Emerging roles of cathepsin e in host defense mechanisms

Biochimica et Biophysica Acta - Proteins and Proteomics

Volumn 1824, Issue 1, 2012, Pages 105-112

  Yamamoto, Kenji ^a   Kawakubo, Tomoyo ^a   Yasukochi, Atsushi ^a   Tsukuba, Takayuki ^b  

^a KYUSHU UNIVERSITY   (Japan)

^b NAGASAKI UNIVERSITY   (Japan)

Author keywords

Aspartic proteinase; Cancer; Cathepsin E; Epidermal differentiation; Peptide mimetic inhibitor and activator

Indexed keywords

ASPARTIC PROTEINASE; CATHEPSIN D; CATHEPSIN E; CATHEPSIN F; CYSTEINE PROTEINASE; LYSOSOME ENZYME; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; PEPTIDOMIMETIC AGENT; SIALOGLYCOPROTEIN; TOLL LIKE RECEPTOR; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND;

ANTIANGIOGENIC ACTIVITY; ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; APOPTOSIS; BACTERICIDAL ACTIVITY; CANCER CELL; CANCER INHIBITION; CANCER THERAPY; CELL DIFFERENTIATION; CELL TYPE; CYTOKINE PRODUCTION; DENDRITIC CELL; ENZYME ACTIVITY; ENZYME DEFICIENCY; EPIDERMIS; ERYTHROCYTE; HOST RESISTANCE; HUMAN; IMMUNE SYSTEM; KIDNEY PROXIMAL TUBULE; LYSOSOME MEMBRANE; MACROPHAGE; MACROPHAGE FUNCTION; MAJOR HISTOCOMPATIBILITY COMPLEX; NEOPLASM; NONHUMAN; OSTEOCLAST; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; SKIN; SPLEEN CELL; STOMACH PARIETAL CELL; TUMOR GROWTH;

ANIMALS; ANTIGEN-PRESENTING CELLS; CATHEPSIN E; HUMANS; IMMUNE SYSTEM; MODELS, BIOLOGICAL; NEOPLASMS; SKIN; SKIN PHYSIOLOGICAL PHENOMENA;

EID: 82755182963     PISSN: 15709639     EISSN: 18781454     Source Type: Journal    
DOI: 10.1016/j.bbapap.2011.05.022     Document Type: Review

References (114)

1. K. Bennett, T. Levine, J.S. Ellis, R.J. Peanasky, I.M. Samloff, J. Kay, and B.M. Chain Antigen processing for presentation by class II major histocompatibility complex requires cleavage by cathepsin E Eur. J. Immunol. 22 1992 1519 1524
2. K. Nishishita, H. Sakai, E. Sakai, Y. Kato, and K. Yamamoto Age-related and dexamethasone-induced changes in cathepsins E and D in rat thymic and splenic cells Arch. Biochem. Biophys. 333 1996 349 358 (Pubitemid 26304900)
3. D.F. Sastradipura, H. Nakanishi, T. Tsukuba, K. Nishishita, H. Sakai, Y. Kato, T. Gotow, Y. Uchiyama, and K. Yamamoto Identification of cellular compartments involved in processing of cathepsin E in primary cultures of rat microglia J. Neurochem. 70 1998 2045 2056 (Pubitemid 28207829)
4. T. Nishioku, K. Hashimoto, K. Yamashita, S.-Y. Liou, Y. Kagamiishi, H. Maegawa, N. Katsube, C. Peters, K. von Figura, P. Saftig, N. Katunuma, K. Yamamoto, and H. Nakanishi Involvement of cathepsin E in exogenous antigen processing in primary cultured murine microglia J. Biol. Chem. 277 2002 4816 4822 (Pubitemid 34968515)
5. C.S.K. Yee, Y. Yao, P. Li, M.J. Klemsz, J.S. Blum, and C.-H. Chan Cathepsin E: a novel target for regulation by class II transactivator J. Immunol. 172 2004 5528 5534 (Pubitemid 38542054)
6. B.M. Chain, P. Free, P. Medd, C. Swetman, A.B. Tabor, and N. Terrazzini The expression and function of cathepsin E in dendritic cell J. Immunol. 174 2005 1791 1800 (Pubitemid 40223918)
7. M. Yanagawa, T. Tsukuba, T. Nishioku, Y. Okamoto, K. Okamoto, R. Takii, Y. Terada, K.I. Nakayama, T. Kadowaki, and K. Yamamoto Cathepsin E deficiency induces a novel form of lysosomal storage disorder showing the accumulation of lysosomal membrane sialoglycoproteins and the elevation of lysosomal pH in macrophages J. Biol. Chem. 282 2007 1851 1862 (Pubitemid 47076688)
