Infarct size is increased in female post-MI rats treated with rapamycin

Canadian Journal of Physiology and Pharmacology

Volumn 87, Issue 6, 2009, Pages 460-470

  Lajoie, Claude ^a   El Helou, Viviane ^b   Proulx, Cindy ^b   Clément, Robert ^b   Gosselin, Hugues ^b   Calderone, Angelino ^b,c  

^a UNIVERSITÉ DU QUÉBEC À TROIS RIVIÈRES   (Canada)

^b MONTREAL HEART INSTITUTE   (Canada)

^c UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

Fibrosis; Gender; Infarction; Ischemia

Indexed keywords

COLLAGEN; ENDOTHELIAL NITRIC OXIDE SYNTHASE; MESSENGER RNA; RAPAMYCIN; S6 KINASE; TRANSFORMING GROWTH FACTOR BETA3;

ANIMAL MODEL; ARTICLE; ATTENUATION; CONTROLLED STUDY; CORONARY ARTERY LIGATION; DRESSLER SYNDROME; DRUG SENSITIVITY; FEMALE; FIBROSIS; HEART INFARCTION SIZE; HEART LEFT VENTRICLE; HEART PROTECTION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; REACTIVE FIBROSIS; RECEPTOR UPREGULATION; SCAR FORMATION; SHAM PROCEDURE; SIGNAL TRANSDUCTION; SURFACE PROPERTY; TREATMENT RESPONSE;

EID: 67449124604     PISSN: 00084212     EISSN: None     Source Type: Journal    
DOI: 10.1139/Y09-031     Document Type: Article

References (44)

