Lafitte J.J., Sculier J.P. Survival improvement in resectable non-small cell lung cancer with (neo)adjuvant chemotherapy: results of a meta-analysis of the literature. Lung Cancer 2005, 49:13-23.
49. Hu Z., Chen X., Zhao Y., Tian T., Jin G., Shu Y., Chen Y., Xu L., Zen K., Zhang C., Shen H. Serum microRNA signatures identified in a genome-wide serum microRNA expression profiling predict survival of non-small-cell lung cancer. J. Clin. Oncol. 2010, 28:1721-1726.
50. Skrzypski M., Szymanowska A., Jassem E., Czapiewski P., Rzepko R., Biernat W., Pawlowski R., Rzyman W., Jassem J. Prognostic value of three microRNA expression profiles in early-stage squamous cell lung cancer (SqCLC). J. Clin. Oncol. 2010, 15s. (Abstract 7028).
51. Blower P., Verducci J., Lin S., Zhou J., Chung J., Dai Z., Liu C., Reinhold W., Lorenzi P., Kaldjian E., Croce C., Weinstein J., Sadee W. MicroRNA expression profiles for the NCI-60 cancer cell panel. Mol Cancer Ther 2007, 6:1483-1491.
52. Blower P., Chung J., Verducci J., Lin S., Park J., Dai Z., Liu C., Schmittgen T., Reinhold W., Croce C., Weinstein J., Sadee W. MicroRNAs modulate the chemosensitivity of tumor cells. Mol. Cancer Ther. 2008, 7:1-9.
53. Ceppi P., Mudduluru G., Kumarswamy R., Rapa I., Scagliotti G., Papotti M., Allgayer H. Loss of miR-200c expression induces an aggressive invasive, and chemoresistant phenotype in non-small cell lung cancer. Mol. Cancer Res. 2010, 8:1207-1216.
54. Ranade A., Cherba D., Sridhar S., Richardson P., Webb C., Paripati A., Bowles B., Weiss G. MicroRNA 92a-2*: a biomarker predictive for chemoresistance and prognostic for survival in patients with small cell lung cancer. J. Thorac. Oncol. 2010, 5:1273-1278.
55. Silahtaroglu A., Pfundheller H., Koshkin A., Tommerup N., Kauppinen S. LNA-modified oligonucleotides are highly efficient as FISH probes. Cytogenet. Genome Res. 2004, 107:32-37.
56. Nuovo G. In situ detection of microRNAs in paraffin embedded, formalin fixed tissues and the co-localization of their putative targets. Methods 2010.
57. Incoronato M, Garofalo M., Urso L., Romano G., Quintavalle C., Zanca C., Iaboni M., Nuovo G., Croce C., Condorelli G. miR-212 increases tumor necrosis factor-related apoptosis-inducing ligand sensitivity in non-small cell lung cancer by targeting the antiapoptotic protein PED. Cancer Res. 2010, 70:3638-3646.
58. Garofalo M., Quintavalle C., Di Leva G., Zanca C., Romano G., Taccioli C., Liu C., Croce C., Condorelli G. MicroRNA signatures of TRAIL resistance in human non-small cell lung cancer. Oncogene 2008, 27:3845-3855.
59. Frieden M., Ørum H. Locked nucleic acid holds promise in the treatment of cancer. Curr. Pharm. Des. 2008, 14:1138-1142.
60. Fluiter K., Mook O., Baas F. The therapeutic potential of LNA-modified siRNAs: reduction of off-target effects by chemical modification of the siRNA sequence. Methods Mol. Biol. 2009, 487:189-203.
61. Galluzzi L., Morselli E., Vitale I., Kepp O., Senovilla L., Criollo A., Servant N., Paccard C., Hupé P., Robert T., Ripoche H., Lazar V., Harel-Bellan A., Dessen P., Barillot E., Kroemer G. miR-181a and miR-630 regulate cisplatin-induced cancer cell death. Cancer Res. 2010, 70:1793-1803.
62. Zhu W., Shan X., Wang T., Shu Y., Liu P. miR-181b modulates multidrug resistance by targeting BCL2 in human cancer cell lines. Int. J. Cancer 2010, 127:2520-2529.
63. Guo L., Liu Y., Bai Y., Sun Y., Xiao F., Guo Y. Gene expression profiling of drug-resistant small cell lung cancer cells by combining microRNA and cDNA expression analysis. Eur. J. Cancer 2010, 46:1692-1702.
64. Johnson C., Esquela-Kerscher A., Stefani G., Byrom M., Kelnar K., Ovcharenko D., Wilson M., Wang X., Shelton J., Shingara J., Chin L., Brown D., Slack F. The let-7 microRNA represses cell proliferation pathways in human cells. Cancer Res. 2007, 67:7713-7722.
65. Bos J. ras oncogenes in human cancer: a review. Cancer Res. 1989, 49:4682-4689.
66. Oh J.S., Kim J.J., Byun J.Y., Kim I.A. Lin28-let7 modulates radiosensitivity of human cancer cells with activation of K-Ras. Int. J. Radiat. Oncol. Biol. Phys. 2010, 76:5-8.
67. Wiggins J., Ruffino L., Kelnar K., Omotola M., Patrawala L., Brown D., Bader A. Development of a lung cancer therapeutic based on the tumor suppressor microRNA-34. Cancer Res. 2010, 70:5923-5930.
68. Trang P., Wiggins J.F., Daige C.L., Cho C., Omotola M., Brown D., Weidhaas J.B., Bader A.G., Slack F.J. Systemic delivery of tumor suppressor microRNA mimics using a neutral lipid emulsion inhibits lung tumors in mice. Mol. Ther. 2011.
69. Lanford R., Hildebrandt-Eriksen E., Petri A., Persson R., Lindow M., Munk M., Kauppinen S., Ørum H. Therapeutic silencing of microRNA-122 in primates with chronic hepatitis C virus infection. Science 2010, 327:198-201.
70. Branch A., Rice C. Antisense gets a grip on miR-122 in chimpanzees. Sci. Transl. Med. 2010, 2(13):s11.