메뉴 건너뛰기




Volumn 6, Issue 12, 2011, Pages

Neuroglobin-deficiency exacerbates Hif1A and c-FOS response, but does not affect neuronal survival during severe hypoxia in vivo

Author keywords

[No Author keywords available]

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1ALPHA; IMMEDIATE EARLY PROTEIN; MESSENGER RNA; NEUROGLOBIN; PROTEIN C FOS; GLOBIN; HIF1A PROTEIN, HUMAN; NERVE PROTEIN;

EID: 82555187208     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0028160     Document Type: Article
Times cited : (42)

References (54)
  • 1
    • 0035160270 scopus 로고    scopus 로고
    • Tissue oxygen tension and brain sensitivity to hypoxia
    • Erecinska M, Silver IA, (2001) Tissue oxygen tension and brain sensitivity to hypoxia. Respir Physiol 128: 263-276.
    • (2001) Respir Physiol , vol.128 , pp. 263-276
    • Erecinska, M.1    Silver, I.A.2
  • 3
    • 34249031561 scopus 로고    scopus 로고
    • Neuroglobin, seven years after
    • Brunori M, Vallone B, (2007) Neuroglobin, seven years after. Cell Mol Life Sci 64: 1259-1268.
    • (2007) Cell Mol Life Sci , vol.64 , pp. 1259-1268
    • Brunori, M.1    Vallone, B.2
  • 4
    • 0035914459 scopus 로고    scopus 로고
    • Biochemical characterization and ligand binding properties of neuroglobin, a novel member of the globin family
    • Dewilde S, Kiger L, Burmester T, Hankeln T, Baudin-Creuza V, et al. (2001) Biochemical characterization and ligand binding properties of neuroglobin, a novel member of the globin family. J Biol Chem 276: 38949-38955.
    • (2001) J Biol Chem , vol.276 , pp. 38949-38955
    • Dewilde, S.1    Kiger, L.2    Burmester, T.3    Hankeln, T.4    Baudin-Creuza, V.5
  • 5
    • 7244245630 scopus 로고    scopus 로고
    • Allosteric Regulation and Temperature Dependence of Oxygen Binding in Human Neuroglobin and Cytoglobin: Molecular mechanisms and physiological significance
    • Fago A, Hundahl C, Dewilde S, Gilany K, Moens L, et al. (2004) Allosteric Regulation and Temperature Dependence of Oxygen Binding in Human Neuroglobin and Cytoglobin: Molecular mechanisms and physiological significance. J Biol Chem 279: 44417-44426.
    • (2004) J Biol Chem , vol.279 , pp. 44417-44426
    • Fago, A.1    Hundahl, C.2    Dewilde, S.3    Gilany, K.4    Moens, L.5
  • 6
    • 33646591497 scopus 로고    scopus 로고
    • Does neuroglobin protect neurons from ischemic insult? A quantitative investigation of neuroglobin expression following transient MCAo in spontaneously hypertensive rats
    • Hundahl C, Kelsen J, Kjaer K, Ronn LC, Weber RE, et al. (2006) Does neuroglobin protect neurons from ischemic insult? A quantitative investigation of neuroglobin expression following transient MCAo in spontaneously hypertensive rats. Brain Res 1085: 19-27.
    • (2006) Brain Res , vol.1085 , pp. 19-27
    • Hundahl, C.1    Kelsen, J.2    Kjaer, K.3    Ronn, L.C.4    Weber, R.E.5
  • 7
    • 17144387217 scopus 로고    scopus 로고
    • Effects of short-term hypoxia on neuroglobin levels and localization in mouse brain tissues
    • Hundahl C, Stoltenberg M, Fago A, Weber RE, Dewilde S, et al. (2005) Effects of short-term hypoxia on neuroglobin levels and localization in mouse brain tissues. Neuropathol Appl Neurobiol 31: 610-617.
