메뉴 건너뛰기




Volumn 23, Issue 1, 2012, Pages 108-118

Arsenic trioxide inhibits Ewing's sarcoma cell invasiveness by targeting p38 MAPK and c-Jun N-terminal kinase

Author keywords

arsenic trioxide; Ewing's sarcoma; invasion; migration; mitogenactivated protein kinase

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 HYDROXYPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANISOMYCIN; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; ARSENIC TRIOXIDE; GELATINASE B; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; STRESS ACTIVATED PROTEIN KINASE;

EID: 82555166027     PISSN: 09594973     EISSN: 14735741     Source Type: Journal    
DOI: 10.1097/CAD.0b013e32834bfd68     Document Type: Article
Times cited : (20)

References (44)
  • 1
    • 47249160783 scopus 로고    scopus 로고
    • Ewing sarcoma: Historical perspectives current state-of-the-art and opportunities for targeted therapy in the future
    • Ludwig JA. Ewing sarcoma: historical perspectives, current state-of-the-art, and opportunities for targeted therapy in the future. Curr Opin Oncol 2008; 20:412-418.
    • (2008) Curr. Opin. Oncol. , vol.20 , pp. 412-418
    • Ludwig, J.A.1
  • 2
    • 10744231796 scopus 로고    scopus 로고
    • Long-term outcome for patients with non-metastatic Ewing's sarcoma treated with adjuvant and neoadjuvant chemotherapies. 402 patients treated at Rizzoli between 1972 and 1992
    • DOI 10.1016/j.ejca.2003.08.022
    • Bacci G, Forni C, Longhi A, Ferrari S, Donati D, De Paolis M, et al. Long-term outcome for patients with non-metastatic Ewing's sarcoma treated with adjuvant and neoadjuvant chemotherapies: 402 patients treated at Rizzoli between 1972 and 1992. Eur J Cancer 2004; 40:73-83. (Pubitemid 37542320)
    • (2004) European Journal of Cancer , vol.40 , Issue.1 , pp. 73-83
    • Bacci, G.1    Forni, C.2    Longhi, A.3    Ferrari, S.4    Donati, D.5    De Paolis, M.6    Barbieri, E.7    Pignotti, E.8    Rosito, P.9    Versari, M.10
  • 5
    • 47549083691 scopus 로고    scopus 로고
    • Changes in incidence and survival of Ewing sarcoma patients over the past 3 decades: Surveillance epidemiology and end results data
    • Esiashvili N, Goodman M, Marcus RB Jr. Changes in incidence and survival of Ewing sarcoma patients over the past 3 decades: Surveillance epidemiology and end results data. J Pediatr Hematol Oncol 2008; 30:425-430.
    • (2008) J. Pediatr. Hematol. Oncol. , vol.30 , pp. 425-430
    • Esiashvili, N.1    Goodman, M.2    Marcus Jr., R.B.3
  • 6
    • 0030610687 scopus 로고    scopus 로고
    • Use of arsenic trioxide As2O3 in the treatment of acute promyelocytic leukemia APL: II clinical efficacy and pharmacokinetics in relapsed patients
    • Shen ZX, Chen GQ, Ni JH, Li XS, Xiong SM, Qiu QY, et al. Use of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia (APL): II. Clinical efficacy and pharmacokinetics in relapsed patients. Blood 1997; 89:3354-3360.
    • (1997) Blood , vol.89 , pp. 3354-3360
    • Shen, Z.X.1    Chen, G.Q.2    Ni, J.H.3    Li, X.S.4    Xiong, S.M.5    Qiu, Q.Y.6
  • 8
    • 33747826981 scopus 로고    scopus 로고
    • Arsenic trioxide concentration determines the fate of Ewing's sarcoma family tumors and neuroblastoma cells in vitro
    • DOI 10.1016/j.febslet.2006.07.077, PII S0014579306009458
    • Jung HS, Kim HS, Lee MJ, Shin HY, Ahn HS, Ryu KH, et al. Arsenic trioxide concentration determines the fate of Ewing's sarcoma family tumors and neuroblastoma cells in vitro. FEBS Lett 2006; 580:4969-4975. (Pubitemid 44286843)
    • (2006) FEBS Letters , vol.580 , Issue.20 , pp. 4969-4975
    • Jung, H.S.1    Kim, H.-S.2    Lee, M.-J.3    Shin, H.Y.4    Ahn, H.S.5    Ryu, K.-H.6    Seoh, J.-Y.7    Kim, C.J.8    Jang, J.J.9
  • 10
    • 39049182694 scopus 로고    scopus 로고
    • Preliminary report of combination chemotherapy including arsenic trioxide for stage III osteosarcoma and Ewing sarcoma
    • Guo W, Tang XD, Tang S, Yang Y. Preliminary report of combination chemotherapy including arsenic trioxide for stage III osteosarcoma and Ewing sarcoma. Zhonghua Wai Ke Za Zhi 2006; 44:805-808.