8. H. Kakehashi, T. Nishioku, T. Tsukuba, T. Kadowaki, S. Nakamura, and K. Yamamoto Differential regulation of the nature and functions of dendritic cells and macrophages by cathepsin E J. Immunol. 179 2007 5728 5737
9. N. Zaidi, T. Herrmann, D. Baechle, S. Schleicher, J. Gogel, C. Driessen, W. Voelter, and H. Kalbacher A new approach for distinguishing cathepsin E and D activity in antigen-processing organelles FEBS J. 274 2007 3138 3149 (Pubitemid 46849095)
10. T. Kawakubo, A. Yasukochi, T. Tsukuba, T. Kadowaki, and K. Yamamoto Gene expression profiling of mammary glands of cathepsin E-deficient mice compared with wild-type littermates Biochimie 90 2008 396 404
11. T. Kageyama, and K. Takahashi A cathepsin D-like acid proteinase from human gastric mucosa: purification and characterization J. Biochem. 87 1980 725 735 (Pubitemid 10119671)
12. N. Muto, K. Murayama-Arai, and S. Tani Purification and properties of a cathepsin D-like acid proteinase from rat gastric mucosa Biochim. Biophys. Acta 745 1983 61 69 (Pubitemid 13040542)
13. I.M. Samloff, R.T. Taggart, T. Shiraishi, T. Branch, W.A. Reid, R. Heath, R.W. Lewis, M.J. Valler, and J. Kay Slow moving proteinase; isolation, characterization, and immunohistochemical localization in gastric mucosa Gastroenterology 93 1987 77 84 (Pubitemid 17084097)
14. T. Saku, H. Sakai, Y. Shibata, Y. Kato, and K. Yamamoto An immunocytochemical study on distinct intracellular localization of cathepsin E and cathepsin D in human gastric cells and various rat cells J. Biochem. 110 1991 956 964
15. H. Sakai, T. Saku, Y. Kato, and K. Yamamoto Quantitation and immunohistochemical localization of cathepsins E and D in rat tissues and blood cells Biochim. Biophys. Acta 991 1989 367 375 (Pubitemid 19136744)
16. K. Hara, K. Fukuyama, H. Sakai, K. Yamamoto, and W.L. Epstein Purification and immunohistochemical localization of aspartic proteinases in rat epidermis J. Invest. Dermatol. 100 1993 394 399 (Pubitemid 23105203)
17. S. Igarashi, T. Takizawa, T. Takizawa, Y. Yasuda, H. Uchiwa, S. Hayashi, H. Brysk, J.M. Robinson, K. Yamamoto, M.M. Brysk, and T. Horikoshi Cathepsin D, but not cathepsin E, degrades desmosomes during epidermal desquamation Br. J. Dermatol. 151 2004 355 361 (Pubitemid 39215149)
18. K. Yamamoto, and V.T. Marchesi Purification and characterization of acid proteinase from human erythrocyte membranes Biochim. Biophys. Acta 790 1984 208 218 (Pubitemid 15221886)
19. K. Yamamoto, M. Takeda, H. Yamamoto, M. Tatsumi, and Y. Kato Human erythrocyte membrane acid proteinase (EMAP): sidedness and relation to cathepsin D J. Biochem. 97 1985 821 830 (Pubitemid 15148388)
20. R. Fiocca, L. Villani, P. Tenti, M. Cornaggia, G. Finzi, C. Riva, C. Capella, J. Bara, I.M. Samloff, and E. Solcia The foveolar cell component of gastric cancer Hum. Pathol. 21 1990 260 270 (Pubitemid 20081225)
21. Y. Yoshimine, T. Tsukuba, R. Isobe, M. Sumi, A. Akamine, K. Maeda, and K. Yamamoto Specific immunocytochemical localization of cathepsin E at the ruffled border membrane of active osteoclasts Cell Tissue Res. 281 1995 85 91
22. H. Sakai, Y. Kato, and K. Yamamoto Synthesis and intracellular distribution of cathepsins E and D in differentiating murine Friend erythroleukemia cells Arch. Biochem. Biophys. 294 1992 412 417
23. M. Yanagawa, T. Tsukuba, K. Okamoto, R. Takii, Y. Terada, T. Kadowaki, and K. Yamamoto Up-regulation, enhanced maturation, and secretion of cathepsin E in mouse macrophages treated with interferon-γ or lipopolysaccharide J. Oral Biosci. 48 2006 218 225