1. Abbate, A., Biondi-Zoccai, G.G., and Baldi, A. 2002. Pathophysiologic role of myocardial apoptosis in post-infarction left ventricular remodelling. J. Cell. Physiol. 193: 145-153. doi:10.1002/jcp.10174. PMID:12384991.
2. Bae, S., and Zhang, L. 2005. Gender differences in cardioprotection against ischemia/reperfusion injury in adult rat hearts: Focus on AKT and protein kinase C signalling. J. Pharmacol. Exp. Ther. 315: 1125-1135. doi:10.1124/jpet.105.090803. PMID: 16099927.
3. Boluyt, M.O., Li, Z.B., Loyd, A.M., Scalia, A.F., Cirrincione, G.M., and Jackson, R.R. 2004. The mTOR/p70S6K signal transduction pathway plays a role in cardiac hypertrophy and influences expression of myosin heavy chain genes in vivo. Cardiovasc. Drugs Ther. 18: 257-267. doi:10.1023/B:CARD.0000041245.61136. 56. PMID:15367823.
4. Chen, M.M., Lam, A., Abraham, J.A., Schreiner, G.F., and Joly, A.H. 2000. CTGF expression is induced by TGF-β in cardiac fibroblasts and cardiac myocytes: a potential role in heart fibrosis. J. Mol. Cell. Cardiol. 32: 1805-1819. doi:10.1006/jmcc.2000.1215. PMID:11013125.
5. Chung, J., Kuo, C.J., Crabtree, G.R., and Blenis, J. 1992. Rapamycin-FKBP specifically blocks growth-dependent activation of and signalling by the 70kd S6 protein kinases. Cell, 69: 1227-1236. doi:10.1016/0092-8674(92)90643-Q. PMID:1377606.
6. Colombo, F., Gosselin, H., El-Helou, V., and Calderone, A. 2003. β-adrenergic receptor-mediated DNA synthesis in cardiac fibroblasts proceeds via a phosphatidylinositol 3-kinase dependent pathway refractory to the antiproliferative action of cyclic AMP. J. Cell. Physiol. 195: 322-330. doi:10.1002/jcp.10251. PMID:12652658.
7. El-Helou, V., Dupuis, J., Proulx, C., Drapeau, J., Clement, R., Gosselin, H., et al. 2005. Resident nestin+ neural-like stem cells and fibers are detected in normal and damaged rat myocardium. Hypertension, 46: 1219-1225. doi:10.1161/01.HYP.0000187888.39665.d9. PMID:16230517. (Pubitemid 41533029)
8. Gao, X.M., Wong, G., Wang, B., Kiriazis, H., Moore, X.L., Su, Y.D., et al. 2006. Inhibition of mTOR reduces chronic pressure-overload cardiac hypertrophy and fibrosis. J. Hypertens. 24: 1663-1670. doi:10.1097/01.hjh. 0000239304.01496.83. PMID:16877971. (Pubitemid 44162470)
9. Garcia-Dorado, D., Theroux, P., Elizaga, J., Fernandez Aviles, F., Alonso, J., and Solares, J. 1988. Influence of tachycardia and arterial hypertension on infarct size in the pig. Cardiovasc. Res. 22: 620-626. doi:10.1093/cvr/22.9.620. PMID:3242833.
10. Gingras, A.C., Raught, B., and Sonenberg, N. 2001. Regulation of translation initiation by FRAP/mTOR. Genes Dev. 15: 807-826. doi:10.1101/gad.887201. (Pubitemid 32295062)
11. Gross, E.R., Hsu, A.K., and Gross, G.J. 2004. Opioid-induced cardioprotection occurs via glycogen synthase kinase β inhibition during reperfusion in intact rat hearts. Circ. Res. 94: 960-966. doi:10.1161/01.RES. 0000122392.33172.09. PMID:14976126.
12. Hayward, C.S., Kelly, R.P., and Collins, P. 2000. The roles of gender, menopause and hormone replacement on cardiovascular function. Cardiovasc. Res. 46: 28-49. doi:10.1016/S0008-6363(00)00005-5. PMID:10727651.
13. Hudson, C.C., Liu, M., Chiang, G.G., Otterness, D.M., Loomis, D.C., Kaper, F., et al. 2002. Regulation of hypoxia-inducible factor 1 alpha expression and function by the mammalian target of rapamycin. Mol. Cell. Biol. 22: 7004-7014. doi:10.1128/MCB.22.20.7004-7014.2002. PMID:12242281.
14. Inoki, K., Ouyang, H., Li, Y., and Guan, K.-L. 2005. Signalling by target of rapamycin proteins in cell growth control. Microbiol. Mol. Biol. Rev. 69: 79-100. doi:10.1128/MMBR.69.1.79-100.2005. PMID:15755954.
15. Jain, M., Liao, R., Podesser, B.K., Ngoy, S., Apstein, C.S., and Eberli, F.R. 2002. Influence of gender on the response to hemodynamic overload after myocardial infarction. Am. J. Physiol. Heart Circ. Physiol. 283: H2544-H2550. PMID:12388328.