    • (2006) Zhonghua. Wai. Ke. Za. Zhi. , vol.44 , pp. 805-808
    • Guo, W.1    Tang, X.D.2    Tang, S.3    Yang, Y.4
  • 11
    • 77955496138 scopus 로고    scopus 로고
    • Arsenic trioxide inhibits osteosarcoma cell invasiveness via MAPK signaling pathway
    • Tingting R, Wei G, Changliang P, Xinchang L, Yi Y. Arsenic trioxide inhibits osteosarcoma cell invasiveness via MAPK signaling pathway. Cancer Biol Ther 2010; 10:251-257.
    • (2010) Cancer Biol. Ther. , vol.10 , pp. 251-257
    • Tingting, R.1    Wei, G.2    Changliang, P.3    Xinchang, L.4    Yi, Y.5
  • 13
    • 0034667593 scopus 로고    scopus 로고
    • Meaningful relationships: The regulation of the Ras/Raf/MEK/ERK pathway by protein interactions
    • Pt 2
    • Kolch W. Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions. Biochem J 2000; 351 (Pt 2):289-305.
    • (2000) Biochem. J. , vol.351 , pp. 289-305
    • Kolch, W.1
  • 14
    • 78649656028 scopus 로고    scopus 로고
    • Regulation of cross-talk in yeast MAPK signaling pathways
    • Saito H. Regulation of cross-talk in yeast MAPK signaling pathways. Curr Opin Microbiol 2010; 13:677-683.
    • (2010) Curr. Opin. Microbiol. , vol.13 , pp. 677-683
    • Saito, H.1
  • 15
    • 0242643610 scopus 로고    scopus 로고
    • Sustained activation of c-jun-terminal kinase (JNK) is closely related to arsenic trioxide-induced apoptosis in an acute myeloid leukemia (M2)-derived cell line, NKM-1
    • DOI 10.1038/sj.leu.2403120
    • Kajiguchi T, Yamamoto K, Hossain K, Akhand AA, Nakashima I, Naoe T, et al. Sustained activation of c-jun-terminal kinase (JNK) is closely related to arsenic trioxide-induced apoptosis in an acute myeloid leukemia (M2)-derived cell line, NKM-1. Leukemia 2003; 17:2189-2195. (Pubitemid 37428385)
    • (2003) Leukemia , vol.17 , Issue.11 , pp. 2189-2195
    • Kajiguchi, T.1    Yamamoto, K.2    Hossain, K.3    Akhand, A.A.4    Nakashima, I.5    Naoe, T.6    Saito, H.7    Emi, N.8
  • 17
    • 77954587919 scopus 로고    scopus 로고
    • Epigallocatechin-3-gallate induces apoptosis and suppresses proliferation by inhibiting the human Indian hedgehog pathway in human chondrosarcoma cells
    • Tang GQ, Yan TQ, Guo W, Ren TT, Peng CL, Zhao H, et al. (-)-Epigallocatechin-3-gallate induces apoptosis and suppresses proliferation by inhibiting the human Indian Hedgehog pathway in human chondrosarcoma cells. J Cancer Res Clin Oncol 2010; 136: 1179-1185.
