6-Thioguanine damages mitochondrial DNA and causes mitochondrial dysfunction in human cells

FEBS Letters

Volumn 585, Issue 24, 2011, Pages 3941-3946

  Daehn, Ilse ^a,b   Brem, Reto ^a   Barkauskaite, Eva ^a,c   Karran, Peter ^a  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

DNA oxidation damage; Mitochondrial DNA; Mitochondrial DNA replication; Mitochondrial DNA transcription; Oxidative metabolism; Thiopurine; Ultraviolet A

Indexed keywords

ADENOSINE TRIPHOSPHATE; DNA DIRECTED DNA POLYMERASE GAMMA; MITOCHONDRIAL DNA; TIOGUANINE;

AEROBIC METABOLISM; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DNA DAMAGE; DNA ISOLATION; DNA REPLICATION; DNA SYNTHESIS; DNA TRANSCRIPTION; ENZYME SYNTHESIS; HUMAN; HUMAN CELL; MITOCHONDRION; PHOTOOXIDATION; PHOTOSENSITIZATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; ULTRAVIOLET A RADIATION;

ADENOSINE TRIPHOSPHATE; ANIMALS; CELL NUCLEUS; DNA DAMAGE; DNA REPLICATION; DNA, MITOCHONDRIAL; GENE EXPRESSION REGULATION; HCT116 CELLS; HUMANS; KINETICS; MICE; MITOCHONDRIA; OXIDATION-REDUCTION; THIOGUANINE; TIME FACTORS; ULTRAVIOLET RAYS;

EID: 82555186987     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/j.febslet.2011.10.040     Document Type: Article

References (26)

