Mycotoxin zearalenone induces AIF- and ROS-mediated cell death through p53- and MAPK-dependent signaling pathways in RAW264.7 macrophages

Toxicology in Vitro

Volumn 25, Issue 8, 2011, Pages 1654-1663

  Yu, Ji Yeon ^a   Zheng, Zhong Hua ^a   Son, Young Ok ^b   Shi, Xianglin ^b   Jang, Young Oh ^c   Lee, Jeong Chae ^a  

^a Chonbuk National University   (South Korea)

^b UNIVERSITY OF KENTUCKY   (United States)

^c Korea Minjok Leadership Academy   (South Korea)

Author keywords

AIF; MAPK; P53; RAW264.7 macrophages; ROS; Zearalenone

Indexed keywords

ADENOSINE TRIPHOSPHATE; APOPTOSIS INDUCING FACTOR; BENZYLOXYCARBONYLISOLEUCYLGLUTAMYLTHREONYLASPARTYL FLUOROMETHYL KETONE; BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; CATALASE; CYTOCHROME C; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN BAX; PROTEIN BCL 2; PROTEIN INHIBITOR; PROTEIN P53; PROTEIN P53 INHIBITOR; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG; ZEARALENONE;

APOPTOSIS; ARTICLE; CELL DEATH; CELL STRAIN; CELL VIABILITY; CONTROLLED STUDY; CYTOPLASM; CYTOTOXICITY; DOSE RESPONSE; ENZYME ACTIVATION; GENETIC TRANSFECTION; MACROPHAGE; MITOCHONDRIAL MEMBRANE POTENTIAL; NECROSIS; PROTEIN DEPLETION; SIGNAL TRANSDUCTION;

ADENOSINE TRIPHOSPHATE; ANIMALS; APOPTOSIS; APOPTOSIS INDUCING FACTOR; BCL-2-ASSOCIATED X PROTEIN; CELL LINE; CYTOCHROMES C; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MAP KINASE SIGNALING SYSTEM; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MITOCHONDRIA; NECROSIS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTO-ONCOGENE PROTEINS C-BCL-2; REACTIVE OXYGEN SPECIES; TUMOR SUPPRESSOR PROTEIN P53; ZEARALENONE;

EID: 82655173963     PISSN: 08872333     EISSN: 18793177     Source Type: Journal    
DOI: 10.1016/j.tiv.2011.07.002     Document Type: Article

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