    • (2010) J. Cancer Res. Clin. Oncol. , vol.136 , pp. 1179-1185
    • Tang, G.Q.1    Yan, T.Q.2    Guo, W.3    Ren, T.T.4    Peng, C.L.5    Zhao, H.6
  • 18
    • 27844539756 scopus 로고    scopus 로고
    • Protein kinase C and the regulation of the actin cytoskeleton
    • DOI 10.1016/j.cellsig.2005.07.010, PII S089865680500183X
    • Larsson C. Protein kinase C and the regulation of the actin cytoskeleton. Cell Signal 2006; 18:276-284. (Pubitemid 41661343)
    • (2006) Cellular Signalling , vol.18 , Issue.3 , pp. 276-284
    • Larsson, C.1
  • 20
    • 0030093706 scopus 로고    scopus 로고
    • Collagenases and tissue inhibitors of metalloproteinases: A functional balance in tissue degradation
    • Reynolds JJ. Collagenases and tissue inhibitors of metalloproteinases: a functional balance in tissue degradation. Oral Dis 1996; 2:70-76. (Pubitemid 126602152)
    • (1996) Oral Diseases , vol.2 , Issue.1 , pp. 70-76
    • Reynolds, J.J.1
  • 21
    • 0034143594 scopus 로고    scopus 로고
    • Apoptosis induction by arsenic: Mechanisms of action and possible clinical applications for treating therapy-resistant cancers
    • DOI 10.1054/drup.2000.0114
    • Bode A, Dong Z. Apoptosis induction by arsenic: mechanisms of action and possible clinical applications for treating therapy-resistant cancers. Drug Resist Updat 2000; 3:21-29. (Pubitemid 30246565)
    • (2000) Drug Resistance Updates , vol.3 , Issue.1 , pp. 21-29
    • Bode, A.1    Dong, Z.2
  • 22
  • 23
    • 77957119311 scopus 로고    scopus 로고
    • Stathmin is involved in arsenic trioxide-induced apoptosis in human cervical cancer cell lines via PI3K linked signal pathway
    • Wang X, Ren JH, Lin F,Wei JX, Long M, Yan L, et al. Stathmin is involved in arsenic trioxide-induced apoptosis in human cervical cancer cell lines via PI3K linked signal pathway. Cancer Biol Ther 2010; 10:632-643.
    • (2010) Cancer Biol. Ther. , vol.10 , pp. 632-643
    • Wang, X.1    Ren, J.H.2    Lin, F.3    Wei, J.X.4    Long, M.5    Yan, L.6
  • 25
    • 13244291368 scopus 로고    scopus 로고
    • Arsenic trioxide prevents radiation-enhanced tumor invasiveness and inhibits matrix metalloproteinase-9 through downregulation of nuclear factor kappaB
    • Wei LH, Lai KP, Chen CA, Cheng CH, Huang YJ, Chou CH, et al. Arsenic trioxide prevents radiation-enhanced tumor invasiveness and inhibits matrix metalloproteinase-9 through downregulation of nuclear factor kappaB. Oncogene 2005; 24:390-398.
    • (2005) Oncogene , vol.24 , pp. 390-398
    • Wei, L.H.1    Lai, K.P.2    Chen, C.A.3    Cheng, C.H.4    Huang, Y.J.5    Chou, C.H.6
  • 26
    • 77951630370 scopus 로고    scopus 로고
    • Impact of EWS-ETS fusion type on disease progression in Ewings sarcoma/peripheral primitive neuroectodermal tumor: Prospective results from the cooperative Euro-E.W.I.N.G 99 trial
    • Le Deley MC, Delattre O, Schaefer KL, Burchill SA, Koehler G, Hogendoorn PC, et al. Impact of EWS-ETS fusion type on disease progression in Ewing's sarcoma/peripheral primitive neuroectodermal tumor: prospective results from the cooperative Euro-E.W.I.N.G. 99 trial. J Clin Oncol 2010; 28:1982-1988.
    • (2010) J. Clin. Oncol. , vol.28 , pp. 1982-1988
    • Le Deley, M.C.1    Delattre, O.2    Schaefer, K.L.3    Burchill, S.A.4    Koehler, G.5    Hogendoorn, P.C.6
  • 28
    • 78650958235 scopus 로고    scopus 로고
    • Arsenic trioxide inhibits human cancer cell growth and tumor development in mice by blocking Hedgehog/GLI pathway
    • Beauchamp EM, Ringer L, Bulut G, Sajwan KP, Hall MD, Lee YC, et al. Arsenic trioxide inhibits human cancer cell growth and tumor development in mice by blocking Hedgehog/GLI pathway. J Clin Invest 2011; 121: 148-160.