24. R. Ullmann, P. Morbini, I. Halbwedl, M. Bongiovanni, M. Gogg-Kammerer, M. Papotti, S. Gabor, H. Renner, and H.H. Ropper Protein expression profiles in adenocarcinomas and squamous cell carcinomas of the lung generated using tissue microarrays J. Pathol. 203 2004 798 807 (Pubitemid 38961566)
25. C. Sakakura, K. Hasegawa, K. Miyagawa, S. Nakashima, T. Yoshikawa, S. Kin, Y. Nakase, S. Yazumi, H. Yamagishi, and T. Okanoue Possible involvement of RUNX3 silencing in the peritoneal metastases of gastric cancers Clin. Cancer Res. 11 2005 6479 6488 (Pubitemid 41338985)
26. S.B.P. Athauda, T. Takahashi, H. Inoue, M. Ichinose, and K. Takahashi Proteolytic activity and cleavage specificity of cathepsin E at the physiological pH as examined towards the B chain of oxidized insulin FEBS Lett. 292 1991 53 56
27. S.B.P. Athauda, and K. Takahashi Distinct cleavage specificity of human cathepsin E at neutral pH with special preference for ArgArg bonds Protein Pept. Lett. 9 2002 15 22 (Pubitemid 34293912)
28. T. Kawakubo, K. Okamoto, J. Iwata, M. Shin, Y. Okamoto, A. Yasukochi, K.I. Nakayama, T. Kadowaki, T. Tsukuba, and K. Yamamoto Cathepsin E prevents tumor growth and metastasis by catalyzing the proteolytic release of soluble TRAIL from tumor cell surface Cancer Res. 67 2007 10869 10878 (Pubitemid 350145916)
29. T. Kageyama Rabbit procathepsin E and cathepsin E: Nucleotide sequence of cDNA, hydrolytic specificity for biologically active peptides and gene expression during development Eur. J. Biochem. 216 1993 717 728 (Pubitemid 23284115)
30. C. Tulone, J. Tsang, Z. Prokopowicz, N. Grosvenor, and B. Chain Natural cathepsin E deficiency in the immune system of C57BL/6J mice Immunogenetics 59 2007 927 935 (Pubitemid 50002834)
31. B.M. Chain, P. Free, P. Medd, C. Swetman, A.B. Tabor, and N. Terrazzini The expression and function of cathepsin E in dendritic cells J. Immunol. 174 2005 1791 1800 (Pubitemid 40223918)
32. H. Nakanishi, T. Tsukuba, T. Kondou, T. Tanaka, and K. Yamamoto Transient forebrain ischemia induces increased expression and specific localization of cathepsins E and D in rat hippocampus and neostriatum Exp. Neurol. 121 1993 215 223 (Pubitemid 23234740)
33. H. Nakanishi, K. Tominaga, T. Amano, I. Hirotsu, T. Inoue, and K. Yamamoto Age-related changes in activities and localizations of cathepsins D, E, B, and L in the rat brain tissues Exp. Neurol. 126 1994 119 128 (Pubitemid 24131109)
34. T. Amano, H. Nakanishi, M. Oka, and K. Yamamoto Increased expression of cathepsins E and D in reactive microglial cells associated with spongiform degeneration in the brain stem of senescence-accelerated mouse Exp. Neurol. 136 1995 171 182
35. H. Nakanishi, T. Amano, D.F. Sastradipura, Y. Yoshimine, T. Tsukuba, K. Tanabe, I. Hirotsu, T. Ohono, and K. Yamamoto Increased expression of cathepsins E and D in neurons of the aged rat brain and their colocalization with lipofuscin and carboxy-terminal fragments of Alzheimer amyloid precursor protein J. Neurochem. 68 1997 739 749 (Pubitemid 27044739)
36. K. Tominaga, H. Nakanishi, Y. Yasuda, and K. Yamamoto Excitotoxin-induced neuronal death is associated with response of a unique intracellular aspartic proteinase, cathepsin E J. Neurochem. 71 1998 2574 2584 (Pubitemid 28531270)
37. N. Shigematsu, T. Fukuda, T. Yamamoto, T. Nishioku, T. Yamaguchi, M. Himeno, K.I. Nakayama, T. Tsukuba, T. Kadowaki, K. Okamoto, S. Higuchi, and K. Yamamoto Association of cathepsin E deficiency with the increased territorial aggressive response of mice J. Neurochem. 105 2008 1394 1404 (Pubitemid 351590799)