1. P. Karran, and N. Attard Thiopurines in current medical practice. molecular mechanisms and contributions to therapy-related cancer Nat Rev Cancer 8 2008 24 36
2. P.F. Swann, T.R. Waters, D.C. Moulton, Y.-Z. Xu, M. Edwards, and R. Mace Role of postreplicative DNA mismatch repair in the cytotoxic action of thioguanine Science 273 1996 1109 1111
3. I. Daehn, and P. Karran Immune effector cells produce lethal DNA damage in cells treated with a thiopurine Cancer Res 69 2008 2393 2399
4. P. O'Donovan, C.M. Perrett, X. Zhang, B. Montaner, Y.-Z. Xu, C.A. Harwood, J.M. McGregor, S.L. Walker, F. Hanaoka, and P. Karran Azathioprine and UVA light generate mutagenic oxidative DNA damage Science 309 2005 1871 1874 (Pubitemid 41325100)
5. X. Ren, F. Li, G. Jeffs, X. Zhang, Y.-Z. Xu, and P. Karran Guanine sulphinate is a major stable product of photochemical oxidation of DNA 6-thioguanine by UVA irradiation Nucleic Acids Res 38 2010 1832 1840
6. X. Zhang, G. Jeffs, X. Ren, P. O'Donovan, B. Montaner, C.M. Perrett, P. Karran, and Y.-Z. Xu Novel DNA lesions generated by the interaction between therapeutic thiopurines and UVA light DNA Repair 6 2007 344 354 (Pubitemid 46329614)
7. R. Brem, F. Li, and P. Karran Reactive oxygen species generated by thiopurine/UVA cause irreparable transcription-blocking DNA lesions Nucleic Acids Res 37 2009 1951 1961
8. F. Li DNA damage and UVA induced oxidation of 6-thioguanine 2010 PhD University of London
9. B.V. Houten, V. Woshner, and J.H. Santos Role of mitochondrial DNA in toxic responses to oxidative stress DNA Repair 5 2006 145 152 (Pubitemid 43069515)
10. K.J. Krishnan, and D.M. Turnbull Mitochondrial DNA and genetic disease Essays Biochem 47 2010 139 151
11. E. Cadenas, and K.J.A. Davies Mitochondrial free radical generation, oxidative stress, and aging Free Radic Biol Med 29 2000 222 230
12. F.M. Yakes, and B.V. Houten Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress Proc Natl Acad Sci USA 94 1997 514 519 (Pubitemid 27053665)
13. M. Ott, V. Gogvadze, S. Orrenius, and B. Zhivotovsky Mitochondria, oxidative stress and cell death Apoptosis 12 2007 913 922 (Pubitemid 46653300)
14. N.C. de Souza-Pinto, D.M. Wilson, T.V. Stevnsner, and V.A. Bohr Mitochondrial DNA, base excision repair and neurodegeneration DNA Repair 7 2008 1098 1109
15. P. Liu, and B. Demple DNA repair in mammalian mitochondria: much more than we thought? Environ Mol Mutagen 51 2010 417 426
16. E. Petit, S. Langouet, H. Akhdar, C. Nicolas-Nicolaz, A. Guillouzo, and F. Morel Differential toxic effects of azathioprine, 6-mercaptopurine and 6-thioguanine on human hepatocytes Toxicol in Vitro 22 2008 632 642
17. M.P. King, and G. Attardi Isolation of human cell lines lacking mitochondrial DNA Methods Enzymol 264 1996 304 313 (Pubitemid 26089319)
18. D. Lebrecht, A. Kokkori, U.P. Ketelsen, B. Setzer, and U.A. Walker Tissue-specific mtDNA lesions and radical-associated mitochondrial dysfunction in human hearts exposed to doxorubicin J Pathol 207 2005 436 444 (Pubitemid 43025692)
19. J. Casademont, A. Barrientos, J.M. Grau, E. Pedrol, X. Estivill, A. Urbano-Marquez, and V. Nunes The effect of zidovudine on skeletal muscle mtDNA in HIV-1 infected patients with mild or no muscle dysfunction Brain 119 1996 1357 1364 (Pubitemid 26300735)
20. M.V. Simpson, C.D. Chin, S.A. Keilbaugh, T.S. Lin, and W.H. Prusoff Studies on the inhibition of mitochondrial DNA replication by 3′-azido-3′-deoxythymidine and other dideoxynucleoside analogs which inhibit HIV-1 replication Biochem Pharmacol 38 1989 1033 1036 (Pubitemid 19088438)
21. A.S. Karhadkar, H.J. Schwartz, M. Arora, and S.K. Dutta Severe muscular weakness: an unusual adverse effect of azathioprine therapy J Cllin Gastroenterol 40 2006 626 628 (Pubitemid 44259770)
22. Hofbauer GFL, Straub G, Dziunycz P, Meyer R, Karran P, Attard N, Kamenisch Y, Berneburg M, French LE, Wuthrich RP, et al. Switching from azathioprine to mycophenolate mofetil improves skin photosensitivity in kidney transplant recipients. Am J Transplant (E pub ahead of print, September 2011).
23. A. Vora, C.D. Mitchell, L. Lennard, T.O. Eden, S.E. Kinsey, J. Lilleyman, S.M. Richards The Medical Research Council; National Cancer Research Network Childhood Leukaemia Working Party Toxicity and efficacy of 6-thioguanine versus 6-mercaptopurine in childhood lymphoblastic leukaemia: a randomised trial Lancet 368 2006 1339 1348 (Pubitemid 44528747)
24. S.A. Geller, M.C. Dubinsky, F.F. Poordad, E.A. Vasiliauskas, A.H. Cohen, M.T. Abreu, T. Tran, P. Martin, J.M. Vierling, and S.R. Targan Early hepatic nodular hyperplasia and submicroscopic fibrosis associated with 6-thioguanine therapy in inflammatory bowel disease Am J Surg Pathol 28 2004 1204 1211 (Pubitemid 39121614)
25. A. Ferlitsch, A. Teml, W. Reinisch, G. Ulbrich, F. Wrba, M. Homoncik, A. Gangl, M. Peck-Radoslavljevic, and H. Vogelsang 6-thioguanine associated nodular regenerative hyperplasia in patients with inflammatory bowel disease may induce portal hypertension Am J Gastroenterol 102 2007 2495 2503 (Pubitemid 47631796)
26. M.C. Dubinsky, E.A. Vasiliauskas, H. Singh, M.T. Abreu, K.A. Papadakis, T. Tran, P. Martin, J.M. Vierling, S.E. Geller, and S.R. Targan 6-Thioguanine can cause serious liver injury in inflammatory bowel disease patients Gastroenterology 125 2003 298 303 (Pubitemid 36929408)