16. ATP channel blockade in rat. Am. J. Physiol. Heart Circ. Physiol. 290: H2644-H2647. doi:10.1152/ajpheart.01291.2005. PMID:16473955.
17. Jonassen, A.K., Sack, M.N., Mjos, O.D., and Yellon, D.M. 2001. Myocardial protection by insulin at reperfusion requires early administration and is mediated via AKT and p70s6 kinase cell-survival signalling. Circ. Res. 89: 1191-1198. doi:10.1161/hh2401.101385. PMID:11739285.
18. Jones, S., Girod, W.G., Palazzo, A.J., Granger, D.N., Grisham, M.B., Jourd'Heuil, D., et al. 1999. Myocardial ischemia-reperfusion injury is exacerbated in absence of endothelial cell nitric oxide synthase. Am. J. Physiol. Heart Circ. Physiol. 276: H1567-H1573.
19. Kenchaiah, S., Pfeffer, M.A., St John Sutton, M., Plappert, T., Rouleau, J.L., Lamas, G.A., et al. 2004. Effect of antecedent systemic hypertension on subsequent left ventricular dilatation after acute myocardial infarction. Am. J. Cardiol. 94: 1-8. doi:10.1016/j.amjcard.2004.03.020. PMID:15219499.
20. Keogh, A., Richardson, M., Ruygrok, P., Spratt, P., Galbraith, A., O'Driscoll, G., et al. 2004. Sirolimus in de novo heart transplant recipients reduces acute rejection and prevents coronary artery disease at 2 years: a randomized clinical trial. Circulation, 110: 2694-2700. doi:10.1161/01.CIR. 0000136812.90177.94. (Pubitemid 39453021)
21. Khan, S.A., Salloum, F., Das, A., Xi, L., Vetrovec, G.W., and Kukreja, R.C. 2006. Rapamycin confers preconditioning-like protection against ischemia-reperfusion injury in isolated mouse heart and cardiomyocytes. J. Mol. Cell. Cardiol. 41: 256-264. doi:10.1016/j.yjmcc.2006.04.014. PMID:16769083.
22. Kido, M., Du, L., Sullivan, C.C., Li, X., Deutsch, R., Jamieson, S.W., et al. 2005. Hypoxia-inducible factor 1-alpha reduces infarction and attenuates progression of cardiac dysfunction after myocardial infarction in the mouse. J. Am. Coll. Cardiol. 46: 2116-2124. doi:10.1016/j.jacc.2005.08.045. PMID:16325051.
23. Kim, C.-H., Cho, Y.-S., Chun, Y.-S., Park, J.-W., and Kim, M.-S. 2002. Early expression of myocardial HIF-1α in response to mechanical stresses. Circ. Res. 90: e25-e30. doi:10.1161/hh0202.104923. PMID:11834720.
24. Kis, A., Yellon, D.M., and Baxter, G.F. 2003. Second window of protection following myocardial preconditioning: an essential role of PI3 kinase and p70S6 kinase. J. Mol. Cell. Cardiol. 35: 1063-1071. doi:10.1016/S0022-2828(03)00208- 6. PMID:12967629.
25. Long, W., Saffer, L., Wei, L., and Barret, E.J. 2000. Amino acids regulate skeletal muscle PHAS-1 and p70 S6-kinase phosphorylation independently of insulin. Am. J. Physiol. Endocrinol. Metab. 279: E301-E306. PMID:10913029.
26. Long, C., Cook, L.G., Hamilton, S.L., Wu, G.-Y., and Mitchell, B.M. 2007. FK506 binding protein 12/12.6 depletion increases endothelial nitric oxide synthase threonine 495 phosphorylation and blood pressure. Hypertension, 49: 569-576. doi:10.1161/01.HYP.0000257914.80918.72. PMID:17261647. (Pubitemid 46263243)
27. Mehilli, J., Ndrepepa, G., Kastrati, A., Nekolla, S.G., Markwardt, C., Bollwein, H., et al. 2005. Gender and myocardial salvage after reperfusion treatment in acute myocardial infarction. J. Am. Coll. Cardiol. 45: 828-831. doi:10.1016/j.jacc.2004.11.054. PMID:15766814.
28. Mendelsohn, M.E., and Karas, R.H. 1999. The protective effects of estrogen on the cardiovascular system. N. Engl. J. Med. 340: 1801-1811. doi:10.1056/NEJM199906103402306. PMID:10362825.
29. Morice, M.C., Serruys, P.W., Sousa, J.E., Fajadet, J., Ban, H.E., Perin, M., et al. 2002. A randomized comparision of a sirolimus-eluting stent with a standard stent for coronary revascularization. N. Engl. J. Med. 346: 1773-1780. doi:10.1056/NEJMoa012843. PMID:12050336.