38. W.E. Lees, S. Kalinka, J. Meech, S.J. Capper, N.D. Cook, and J. Kay Generation of human endothelin by cathepsin E FEBS Lett. 273 1990 99 102 (Pubitemid 20362442)
39. T. Kageyama, M. Ichinose, and S. Yonezawa Processing of the precursors to neurotensin and other bioactive peptides by cathepsin E J. Biol. Chem. 270 1995 19135 19140
40. F. Henningsson, K. Yamamoto, P. Saftig, T. Reinheckel, C. Peters, S.D. Knight, and G. Pejler A role for cathepsin E in the processing of mast-cell carboxypeptidase A J. Cell Sci. 118 2005 2035 2042 (Pubitemid 40723846)
41. T. Tsukuba, K. Okamoto, Y. Okamoto, M. Yanagawa, K. Kohmura, Y. Yasuda, H. Uchi, T. Nakahara, M. Furue, K. Nakayama, T. Kadowaki, K. Yamamoto, and K.I. Nakayama Association of cathepsin E deficiency with development of atopic dermatitis J. Biochem. 134 2003 893 902 (Pubitemid 38248365)
42. T. Tsukuba, S. Yamamoto, M. Yanagawa, K. Okamoto, Y. Okamoto, K.I. Nakayama, T. Kadowaki, and K. Yamamoto Cathepsin E-deficient mice show increased susceptibility to bacterial infection associated with the decreased expression of multiple cell surface Toll-like receptors J. Biochem. 140 2006 57 66 (Pubitemid 44433546)
43. T. Tsukuba, M. Yanagawa, K. Okamoto, Y. Okamoto, Y. Yasuda, K.I. Nakayama, T. Kadowaki, and K. Yamamoto Impaired chemotaxis and cell adhesion due to decrease in several cell-surface receptors in cathepsin E-deficient macrophages J. Biochem. 145 2009 565 573
44. R.J. Riese, P.R. Wolf, D. Bromme, L.R. Natkin, J.A. Villadangos, H.L. Ploegh, and H.A. Chapman Essential role for cathepsin S in MHC class II-associated invariant chain processing and peptide loading Immunity 4 1996 357 366 (Pubitemid 26174051)
45. J.A. Villadangos, R.J. Riese, C. Peters, H.A. Chapman, and H.L. Ploegh Degradation of mouse invariant chain: roles of cathepsins S and D and the influence of major histocompatibility complex polymorphism J. Exp. Med. 186 1997 549 560 (Pubitemid 27360799)
46. T. Nakagawa, W. Roth, P. Wong, A. Nelson, A. Farr, J. Deussing, J.A. Villadangos, H. Ploegh, C. Peters, and A.Y. Rudensky Cathepsin L: critical role in Ii degradation and CD4 T cell selection in the thymus Science 280 1998 450 453 (Pubitemid 28208170)
47. P. Pierre, and I. Mellman Developmental regulation of invariant chain proteolysis controls MHC class II trafficking in mouse dendritic cells Cell 93 1998 1135 1145 (Pubitemid 28307419)
48. C. Driessen, R.A.R. Bryant, A.-M. Lennon-Dumenil, J.A. Villadangos, P.W. Bryant, G.-P. Shi, H.A. Chapman, and H.L. Ploegh Cathepsin S controls the trafficking and maturation of MHC class II molecules in dendritic cells J. Cell Biol. 147 1999 775 790
49. G.-P. Shi, J.A. Villadangos, G. Dranoff, C. Small, L. Gu, K.J. Haley, R. Riese, H.L. Ploegh, and H.A. Chapman Cathepsin S required for normal MHC class II peptide loading and germinal center development Immunit. 10 1999 197 206 (Pubitemid 29115625)
50. T.Y. Nakagawa, W.H. Brissette, P.D. Lira, R.J. Griffith, N. Petrushova, J. Stck, J.D. McNeish, S.E. Eastman, E.D. Howard, S.R.M. Clarke, E.F. Rosloniec, E.A. Elliott, and A.Y. Rudensky Impaired invariant chain degradation and antigen presentation and diminished collagen-induced arthritis in cathepsin S null mice Immunity 10 1999 207 217 (Pubitemid 29115626)