    • (2011) J. Clin. Invest , vol.121 , pp. 148-160
    • Beauchamp, E.M.1    Ringer, L.2    Bulut, G.3    Sajwan, K.P.4    Hall, M.D.5    Lee, Y.C.6
  • 29
    • 41549102101 scopus 로고    scopus 로고
    • Berberine enhances inhibition of glioma tumor cell migration and invasiveness mediated by arsenic trioxide
    • Lin TH, Kuo HC, Chou FP, Lu FJ. Berberine enhances inhibition of glioma tumor cell migration and invasiveness mediated by arsenic trioxide. BMC Cancer 2008; 8:58.
    • (2008) BMC Cancer , vol.8 , pp. 58
    • Lin, T.H.1    Kuo, H.C.2    Chou, F.P.3    Lu, F.J.4
  • 30
    • 0025611427 scopus 로고
    • Type IV collagenases in tumor invasion and metastasis
    • Stetler-Stevenson WG. Type IV collagenases in tumor invasion and metastasis. Cancer Metastasis Rev 1990; 9:289-303.
    • (1990) Cancer Metastasis Rev. , vol.9 , pp. 289-303
    • Stetler-Stevenson, W.G.1
  • 31
    • 79961016507 scopus 로고    scopus 로고
    • Arsenic trioxide and radiation enhance apoptotic effects in HL-60 cells through increased ROS generation and regulation of JNK and p38 MAPK signaling pathways
    • Ho SY,Wu WJ, Chiu HW, Chen YA, Ho YS, Guo HR, et al. Arsenic trioxide and radiation enhance apoptotic effects in HL-60 cells through increased ROS generation and regulation of JNK and p38 MAPK signaling pathways. Chem Biol Interact 2011; 193:162-171.
    • (2011) Chem. Biol. Interact , vol.193 , pp. 162-171
    • Ho, S.Y.1    Wu, W.J.2    Chiu, H.W.3    Chen, Y.A.4    Ho, Y.S.5    Guo, H.R.6
  • 32
    • 33745936962 scopus 로고    scopus 로고
    • Opposing effects of arsenic trioxide on hepatocellular carcinomas in mice
    • DOI 10.1111/j.1349-7006.2006.00230.x
    • Liu B, Pan S, Dong X, Qiao H, Jiang H, Krissansen GW, et al. Opposing effects of arsenic trioxide on hepatocellular carcinomas in mice. Cancer Sci 2006; 97:675-681. (Pubitemid 44056616)
    • (2006) Cancer Science , vol.97 , Issue.7 , pp. 675-681
    • Liu, B.1    Pan, S.2    Dong, X.3    Qiao, H.4    Jiang, H.5    Krissansen, G.W.6    Sun, X.7
  • 33
    • 77950058429 scopus 로고    scopus 로고
    • Blockage of JNK pathway enhances arsenic trioxide-induced apoptosis in human keratinocytes
    • Huang HS, Liu ZM, Hong DY. Blockage of JNK pathway enhances arsenic trioxide-induced apoptosis in human keratinocytes. Toxicol Appl Pharmacol 2010; 244:234-241.
    • (2010) Toxicol. Appl. Pharmacol. , vol.244 , pp. 234-241
    • Huang, H.S.1    Liu, Z.M.2    Hong, D.Y.3
  • 34
    • 0029926229 scopus 로고    scopus 로고
    • Stimulation of 92-kDa gelatinase B promoter activity by ras is mitogen-activated protein kinase kinase 1-independent and requires multiple transcription factor binding sites including closely spaced PEA3/ets and AP-1 sequences
    • Gum R, Lengyel E, Juarez J, Chen JH, Sato H, Seiki M, et al. Stimulation of 92-kDa gelatinase B promoter activity by ras is mitogen-activated protein kinase kinase 1-independent and requires multiple transcription factor binding sites including closely spaced PEA3/ets and AP-1 sequences. J Biol Chem 1996; 271:10672-10680.
    • (1996) J. Biol. Chem. , vol.271 , pp. 10672-10680
    • Gum, R.1    Lengyel, E.2    Juarez, J.3    Chen, J.H.4    Sato, H.5    Seiki, M.6
  • 35
    • 0033848986 scopus 로고    scopus 로고
    • Matrix metalloproteinases: Effectors of development and normal physiology
    • Vu TH, Werb Z. Matrix metalloproteinases: effectors of development and normal physiology. Genes Dev 2000; 14:2123-2133.