30. Morris, R.E. 1993. Prevention and treatment of allograft rejection in vivo by rapamycin: molecular and cellular mechanisms of action. Ann. N. Y. Acad. Sci. 685: 68-72. doi:10.1111/j.1749-6632.1993.tb35853.x. PMID:8363274.
31. Mozaffari, M.S., and Schaffer, S.W. 2003. Effect of hypertension and hypertension-glucose intolerance on myocardial ischemic injury. Hypertension, 42: 1042-1049. doi:10.1161/01.HYP.0000095614.91961.40. PMID:14557278. (Pubitemid 37413750)
32. Neef, M., Ledermann, M., Saegesser, H., Schneider, V., and Reichen, J. 2006. Low-dose oral rapamycin treatment reduces fibrogenesis, improves liver function, and prolongs survival in rats with established liver cirrhosis. J. Hepatol. 45: 786-796. doi:10.1016/j.jhep.2006.07.030. PMID:17050028. (Pubitemid 44646687)
33. Nguyen, Q.T., Colombo, F., Clement, R., Rouleau, J.L., and Calderone, A. 2003. AT1 receptor antagonist therapy preferentially ameliorated right ventricular function and phenotype during the early phase of remodeling post-MI. Br. J. Pharmacol. 138: 1485-1494. doi:10.1038/sj.bjp.0705212. PMID:12721104.
34. Nielsen, F.T., Starklint, H., and Dieperink, H. 2005. Impaired glomerular and tubular function as a short-term effect of sirolimus treatment in the rat. Am. J. Nephrol. 25: 411-416. doi:10.1159/000087275. PMID:16088082.
35. Pap, M., and Cooper, G.M. 1998. Role of glycogen synthase kinase-3 in the phosphatidylinositol 3-kinase/AKT cell survival pathway. J. Biol. Chem. 273: 19929-19932. doi:10.1074/jbc.273.32.19929. PMID:9685326.
36. Pearson, R.B., Dennis, P.B., Han, J.W., Williamson, N.A., Kozma, S.C., Wettenhall, R.E., et al. 1995. The principal target of rapamycin-induced p70s6K inactivation is a novel phosphorylation site within a conserved hydrophobic domain. EMBO J. 14: 5279-5287. PMID:7489717.
37. Pfeffer, M.A., Pfeffer, J.M., Fishbein, M.C., Fletcher, P.J., Spadaro, J., Kloner, R.A., et al. 1979. Myocardial infarct size and ventricular function in rats. Circ. Res. 44: 503-512. PMID:428047.
38. Proulx, C., El-Helou, V., Gosselin, H., Clement, R., and Calderone, A. 2007. Antagonism of the SDF-1α/CXCR4 axis reduced infarct size and improved ventricular function following myocardial infarction. Pflugers Arch. 455: 241-250. doi:10.1007/s00424-007-0284-5. PMID:17520275.
39. Sarbassov, D.V., Ali, S.M., Sengupta, S., Sheen, J.-H., Hsu, P.P., Bagley, A.F., et al. 2006. Prolonged rapamycin treatment inhibits mTORC2 assembly and AKT/PKB. Mol. Cell, 22: 159-168. doi:10.1016/j.molcel.2006.03.029. PMID:16603397.
40. Shihab, F.S., Bennet, W.M., Yi, H., and Andoh, T.F. 2006. Effect of cyclosporine and sirolimus on the expression of connective tissue growth factor in rat experimental chronic nephrotoxicity. Am. J. Nephrol. 26: 400-407. doi:10.1159/000095300. PMID:16926534.
41. Smith, R.S., Jr., Agata, J., Xia, C.-F., Chao, L., and Chao, J. 2005. Human endothelial nitric oxide synthase gene delivery protects against cardiac remodeling and reduces oxidative stress after myocardial infarction. Life Sci. 76: 2457-2471. doi:10.1016/j.lfs.2004.11.028. PMID:15763077. (Pubitemid 40341962)
42. Takano, H., Manchikalapudi, S., Tang, X.-L., Qiu, Y., Rizvi, A., Jadoon, A.K., et al. 1998. Nitric oxide synthase is the mediator of late preconditioning against myocardial infarction in conscious rabbits. Circulation, 98: 441-449. PMID:9714095. (Pubitemid 28357947)
43. Yue, P., Massie, B.M., Simpson, P.C., and Long, C.S. 1998. Cytokine expression increases in nonmyocytes from rats with postinfarction heart failure. Am. J. Physiol. Heart Circ. Physiol. 275: H250-H258.
44. Zampino, M., Yuzhakova, M., Hansen, J., McKinney, R.D., Goldspink, P.H., Geenen, D.L., et al. 2006. Sex-related dimorphic response of HIF-1α expression in myocardial ischemia. Am. J. Physiol. Heart Circ. Physiol. 291: H957-H964. doi:10.1152/ajpheart.00580.2005. PMID:16603692.