51. G.-P. Shi, R.A.R. Bryant, R. Riese, S. Verhelst, C. Driessen, Z. Li, D. Bromme, H.L. Ploegh, and H.A. Chapman Role for cathepsin F in invariant chain processing and major histocompatibility complex class II peptide loading by macrophages J. Exp. Med. 191 2000 1177 1186
52. M.A. Marric, M.D. Taylor, and J.S. Blum Endosomal aspartic proteinases are required for invariant-chain processing Proc. Natl. Acad. Sci. U. S. A. 91 1994 2171 2175 (Pubitemid 24092065)
53. S. Diment Different roles for thiol and aspartyl proteases in antigen presentation of ovalbumin J. Immunol. 145 1990 417 422 (Pubitemid 20252343)
54. G.M. Rodriguez, and S. Diment Role of cathepsin D in antigen presentation of ovalbumin J. Immunol. 149 1992 2894 2898
55. J.M. van Noort, and M.J.M. Jacobs Cathepsin D, but not cathepsin B, releases T cell stimulatory fragments from lysozyme that are functional in the context of multiple murine class II MHC molecules Eur. J. Immunol. 24 1994 2175 2180 (Pubitemid 24276552)
56. J. Deussing, W. Roth, P. Saftig, C. Peters, H.L. Ploegh, and J.A. Villadangos Cathepsins B and D are dispensable for major histocompatibility complex class II-mediated antigen presentation Proc. Natl. Acad. Sci. U. S. A. 95 1998 4516 4521 (Pubitemid 28207944)
57. M. Fukuda Lysosomal membrane glycoproteins. Structure, biosynthesis, and intracellular trafficking J. Biol. Chem. 266 1991 21327 21330 (Pubitemid 121000182)
58. E.-L. Eskelinen, Y. Tanaka, and P. Saftig At the acidic edge: emerging functions for lysosomal membrane proteins Trends Cell Biol. 13 2003 137 145 (Pubitemid 36293786)
59. J.M. Holopainen, J. Saarikoski, P.K.J. Kinnunen, and I. Järvelä Elevated lysosomal pH in neuronal ceroid lipofuscinoses (NCLs) Eur. J. Biochem. 268 2001 5851 5856 (Pubitemid 33079320)
60. J.A. Schmid, L. Mach, E. Paschke, and J. Glössl Accumulation of sialic acid in endocytic compartments interferes with the formation of mature lysosomes. Impaired proteolytic processing of cathepsin B in fibroblasts of patients with lysosomal sialic acid storage disease J. Biol. Chem. 274 1999 19063 19071
61. P.J. Meikle, D.A. Brooks, E.M. Ravenscroft, M. Yan, R.E. Williams, A.E. Jaunzems, T.K. Chataway, L.E. Karageorgos, R.C. Davey, C.D. Boulter, S.R. Carlsson, and J.J. Hopwood Diagnosis of lysosomal storage disorders: evaluation of lysosome-associated membrane protein LAMP-1 as a diagnostic marker Clin. Chem. 43 1997 1325 1335 (Pubitemid 27329777)
62. C.T. Hua, J.J. Hopwood, S.R. Carlsson, R.J. Harris, and P.J. Meikle Evaluation of the lysosome-associated membrane protein LAMP-2 as a marker for lysosomal storage disorders Clin. Chem. 44 1998 2094 2102 (Pubitemid 28447055)
63. J. Banchereau, F. Briere, C. Caux, J. Davoust, S. Lebecque, Y.J. Liu, B. Pulendran, and K. Palucka Immunobiology of dendritic cells Annu. Rev. Immunol. 18 2000 767 811 (Pubitemid 30365397)
64. R.M. Steinman, and M.C. Nussenzweig Avoiding horror autotoxicus: the importance of dendritic cells in peripheral T cell tolerance Proc. Natl. Acad. Sci. U. S. A 99 2002 351 358 (Pubitemid 34060366)
65. C.X. Moss, J.A. Villadangos, and C. Watts Destructive potential of the aspartyl protease cathepsin D in MHC class II-restricted antigen processing Eur. J. Immunol. 35 2005 3442 3451 (Pubitemid 43025525)
66. D.J. Lenschow, T.L. Walunas, and J.A. Bluestone CD28/B7 system of T cell costimulation Annu. Rev. Immunol. 14 1996 233 258 (Pubitemid 26130184)
67. I.S. Grewal, and R.A. Flavell CD40 and CD154 in cell-mediated immunity Annu. Rev. Immunol. 16 1998 111 135 (Pubitemid 28183361)