    • (2005) Neuropathol Appl Neurobiol , vol.31 , pp. 610-617
    • Hundahl, C.1    Stoltenberg, M.2    Fago, A.3    Weber, R.E.4    Dewilde, S.5
  • 8
    • 77951294323 scopus 로고    scopus 로고
    • Anatomical characterization of cytoglobin and neuroglobin mRNA and protein expression in the mouse brain
    • Hundahl CA, Allen GC, Hannibal J, Kjaer K, Rehfeld JF, et al. (2010) Anatomical characterization of cytoglobin and neuroglobin mRNA and protein expression in the mouse brain. Brain Res 1331: 58-73.
    • (2010) Brain Res , vol.1331 , pp. 58-73
    • Hundahl, C.A.1    Allen, G.C.2    Hannibal, J.3    Kjaer, K.4    Rehfeld, J.F.5
  • 10
    • 0035909992 scopus 로고    scopus 로고
    • Neuroglobin is up-regulated by and protects neurons from hypoxic- ischemic injury
    • Sun Y, Jin K, Mao XO, Zhu Y, Greenberg DA, (2001) Neuroglobin is up-regulated by and protects neurons from hypoxic- ischemic injury. Proc Natl Acad Sci USA 98: 15306-15311.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 15306-15311
    • Sun, Y.1    Jin, K.2    Mao, X.O.3    Zhu, Y.4    Greenberg, D.A.5
  • 11
    • 2642522806 scopus 로고    scopus 로고
    • Cytoglobin expression is upregulated in all tissues upon hypoxia: an in vitro and in vivo study by quantitative real-time PCR
    • Fordel E, Geuens E, Dewilde S, Rottiers P, Carmeliet P, et al. (2004) Cytoglobin expression is upregulated in all tissues upon hypoxia: an in vitro and in vivo study by quantitative real-time PCR. Biochem Biophys Res Commun 319: 342-348.
    • (2004) Biochem Biophys Res Commun , vol.319 , pp. 342-348
    • Fordel, E.1    Geuens, E.2    Dewilde, S.3    Rottiers, P.4    Carmeliet, P.5
  • 12
    • 33845224148 scopus 로고    scopus 로고
    • Neuroglobin-overexpressing transgenic mice are resistant to cerebral and myocardial ischemia
    • Khan AA, Wang Y, Sun Y, Mao XO, Xie L, et al. (2006) Neuroglobin-overexpressing transgenic mice are resistant to cerebral and myocardial ischemia. Proc Natl Acad Sci U S A 103: 17944-17948.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 17944-17948
    • Khan, A.A.1    Wang, Y.2    Sun, Y.3    Mao, X.O.4    Xie, L.5
  • 13
    • 0037452987 scopus 로고    scopus 로고
    • Neuroglobin protects the brain from experimental stroke in vivo
    • Sun Y, Jin K, Peel A, Mao XO, Xie L, et al. (2003) Neuroglobin protects the brain from experimental stroke in vivo. Proc Natl Acad Sci USA 100: 3497-3500.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 3497-3500
    • Sun, Y.1    Jin, K.2    Peel, A.3    Mao, X.O.4    Xie, L.5
  • 14
    • 77649150656 scopus 로고    scopus 로고
    • Neuroglobin expression in ischemic stroke
    • Jin K, Mao Y, Mao X, Xie L, Greenberg DA, (2010) Neuroglobin expression in ischemic stroke. Stroke 41: 557-559.
    • (2010) Stroke , vol.41 , pp. 557-559
    • Jin, K.1    Mao, Y.2    Mao, X.3    Xie, L.4    Greenberg, D.A.5
  • 15
    • 46249131382 scopus 로고    scopus 로고
    • Effects of Neuroglobin Overexpression on Acute Brain Injury and Long-Term Outcomes After Focal Cerebral Ischemia
    • Wang X, Liu J, Zhu H, Tejima E, Tsuji K, et al. (2008) Effects of Neuroglobin Overexpression on Acute Brain Injury and Long-Term Outcomes After Focal Cerebral Ischemia. Stroke 39: 1869-1874.
    • (2008) Stroke , vol.39 , pp. 1869-1874
    • Wang, X.1    Liu, J.2    Zhu, H.3    Tejima, E.4    Tsuji, K.5
  • 19
    • 53849095142 scopus 로고    scopus 로고
    • Neuroglobin in the rat brain (II): co-localisation with neurotransmitters
    • Hundahl CA, Kelsen J, Dewilde S, Hay-Schmidt A, (2008) Neuroglobin in the rat brain (II): co-localisation with neurotransmitters. Neuroendocrinology 88: 183-198.
