Structure-activity relationships in toll-like receptor 2-agonists leading to simplified monoacyl lipopeptides

Journal of Medicinal Chemistry

Volumn 54, Issue 23, 2011, Pages 8148-8160

  Agnihotri, Geetanjali ^a   Crall, Breanna M ^a   Lewis, Tyler C ^a   Day, Timothy P ^a   Balakrishna, Rajalakshmi ^a   Warshakoon, Hemamali J ^a   Malladi, Subbalakshmi S ^a   David, Sunil A ^a  

^a UNIVERSITY OF KANSAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

(2,2') DIMETHYL 2,2' (((2,2') 3,3' DISULFANEDIYLBIS(2 ((TERTBUTOXYCARBONYL)AMINO)PROPANOYL))BIS(AZANEDIYL))BIS(3(TERTBUTOXY)PROPANOATE); 2 ((2 AMINO 3 ((3 HYDROXY 1 METHOXY 1 OXOPROPAN 2 YL)AMINO) 3 OXOPROPYL)THIO)ETHYL PALMITATE, TRIFLUOROACETATE; 2 ((3 ((3 (TERTBUTOXY) 1 METHOXY 1 OXOPROPAN 2 YL)AMINO) 2 ((TERTBUTOXYCARBONYL) AMINO) 3 OXOPROPYL)THIO)ETHYL PALMITATE; 2 ((3 ((3 (TERTBUTOXY) 1 METHOXY 1 OXOPROPAN 2 YL)AMINO) 2 ((TERTBUTOXYCARBONYL)AMINO) 3 OXOPROPYL)THIO)ACETIC ACID; 3 ((2 AMINO 3 ((3 HYDROXY 1 METHOXY 1 OXOPROPAN 2 YL)AMINO) 3 OXOPROPYL)THIO)PROPYL PALMITATE, TRIFLUOROACETATE; 3 ((3 ((3 (TERTBUTOXY) 1 METHOXY 1 OXOPROPAN 2 YL)AMINO) 2 ((TERTBUTOXYCARBONYL) AMINO) 3 OXOPROPYL)THIO)PROPYL PALMITATE; 3 ((3 ((3 (TERTBUTOXY) 1 METHOXY 1 OXOPROPAN 2 YL)AMINO) 2 ((TERTBUTOXYCARBONYL)AMINO) 3 OXOPROPYL)THIO)PROPANOIC ACID; CARBONYL DERIVATIVE; ESTER DERIVATIVE; GLYCEROL; LIPOPEPTIDE; METHYL 2 (2 AMINO 3 ((2 (HEXADECYLOXY) 2 OXOETHYL)THIO)PROPANAMIDO) 3 HYDROXYPROPANOATE, TRIFLUOROACETATE; METHYL 2 (2 AMINO 3 ((3(HEXADECYLOXY) 3 OXOPROPYL)THIO)PROPANAMIDO) 3 HYDROXYPROPANOATE, TRIFLUOROACETATE; METHYL 3 (TERTBUTOXY) 2 (2 ((TERTBUTOXYCARBONYL)AMINO) 3 ((2 (HEXADECYLOXY) 2 OXOETHYL)THIO)PROPANAMIDO)PROPANOATE; METHYL 3 (TERTBUTOXY) 2 (2 ((TERTBUTOXYCARBONYL)AMINO) 3 ((2 HYDROXYETHYL)THIO)PROPANAMIDO)PROPANOATE; METHYL 3 (TERTBUTOXY) 2 (2 ((TERTBUTOXYCARBONYL)AMINO) 3 ((3 (HEXADECYLOXY) 3 OXOPROPYL)THIO)PROPANAMIDO)PROPANOATE; METHYL 3 (TERTBUTOXY) 2 (2 ((TERTBUTOXYCARBONYL)AMINO) 3 ((3 HYDROXYPROPYL)THIO)PROPANAMIDO)PROPANOATE; METHYL 3 (TERTBUTOXY) 2 (2 ((TERTBUTOXYCARBONYL)AMINO)3MERCAPTOPROPANAMIDO)PROPANOATE; PENICILLAMINE DERIVATIVE; SERINE; SULFIDE; TOLL LIKE RECEPTOR 2 AGONIST; TOLL LIKE RECEPTOR AGONIST; UNCLASSIFIED DRUG;

ARTICLE; CRYSTAL STRUCTURE; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; FLOW CYTOMETRY; HYDROGEN BOND; MOUSE; NONHUMAN;

ADJUVANTS, IMMUNOLOGIC; ALPHA-LINOLENIC ACID; ANIMALS; HUMANS; LINOLEIC ACIDS; LIPOPEPTIDES; MICE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; SOLUBILITY; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TOLL-LIKE RECEPTOR 2;

EID: 82555185514     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm201071e     Document Type: Article

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