68. A.J. Coyle, and J.-C. Gutierrez-Ramos The expanding B7 superfamily: increasing complexity in costimulatory signals regulating T cell function Nat. Immunol. 2 2001 203 209 (Pubitemid 33705995)
69. G. Kroemer, and M. Jäättelä Lysosomes and autophagy in cell death control Nat. Rev. Cancer 5 2005 886 897 (Pubitemid 41746033)
70. V. Karantza-Wadsworth, S. Patel, O. Kravchuk, G. Chen, R. Mathew, S. Jin, and E. White Autophagy mitigates metabolic stress and genome damage in mammary tumorigenesis Genes Dev. 21 2007 1621 1635 (Pubitemid 47026367)
71. M. Ogata, S. Hino, A. Saito, K. Morikawa, S. Kondo, S. Kanemoto, T. Murakami, M. Taniguchi, I. Tanii, K. Yoshinaga, S. Shiosaka, J.A. Hammarback, F. Urano, and K. Imaizumi Autophagy is activated for cell survival after endoplasmic reticulum stress Mol. Cell. Biol. 26 2006 9220 9231 (Pubitemid 44904418)
72. W.X. Ding, H.M. Ni, W. gao, Y.F. Hou, M.A. Melan, X. Chen, D.B. Stolz, Z.M. Shao, and X.M. Yin Differential effects of endoplasmic reticulum stress-induced autophagy on cell survival J. Biol. Chem. 282 2007 4702 4710 (Pubitemid 47101001)
73. R. Mathew, V. Karantza-Wadsworth, and E. White Role of autophagy in cancer Nat. Rev. Cancer 7 2007 961 967 (Pubitemid 350165856)
74. P. Tenti, S. Romagnoli, E. Silini, R. Zappatore, P. Giunta, G. Stella, and L. Carnevali Cervical adenocarcinomas express markers common to gastric, intestinal, and pancreatobiliary epithelial cells Pathol. Res. Pract. 190 1994 342 349 (Pubitemid 24139330)
75. K. Matsuo, I. Kobayashi, T. Tsukuba, T. Kiyoshima, Y. Ishibashi, A. Miyoshi, K. Yamamoto, and H. Sakai Immunohistochemical localization of cathepsins D and E in human gastric cancer: a possible correlation with local invasive and metastatic activities of carcinoma cells Hum. Pathol. 27 1996 184 190 (Pubitemid 26049473)
76. F. Mota, J.H.C. Kanan, N. Rayment, T. Mould, A. Singer, and B.M. Chain Cathepsin E expression by normal and premalignant cervical epithelium Am. J. Pathol. 150 1997 1223 1229 (Pubitemid 27152641)
77. B. Terris, E. Blaveri, T.T. Crnogorac-Jurcevic, M. Jones, E. Missiaglia, P. Ruszniewski, A. Sauvanet, and N.R. Lemoine Characterization of gene expression profiles in intraductal papillary-mucinous tumors of the pancreas Am. J. Pathol. 160 2002 1745 1754 (Pubitemid 34525654)
78. E. Blaveri, J.P. Simko, J.E. Korkola, J.L. Brewer, F. Baehner, K. Mehta, S. DeVries, T. Koppie, S. Pejavar, P. Carroll, and F.M. Waldman Bladder cancer outcome and subtype classification by gene expression Clin. Cancer Res. 11 2005 4044 4055 (Pubitemid 40791568)
79. P.J. Wild, A. Herr, C. Wissmann, R. Stoehr, A. Rosenthal, D. Zaak, R. Simon, R. Knuechel, C. Pilarsky, and A. Hartmann Gene expression profiling of progressive papillary noninvasive carcinomas of the urinary bladder Clin. Cancer Res. 11 2005 4415 4429 (Pubitemid 40825632)
80. B.C. Lewis, D.S. Klimstra, N.D. Socci, S. Xu, J.A. Koutcher, and H.E. Varmus The absence of p53 promotes metastasis in a novel somatic mouse model for hepatocellular carcinoma Mol. Cell. Biol. 25 2005 1228 1237 (Pubitemid 40204903)
81. L. Busquets, H. Guillen, M.E. DeFord, M.A. Suckow, R.M. Navari, F.J. Castellino, and M. Prorok Cathepsin E is a specific marker of dysplasia in APC mouse intestine Tumor Biol. 27 2006 36 42 (Pubitemid 41832702)
82. H.E. Marin, M.A. Peraza, A.N. Billin, T.M. Willson, J.M. Ward, M.J. Kennett, F.J. Gonzalez, and J.M. Peters Ligand activation of peroxisome proliferator-activated receptor β inhibits colon carcinogenesis Cancer Res. 66 2006 4394 4401