    • (2008) Neuroendocrinology , vol.88 , pp. 183-198
    • Hundahl, C.A.1    Kelsen, J.2    Dewilde, S.3    Hay-Schmidt, A.4
  • 20
    • 77949394153 scopus 로고    scopus 로고
    • Neuroglobin expression in the rat suprachiasmatic nucleus: Colocalization, innervation, and response to light
    • Hundahl CA, Hannibal J, Fahrenkrug J, Dewilde S, Hay-Schmidt A, (2010) Neuroglobin expression in the rat suprachiasmatic nucleus: Colocalization, innervation, and response to light. J Comp Neurol 518: 1556-1569.
    • (2010) J Comp Neurol , vol.518 , pp. 1556-1569
    • Hundahl, C.A.1    Hannibal, J.2    Fahrenkrug, J.3    Dewilde, S.4    Hay-Schmidt, A.5
  • 22
    • 0036226603 scopus 로고    scopus 로고
    • BLAT-the BLAST-like alignment tool
    • Kent WJ, (2002) BLAT-the BLAST-like alignment tool. Genome Res 12: 656-664.
    • (2002) Genome Res , vol.12 , pp. 656-664
    • Kent, W.J.1
  • 23
    • 34547571030 scopus 로고    scopus 로고
    • g:Profiler-a web-based toolset for functional profiling of gene lists from large-scale experiments
    • Reimand J, Kull M, Peterson H, Hansen J, Vilo J, (2007) g:Profiler-a web-based toolset for functional profiling of gene lists from large-scale experiments. Nucleic Acids Res 35: W193-200.
    • (2007) Nucleic Acids Res , vol.35
    • Reimand, J.1    Kull, M.2    Peterson, H.3    Hansen, J.4    Vilo, J.5
  • 24
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method
    • Livak KJ, Schmittgen TD, (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25: 402-408.
    • (2001) Methods , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 25
    • 0034706057 scopus 로고    scopus 로고
    • Development of hypoxia-induced Fos expression in rat caudal hypothalamic neurons
    • Horn EM, Kramer JM, Waldrop TG, (2000) Development of hypoxia-induced Fos expression in rat caudal hypothalamic neurons. Neuroscience 99: 711-720.
    • (2000) Neuroscience , vol.99 , pp. 711-720
    • Horn, E.M.1    Kramer, J.M.2    Waldrop, T.G.3
  • 26
    • 0030833070 scopus 로고    scopus 로고
    • Expression of c-fos in the rat brainstem after exposure to hypoxia and to normoxic and hyperoxic hypercapnia
    • Teppema LJ, Veening JG, Kranenburg A, Dahan A, Berkenbosch A, et al. (1997) Expression of c-fos in the rat brainstem after exposure to hypoxia and to normoxic and hyperoxic hypercapnia. J Comp Neurol 388: 169-190.
    • (1997) J Comp Neurol , vol.388 , pp. 169-190
    • Teppema, L.J.1    Veening, J.G.2    Kranenburg, A.3    Dahan, A.4    Berkenbosch, A.5
  • 27
    • 33846254999 scopus 로고    scopus 로고
    • RACK1 competes with HSP90 for binding to HIF-1alpha and is required for O(2)-independent and HSP90 inhibitor-induced degradation of HIF-1alpha
    • Liu YV, Baek JH, Zhang H, Diez R, Cole RN, et al. (2007) RACK1 competes with HSP90 for binding to HIF-1alpha and is required for O(2)-independent and HSP90 inhibitor-induced degradation of HIF-1alpha. Mol Cell 25: 207-217.
    • (2007) Mol Cell , vol.25 , pp. 207-217
    • Liu, Y.V.1    Baek, J.H.2    Zhang, H.3    Diez, R.4    Cole, R.N.5
  • 28
    • 0033982936 scopus 로고    scopus 로고
    • KEGG: kyoto encyclopedia of genes and genomes
    • Kanehisa M, Goto S, (2000) KEGG: kyoto encyclopedia of genes and genomes. Nucleic Acids Res 28: 27-30.