    • (2000) Genes Dev , vol.14 , pp. 2123-2133
    • Vu, T.H.1    Werb, Z.2
  • 36
    • 0038495741 scopus 로고    scopus 로고
    • JNK phosphorylates paxillin and regulates cell migration
    • DOI 10.1038/nature01745
    • Huang C, Rajfur Z, Borchers C, Schaller MD, Jacobson K. JNK phosphorylates paxillin and regulates cell migration. Nature 2003; 424:219-223. (Pubitemid 36858692)
    • (2003) Nature , vol.424 , Issue.6945 , pp. 219-223
    • Huang, C.1    Rajfur, Z.2    Borchers, C.3    Schaller, M.D.4    Jacobson, K.5
  • 37
    • 77954840281 scopus 로고    scopus 로고
    • Activation of toll-like receptors 2 3 or 5 induces matrix metalloproteinase-1 and -9 expression with the involvement of MAPKs and NF-kappaB in human epidermal keratinocytes
    • Lee Y, Kim H, Kim S, Kim KH, Chung JH. Activation of toll-like receptors 2, 3 or 5 induces matrix metalloproteinase-1 and -9 expression with the involvement of MAPKs and NF-kappaB in human epidermal keratinocytes. Exp Dermatol 2010; 19: e44-e49.
    • (2010) Exp. Dermatol. , vol.19
    • Lee, Y.1    Kim, H.2    Kim, S.3    Kim, K.H.4    Chung, J.H.5
  • 38
    • 79955424699 scopus 로고    scopus 로고
    • C-Jun N-terminal kinase 2 JNK2 enhances cell migration through epidermal growth factor substrate 8 EPS8
    • Mitra S, Lee JS, Cantrell M, Van den Berg CL. c-Jun N-terminal kinase 2 (JNK2) enhances cell migration through epidermal growth factor substrate 8 (EPS8). J Biol Chem 2011; 286:15287-15297.
    • (2011) J. Biol. Chem. , vol.286 , pp. 15287-15297
    • Mitra, S.1    Lee, J.S.2    Cantrell, M.3    Van Den Berg, C.L.4
  • 39
    • 77958008016 scopus 로고    scopus 로고
    • Alpha-solanine inhibits human melanoma cell migration and invasion by reducing matrix metalloproteinase-2/9 activities
    • Lu MK, Shih YW, Chang Chien TT, Fang LH, Huang HC, Chen PS. alpha-Solanine inhibits human melanoma cell migration and invasion by reducing matrix metalloproteinase-2/9 activities. Biol Pharm Bull 2010; 33:1685-1691.
    • (2010) Biol. Pharm. Bull. , vol.33 , pp. 1685-1691
    • Lu, M.K.1    Shih, Y.W.2    Chang Chien, T.T.3    Fang, L.H.4    Huang, H.C.5    Chen, P.S.6
  • 40
    • 76549130383 scopus 로고    scopus 로고
    • P38 mitogen-activated protein kinase-driven MAPKAPK2 regulates invasion of bladder cancer by modulation of MMP-2 and MMP-9 activity
    • Kumar B, Koul S, Petersen J, Khandrika L, Hwa JS, Meacham RB, et al. p38 mitogen-activated protein kinase-driven MAPKAPK2 regulates invasion of bladder cancer by modulation of MMP-2 and MMP-9 activity. Cancer Res 2010; 70:832-841.
    • (2010) Cancer Res. , vol.70 , pp. 832-841
    • Kumar, B.1    Koul, S.2    Petersen, J.3    Khandrika, L.4    Hwa, J.S.5    Meacham, R.B.6
  • 41
  • 42
    • 0025720735 scopus 로고
    • The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation
    • Angel P, Karin M. The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation. Biochim Biophys Acta 1991; 1072: 129-157. (Pubitemid 121007534)
    • (1991) Biochimica et Biophysica Acta - Reviews on Cancer , vol.1072 , Issue.2-3 , pp. 129-157
    • Angel, P.1    Karin, M.2
  • 43
    • 0029032249 scopus 로고
    • The regulation of AP-1 activity by mitogen-activated protein kinases
    • Karin M. The regulation of AP-1 activity by mitogen-activated protein kinases. J Biol Chem 1995; 270:16483-16486.
    • (1995) J. Biol. Chem. , vol.270 , pp. 16483-16486
    • Karin, M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.