83. J.L. Page, S.C. Strom, and C.J. Omiecinski Regulation of the human cathepsin E gene by the constitutive andorostane receptor Arch. Biochem. Biophys. 467 2007 132 138 (Pubitemid 47625302)
84. M. Caruso, J. Moore, G.J. Goodall, M. Thomas, S. Phillis, A. Tyskin, G. Cheetham, N. Lerda, H. Takahashi, and A. Ruszkiewicz Over-expression of cathepsin E and trefoil factor 1 in sessile serrated adenomas of the colorectum identified by gene expression analysis Virchows Arch. 454 2009 291 302
85. H. Rochefort Cathepsin D in breast cancer: a tissue marker associated with metastasis Eur. J. Cancer 28A 1992 1780 1783
86. G. Ferrandina, G. Scambia, F. Bardelli, P. Benedetti, P. Panici, S. Mancuso, and A. Messori Relationship between cathepsin D content and disease-free survival in node-negative breast cancer patients: a meta-analysis Br. J. Cancer 76 1997 661 666 (Pubitemid 27354682)
87. J.P. Cherry, J.A. Mordente, J.R. Chapman, M.S. Choudhury, H. Tazaki, C. Mallouh, and S. Konno Analysis of cathepsin D forms and their clinical implications in human prostate cancer J. Urol. 160 1998 2223 2228 (Pubitemid 128703659)
88. J.A. Foekens, M.P. Look, B.J. Vries, M.E. Meijer-van Gelder, W.L. von Putten, and J.G. Klijin Cathepsin D in primary breast cancer: prognostic evaluation involving 2810 patients Br. J. Cancer 79 1999 300 307 (Pubitemid 29002300)
89. T. Nomura, and N. Katunuma Invovement of cathepsins in the invasion, metastasis and proliferation of cancer J. Med. Invest. 52 2005 1 9
90. M.M. Mohamed, and B.F. Sloane Cysteine cathepsins: multifunctional enzymes in cancer Nat. Rev. Cancer 6 2006 764 775 (Pubitemid 44450465)
91. C.M. Overall, and O. Kleifeld Tumor microenvironment-opinion: validating matrix metalloproteinases as drug targets and anti-targets for cancer therapy Nat. Rev. Cancer 6 2006 227 239 (Pubitemid 43292566)
92. K. Uno, T. Azuma, M. Nakajima, K. Yasuda, T. Hayakumo, H. Mukai, T. Sakai, and K. Kawai Clinical significance of cathepsin E in pancreatic juice in the diagnosis of pancreatic ductal adenocarcinoma J. Gastroenterol. Hepatol. 15 2000 1333 1338
93. T. Saku, H. Sakai, N. Tsuda, H. Okabe, Y. Kato, and K. Yamamoto Cathepsins D and E in normal, metaplastic, dysplastic, and carcinomatous gastric tissue: an immunohistochemical study Gut 31 1990 1250 1255
94. V. Cavailles, P. Augereau, and H. Rochefort Cathepsin D gene is controlled by a mixed promoter, and estrogens stimulate only TATA-dependent transcription in breast cancer cells Proc. Natl. Acad. Sci. U. S. A. 90 1993 203 207 (Pubitemid 23010278)
95. M. Glondu, P. Coopman, V. Laurent-Matha, M. Garcia, H. Rochefort, and E. Liaudet-Coopman A mutated cathepsin-D devoid of its catalytic activity stimulates the growth of cancer cells Oncogene 20 2001 6920 6929 (Pubitemid 33052181)
96. V. Vetvicka, J. Vetvickova, and M. Fusek Role of procathepsin D activation peptide in prostate cancer growth Prostate 44 2000 1 7 (Pubitemid 30390059)
97. M. Beaujouin, C. Prébois, D. Derocq, V. Laurent-Matha, O. Masson, S. Pattingre, P. Coopman, N. Bettache, J. Grossfield, R.E. Hollingsworth, H. Zhang, Z. Yao, B.T. Hyman, P. van der Geer, G.K. Smith, and E. Liaudet-Coopman Pro-cathepsin D interacts with the extracellular domain of the beta chain of LRP1 and promotes LRP1-dependent fibroblast outgrowth J. Cell Sci. 123 2010 3336 3346
98. S.R. Wiley, K. Schooley, P.J. Smolak, W.S. Din, C.-P. Huang, J.K. Nicholl, G.R. Sutherland, T.D. Smith, C. Rauch, C.A. Smith, and R.G. Goodwin Identification and characterization of a new member of the TNF family that induces apoptosis Immunity 3 1995 673 682 (Pubitemid 26091143)