    • (2000) Nucleic Acids Res , vol.28 , pp. 27-30
    • Kanehisa, M.1    Goto, S.2
  • 31
    • 38349056675 scopus 로고    scopus 로고
    • Hypoxia regulates TSC1/2-mTOR signaling and tumor suppression through REDD1-mediated 14-3-3 shuttling
    • DeYoung MP, Horak P, Sofer A, Sgroi D, Ellisen LW, (2008) Hypoxia regulates TSC1/2-mTOR signaling and tumor suppression through REDD1-mediated 14-3-3 shuttling. Genes Dev 22: 239-251.
    • (2008) Genes Dev , vol.22 , pp. 239-251
    • DeYoung, M.P.1    Horak, P.2    Sofer, A.3    Sgroi, D.4    Ellisen, L.W.5
  • 32
    • 69049111041 scopus 로고    scopus 로고
    • An integrative genomics approach identifies Hypoxia Inducible Factor-1 (HIF-1)-target genes that form the core response to hypoxia
    • Benita Y, Kikuchi H, Smith AD, Zhang MQ, Chung DC, et al. (2009) An integrative genomics approach identifies Hypoxia Inducible Factor-1 (HIF-1)-target genes that form the core response to hypoxia. Nucleic Acids Res 37: 4587-4602.
    • (2009) Nucleic Acids Res , vol.37 , pp. 4587-4602
    • Benita, Y.1    Kikuchi, H.2    Smith, A.D.3    Zhang, M.Q.4    Chung, D.C.5
  • 33
    • 29144475158 scopus 로고    scopus 로고
    • Effect of hypoxic preconditioning on brain genomic response before and following ischemia in the adult mouse: identification of potential neuroprotective candidates for stroke
    • Tang Y, Pacary E, Freret T, Divoux D, Petit E, et al. (2006) Effect of hypoxic preconditioning on brain genomic response before and following ischemia in the adult mouse: identification of potential neuroprotective candidates for stroke. Neurobiol Dis 21: 18-28.
    • (2006) Neurobiol Dis , vol.21 , pp. 18-28
    • Tang, Y.1    Pacary, E.2    Freret, T.3    Divoux, D.4    Petit, E.5
  • 34
    • 66149086544 scopus 로고    scopus 로고
    • What is the function of neuroglobin?
    • Burmester T, Hankeln T, (2009) What is the function of neuroglobin? J Exp Biol 212: 1423-1428.
    • (2009) J Exp Biol , vol.212 , pp. 1423-1428
    • Burmester, T.1    Hankeln, T.2
  • 35
    • 58249102180 scopus 로고    scopus 로고
    • Regulation and role of neuroglobin and cytoglobin under hypoxia
    • Burmester T, Gerlach F, Hankeln T, (2007) Regulation and role of neuroglobin and cytoglobin under hypoxia. Adv Exp Med Biol 618: 169-180.
    • (2007) Adv Exp Med Biol , vol.618 , pp. 169-180
    • Burmester, T.1    Gerlach, F.2    Hankeln, T.3
  • 37
    • 78650720495 scopus 로고    scopus 로고
    • Neuroglobin, cytoglobin, and myoglobin contribute to hypoxia adaptation of the subterranean mole rat Spalax
    • Avivi A, Gerlach F, Joel A, Reuss S, Burmester T, et al. (2010) Neuroglobin, cytoglobin, and myoglobin contribute to hypoxia adaptation of the subterranean mole rat Spalax. Proc Natl Acad Sci U S A 107: 21570-21575.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 21570-21575
    • Avivi, A.1    Gerlach, F.2    Joel, A.3    Reuss, S.4    Burmester, T.5
  • 38
    • 33745264870 scopus 로고    scopus 로고
    • Hypoxia differentially regulates the expression of neuroglobin and cytoglobin in rat brain
    • Li RC, Lee SK, Pouranfar F, Brittian KR, Clair HB, et al. (2006) Hypoxia differentially regulates the expression of neuroglobin and cytoglobin in rat brain. Brain Res 1096: 173-179.