99. R.M. Pitti, S.A. Marsters, S. Ruppert, C.J. Donahue, A. Moore, and A. Ashkenazi Induction of apoptosis by apo-2 ligand, a new member of the tumor necrosis factor cytokine family J. Biol. Chem. 271 1996 12687 12690 (Pubitemid 26175834)
100. H. Walczak, R.E. Miller, K. Ariail, B. Gliniak, T.S. Griffith, M. Kubin, W. Chin, J. Jones, A. Woodward, T. Le, C. Smith, P. Smolak, R.G. Goodwin, C.T. Rauch, J.C.L. Schuh, and D.H. Lynch Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo Nat. Med. 5 1999 157 163 (Pubitemid 29068521)
101. A. Ashkenazi, R.C. Pai, S. Fong, S. Leung, D.A. Lowrence, S.A. Marsters, C. Blackie, L. Chang, A.E. McMurtrey, A. Hebert, L. DeForge, I.L. Koumenis, D. Lewis, L. Harris, J. Bussiere, H. Koeppen, Z. Shahrokh, and R.H. Schwall Safety and antitumor activity of recombinant soluble Apo2 ligand J. Clin. Invest. 104 1999 155 162
102. T.S. Griffith, S.R. Wiley, M.Z. Kubin, L.M. Sedger, C.R. Maliszewski, and N.A. Fanger Monocyte-mediated tumoricidal activity via the tumor-necrosis factor-related cytokine, TRAIL J. Exp. Med. 189 1999 1343 1354
103. M.R. Hussein Tumor-associated macrophages and melanoma tumorigenesis: integrating the complexity Int. J. Exp. Pathol. 87 2006 163 176 (Pubitemid 43781682)
104. J. Condeelis, and J.W. Pollard Macrophages: obligate partners for tumor cell migration, invasion, and metastasis Cell 124 2006 263 266 (Pubitemid 43121975)
105. Y.C. Wang, F. He, F. Feng, X.W. Liu, G.Y. Dong, H.Y. Qin, X.B. Hu, M.H. Zheng, L. Liang, L. Feng, Y.M. Liang, and H. Han Notch signaling determines the M1 versus M2 polarization of macrophages in antitumor immune responses Cancer Res. 70 2010 4840 4849
106. M. Shin, T. Kadowaki, J. Iwata, T. Kawakubo, N. Yamaguchi, R. Takii, T. Tsukuba, and K. Yamamoto Association of cathepsin E with tumor growth arrest through angiogenesis inhibition and enhanced immune responses Biol. Chem. 388 2007 1173 1181 (Pubitemid 350059628)
107. A. Yasukochi, T. Kawakubo, S. Nakamura, and K. Yamamoto Cathepsin E enhances anticancer activity of doxorubicin on human prostate cancer cells showing resistance to TRAIL-mediated apoptosis Biol. Chem. 391 2010 947 958
108. T. Kawakubo, A. Yasukochi, K. Okamoto, Y. Okamoto, S. Nakamura, and K. Yamamoto The role of cathepsin E in terminal differentiation of keratinocytes Biol. Chem. 392 2011 571 585
109. F. Egberts, M. Heinrich, J.-M. Jensen, S. Winoto-Morbach, S. Pfeiffer, M. Wickel, M. Schunck, J. Steude, P. Saftig, E. Proksch, and S. Schütze Cathepsin D is involved in the regulation of transglutaminase 1 and epidermal differentiation J. Cell Sci. 117 2004 2295 2307 (Pubitemid 38807497)
110. K. Yamamoto Cathepsin E and cathepsin D: biosynthesis, processing and subcellular location K. Takahashi, Aspartic Proteinases: Structure, Function, Biology, and Biomedical Implications 1995 Plenum Press New York 223 229
111. K. Yamamoto Cathepsin E and cathepsin D V. Turk, Proteases: New Perspectives 1999 Birkhäuser Verlag Basel 5971
112. T. Tsukuba, K. Okamoto, Y. Yasuda, W. Morikawa, H. Nakanishi, and K. Yamamoto New functional aspects of cathepsin D and cathepsin E Mol. Cells 10 2000 601 611
113. N. Zaidi, and H. Kalbacher Cathepsin E: a mini review Biochem. Biophys. Res. Commun. 367 2008 517 522
114. N. Zaidi, C. Hermann, T. Herrmann, and H. Kalbacher Emerging functional roles of cathepsin E Biochem. Biophys. Res. Commun. 377 2008 327 330