    • (2006) Brain Res , vol.1096 , pp. 173-179
    • Li, R.C.1    Lee, S.K.2    Pouranfar, F.3    Brittian, K.R.4    Clair, H.B.5
  • 39
    • 33746032975 scopus 로고    scopus 로고
    • Neuroglobin mRNA expression after transient global brain ischemia and prolonged hypoxia in cell culture
    • Schmidt-Kastner R, Haberkamp M, Schmitz C, Hankeln T, Burmester T, (2006) Neuroglobin mRNA expression after transient global brain ischemia and prolonged hypoxia in cell culture. Brain Res 1103: 173-180.
    • (2006) Brain Res , vol.1103 , pp. 173-180
    • Schmidt-Kastner, R.1    Haberkamp, M.2    Schmitz, C.3    Hankeln, T.4    Burmester, T.5
  • 40
    • 78049458153 scopus 로고    scopus 로고
    • Neuroglobin protects neurons against oxidative stress in global ischemia
    • Li RC, Guo SZ, Lee SK, Gozal D, (2010) Neuroglobin protects neurons against oxidative stress in global ischemia. J Cereb Blood Flow Metab 30: 1874-1882.
    • (2010) J Cereb Blood Flow Metab , vol.30 , pp. 1874-1882
    • Li, R.C.1    Guo, S.Z.2    Lee, S.K.3    Gozal, D.4
  • 41
    • 70450223507 scopus 로고    scopus 로고
    • Generating specificity and diversity in the transcriptional response to hypoxia
    • Lendahl U, Lee KL, Yang H, Poellinger L, (2009) Generating specificity and diversity in the transcriptional response to hypoxia. Nat Rev Genet 10: 821-832.
    • (2009) Nat Rev Genet , vol.10 , pp. 821-832
    • Lendahl, U.1    Lee, K.L.2    Yang, H.3    Poellinger, L.4
  • 42
    • 33644622570 scopus 로고    scopus 로고
    • HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption
    • Papandreou I, Cairns RA, Fontana L, Lim AL, Denko NC, (2006) HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption. Cell Metab 3: 187-197.
    • (2006) Cell Metab , vol.3 , pp. 187-197
    • Papandreou, I.1    Cairns, R.A.2    Fontana, L.3    Lim, A.L.4    Denko, N.C.5
  • 43
    • 50149097983 scopus 로고    scopus 로고
    • Hypoxia, HIF1 and glucose metabolism in the solid tumour
    • Denko NC, (2008) Hypoxia, HIF1 and glucose metabolism in the solid tumour. Nat Rev Cancer 8: 705-713.
    • (2008) Nat Rev Cancer , vol.8 , pp. 705-713
    • Denko, N.C.1
  • 44
    • 79953002264 scopus 로고    scopus 로고
    • Small ubiquitin-related modifier (SUMO)-1 promotes glycolysis in hypoxia
    • Agbor TA, Cheong A, Comerford KM, Scholz CC, Bruning U, et al. (2011) Small ubiquitin-related modifier (SUMO)-1 promotes glycolysis in hypoxia. J Biol Chem 286: 4718-4726.
    • (2011) J Biol Chem , vol.286 , pp. 4718-4726
    • Agbor, T.A.1    Cheong, A.2    Comerford, K.M.3    Scholz, C.C.4    Bruning, U.5
  • 45
    • 63549129144 scopus 로고    scopus 로고
    • SUMOylation and De-SUMOylation: wrestling with life's processes
    • Yeh ET, (2009) SUMOylation and De-SUMOylation: wrestling with life's processes. J Biol Chem 284: 8223-8227.
    • (2009) J Biol Chem , vol.284 , pp. 8223-8227
    • Yeh, E.T.1
  • 46
    • 34147161066 scopus 로고    scopus 로고
    • Hypoxia-induced and stress-specific changes in chromatin structure and function
    • Johnson AB, Barton MC, (2007) Hypoxia-induced and stress-specific changes in chromatin structure and function. Mutat Res 618: 149-162.
    • (2007) Mutat Res , vol.618 , pp. 149-162
    • Johnson, A.B.1    Barton, M.C.2
  • 47
    • 40649114443 scopus 로고    scopus 로고
    • Hypoxia induces a novel signature of chromatin modifications and global repression of transcription
    • Johnson AB, Denko N, Barton MC, (2008) Hypoxia induces a novel signature of chromatin modifications and global repression of transcription. Mutat Res 640: 174-179.
    • (2008) Mutat Res , vol.640 , pp. 174-179
    • Johnson, A.B.1    Denko, N.2    Barton, M.C.3
  • 48
    • 33749494456 scopus 로고    scopus 로고
    • Hypoxic stress induces dimethylated histone H3 lysine 9 through histone methyltransferase G9a in mammalian cells
    • Chen H, Yan Y, Davidson TL, Shinkai Y, Costa M, (2006) Hypoxic stress induces dimethylated histone H3 lysine 9 through histone methyltransferase G9a in mammalian cells. Cancer Res 66: 9009-9016.
    • (2006) Cancer Res , vol.66 , pp. 9009-9016
    • Chen, H.1    Yan, Y.2    Davidson, T.L.3    Shinkai, Y.4    Costa, M.5
  • 49
    • 74049085411 scopus 로고    scopus 로고
    • Hypoxic repression of endothelial nitric-oxide synthase transcription is coupled with eviction of promoter histones
    • Fish JE, Yan MS, Matouk CC, St Bernard R, Ho JJ, et al. (2010) Hypoxic repression of endothelial nitric-oxide synthase transcription is coupled with eviction of promoter histones. J Biol Chem 285: 810-826.
    • (2010) J Biol Chem , vol.285 , pp. 810-826
    • Fish, J.E.1    Yan, M.S.2    Matouk, C.C.3    St Bernard, R.4    Ho, J.J.5
  • 50
    • 33645823895 scopus 로고    scopus 로고
    • Permissive effects of oxygen on cyclic AMP and interleukin-1 stimulation of surfactant protein A gene expression are mediated by epigenetic mechanisms
    • Islam KN, Mendelson CR, (2006) Permissive effects of oxygen on cyclic AMP and interleukin-1 stimulation of surfactant protein A gene expression are mediated by epigenetic mechanisms. Mol Cell Biol 26: 2901-2912.
    • (2006) Mol Cell Biol , vol.26 , pp. 2901-2912
    • Islam, K.N.1    Mendelson, C.R.2
  • 51
    • 69749090698 scopus 로고    scopus 로고
    • c-Myc mediates a hypoxia-induced decrease in acetylated histone H4
    • Li Q, Costa M, (2009) c-Myc mediates a hypoxia-induced decrease in acetylated histone H4. Biochimie 91: 1307-1310.
    • (2009) Biochimie , vol.91 , pp. 1307-1310
    • Li, Q.1    Costa, M.2
  • 52
    • 77954319020 scopus 로고    scopus 로고
    • Sequencing of 50 human exomes reveals adaptation to high altitude
    • Yi X, Liang Y, Huerta-Sanchez E, Jin X, Cuo ZX, et al. (2010) Sequencing of 50 human exomes reveals adaptation to high altitude. Science 329: 75-78.
    • (2010) Science , vol.329 , pp. 75-78
    • Yi, X.1    Liang, Y.2    Huerta-Sanchez, E.3    Jin, X.4    Cuo, Z.X.5
  • 53
    • 72849111523 scopus 로고    scopus 로고
    • RNA-binding proteins implicated in the hypoxic response
    • Masuda K, Abdelmohsen K, Gorospe M, (2009) RNA-binding proteins implicated in the hypoxic response. J Cell Mol Med 13: 2759-2769.
    • (2009) J Cell Mol Med , vol.13 , pp. 2759-2769
    • Masuda, K.1    Abdelmohsen, K.2    Gorospe, M.3
  • 54
    • 18144376727 scopus 로고    scopus 로고
    • Human hHpr1/p84/Thoc1 regulates transcriptional elongation and physically links RNA polymerase II and RNA processing factors
    • Li Y, Wang X, Zhang X, Goodrich DW, (2005) Human hHpr1/p84/Thoc1 regulates transcriptional elongation and physically links RNA polymerase II and RNA processing factors. Mol Cell Biol 25: 4023-4033.
    • (2005) Mol Cell Biol , vol.25 , pp. 4023-4033
    • Li, Y.1    Wang, X.2    Zhang, X.3    Goodrich, D.W.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.